ЭЛЕКТРОННЫЙ МОНИТОР АРТЕРИАЛЬНОГО ДАВЛЕНИЯ (ВАРИАНТЫ)

Изобретение относится к монитору артериального давления с усовершенствованной функцией отображения результатов измерения. В электронном мониторе артериального давления секция сохранения данных сохраняет данные артериального давления, полученные измерением артериального давления, в памяти в связи с условиями на момент измерения артериального давления. Секция вычисления среднего значения вычисляет средние данные артериального давления на основании группы данных артериального давления, измеренных после вставания с постели, в памяти, а также вычисляет средние данные артериального давления на основании группы данных артериального давления, измеренных перед укладыванием в постель, в памяти. Секция управления отображением отображает отношение между вычисленными средними данными артериального давления на дисплейной секции заданным методом отображения. Устройство обеспечивает повышенную информационную наглядность отображения результатов в разных условиях измерения. 5 н. и 11 з.п. ф-лы, 36 ил.

КОЛИЧЕСТВЕННЫЙ ПОКАЗАТЕЛЬ ПРЕДУПРЕЖДЕНИЯ ОБ УХУДШЕНИИ РАБОТЫ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ

Изобретение относится к медицине, а именно к медицинскому мониторингу. Предложены некратковременный носитель для хранения инструкций с целью медицинского мониторинга и монитор, содержащий: дисплейную часть; датчики, считывающие жизненные показатели обследуемого человека, в том числе по меньшей мере один параметр сердечно-сосудистой системы и по меньшей мере один параметр дыхания; и микропроцессор или микроконтроллер, запрограммированный на выполнение способа определения количественных показателей раннего предупреждения для сердечно-сосудистой системы (ОКПРПССС), включающего следующие операции: (i) классифицирование обследуемого человека с использованием классификаторов ухудшения работы сердечно-сосудистой системы, каждый из которых обучен для классифицирования обследуемого человека в соответствии с различным типом ухудшения работы сердечно-сосудистой системы, для генерирования количественных показателей раннего предупреждения для сердечно-сосудистой системы по различным типам ухудшения ...

МЕТАБОЛИЧЕСКИЙ КОНТРОЛЬ, СПОСОБ И УСТРОЙСТВО ДЛЯ ПОЛУЧЕНИЯ ПОКАЗАНИЙ ОБ ОПРЕДЕЛЯЮЩЕМ ЗДОРОВЬЕ СОСТОЯНИИ ОБСЛЕДУЕМОГО ЛИЦА

Группа изобретений относится к медицинской технике и предназначено для получения показаний об определяющем здоровье состоянии обследуемого лица. Устройство содержит входной интерфейс, предиктор, фильтр, выходной интерфейс. Входной интерфейс выполнен с возможностью получения исходной последовательности замеров первого биологического количественного параметра и получения исходной последовательности замеров второго биологического количественного параметра. Предиктор предназначен для обеспечения, для некоторого момента времени, для которого не существует замера первого биологического количественного параметра, расчетного значения первого биологического количественного параметра в качестве спрогнозированного замера с использованием замеров второго биологического количественного параметра и, насколько возможно, замеров первого количественного параметра. Фильтр используется для фильтрации последовательности, содержащей замеры первого биологического количественного параметра и, по меньшей мере, ...

АВТОМАТИЧЕСКАЯ ИДЕНТИФИКАЦИЯ ИНФАРКТ-ЗАВИСИМОЙ КОРОНАРНОЙ АРТЕРИИ ПУТЕМ АНАТОМИЧЕСКИ ОРИЕНТИРОВАННОГО ОТОБРАЖЕНИЯ НА ДИСПЛЕЕ ДАННЫХ ЭКГ

Изобретение относится к медицинской технике. Система мониторирования ЭКГ для определения инфаркт-зависимой коронарной артерии, связанной с острым инфарктом миокарда, содержит ряд электродов для сбора данных по электрической активности сердца от разных точек наблюдения по отношению к сердцу. С электродами связан модуль сбора данных ЭКГ. Процессор ЭКГ реагирует на сигналы электродов для образования множества сигналов отведений и обнаруживает подъемы ST в сигналах отведений. Дисплей реагирует на обнаруженные подъемы ST и графически отображает каждое множество данных подъема ST по отношению к анатомическим позициям отведений. Графическое изображение на дисплее идентифицирует подозреваемую инфаркт-зависимую коронарную артерию или ветвь, связанную с острым ишемическим приступом. При этом принимают сигналы ЭКГ в n-отведениях. Анализируют сигналы ЭКГ применительно к данным о подъемах ST. Графически отображают на дисплее данные о каждом множестве подъемов ST по отношению к анатомическим позициям ...

ГЕМОДИНАМИЧЕСКИЕ МОНИТОРЫ И УСТРОЙСТВА ТРЕВОЖНОЙ СИГНАЛИЗАЦИИ

Изобретение относится к медицинской технике, а именно к системам медицинского контроля. Прибор для гемодинамического мониторирования содержит процессор и устройство вывода с устройством тревожной сигнализации. Процессор выполнен с возможностью получения физиологических параметров, характеризующих частоту сердечных сокращений и артериальное давление, и вычисления гемодинамического параметра в соответствии с системным сосудистым сопротивлением (SVR). В способе мониторирования вычисленный количественный гемодинамический параметр количественно выражает эвристическое правило «количественный измеренный показатель АВР является низким, И количественный измеренный показатель HR является немного повышенным или высоким», ИЛИ «количественный измеренный показатель АВР является очень низким», при этом при его вычислении определяют первую нечеткую переменную, указывающую, является ли количественный измеренный показатель HR немного повышенным или высоким, вторую нечеткую переменную, указывающую, является ...

Процессор для обработки данных электропроводности кожи и устройство для обнаружения по меньшей мере одной стадии синдрома выгорания и/или синдрома хронической усталости живого существа

Группа изобретений относится к медицине. Способ обработки данных осуществляют с помощью устройства для обнаружения стадий стрессового состояния живого существа. Устройство содержит измерительный блок для измерения данных электропроводности кожи за промежуток времени и процессор (10) для обработки данных электропроводности кожи живого существа. Процессор содержит блок (12) ввода для приема сигнала (13) данных электропроводности кожи, содержащего пиковые данные, вычислительный блок (14) и анализирующий блок (16). Вычислительный блок (14) осуществляет вычисление сигнала данных пиковых значений электропроводности кожи за день путем получения характеристики, связанной с указанными пиками данных, и формирования суммы значений указанной характеристики за единицу времени. Анализирующий блок (16) анализирует среднее значение и/или абсолютное значение сигнала данных пиковых значений электропроводности кожи за часть указанного периода времени для получения информации о стадии стрессового состояния ...

МЕДИЦИНСКАЯ СИСТЕМА УДАЛЕННОГО МОНИТОРИНГА, АНАЛИЗА И ПРОГНОЗИРОВАНИЯ СОСТОЯНИЯ ПАЦИЕНТА ПО ПОСЛЕДОВАТЕЛЬНОСТИ ЭЛЕКТРОКАРДИОГРАММ СЕРДЦА ПЕРВОГО ОТВЕДЕНИЯ И КОМПЬЮТЕРИЗИРОВАННЫЙ СПОСОБ МОНИТОРИНГА, АНАЛИЗА И ПРОГНОЗИРОВАНИЯ СОСТОЯНИЯ ПАЦИЕНТА

Группа изобретений относится к медицине, а именно к системе и компьютеризированному способу удаленного мониторинга, анализа и прогнозирования состояния пациента по последовательности электрокардиограмм (ЭКГ). При этом для каждого пациента из наблюдаемого множества осуществляют накопление в базе данных последовательности его ЭКГ, маркированных идентификаторами пациента. Выделяют по запросу врача подмножество ЭКГ, которые объединяют в целевую группу по идентификаторам пациента и в соответствии с заданными в запросе врача ограничениями. Осуществляют кластеризацию выделенного подмножества путем объединения ЭКГ в кластер по признаку взаимного подобия их форм. Определяют меру подобия форм в пространстве признаков форм ЭКГ. Каждой ЭКГ ставят в соответствие дискретизированную ЭКГ (ДЭКГ), представляющую собой точку с координатами, значения которых несут информацию о форме исходной ЭКГ. Мера подобия форм между парами ЭКГ задается в виде расстояния между соответствующими им парами точек ДЭКГ. Для ...

УСТРОЙСТВО МОНИТОРИНГА СЕРДЕЧНЫХ СОКРАЩЕНИЙ

Группа изобретений относится к медицинской технике. Способ мониторинга сердечных сокращений пользователя осуществляется с помощью устройства (100) мониторинга сердечных сокращений. Устройство содержит основной датчик (110) для измерения частоты сердечных сокращений пользователя, вспомогательный датчик (120) для измерения одного физиологического показателя, блок (160) управления питанием для управления работой основного датчика (110) на основании информации (126), полученной от вспомогательного датчика (120), блок (133) модели для оценки частоты сердечных сокращений пользователя на основании модели, которая хранится в блоке (133) модели, и информации (126), полученной от вспомогательного датчика (120). Основной датчик (110) имеет первый уровень потребления энергии. Вспомогательный датчик (120) имеет второй уровень потребления энергии, который ниже первого уровня потребления энергии. Блок (133) модели соединен с блоком (160) управления питанием с помощью контура обратной связи. Блок (160) ...

Система поддержки принятия клинических решений на основе принятия решений по сортировке пациентов

Группа изобретений относится к медицине, а именно к системе поддержки принятия клинических решений на основе принятия решений по сортировке пациентов. Система поддержки принятия клинических решений, содержащая машиночитаемый носитель данных для поддержки принятия клинических решений, закодированный машиночитаемыми командами для выполнения способа, причем система содержит вычислительную систему, которая включает в себя: по меньшей мере один вычислительный процессор; средства ввода/вывода и машиночитаемый носитель данных, закодированный модулем сортировки пациентов, при этом средства ввода/вывода выполнены с возможностью приема электрического сигнала, который включает в себя набор по меньшей мере двух измеренных физиологических параметров пациента, причем измерения одного и того же физиологического показателя выполнены в разных местах тела пациента; и по меньшей мере один вычислительный процессор выполнен с возможностью выполнения команд модуля сортировки пациентов, которые включают: сравнение ...

СПОСОБ И АППАРАТ ДЛЯ ОПРЕДЕЛЕНИЯ РИСКА ПОКИДАНИЯ ПАЦИЕНТОМ БЕЗОПАСНОЙ ОБЛАСТИ

Приемник для приема данных об аналите и способ его работы

Группа изобретений относится к медицине, а именно к работе приемника для приема данных об аналите. Предложен приемник для реализации способа, причем приемник выполнен с возможностью приема значений аналита, регистрируемых контролирующим аналит биосенсором, выполняемого посредством приемного узла через временные интервалы, для которых установлено первое значение временного интервала, выполняемого посредством приемного узла приема настоящего значения аналита, получения скорости изменения значений аналита, определения будущего значения аналита на основании настоящего значения аналита, первого значения временного интервала и скорости изменения значений аналита, получения диапазона значений аналита, задания второго значения временного интервала, которое меньше первого значения временного интервала, если будущее значение аналита находится за пределами диапазона значений аналита, и больше или равно первому значению временного интервала, если будущее значение аналита находится в пределах диапазона ...

ЭЛЕКТРОННЫЙ МОНИТОР АРТЕРИАЛЬНОГО ДАВЛЕНИЯ, ПОЗВОЛЯЮЩИЙ ВЫЧИСЛЯТЬ КОЛИЧЕСТВЕННУЮ ОЦЕНКУ, СВЯЗАННУЮ С РИСКОМ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ

Изобретение относится к электронному монитору артериального давления, позволяющему вычислять количественную оценку, связанную с риском сердечно-сосудистых заболеваний. В соответствии с главной программой, выполняемой центральным процессором (ЦП), совокупность фрагментов данных результатов измерения, измеренных в предписанный период, извлекается из данных артериального давления, сохраненных в памяти. ЦП определяет, присутствует ли, по меньшей мере, совокупность из предписанного количества фрагментов данных артериального давления, соответствующих каждому из совокупности условий измерения в извлеченной совокупности фрагментов данных артериального давления. Когда ЦП определяет, что, по меньшей мере, совокупность из предписанного количества фрагментов данных артериального давления существует, он вычисляет среднее значение группы данных артериального давления, которая включает в себя, по меньшей мере, совокупность из предписанного количества фрагментов данных артериального давления для каждого ...

СИСТЕМА И СПОСОБ ОПРЕДЕЛЕНИЯ КОЛИЧЕСТВЕННОГО ПОКАЗАТЕЛЯ РИСКА ГЕМОДИНАМИЧЕСКОЙ НЕСТАБИЛЬНОСТИ У ПЕДИАТРИЧЕСКИХ СУБЪЕКТОВ

ВЫБОР ДЫХАТЕЛЬНОГО ЦИКЛА ДЛЯ АНАЛИЗА

УСТРОЙСТВО (ВАРИАНТЫ) И СПОСОБ АВТОМАТИЧЕСКОГО МОНИТОРИНГА ПРИВЫЧЕК ПИТАНИЯ

УСТРОЙСТВА И СПОСОБЫ ДЛЯ ДИАГНОСТИКИ ДИСФУНКЦИИ ГЛОТАНИЯ

... 1. Устройство, содержащее гибкую подложку и по меньшей мере одну печатную электронную схему, выбранную из группы, состоящей из микроконтроллера, по меньшей мере одного датчика, антенны и их комбинаций, в котором гибкая подложка и, по меньшей мере, одна печатная электронная схема заключены в полимерную пленку.2. Устройство по п.1, в котором гибкая подложка содержит полимер, выбранный из группы, состоящей из полиэтиленнафталата (ПЭН), полиэтилентерефталата (ПЭТ) и их комбинации.3. Устройство тестирования глотания, содержащее:устройство, содержащее гибкую подложку и по меньшей мере одну печатную электронную схему, выбранную из группы, состоящей из микроконтроллера, по меньшей мере одного датчика, антенны и их комбинаций, в котором гибкая подложка и по меньшей мере одна печатная электронная схема заключены в полимерную пленку; ибазу данных пациента, содержащую статистически значимые данные, относящиеся к по меньшей мере одному профилю глотания.4. Устройство тестирования глотания по п.3, в котором ...

БИОМЕДИЦИНСКИЕ УСТРОЙСТВА ДЛЯ ПЕРЕДАЧИ БИОМЕТРИЧЕСКОЙ ИНФОРМАЦИИ С ВОЗМОЖНОСТЬЮ ОБРАТНОЙ СВЯЗИ

СПОСОБ ВЫЯВЛЕНИЯ ОРДС И СИСТЕМЫ ДЛЯ ВЫЯВЛЕНИЯ ОРДС

ИЗМЕРИТЕЛЬ ВЛАГИ И ИЗМЕРИТЕЛЬ ВЛАГИ ТЕЛА

... 1. Измеритель влаги для измерения влагосодержания пациента, содержащий:измерительный блок для измерения влаги, удерживаемый подмышкой пациента, для измерения количества влаги пациента при нахождении в контакте с поверхностью кожи подмышки;измерительный блок для измерения температуры и влажности окружающей среды пациента ивычислительный блок, который получает количество влаги пациента от измерительного блока для измерения влаги, задает значение температуры по шаровому влажному термометру (WBGT) из соотношения между температурой и влажностью от измерительного блока и определяет показатель риска теплового удара путем обращения к таблице соотношений между количеством влаги пациента и значением температуры по шаровому влажному термометру (WBGT).2. Измеритель по п.1, содержащий:основной корпусный блок;крепежный блок для прикрепления измерительного блока, который размещен на одном конце основного корпусного блока, удерживает измерительный блок для измерения влаги и вставлен посередине подмышки ...

СПОСОБ И СИСТЕМА ДЛЯ УЛУЧШЕНИЯ ФИЗИОЛОГИЧЕСКОЙ РЕАКЦИИ

СПОСОБ ОЦЕНКИ СТЕПЕНИ РЕАБИЛИТАЦИИ С ИСПОЛЬЗОВАНИЕМ АКТИВНОГО ЭКЗОСКЕЛЕТА У ПАЦИЕНТОВ С НАРУШЕНИЯМИ ОПОРНО-ДВИГАТЕЛЬНОГО АППАРАТА

СПОСОБ АНАЛИЗА ФОРМИРОВАНИЯ ПСИХИЧЕСКИХ ОСОБЕННОСТЕЙ ЛИЧНОСТИ И ПАТОЛОГИЧЕСКИХ ОТКЛОНЕНИЙ ПСИХИКИ

... 1. Способ анализа формирования психических особенностей личности и патологических отклонений психики, включающий психодиагностическое исследование, отличающийся тем, что психодиагностическое исследование начинают со сбора анамнестических данных обследуемого человека и членов его рода, затем производят анализ биографических данных каждого члена рода обследуемого человека с определением типа личности, особенности и динамики его семейных отношений методом интегральной психогенетической реконструкции и устанавливают родовой анамнез обследуемого человека с учетом временных факторов, социально-исторических, этнических особенностей и условий жизни обследуемого человека и членов его рода, затем составляют родовую психогенограмму обследуемого человека, после чего определяют психическое состояние обследуемого человека на момент обследования и прогнозируют возможность патологических отклонений психики исходя из условия, что основные параметры формирования психических свойств и качеств личности наследуются ...

СПОСОБ ИСПЫТАНИЯ АНАЛИТА И СИСТЕМА ОПОВЕЩЕНИЯ О ТЕНДЕНЦИЯХ ПОКАЗАНИЙ В СТОРОНУ ПОВЫШЕНИЯ И ПОНИЖЕНИЯ УРОВНЯ ГЛЮКОЗЫ В КРОВИ

... 1. Способ уведомления пользователя о тенденции изменения показаний в сторону понижения или повышения уровня глюкозы в крови, которые были получены при помощи устройства для управления течением диабета, содержащего микропроцессор, соединенный с дисплеем, постоянное запоминающее устройство и кнопки интерфейса пользователя; при этом способ содержит этапы:выполняют при помощи микропроцессора множество измерений уровня глюкозы в крови пользователя;сохраняют в запоминающем устройстве множество измерений уровня глюкозы в крови;определяют, является ли последнее измерение уровня глюкозы в крови, проведенное в заданный момент времени в течение дня, ниже первого порога, который составляет около 70 мг глюкозы на децилитр крови, или выше второго порога, который составляет около 150 мг глюкозы на децилитр крови;оценивают при помощи микропроцессора, было ли, по меньшей мере, одно измерение уровня глюкозы из множества измерений, проведенных в интервале времени продолжительностью приблизительно 3 ч относительно ...

СПОСОБ, УСТРОЙСТВО И СИСТЕМА ДЛЯ АВТОМАТИЧЕСКОГО УПРАВЛЕНИЯ ПОДАЧЕЙ ВДЫХАЕМОГО КИСЛОРОДА

СИСТЕМА И СПОСОБ КОНТРОЛЯ ЛЕГОЧНОЙ ГИПЕРЕМИИ

... 1. Система, выполненная с возможностью контроля легочной гиперемии у субъекта, причем упомянутая система содержит:интерфейс пользователя, выполненный с возможностью обеспечения взаимодействия пользователя с системой;один или более процессоров, выполненных с возможностью реализации множества компьютерных программных модулей, причем компьютерные программные модули, содержат:модуль параметров, выполненный с возможностью приема выходных сигналов от одного или более датчиков, выполненных с возможностью контроля газа вдыхаемого субъектом, причем выходные сигналы несут информацию о газе, вдыхаемом субъектом, и модуль параметров дополнительно выполнен с возможностью определения одного или более параметров дыхания субъекта из принятых выходных сигналов;модуль контроля гиперемии, выполненный с возможностью идентификации легочной гиперемии у субъекта, основываясь на одном или более параметрах дыхания субъекта, определенных модулем параметров; имодуль уведомления, выполненный с возможностью управления ...

УСТРОЙСТВО ДЛЯ ИСПОЛЬЗОВАНИЯ В ДЕТЕКТОРЕ ПАДЕНИЯ ИЛИ СИСТЕМЕ ОБНАРУЖЕНИЯ ПАДЕНИЙ И СПОСОБ УПРАВЛЕНИЯ ТАКИМ УСТРОЙСТВОМ

... 1. Способ управления детектором падения, при этом способ содержит этапы, на которых:при обнаружении события падения, совершенного пользователем детектора падения, измеряют, по меньшей мере, одну физиологическую характеристику пользователя; ииспользуют результат измерения, по меньшей мере, одной физиологической характеристики для определения, следует ли отправлять сигнал тревоги о том, что пользователь совершил падение, путемопределения, отклоняется ли результат измерения, по меньшей мере, одной физиологической характеристики от нормального значения, по меньшей мере, для этой одной физиологической характеристики;отправки сигнала тревоги о том, что пользователь совершил падение, если, по меньшей мере, одна физиологическая характеристика отклоняется от нормального значения, по меньшей мере, для этой одной физиологической характеристики; ивыдачи несрочного сигнала тревоги о том, что пользователь совершил падение, если, по меньшей мере, одна физиологическая характеристика не отклоняется от нормального ...

МАГНИТОРЕЗОНАНСНАЯ ТЕРМОГРАФИЯ: ФОРМИРОВАНИЕ ИЗОБРАЖЕНИЙ ВЫСОКОГО РАЗРЕШЕНИЯ ДЛЯ ТЕПЛОВЫХ АНОМАЛИЙ

... 1. Магниторезонансная система (10), содержащая:магниторезонансный сканнер (12), сконфигурированный для термографического измерения;один или более процессоров (28), который принимает (56) данные теплового изображения от магниторезонансного сканнера и реконструирует по меньшей мере одно тепловое изображение, в котором каждый воксел представляющей интерес области включает в себя меру изменения температуры; и идентифицирует (58) вокселы с тепловой аномалией в тепловом изображении;устройство (44) отображения, которое отображает по меньшей мере одно реконструированное изображение с идентифицированными вокселами с тепловой аномалией.2. Магниторезонансная система (10) по п. 1, дополнительно включающая в себя диагностическую базу (38) данных, которая хранит по меньшей мере характеристику измерений изменения температуры по меньшей мере одного аномального состояния; и в которой процессор дополнительно сравнивает измеренные тепловые изменения с изменениями температуры сохраненной характеристики.3.

ЭЛЕКТРОННЫЙ МОНИТОР АРТЕРИАЛЬНОГО ДАВЛЕНИЯ И УСТРОЙСТВО И СПОСОБ ОБРАБОТКИ ДАННЫХ ИЗМЕРЕНИЯ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ

... 1. Электронный монитор (1) артериального давления, содержащий блок измерения артериального давления, измеряющий артериальное давление обследуемого лица; блок (12) памяти; дисплей (4); блок (30) сохранения данных, сохраняющий данные артериального давления, показывающие упомянутое артериальное давление, измеренное упомянутым блоком измерения артериального давления, в упомянутом блоке памяти в связи с типом условий измерения на момент измерения артериального давления; и блок (20) управления; при этом упомянутый блок управления выполнен с возможностью считывания группы данных артериального давления, измеренных в упомянутых условиях измерения первого типа, и группы данных артериального давления, измеренных в упомянутых условиях измерения второго типа, отличающегося от упомянутого первого типа, из упомянутого блока памяти, отображения каких-то одних из репрезентативных данных артериального давления, представляющих считанную группу данных артериального давления, измеренных в упомянутых условиях ...

Antihypertensive agents and use.

The invention is a pharmaceutical composition comprising a carboxyalkylether of the formula (I) wherein RI, R2, R3, and R4 include alkyl, alkenyl, and alkynyl, m and n are integers from 2 to 9, Y1 and Y2 include COOH, CHO, tetrazole, COOR5 where R5 is alkyl, alkenyl, or alkynyl, or a pharmaceutically acceptable salt thereof, and an antihypertensive agent, said composition being useful for treating vascular diseases. The invention includes a method of treating hypertension comprising administering a carboxyalkylether.

Antihypertensive agents and use.

Antihypertensive agents and use

EVALUATION PROCEDURE FOR PROCESSING A GLUCOSE CONCENTRATION SIGNAL

IMPLANTIERBARES MULTIPLE PARAMETER PERCEPTION SYSTEM AND PROCEDURE

PROCEDURE AND EQUIPMENT FOR RECOGNIZING HEART WEAKNESS

Methods of identifying schizophrenia patients at risk for relapse

The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use symptom monitoring according to a subset of Positive and Negative Syndrome Scale (PNASS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.

Breath selection for analysis

Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured. - 39- ...

A system for determining fluid level in a biological subject

A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

Analyte detection system

A system for detecting analytes in a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, and wherein a presence, absence, level or concentration of analytes is able to be detected by contact of the microneedles with the analytes causing a change in appearance in at least one of the microstructures, the substrate or the stratum corneum of the subject.

Implantable cardiac sensors

An implantable measurement device is disclosed which includes a first anchoring component which engages a first inner wall defining a first chamber of a heart, a first sensing element which performs physiologic measurements in the first chamber, and a second sensing element which performs physiologic measurements in the second chamber.

Systems and methods for detecting worsening heart failure

SYSTEMS AND METHODS FOR DETECTING WORSENING HEART FAILURE Systems and methods for detecting worsening cardiac conditions such as worsening heart failure events are de- scribed. A system may include sensor circuits to sense physiological signals and signal processors to generate from the physiological signals first and second signal metrics. The system may include a risk stratifier circuit to produce a cardiac risk indication. The system may use at least the first signal metric to generate a primary detection indication, and use at least the second signal metric and the risk indication to generate a secondary detection indication. The risk indication may be used to modulate the second signal metric. A detector circuit may detect the worsening cardiac event using the primary and secondary detection indications.

Negative pressure wound therapy system using eulerian video magnification

Embodiments of tissue monitoring in combination with negative pressure wound therapy systems and methods are disclosed. In some embodiments, a monitoring and therapy system comprises collecting video images of a tissue site and amplifying said video images via Eulerian Video Magnification. Depending upon the changes detected via Eulerian Video magnification, negative pressure wound therapy may be delivered to the tissue site, stopped, or altered in some manner.

Anaesthesia and Consciousness Depth Monitoring System

The present invention relates to the field of evoked electrophysiological potential signal monitoring and in particular can be applied as a means to determine the sentient state of an individual, and as a means to authenticate the physiological, electrical or electromagnetic source of a signal.

Glycemic urgency assessment and alerts interface

Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user - entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump. 0) E r-~ cz1 < <1 00 0I C\j _r _r *o 'o ii I 10 * ID C) C)C) )CDC C* I' )U' D *o :1 * l/w :1onE ...

UTILIZING A MACHINE LEARNING MODEL TO IDENTIFY ACTIVITIES AND DEVIATIONS FROM THE ACTIVITIES BY AN INDIVIDUAL

A device receives historical information associated with an individual to be monitored, wherein the historical information includes at least one of information associated with a health history of the individual, health histories of other individuals, activities of the individual, or activities of the other individuals. The device receives monitored information associated with the individual from one or more client devices associated with the individual, and pre processes the monitored information to generate pre-processed monitored information that is understood by the trained machine learning model. The device processes the pre processed monitored information, with a trained machine learning model, to identify one or more activities of the individual and one or more deviations from the one or more activities by the individual, and performs one or more actions based on the one or more activities of the individual and/or the one or more deviations from the one or more activities. 0095-0438AU ...

Multivariate residual-based health index for human health monitoring

Ambulatory or in-hospital monitoring of patients is provided with early warning and prioritization, enabling proactive intervention and amelioration of both costs and risks of health care. Multivariate physiological parameters are estimated by empirical model to remove normal variation. Residuals are tested using a multivariate probability density function to provide a multivariate health index for prioritizing medical effort.

Vaginal temperature sensing apparatus and methods

Embodiments of a vaginal temperature sensing apparatus, a visually sense-able battery power-on indicator (16), manufacturing with cure temperatures that protect a battery, substantially error-free, user-initiated device activation componentry (30) to start battery power, and a timer to automatically terminate flow of battery power. Data can by an automatic data transform recalculator (138) with body temperature dips in transformed and recalculated diurnal high body temperatures predict an ovulation event and provide an indication through a zenith based ovulation indicator (106). Systems can include neural network based artificial intelligence to automatically self-improve by using historical or even other, multi user data and user input and improve its indication result.

Improved healthcare interoperability environment system

The invention concerns an Interoperability Environment comprising: a core software engine comprising means to collect and transfer electronic data from any number of sources including medical devices, clinical information systems, hospital information systems, a means to apply rules to improve compliance with hospital approved protocols, standards and guidances, a means to update all subsystems using any given parameter when the parameter is updated in the official recognized source of truth for that parameter, a means to populate the CIS with all required patient information, while at the same time maintaining all quality and process control data in a format supporting advanced analytics separate from the CIS data, a means to communicate notifications to any number of remote electronic devices without limitation of platform and comprising a hardware eco system comprising means to collect, translate, store and send electronic data to the core software engine for any electronic source via ...

Diagnostic method for detection of fluid changes

C:\Interwoen\NRPortbl\DCC\DER493206_l.doex- 1/1/2019 A method for monitoring changes in a medium in a patient's head, the method comprising: placing a headset on the patient's head, wherein the headset comprises: a housing; a processor in the housing; a transmitter; and a receiver coupled with the headset such that it is located on approximately an opposite side of the patient's head from the transmitter when the headset is applied to the patient's head; transmitting from the transmitter a first time-varying magnetic field comprising a first plurality of frequencies that are harmonics of a first fundamental frequency; receiving the first time-varying magnetic field with the receiver; determining at least one of a first phase shift or a first magnitude change between the transmitted first magnetic field and the received first magnetic field; transmitting from the transmitter, at a later time, a second time-varying magnetic field comprising a second plurality of frequencies that are harmonics ...

Systems and methods for display device and sensor electronics unit communication

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Methods and systems for forecasting seizures

Abstract A method of estimating the probability of a seizure in a subject, the method comprising: receiving historical data associated with epileptic events experienced by the subject over a first time period, the historical data comprising physiological data associated with each epileptic event and a time at which each epileptic event occurred; generating a temporal probability model of future epileptic events based on the time of each of the epileptic events, the temporal probability model representing a probability of a future seizure occurrence in each of a plurality of time windows; generating a probabilistic model based on the physiological data associated with each epileptic event; weighting the probabilistic model based on the temporal probability model to generate a weighted probabilistic model of future seizure activity; and outputting an estimate of seizure probability in the subject using the weighted probabilistic model.

Assessing the condition of a joint and preventing damage

Method and apparatus for analyzing amniotic fluid

Within-patient algorithm to manage decompensation

Techniques for prediction and monitoring of clinical episodes

SYSTEM AND METHOD FOR ASSESSMENT OF HEALTH RISKS AND VISUALIZATION OF WEIGHT LOSS AND MUSCLE GAIN

Monitoring compliance using venous refill detection

MONITORING COMPLIANCE USING VENOUS REFILL Abstract Monitoring patient compliance with a compression therapy regimen (10). 5 Venous Refill Time (VRT) is monitored via a pressure sensor in a bladder of a compression system. A controller (26) of the compression system (10) correlates the monitored VRT to a predetermined threshold to determine whether the patient is using the compression system (10). C) 1/14 (NLU' LA Lu LUi =) 0 Iz LOfIZ Iz w 0Z 0 A 2ce i I c ceC00U ...

Event monitoring dosimetry apparatuses and methods thereof

A dosimetry apparatus includes at least one sensor in a housing, a cover configured to permit compression waves to pass through, the cover is seated over the at least one sensor, and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the at least one sensor; storing the readings with a time and date stamp when obtained; conducting an analysis based on the obtained readings; and outputting at least one of the stored readings or the conducted analysis.

System and process for analyzing a medical condition of a user

Methods for assessing erythema

The present invention relates to methods for an objective and quantitative erythema documentation and analysis. In particular, the invention relates to a method for assessing erythema of a subject comprising the steps of measuring the light reflectance of a skin or mucosal area of the subject, obtaining the L* value and the a* value of said measurement according to the L*a*b* color space, and calculating the erythema value according to the formula (L* ...

Systems and methods for providing an automated titration for oral appliance therapy

Provided herein are systems, methods and devices for performing one or more titrations for oral appliance therapy. For example, a method for evaluating an outcome of oral appliance therapy in a subject is discussed herein. The method can include positioning an adjustable mandibular displacement device in an oral cavity of a subject and implementing an automatic titration protocol. The protocol can include controlling a protrusion level of the adjustable mandibular displacement device during a test period, monitoring physiological information from the subject during the test period, and analyzing the physiological information to evaluate the outcome of oral appliance therapy.

BIOMEDICAL DEVICES FOR BIOMETRIC BASED INFORMATION COMMUNICATION

Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. The communication system may convey the biometric results to a processing system which may include resources such as servers to store the results in personalized databases. A biometric measurement result may trigger a communication of a biometric based information communication message based on the current measurement and historical measurements. 2813401vl z'110 120 -2 105 ...

BIOMEDICAL DEVICES FOR BIOMETRIC BASED INFORMATION COMMUNICATION AND SLEEP MONITORING

Methods and apparatus to form a biometric based information communication system are described. In some examples, the biometric based information communication system comprises biomedical devices with sensing means, wherein the sensing means produces a biometric result. 5 In some examples the biometric based information communication system may comprise a user device such as a smart phone paired in communication with the biomedical device. A biometric measurement result may trigger a communication of a biometric based information communication message. 2812654vl 130 -115 ...

Method and system of assessing or analyzing muscle characteristics including strength and tenderness using ultrasound

A method and system of predicting a muscle characteristic using ultrasound. The characteristic may include a tenderness characteristic and/or a strength characteristic. An analysis of muscle structure is performed for a sample using ultrasound data of the sample. The analysis may include determining a relative number of bundles, fascicles, sarcomeres, fibers, and/or sheath thickness from the ultrasound data. Thereafter, the muscle characteristic is predicted for the sample based on the analysis.

Exercise system and method

We here describe an exercise system and control method thereof to obtain exercise protocols relating to the individual user's optimal exercise intensity. The system and method comprise the monitoring of the transition between the aerobic and anaerobic training zones and an estimate of the maximal lactate steady state, which is an important physiological indicator of the user's cardio respiratory fitness. Together with individual models of how the user's heart rate responds to exercise intensity, it is possible to predict the needed exercise intensity that should be performed to obtain the wanted exercise goal. The analysis can (preferably) be performed in real-time during exercise.

A system and method for determining psychological stress of a person

A SYSTEM AND METHOD FOR DETERMINING PSYCHOLOGICAL STRESS OF A A system for determining stress level of a person in real-time have been disclosed. In one aspect, the system captures physiological data associated to the person. In one embodiment, the physiological data may be captured by using a plurality of sensors attached at wrist or ankle or neck or waist or hip of the person, for a predetermined time interval. The plurality of sensors may include a wrist watch or a wristband or a textile material. The system further pre-processes the physiological data in order to extract one or more physiological parameters. In one aspect, the pre-processing may include performing an analysis on the physiological data. The system further determines the stress level of the person upon performing the statistical analysis on the one or more physiological parameters. According to another embodiment, a method for real time determination of stress level of the person has also been provided. [To be published ...

Anaesthesia and Consciousness Depth Monitoring System

The present invention relates to the field of evoked electrophysiological potential signal monitoring and in particular can be applied as a means to determine the sentient state of an individual, and as a means to authenticate the physiological, electrical or electromagnetic source of a signal.

Diagnostic system for detection of fluid changes

A diagnostic system for monitoring changes in a medium is disclosed. The system includes a transmitter configured to generate and transmit a time-varying magnetic field into a medium responsive to a first signal. The system also includes a receiver positioned on an opposite side of the medium from the transmitter and configured to generate a second signal responsive to a received magnetic field at the receiver. The system also includes a processing unit configured to determine a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.

Method and system of assessing or analyzing muscle characteristics including strength and tenderness using ultrasound

A method and system of predicting a muscle characteristic using ultrasound. The characteristic may include a tenderness characteristic and/or a strength characteristic. An analysis of muscle structure is performed for a sample using ultrasound data of the sample. The analysis may include determining a relative number of bundles, fascicles, sarcomeres, fibers, and/or sheath thickness from the ultrasound data. Thereafter, the muscle characteristic is predicted for the sample based on the analysis.

Computer mouse system and associated, computer medium and computer-implemented methods for monitoring and improving health and productivity of employees

Provided are embodiments of systems, computer medium and computer-implemented methods for sensing health characteristics of a user using a computer mouse including, a temperature sensor, a blood condition sensor and a blood pressure sensor. A method for sensing health characteristics of a user using a computer mouse including receiving, from the temperature sensor, temperature data corresponding to a sensed body temperature of the user, receiving, from the blood condition sensor, blood condition data corresponding to a sensed blood saturation level of the user, receiving, from the blood pressure sensor, blood pressure data corresponding to a sensed blood pressure of the user, and transmitting, to the computer workstation, health data corresponding to the temperature data, the blood condition data, and the blood pressure data for use in determining the body temperature, the blood saturation level, and the blood pressure of the user.

Analyte meter with operational range configuration technique

Described are techniques governing the glycemic ranges that are applied and governed in the meter so the user is not required to understand or know the editing rules in order to use or set up the meter. These guiding principles will come into effect each time the user chooses to edit the ranges. There will be appropriate warning messages to inform the user if the user does not set the ranges correctly.

Automatic differential diagnosis of worsening heart failure

Devices and methods for differentially diagnosing between worsening heart failure (HF) and other diseases or medical conditions are described. A medical system can receive patient information including one or more physiologic signals, and detect a respective physiologic feature from each of the one or more received physiologic signals. The medical system can include a differential diagnosis circuit that generates one or more signal metrics, receive two or more candidate conditions associated with the change in patient physical or physiological status, and determine a respective diagnostic score for each of the candidate conditions. The diagnostic score can indicate likelihood the change in the patient physical or physiologic status being caused by the corresponding candidate condition. A user interface can be provided to generate a presentation of the detected physiologic features and the diagnostic scores associated with the candidate conditions.

System, device and method of dynamic glucose profile response to physiological parameters

Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.

Method and system for patient-specific modeling of blood flow

C:\Users\kll\AppData\Local\Temp12713 IDAOBAFC.DOCX-22 12/2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Apparatus, systems and methods for predicting, screening and monitoring of encephalopathy / delirium

The disclosed apparatus, systems and methods relate to predicting, screening, and monitoring for delirium. Systems and methods may include receiving one or more signals from one or more sensing devices; processing the one or more signals to extract one or more features from the one or more signals; analyzing the one or more features to determine one or more values for each of the one or more features; comparing at least one of the one or more values or a measure based on at least one of the one or more values to a threshold; determining a presence, absence, or likelihood of the subsequent development of delirium for a patient based on the comparison; and outputting an indication of the presence, absence, or likelihood of the subsequent development of delirium for the patient.

Method and Apparatus for Monitoring Cardio-Pulmonary Health

... 11 (K Disclosed is a cardio-pulmonary health monitoring apparatus. The apparatus comprises a contactless motion sensor configured to generate one or more movement signals representing bodily movement of a patient during a monitoring session; a processor; and a memory storing program instructions configured to cause the processor to carry out a method of processing the one or more movement signals. The method comprises extracting one or more sleep disordered breathing features from the one or more movement signals, and predicting whether a clinical event is likely to occur during a predetermined prediction horizon based on the one or more sleep disordered breathing features. A29446532.0116 ...

Method and system for patient-specific modeling of blood flow

Abstract A system for determining cardiovascular information for a patient, the system comprising: at least one computer system configured to: receive patient specific data regarding a geometry of an anatomical structure of the patient; create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet; create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on modeling a condition of hyperemia; and determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three dimensional model and the at least one boundary condition model. cCD Co co VC C C) C) f I co C, Loij 0~ u~ EtIt C3oI ...

Cardiac vulnerability tracking method and apparatus

Method for determining care and prevention pathways for clinical management of wounds

Assessing the condition of a joint and preventing damage

MANAGING AND PROCESSING SELF-MONITORING BLOOD GLUCOSE

A method, system, and computer program product related to the maintenance of optimal control of diabetes, and is directed to predicting the long-term exposure to hyperglycemia, and the long-term and short-term risks of severe or moderate hypoglycemia in diabetics, based on blood glucose readings collected by a self-monitoring blood glucose device(710). The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting both HbA1c and periods of increased risk of hypoglycemia, and to the enhancement of emerging continuous monitoring devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia and hypoglycemia ...

SYSTEMS AND METHODS FOR TISSUE IMAGING

The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods employ functional diffusion map algorithms for imaging changes in tissue regions over time and/or in response to therapeutic interventions.

SENSORY TESTING DATA ANALYSIS BY CATEGORIES

This invention is related to systems and methods of analyzing sensory ability data. One embodiment of the present invention includes a method comprising the steps of receiving data from a remote location. The data is comprised of sensory ability data and demographic data associated with a subject. The data may then be stored. Further, the method includes identifying a potential evaluation level associated with the subject. The evaluation level is identified, at least in part, utilizing a sports tree function. The method also includes retrieving peer data associated with the potential evaluation level. Additionally, the method includes determining when the peer data is statistically powerful for use in generating a comparative profile of the sensory ability data associated with the subject. Additional embodiments develop training programs based on one or more training program functions.

MULTIVARIATE RESIDUAL-BASED HEALTH INDEX FOR HUMAN HEALTH MONITORING

Ambulatory or in-hospital monitoring of patients is provided with early warning and prioritization, enabling proactive intervention and amelioration of both costs and risks of health care. Multivariate physiological parameters are estimated by empirical model to remove normal variation. Residuals are tested using a multivariate probability density function to provide a multivariate health index for prioritizing medical effort.

QUANTIFICATION OF AN ABSORBER THROUGH A SCATTERING MEDIUM

There is described a method for determining a quantitative parameter of a compound in an analysis sample, comprising: providing a scattering medium in physical contact with the analysis sample, the scattering medium having at least one layer, an index of refraction of the scattering medium being superior to an index of refraction of the analysis sample; propagating, in the scattering medium, an incident beam of light having a wavelength substantially corresponding to an absorption wavelength of the compound such that an evanescent wave is generated at an interface between the scattering medium and the analysis sample; taking n intensity measurements of a reflected beam of light for the analysis sample, n being superior to one; and determining the quantitative parameter of the compound using the n intensity measurements for the analysis sample.

SUBSTANCE DELIVERY PLANNING SYSTEM

Some embodiments relate to a method for generating a delivery regimen of at least one active substance to a user, comprising: receiving input including one or both of timed activities to be engaged by the user, timed preferred user experiences; and automatically generating a delivery regimen including at least one of delivery times and amounts of the at least one active substance, based on: (a) estimating at least one of a timing and magnitude of at least one effect expected to be induced by the at least one active substance on the user; and (b) estimating an impact of the at least one effect on the timed activities and/or the timed preferred user experiences.

COMPUTER-IMPLEMENTED METHOD AND APPARATUS FOR DIABETES MANAGEMENT

A computer-implemented method and apparatus assists a user with diabetes management. The apparatus and method enables the user to record a plurality of their life events; record a plurality of their emotions, each corresponding to one of the plurality of life events; record a plurality of their blood glucose levels, each corresponding to one of the plurality of life events; and predict their glucose changes corresponding to their engaging in one of the recorded life events, and having the corresponding emotion to prevent hypoglycemia.

TECHNIQUES FOR PREDICTING RECURRENCE OF CANCEROUS CELLS USING IMPEDANCE DETECTION

One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.

BIOMETRIC SENSOR DEVICE FOR DIGITAL QUANTITATIVE PHENOTYPING

A biometric sensor device system including a biometric sensor device, and a prediction computer. The biometric sensor device includes at least one camera, and a biometric sensor device processor configured to record a time synchronized communicative interaction between participants, by controlling at least one camera to record the participants over a time period, and transfer the recorded communicative interaction to the prediction computer. The prediction computer including a prediction computer processor configured to extract, from the recorded communicative interaction, a physical characteristic of each of the participants over the time period, compare the physical characteristic of at least one of the participants with the physical characteristic of at least another one of the participants over the time period, and classify or score at least one of the participants according to a predetermined classification or dimensional scoring scheme based on the comparison.

MAINTAINING MAXIMUM DOSING LIMITS FOR CLOSED LOOP INSULIN MANAGEMENT SYSTEMS

A system and a method for management of diabetes are provided. The system includes an infusion pump, glucose sensor, and controller that is programmed to control insulin delivery based upon at least one stored variable. The controller calculates a maximum insulin delivery rate based on the default basal insulin delivery rate, temporary basal insulin delivery rate, extended bolus rate, or a combination thereof.

SEM TREND ANALYSIS

The present disclosure provides for, and includes, a method of detecting tissue damage before it is visible on a patient's skin, comprising: measuring a plurality of sub-epidermal moisture (SEM) values at a single location at incremental times, calculating a slope between the latest SEM value and the immediately prior SEM value, comparing this slope to a threshold value, and determining that there is tissue damage if the slope exceeds the threshold value.

METHOD AND SYSTEM FOR QUANTIFYING BIOMARKER OF A TISSUE

The present disclosure relates to a method and a system for quantifying a biomarker of a biological tissue. Two spectral sub-intervals are determined from a plurality of images of the tissue acquired at discrete wavelengths within a main wavelength interval using an imaging sensor in a manner such that the combination of the image data in the at least two spectral sub-intervals are correlated with a clinical variable of interest. The tissue is illuminated using one or more light sources with wavelengths within the at least two spectral sub-intervals. A measurement is of the light reflected by the tissue is acquired using an imaging sensor; and a measure of the biomarker of the tissue is calculated using the acquired measurement. The main wavelength interval is broader than each of the at least two spectral sub-intervals and at least one spectral confounder causing a spectral variability of the acquired image is present in the tissue.

AN APPARATUS AND A METHOD FOR QT CORRECTION

A method for QT correction is provided, the method comprising receiving an ECG signal; extracting a plurality of beat-to-beat (RR) intervals; extracting a plurality of QT intervals; computing a first probability distribution for a range of QT values based on the plurality of QT intervals; computing a second probability distribution for a range of QT values based on the plurality of QT intervals and the plurality of RR intervals; solving one or more points, wherein the first probability distribution and the second probability distribution intersect or wherein a difference between the first probability distribution and the second probability distribution is below a pre-defined difference threshold; designating one of one or more QT values corresponding to the one or more points as a corrected QT interval for a given QT interval of the plurality of QT intervals.

LIGHTWEIGHT CLINICAL PREGNANCY PRETERM BIRTH PREDICTIVE SYSTEM AND METHOD

A lightweight clinical pregnancy preterm birth predictive system includes a data store configured to receive and store patient data consisting of only health insurance claim data associated with a plurality of patients, a predictive model including a plurality of weighted risk variables and risk thresholds, a risk logic module configured to identify a pool of pregnant patients and to apply the predictive model to the patient data of the pool of pregnant patients to determine a risk score for each pregnant patient to identify at least one patient who is at risk for preterm birth, and a data presentation module operable to present notification and information to an intervention coordination team about the identified at least one high-risk patient.

SYSTEMS AND METHODS FOR ASSESSING AND EVALUATING RENAL HEALTH DIAGNOSIS, STAGING, AND THERAPY RECOMMENDATION

A system for assessing kidney health includes a processing device including an input module configured to receive input values related to kidney function of a patient, and a prediction module having a computation algorithm and/or a model configured to predict a kidney condition and calculate a kidney health score related to at least one of a severity and a probability of the predicted kidney condition, the kidney health score calculated based on the one or more input values. The system also includes an output module configured to present the predicted kidney condition and the kidney health score to a medical professional.

SYSTEMS AND METHODS FOR PROVIDING REAL-TIME PERFUSION GUIDED TARGETS FOR PERIPHERAL INTERVENTIONS

Disclosed herein are computer-implemented real-time systems and methods for determining success of a revascularization procedure and/or wound healing of a patient, that can involve measuring blood perfusion characteristics utilizing diffuse speckle contrast analysis (DSCA), and determining blood perfusion and vascular health indices predictive of a likely positive or negative patient outcome, and communicating that outcome to an operator utilizing a display, etc.

PERSONALIZED TREATMENT TOOL

The present invention relates to a computer-implemented method for aiding in the guidance of diabetes drug therapy of an individual suffering from diabetes mellitus. The method is based on glucose data from said individual that are received at a processing unit, wherein said glucose data comprise at least three fasting glucose measurement values from said individual, and/or at least three matched pre-prandial glucose measurement values and post-prandial glucose measurement values at the same meal from said individual. Further contemplated by the present invention is a device for aiding in the guidance of drug diabetes therapy of an individual suffering from diabetes, said device comprising a processing unit, and a computer program including computer-executable instructions, wherein said instructions, when executed by the processing unit, causes the processing unit to perform the computer-implemented method of the present invention.

Compartment Syndrome Monitoring Systems and Methods

Embodiments of a compartment monitor that can be implanted and left in situ to continuously (or semi-continuously) measure compartment pressures are presented. An exemplary monitor includes a pressure sensor adapted to be implanted in a compartment, a transmitter external to the compartment and coupled to the pressure sensor, and a receiver in communication with the transmitter to receive and process pressure data received from the transmitter. The monitor may also be configured to transmit measured pressure data to a networkable device. The networkable device can then communicate the patient's status and condition to a healthcare provider through a local area network (LAN) or wide area network (WAN). This communication allows the healthcare provider to remotely monitor a patient. The networkable device, or associated computing system, can record and display trends in the pressure data over time, and log the data to the patient's electronic health records.

Method and System For Patient-Specific Modeling of Blood Flow

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

Metrics and algorithms for interpretation of muscular use

A muscle assessment method utilizing a computing system, surface electromyometry (sEMG) sensors, and other sensors to gather data for one or more subjects engaged in an activity through operably coupling the one or more sensors to the computing system, and directing a computing system to select one or more muscle assessment protocols related to a number of different metrics. For a user subject engaged in a physical activity, assessing muscle condition, the muscle activity, and statistically related averages provide information to the user and about muscle and whole body fitness.

Management Method And System For Implementation, Execution, Data Collection, and Data Analysis Of A Structured Collection Procedure Which Runs On A Collection Device

A collection device for performing a structured collection procedure may include a processor that executes program instructions communicably coupled to at least one memory. The processor can initiate a schedule of events of the structured collection procedure upon one or more entry criterions being met and segregate the at least one memory into a primary data store and a secondary data store. The processor can write structured patient data collected in accordance to the schedule of events to the secondary data store. The processor can transform a relevant portion of the structured patient data into an evaluated data object. The processor can generate a data abstraction based in part upon the evaluated data object. The processor can link the primary data store and the secondary data store with the data abstraction.

Devices for diagnosing sleep apnea or other conditions and related systems and methods

A system includes a sensor device having a body configured to be inserted into an airway of a patient and one or more sensors mounted in or on the body. The one or more sensors are configured to collect sensor data associated with the airway of the patient. The system also includes a signal analyzer configured to analyze the sensor data. The one or more sensors could include one or more microphones. The signal analyzer could identify volume and/or pitch characteristics of the sensor data, perform pattern recognition to identify one or more patterns using the volume and/or pitch characteristics, and use the one or more patterns to identify a type, a location, and/or a degree of airway obstruction. This could be done, for instance, to determine if the patient suffers from obstructive sleep apnea or other condition that affects his or her airway.

Determination and application of glucose sensor reliability indicator and/or metric

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

Method and Apparatus For Early Warning of Critical Care Patient Hemodynamic Instability

A method and apparatus for providing a computing environment for a user which gives early warning of critical care patient instability. The method and apparatus use the entropy of monitored channels which are paired, each channel being paired once with each other channel. The entropies within each pair are compared to create an information exchange ratio. The information exchange ratios are integrated and a maximum of the integrated information exchange ratios is determined. Then, an alarm condition occurs at a user determined percentage of the maximum integrated information exchange ratio.

Glycemic health metric determination and application

Disclosed are methods, apparatuses, etc. for determination and application of a unidimensional metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy. In another implementation, a computed unidimensional metric may be used to balance risks of hyperglycemia and hypoglycemia.

Methods for monitoring exposure to an event and devices thereof

A method, non-transitory computer readable medium, and apparatus that includes obtaining, by a dosimetry computing device, sensor readings from at least one sensor. An event is identified, by the dosimetry computing device, based on at least one of one or more of the obtained sensor readings or one or more determinations based on the obtained sensor readings meeting one or more selection. At least one of the one or more determinations or the sensor readings which meet one or more of the selection criteria when the event is identified is stored by the dosimetry computing device.

Health monitoring appliance

A heart monitoring system for a person includes one or more wireless nodes; and a wearable appliance in communication with the one or more wireless nodes, the appliance monitoring vital signs. Other implementations can monitor heart rate, heart rate variability, respiratory rate, fluid status, posture and activity.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

System and method for scoring illness complexity to predict healthcare cost

A processor-based method for presenting patient test data includes acts of obtaining values of factors indicative of different patient health parameters and operatively associating the values of the factors with a unique identifier in a database borne by a physical computer-readable medium. Using a processor, a Z-score is determined for each factor and absolute values for each Z-score are converted into logarithm values. On a display, a radar graph depicts the Z-scores for the plurality of factors, the radar graph defining at least an arc subdivided into a plurality of sectors, each sector being subdivided into a plurality of arcuate sections, wherein log values are plotted from a center point of the radar graph, with the Z-scores of identified ones of the plurality of factors being representing as highlighted arcuate sections extending from the center point of the radar graph outwardly in correspondence with a magnitude of each Z-score.

Hemodynamic Reserve Monitor and Hemodialysis Control

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.

Devices, systems and methods to analyze evoked responses to pre-pacing pulses to predict imminent vt/vf, estimate ischemic burden and/or characterize electrical substrates

Described herein are implantable systems, and methods for use therewith, to predict whether ventricular tachycardia (VT) or ventricular fibrillation (VF) is imminent, estimate ischemic burden and/or characterize an electrical substrate of the LV chamber. For each of a plurality of cardiac cycles, a pacing vector comprising a first set of electrodes is used to deliver a pre-pacing pulse at a site within the LV chamber (wherein the pre-pacing pulse is delivered prior to an intrinsic activation of the LV chamber), and a sensing vector comprising a second set of electrodes is used to detect an evoked response to the pre-pacing pulse. The detected evoked responses to the pre-pacing pulses are analyzed, and results of the analysis are used predict whether VT or VF is imminent, estimate ischemic burden and/or characterize an electrical substrate of the LV chamber.

Biological body state assessment device

Disclosed is a biological body state assessment device capable of accurately assessing an absentminded state of a driver. The biological body state assessment device first acquires face image data of a face image capturing camera, detects an eye open time and a face direction left/right angle of a driver from face image data, calculates variation in the eye open time of the driver and variation in the face direction left/right angle of the driver, and performs threshold processing on the variation in the eye open time and the variation in the face direction left/right angle to detect the absentminded state of the driver. The biological body state assessment device assesses the possibility of the occurrence of drowsiness of the driver in the future using a line fitting method on the basis of an absentminded detection flag and the variation in the eye open time, and when it is assessed that there is the possibility of the occurrence of drowsiness, estimates an expected drowsiness occurrence time of the driver.

Method And Apparatus For A Predictive Tracking Device

A predictive tracking method and apparatus utilizing objective and subjective data in order to predict user states is provided herein. For example, some such embodiments may allow a user to track their mood or health symptoms in relation to retrieved data regarding their environmental in order to reveal patterns that can help forecast and proactively manage mood or health symptoms.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

System for use in administering inhaled nitric oxide gas

Disclosed are systems for use in administering inhaled nitric oxide gas as a therapeutic treatment, where the systems reduce the risk of inducing an increase in pulmonary capillary wedge pressure leading to pulmonary edema in neonatal patients who have hypoxic respiratory failure and are candidates for inhaled nitric oxide treatment, the system comprising a source of pharmaceutically acceptable nitric oxide gas for inhalation, a delivery device suitable for delivering nitric oxide gas from the source to a term or near-term neonate patient, and instructions for use in operating the system.

ADHERENT DEVICE WITH MULTIPLE PHYSIOLOGICAL SENSORS

An adherent device to monitor a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a hydration signal of the patient. Electrocardiogram circuitry is coupled to at least two of the at least four electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate a signal in response to at least one of an activity or a position of the patient. 190-. (canceled)91. An adherent device to monitor a patient , the device comprising:an adhesive patch configured to adhere to the skin of the patient continuously for at least seven days;at least two electrodes connected to the patch and configured to electrically couple to the patient;a processor system coupled to the at least two electrodes and configured to monitor a physiologic signal of the patient using the electrodes and, based at least in part on the physiologic signal measured from the patient, detect a cardiac event of the patient; andwireless communications circuitry coupled to the processor, wherein the processor is further configured to communicate an alert via the wireless communications circuitry to a remote receiver in response to the detection of the cardiac event.92. The adherent device of claim 91 , wherein the cardiac event is an impending cardiac decompensation claim 91 , and the alert is an alert of the impending cardiac decompensation.93. The adherent device of claim 91 , wherein the processor is further configured to transmit data describing the physiologic signal via the wireless communications circuitry to the remote receiver.94. The adherent device of claim 91 , wherein:the physiologic signal is a first physiologic signal;the processor system is further configured to monitor a second physiologic signal of the patient; andthe alert ...

Method and device for detecting a critical hemodynamic event of a patient

The invention relates to a method and a device for detecting a critical physiological state of a patient, especially for detecting a critical hemodynamic event. A set of values of physiological parameters is measured, including the heart rate and the pulse arrival time. On the basis of these measurements, a risk assessment is performed including the allocation of a representation of the measured set of values as a vector in a vector space to a risk level representing the risk of the occurrence of a critical hemodynamic event.

Method and/or system for multicompartment analyte monitoring

Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Polar plot to represent glucose sensor performance

Disclosed are methods, apparatuses, etc. for providing a visual expression of the performance of one or more blood glucose sensors. In one particular example, a relative comparison of a rate of change sensor blood glucose and a rate of change in reference blood glucose may be expressed in a polar plot or graph. The polar plot or graph may then be generated onto a visual medium.

Biological information processing method and device, recording medium and program

Provided is a biological information processing method and a device, a recording medium and a program that are able to predict and control changes in the state of an organism. The expression level of molecules in an organism is measured over a specific time interval; the measured time-series data is divided into a periodic component, an environmental stimulus response component and a baseline component; constant regions of the time-series data are identified from variations in the baseline component or from the amplitude or periodic variations of the periodic component; and causal relation between the identified constant regions is identified. The relation between the external environment and variations in the internal environment is identified and from the identified causal relation between the constant regions, changes in the state of the organism are inferred.

SYSTEM AND METHOD FOR ANALYZING A PATIENT STATUS FOR CONGESTIVE HEART FAILURE FOR USE IN AUTOMATED PATIENT CARE

A system and method for providing diagnosis and monitoring of congestive heart failure for use in automated patient care is described. At least one recorded physiological measure is compared to at least one other recorded physiological measure on a substantially regular basis to quantify a change in patient pathophysiological status for equivalent patient information. An absence, an onset, a progression, a regression, and a status quo of congestive heart failure is evaluated dependent upon the change in patient pathophysiological status. 1. A medical device providing physiometry for use in remote automated congestive heart failure patient management , comprising:one or more sensors to directly sense raw physiometry for a patient;sensing circuitry to regularly monitor and record the raw physiometry as collected device measures;memory to temporarily store the collected device measures pending interrogation by an externally interfaceable device; anda telemetry interface to provide access to the collected device measures, wherein derived device measures are thereafter determined to provide derivative physiometry based on the collected device measures and the collected and derived device measures quantify a pathophysiology indicative of congestive heart failure.2. The medical device of claim 1 , further comprising:programming parameters for the medical device, wherein the collected device measures are recorded subsequent to application of the programming parameters.3. The medical device of claim 1 , wherein the medical device comprises one of an implantable medical device and an external medical device.4. The medical device of claim 1 , wherein one or more of the collected and derived device measures are selected from the group comprising self referencing and and general population physiometric measures.5. A method for processing physiometry for use in remote automated congestive heart failure patient management claim 1 , comprising:identifying a patient enrolled in ...

Management of patient fall risk

Methods, computer systems, and computer-storage media are provided for facilitating the management of a patient's fall risk. It is determined that the patient has previously been classified as a fall risk. Inputs are automatically received from fall risk sensors located in the patient's clinical care room, and, based on the inputs received from the fall risk sensors, it is determined that the patient is currently at risk for falling. Alerts are initiated and settings for components within the clinical care room are adjusted to decrease the patient's fall risk.

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for generating analyte measurements of a host , the method comprising:generating sensor data during a first time period using an analyte sensor coupled to a sensor electronics unit, wherein the sensor electronics unit is adhered to a body of a host;receiving, using a receiver in wireless communication with the sensor electronics unit, a reference analyte value generated by a reference analyte monitor;responsive to receiving the reference analyte value, determining a first estimated analyte concentration value to display using a first algorithm, wherein determining the first estimated analyte concentration to display includes using the reference analyte value in a first algorithm;determining a second estimated analyte concentration value to display using the reference analyte value and the sensor data for the first time period in a second algorithm that is different from the first algorithm; anddisplaying, on a display of the receiver, a numerical analyte value selected from the first estimated analyte value and the second estimated analyte value, wherein the first estimated analyte concentration value is selected as the displayed numerical value until the second estimated analyte concentration is available, and subsequently selecting the second estimated analyte concentration value to be the displayed numerical value.2. The method of claim 1 , wherein the sensor data for the first time period is not used ...

DEVICE AND METHOD FOR DETECTING AN EMBOLUS MOVING IN A BLOOD VESSEL

The invention provides a device for detecting a moving embolism in a blood vessel. One or more sources of electromagnetic radiation deliver electromagnetic radiation to the blood vessel. First and second optical detectors, positioned at a downstream and an upstream location, respectively, along the flow axis of the blood vessel, detect electromagnetic radiation emitted by the sources at the downstream and upstream locations, after having been reflected from, or transmitted through, the blood vessel. A processor monitors one or more parameters of the electromagnetic radiation detected by the downstream and upstream detectors. An embolus in the blood vessel is detected when a transient change in a monitored parameter is first detected by the downstream detector, and, after a time lag, is then detected by the upstream detector. 121-. (canceled)22. A device for detecting a moving embolism in a first blood vessel comprising: (i) a source of electromagnetic radiation adapted to deliver electromagnetic radiation to the first blood vessel;', '(ii) a first optical detector detecting electromagnetic radiation produced by the source of electromagnetic radiation after the electromagnetic radiation has interacted with blood flowing in the first blood vessel;', '(iii) a second optical detector detecting electromagnetic radiation produced by the source of electromagnetic radiation after the electromagnetic radiation has interacted with blood flowing in the first blood vessel, the source of electromagnetic radiation being positioned between the first and second optical detectors;, '(a) one or more optical assemblies, each optical assembly comprising (i) monitor one or more parameters of the electromagnetic radiation detected by the first optical detector and monitor the one or more parameters of the electromagnetic radiation detected by the second optical detector; and', '(ii) detect a first predetermined or statistically significant transient change in one or more of the monitored ...

SYSTEMS, DEVICES, AND METHODS FOR PROVIDING FOOT LOADING FEEDBACK TO PATIENTS AND PHYSICIANS DURING A PERIOD OF PARTIAL WEIGHT BEARING

Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician. 1. A system for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria including a weight range and a prescribed number of steps , the system including:a receiving module that receives force data from a non-compressible force transmitter that is assigned to a user;a processing module that accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range, the pressure compliance range specifying a prescribed range of pressure that is to be applied during a PWB period; anda communications module that, upon receiving a compliance data request, communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to at least one of the user and the user's physician.2. The system of claim 1 , wherein the non-compressible force transmitter is positioned within a cavity of a housing oriented on the plantar surface of the user's foot.3. The system of claim 2 , wherein the non-compressible force transmitter is further positioned adjacent to a pressure sensor to transmit pressure within the housing.4. The system ...

Disease simulation system and method

A method of diabetes management including receiving a plurality of readings over time from an analyte sensor, processing each of the readings to generate analyte data, receiving information about external factors, using the analyte data to estimate an amount of medication to be dispensed from a single dose medication device based on the analyte data in combination with the external factors, and displaying an instruction to deliver the amount of medication.

SYSTEM FOR THE AUTOMATIC DETECTION OF RESPIRATORY DISEASES AND FOR THE PREDICTION OF FUTURE ACUTE AIRWAY INSTABILITIES

A system for automatically predicting acute airway events in patients, comprising: a device for measuring the respiratory impedance of a human subject during a plurality of respiratory cycles of said human subject; said respiratory impedance comprising a real part and an imaginary part; said device measuring said respiratory impedance two times per day to provide a plurality of measurements; means for calculating the relative variation of said plurality of measurements; means for evaluating the probability of respiratory pathology presence in the subject under examination when the value of the imaginary part of said impedance is greater than 35%; means for predicting a relapse in the patent under examination within an established future time window, once the presence of the pathology has been ascertained, if the variation coefficient of the real part of said impedance is greater than 0.4. 1. A system for automatically predicting acute airway events in patients , comprising: a device for measuring the respiratory impedance of a human subject during a plurality of respiratory cycles of said human subject; said respiratory impedance comprising a real part and an imaginary part; said device measuring said respiratory impedance two times per day to provide a plurality of measurements; means for calculating the relative variation of said plurality of measurements; means for evaluating the probability of respiratory pathology presence in the subject under examination when the value of the imaginary part of said impedance is greater than 35%; means for predicting a relapse in the patent under examination within an established future time window , once the presence of the pathology has been ascertained , if the variation coefficient of the real part of said impedance is greater than 0.4.2. A system as claimed in claim 1 , characterised in that said respiratory impedance is calculated during the inspiration of said subject.4. A system as claimed in claim 1 , characterised in ...

SYSTEMS AND METHODS FOR AUTOMATED PREDICTION OF RISK FOR PERIOPERATIVE COMPLICATIONS BASED ON THE LEVEL OF OBSTRUCTIVE SLEEP APNEA

A system for predicting risk for perioperative complications is described including a user device for receiving a set of risk factors to determine perioperative complications for a patient including patient data useful to determine the likelihood of obstructive sleep apnea. The system also includes an acquisition module to receive data from an obstructive sleep apnea sleep study of the patient. Further a determination module can determine the severity of obstructive sleep apnea for the patient. The system can also include an analysis module having a predictive model that incorporates one or more prediction equations for predicting perioperative complications derived from one or more databases having multiple patient data relevant to predict perioperative complications. The analysis module can be configured to apply the one or more prediction equations to the set of risk factors and the severity of obstructive sleep apnea for the patient in order to identify perioperative complication risks of that patient and to generate a perioperative complications report for the patient. 1a user device for receiving a set of risk factors to determine perioperative complications for a patient including patient data useful to determine the likelihood and severity of sleep apnea;an acquisition module to receive data from a sleep apnea sleep study of the patient;a determination module to determine the severity of sleep apnea for the patient; andan analysis module having a predictive model that incorporates one or more prediction equations for predicting perioperative complications derived from one or more databases having multiple patient data relevant to predict perioperative complications, the analysis module configured to apply the one or more prediction equations to the set of risk factors and the severity of sleep apnea for the patient in order to identify and report the likelihood of perioperative complication risks of that patient.. A system for predicting risk for ...

Multiple wavelength sensor emitters

A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

USER INTERFACE FEATURES FOR A DIABETES MANAGEMENT APPLICATION

A method is provided for contextualizing manual entries of blood glucose measures for a patient into a patient log of a portable computing device. The method includes: administering a structured collection procedure, where the structured collection procedure specifies two or more collection actions for obtaining blood glucose measures from a patient; generating a reminder notification for a given collection action of the structured collection procedure, where the given collection action is associated with a given event of patient; and displaying a data entry interface upon receipt of an acceptance input from a user in response to the reminder notification, where the data entry interface includes a first input for a blood glucose measure and a second input for an event associated with the blood glucose measure, such that value for the second input is defaulted to the given event from the reminder notification. 1. A computer-implemented method for contextualizing manual entries of blood glucose measures for a patient into a patient log of a portable computing device , comprising:administering, by the computing device, a structured collection procedure, where the structured collection procedure specifies two or more collection actions for obtaining blood glucose measures from a patient;generating, by the computing device, a reminder notification for a given collection action of the structured collection procedure;displaying, on a display of the computing device, a data entry interface upon receipt of an acceptance input from a user in response to the reminder notification, where the data entry interface includes a first input for a blood glucose measure and a second input for specifying a type of collection action associated with the blood glucose measure, such that value for the second input is defaulted to the given collection action from the reminder notification.receiving input via the data entry interface from the user of the computing device, including a value ...

Tissue profile wellness monitor

A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.

Breast classification based on impedance measurements

A method of screening for breast cancer, including determining at least one first electrical impedance related characteristic for a first breast of a patient, determining at least one second electrical impedance related characteristic for a second breast of a patient and classifying the patient as requiring additional testing, responsive to the value of the first and second characteristics, wherein classifying is not based on a difference between the first and second characteristics.

AUTOREGULATION MONITORING

A method may include controlling a ventilator to introduce mean airway pressure (MAP) variations in a patient to induce slow waves of substantially fixed amplitude and period to the patient. The method may also include analyzing arterial blood pressure in the patient with respect to the MAP variations and determining, based on the analyzing, whether an autoregulatory mechanism associated with the patient's brain is operating properly. 1. A method , comprising:controlling a ventilator to introduce mean airway pressure (MAP) variations in a patient to induce slow waves of substantially fixed amplitude and period to the patient;analyzing arterial blood pressure in the patient with respect to the MAP variations; anddetermining, based on the analyzing, whether an autoregulatory mechanism associated with the patient's brain is operating properly.2. The method of claim 1 , wherein the analyzing is performed at a frequency corresponding to a frequency of the slow waves.3. The method of claim 2 , wherein a frequency associated with the MAP variations is less than 0.1 hertz (Hz) and the analyzing is performed at the frequency of the MAP variations.4. The method of claim 2 , wherein the determining comprises:determining whether peak blood volume in the brain is phase shifted with respect to the arterial blood pressure.5. The method of claim 1 , wherein the determining comprises:comparing arterial blood pressure of the patient to intracranial pressure of the patient in a frequency domain, andidentifying a phase angle difference between the arterial blood pressure and the intracranial pressure.6. The method of claim 5 , wherein the determining further comprises:determining that the autoregulatory mechanism is functioning properly in response to identifying that the phase angle difference is within a predetermined range.7. The method of claim 1 , wherein the controlling a ventilator comprises:controlling positive end-expiratory pressure (PEEP) provided to the patient to vary PEEP ...

PATIENT MONITORING APPLIANCE

A wireless system for a person includes a wearable appliance monitoring one or more body parameters; a plurality of wireless nodes in communication with the wearable appliance; and a remote computer coupled to the wireless nodes to provide information to an authorized remote user. 1. A wireless system for a person , comprising:a wearable appliance monitoring one or more body parameters;a plurality of wireless nodes in communication with the wearable appliance; anda remote computer coupled to the wireless nodes to provide information to an authorized remote user.2. The system of claim 1 , comprising an accelerometer to detect a dangerous condition and to generate a warning when the dangerous condition is detected.3. The system of claim 1 , wherein the appliance is wirelessly coupled to a hospital monitoring equipment.4. The system of claim 1 , comprising one of: EKG detector claim 1 , ECG detector claim 1 , electromagnetic detector claim 1 , ultrasonic detector claim 1 , optical detector claim 1 , a Hidden Markov Model (HMM) recognizer claim 1 , a dynamic time warp (DTW) recognizer claim 1 , a neural network claim 1 , a fuzzy logic engine.5. The system of claim 1 , wherein the appliance monitors patient movement.6. The system of claim 1 , comprising a positioning system from an 802.X station to provide location information.7. The system of claim 1 , comprising a call center coupled to the appliance to provide a human response.8. The system of claim 1 , comprising a web server coupled to the wireless nodes to provide information to an authorized remote user.9. The system of claim 1 , comprising a heart disease recognizer to detect stroke symptom or heart attack symptom.10. The system of claim 1 , comprising code to store and analyze patient information.11. The system of claim 1 , comprising code to store medicine taking habits claim 1 , eating and drinking habits claim 1 , sleeping habits claim 1 , or excise habits.12. The system of claim 1 , wherein the wireless ...

Potential Artery-to-Vein Disease State Detection

A method/apparatus/system for detection of a potential disease state is disclosed. A pair of electrodes is attached to a limb and the electrodes are energized. The energizing of the electrodes creates a first signal in the form of current data. If the first signal is consistent with a potential disease state, including a potential artery-to-vein disease state, an indication of the potential disease state is provided. 1. A method for identifying a potential vascular disease state of a limb of a patient , the limb comprising an outer surface and a first region , the method comprising:placing a plurality of electrodes on the limb, including a first electrode on the outer surface of the limb adjacent the first region;energizing at least some of the electrodes while the limb of the patient is in a first arterial to vein transport state so as to generate a first signal with the first electrode;determining that the first signal is consistent with the potential vascular disease state of the limb in response to the first signal; andproviding an indication of the potential vascular disease state of the limb.2. The method recited in claim 1 , the first region of the limb including tissue with associated veins and arteries claim 1 , further comprising:placing a second electrode pair on the outer surface of the limb adjacent a second region of the limb, the second region including tissue with associated veins and arteries; andgenerate a second signal with the second electrode; anddetermining the first signal and the second signal correspond to the potential vascular disease state, the potential vascular disease state comprising an artery-to-vein disease state.3. The method recited in claim 2 , further comprising:localizing the potential vascular disease state in the first region in response to the first and second signals; andselectively directing therapy to the first region so as to mitigate the potential vascular disease state.4. The method of claim 3 , the tissue of the first ...

Heart Age Assessment

An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject; receiving, from the user, a plurality of said inputs; determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age. 122-. (canceled)23. An automated method of estimating blood lipid levels of a subject , said method carried out on a computer system and comprising the automated steps of:a) receiving a plurality of data values, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject, the data values not including any quantitative measure of a cholesterol level of the subject, said data values either provided by the user through a user input device of the computer system or transferred electronically from another device;b) calculating a CVD risk for the subject based on said data values using a first algorithm stored in a database on the computer system;c) determining one or a range of possible total cholesterol levels and HDL cholesterol levels for the subject consistent with the calculated first CVD risk by comparison of the first CVD risk with statistical average CVD risk as a function of measured total and HDL cholesterol levels in a population;d) determining a statistical average total cholesterol level ...

Active implantable medical device comprising means for the diagnosis of heart failure

Methods, devices, and processor-readable storage media are provided for the diagnosis of heart failure. A method in this context includes collecting, using an implantable device, reference episodes, the reference episodes comprising, at least one of: electrical activity signals of a myocardium; myocardium hemodynamic activity signals, or indicators reflecting variation of physical parameters, variation of activity, and variation of hemodynamic phases between phases of effort and phases of recovery; generating an in-suspicion model-cycle and an off-suspicion model-cycle based on the reference episodes; and determining whether to generate an early heart failure alert, based on a difference between the in-suspicion model-cycle and the off-suspicion model-cycle.

Method and apparatus for monitoring a blood oxygen saturation level relative to a saturation threshold value

A method and apparatus for monitoring a blood oxygen saturation level within a subject's tissue is provided. The method includes the steps of: a) sensing the subject's tissue using a near infrared spectrophotometric oximeter, and producing a value representative of the oxygen saturation level within the sensed tissue; b) comparing the determined saturation value to a predetermined threshold oxygen saturation value; and c) determining at least one of a time under threshold (TUT) value or an area under threshold (AUT) value using the determined saturation value and the threshold value.

COMPUTER BASED ANALYSIS OF MRI IMAGES

A method for computer based analysis of a low field MR image including a trabecular region of bone for extracting from said image diagnostic information by applying a trained statistical classifier which has been trained on similar labelled according to the severity of a trabecular bone altering disease suffered at the time or later. For each image in the training set a region of interest (ROI) is defined, textural information relating to the intensities of voxels within the ROI is obtained, and combinations of features of said textural information are found which suitably classify the images according to said labelling. An image under study is treated similarly and features of said textural information for the voxels within the ROI of the image are combined as learnt in the training of the classifier to estimate a level of said trabecular bone altering disease or propensity to develop said bone altering disease or a level thereof associated with said image. 1. A method for computer based analysis of a low field MR image including a trabecular region of bone for extracting from said image diagnostic information , said method comprising applying to said image a trained statistical classifier which has been trained on a training set of low field MRI images containing said trabecular region of bone each of which images has been labelled according to the severity of a trabecular bone altering disease suffered by a person from whom the image derived , wherein in said training of the classifier , for each image in the training set a region of interest (ROI) was defined , and textural information relating to the intensities of voxels within the ROI was obtained , and combinations of features of said textural information were found which suitably classify said training set images according to said labelling , and wherein , in applying said trained statistical classifier to said image , in a computer the region of interest (ROI) is found in said image , and textural ...

Estimation of insulin sensitivity from cgm and subcutaneous insulin delivery in type 1 diabetes

In a method of determining insulin sensitivity in a patient, glucose level is sensed continuously. A first area under the curve representing the glucose level over time is calculated. An amount of insulin that has been administered to the patient is sensed. An estimation of insulin on board the patient is calculated based on the glucose level and the amount of insulin administered to the patient. A second area under the curve representing the insulin on board over time is calculated. Patient data indicative of at least one patient physical parameter is received. Information indicative of amount of glucose ingested by the patient during a meal is received. An insulin sensitivity output indicative of ability of insulin to stimulate glucose utilization and inhibit glucose production in the patient based on the first and second area under the curve, the patient data and the meal information is generated.

System and method to predict and avoid musculoskeletal injuries

A miniaturized, ruggedized, field-deployable Portable Exposure Assessment System (PEAS) is used to remotely monitor workers and provide real-time warning of exposure to musculoskeletal injury conditions via alarm and smart-phone transmission. The PEAS unit wirelessly acquires exposure data from sensors; conducts initial data analysis; triggers proximal and remote alarms; sends out text messages with abnormal data, GPS locations, and time stamps to a safety office; and saves data for more extensive assessment. Sensor technology is used in this field-deployable system to simultaneously measure and collect the body loads and awkward postures imposed by package handling as well as driving-related, low-frequency vibration exposures. Wireless technology is used to set up wireless communication links between the sensors and a data logger and between the data logger and a smart phone with GPS, date/time stamp and text messaging capabilities.

METHODS FOR DIAGNOSIS OF COLORECTAL CANCER

Methods and systems for use of phenotypic markers, principally oral mucosal vascular density alone or in combination with detection of other markers, to identify individuals afflicted with or having an increased risk of hereditary colorectal cancer, especially familial adenomatous polyposis, are disclosed. 1. A method for diagnosing familial adenomatous polyposis (FAP) or an increased risk of FAP in a test subject believed to be at risk for such cancer , the method comprising:(a) positioning a sampling area of the oral mucosa of the test subject in a system for measuring the oral mucosal vascular density (OMVD);(b) transilluminating the sampling area of the oral mucosa of the test subject with a light source from the system in a range of wavelengths from 470 nm to 700 nm for a period of time;(c) obtaining at least one or more images of the illuminated sampling area of the test subject using a camera from the system;(d) storing the at least one or more images of (c) on an electronic storage device on a computer;(e) analyzing the at least one or more images of the test subject stored on the electronic storage device to provide an oral mucosal vascular density (OMVD) value from a selected portion of the one or more images; and(f) comparing the OMVD values of the at least one or more images of the test subject to one or more OMVD values of one or more control subjects which are not afflicted with colorectal cancer; and(g) diagnosing the test subject has having adenomatous polyposis (FAP) or an increased risk of FAP when there is found a statistically significant increase in OVMD value in the test subject when compared to the one or more control subjects.26.-. (canceled)7. The method of claim 1 , further comprising analysis of oral mucosal reflectance (OMR) in the one or more subjects compared to controls.8. (canceled)9. The method of claim 7 , wherein the difference between the OMR measurements in the one or more subjects does not differ from the OMR measurements in the ...

IMPLANTABLE MEDICAL DEVICE

An implantable medical device comprising a coronary perfusion measurement unit is adapted to measure and determine parameters related to coronary perfusion of heart tissue. The parameters include time periods and perfusion magnitudes. The coronary perfusion measurement unit is configured to determine a time period T related to a perfusion event of a coronary vessel and including includes a reperfusion time period, where a perfusion event is defined as a decrease of coronary perfusion followed by reperfusion, and to generate a time period signal in dependence thereto. The implantable medical device further comprises a coronary flow calculation unit that is adapted to receive the time period signal and that is adapted to process the time period and to generate an ischemia risk indicating index I in dependence of the time period. 1. An implantable medical device comprising:a coronary perfusion measurement unit adapted to measure and determine parameters related to coronary perfusion of heart tissue, the parameters including time periods and perfusion magnitudes, wherein the coronary perfusion measurement unit is configured to determine a time period T related to a perfusion event of a coronary vessel and includes a reperfusion time period, wherein the perfusion event is defined as a decrease of coronary perfusion followed by reperfusion, and wherein the coronary perfusion measurement unit is configured to generate a time period signal in dependence thereto; anda coronary flow calculation unit adapted to receive the time period signal and adapted to process the time period and generate an ischemia risk indicating index I in dependence of the time period.2. The implantable medical device according to claim 1 , wherein the time period T is determined as the time period that starts when the perfusion magnitude is at its minimum and ends when the perfusion magnitude is back to an initial perfusion level.3. The implantable medical device according to claim 1 , wherein the ...

System and method for determining physiological parameters based on electrical impedance measurements

A system and method for determining physiological parameters based on electrical impedance measurements is provided. One method includes obtaining electrical measurement signals acquired from a plurality of transducers coupled to a surface of an object and spatially pre-conditioning the obtained electrical measurement signals. The method also includes performing multiple-input-multiple-output (MIMO) analog to information conversion (AIC) of the spatially pre-conditioned electrical measurement signals to correlate the spatially pre-conditioned electrical measurement signals to separate the electrical measurement signals.

EXERCISE-ASSISTING DEVICE FOR FORECASTING THE CHANGE IN A PHYSIOLOGICAL PARAMETER AS A FUNCTION OF AN ITINERARY

A device () for assisting with physical exertion management, includes a physiological sensor, a positioning device, at least one memory in which data representative of the itinerary to be travelled during the physical exertion can be recorded, and at least one data processing unit organised so as to produce forecast data representative of the change in an physical exertion parameter over the remaining itinerary to be travelled by the individual, to compare these forecast data with predetermined data, and to produce and transmit a message, the content of which depends on the result of the comparison of the forecast data and the predetermined data, with a view to communicating the message to a user. 11. Portable device () for assisting the management of a physical exertion provided by a subject , comprising:{'b': 10', '11', '12, 'at least one sensor (, , ) for a physiological parameter, called exertion parameter, evolving as a function of the physical exertion, said sensor being suitable to provide digital data, called exertion data, that are representative of said exertion parameter,'}{'b': '20', 'at least one device, called positioning device (), that is suitable to determine its own position in a given topographical frame of reference and to provide digital data, called positioning data, that are representative of this position,'}{'b': 98', '99, 'at least one interface (, ) for communication with a user,'}{'b': '4', 'claim-text': positioning data provided by said positioning device,', 'exertion data,', 'data that are representative of an itinerary to be travelled in said topographical frame of reference by said subject in the course of the physical exertion,, 'at least one memory () in which data, called input data, are capable of being recorded, comprising at least{'b': '30', 'claim-text': to generate data, called forecast data, that are representative of the evolution of at least one exertion parameter over the itinerary remaining to be travelled by the subject, ...

Method and Apparatus for Detecting Change in Intrathoracic Electrical Impedance

A method and apparatus for detection of changes in impedance a patient that includes generating measured impedances, generating an adaptive baseline trend of the measured impedances corresponding to a first time period, generating a short term trend of the measured impedances corresponding to a second time period less than the first time period, determining changes in relative position of the short term trend and the baseline trend, the determined changes in relative position corresponding to determining intersecting of the baseline trend by the short term trend, determining differences between the baseline trend and calculated period average impedances, and accumulating, in response to determining no intersecting of the baseline trend by the short term trend, the determined differences between the baseline trend and the calculated period average impedances. 1. An implantable medical device , comprising:a plurality of electrodes;an output circuit outputting a plurality of output pulse signals along a vector formed by electrodes of the plurality of electrodes;a measurement circuit generating a corresponding plurality of measurement signals in response to the plurality of output pulse signals; anda microprocessor configured to determine a plurality of period average impedances in response to the plurality of output pulse signals and the plurality of measurement signals corresponding to a predetermined time period, determine an adaptive baseline trend of period average impedances of the plurality of period average impedances corresponding to a first time period, determine a short term trend of period average impedances of the plurality of period average impedances corresponding to a second time period different from the first time period, determine changes in relative position of the short term trend and the baseline trend, determine differences between the baseline trend and the calculated period average impedances, and accumulate, in response to determining no ...

SYSTEM AND METHOD TO EVALUATE CARDIOVASCULAR HEALTH

Systems and methods are described herein to evaluate a candidate medication as it relates to a subject's cardiovascular health. A processing component is employed to measure a first value of one or more cardiovascular markers, via a computer, which are associated with a circulatory system of each subject that is to receive the candidate medication. The candidate medication is administered to each subject and a second value of one or more cardiovascular markers are measured subsequent to the administration as of the candidate medication. Continued testing of the candidate medication can be continued dependent upon the change in the one or more cardiovascular markers. 1. A method , comprising:a processing component employed to calculate a first stroke volume of a subject;administering a medication to the subject;calculating a second stroke volume of the subject; andevaluating the disparity between the first stroke volume and the second stroke volume to determine whether to continue administration of the medication,wherein if the second stroke volume is less than or equal to the first stroke volume, administration of the medication is continued and if the second stroke volume is greater than the first stroke volume, administration of the medication is discontinued.2. The method according to claim 1 , wherein the medication is related to modification of the cardiovascular system of the subject.3. The method according to claim 2 , wherein the cardiovascular medication is related to hypertension.4. The method according to claim 1 , wherein the first and second stroke volumes are calculated based upon the same cardiovascular markers.5. The method according to claim 1 , wherein the first and second stroke volumes are calculated based upon a cardiac output and a heart rate of the subject claim 1 , wherein the first and second stroke volumes are each equal to the cardiac output divided by the heart rate.6. The method according to claim 1 , wherein the first and second stroke ...

REAL TIME CLINICAL DECISION SUPPORT SYSTEM HAVING MEDICAL SYSTEMS AS DISPLAY ELEMENTS

A clinical decision support system for patient treatment that incorporates patient data to display information in readily identifiable icons for vital organs and medical systems, and in a useable, real-time, updated fashion that extracts data from the medical history, the current medical management, the current physiologic monitors, and associated medical systems to produce warnings and alerts to enable caregivers to be made aware of physiologic systems at risk. These data are not only presented, but also use real-time queries and calculations to enable caregivers to have the types of data that would traditionally assist them in patient care but only be available by reviewing the medical literature and/or doing retrospective individual calculations while providing patient care. 1. A clinical decision support system for patient treatment comprising:a monitoring system operably coupled to a patient, said monitoring system passively engaging with the patient, said monitoring system outputting a first monitoring signal in response to a measured parameter of the patient, said monitoring system further operably coupled to a medical system associated with the patient, the medical system actively engaging with the patient to effect a physiological response in the patient, said monitoring system outputting a second monitoring signal in response to a detected condition of the medical system;a controller receiving said first and second monitoring signals and continuously calculating a secondary, non-measurable parameter of the patient based on said measured parameter, said controller outputting a display signal; anda display device operably coupled to said controller and receiving said display signal, said display device having a plurality of display indicia where at least one of the plurality of display indicia is responsive to said display signal, wherein at least one of said plurality of display indicia being substantially shaped as a readily-identifiable organ and operable ...

METHODS AND SYSTEM FOR MONITORING PATIENTS FOR CLINICAL EPISODES

Apparatus and methods are described for monitoring a subject. A motion sensor senses motion of the subject and generates a sensor signal in response thereto. A control unit includes a filter configured to extract from the sensor signal at least one signal selected from the group consisting of: a breathing-related signal and a heartbeat-related signal. The control unit is configured to analyze the selected signal and to detect changes in body posture of the subject at least partially in response thereto. Other applications are also described. 1116-. (canceled)117. Apparatus for monitoring a subject , the apparatus comprising:a motion sensor configured to sense motion of the subject and generate a sensor signal in response thereto; anda control unit comprising a filter configured to extract from the sensor signal at least one signal selected from the group consisting of: a breathing-related signal and a heartbeat-related signal,the control unit being configured to analyze the selected signal and to detect changes in body posture of the subject at least partially in response thereto.118. The apparatus according to claim 117 , wherein the control unit is configured to analyze frequency and timings of the changes in body posture claim 117 , to detect restlessness of the subject in response thereto claim 117 , and to generate an output in response to detecting the restlessness.119. The apparatus according to claim 117 , wherein the control unit is configured to analyze frequency and timings of the detected changes in body posture claim 117 , to detect restlessness of the subject in response thereto claim 117 , and claim 117 , in response to detecting the restlessness claim 117 , to discard data sensed by the sensor during the restlessness.120. The apparatus according to claim 117 , wherein the control unit is configured to detect the changes in body posture by analyzing a relationship between the breathing-related signal and the heartbeat-related signal.121. The apparatus ...

SYSTEM, STETHOSCOPE AND METHOD FOR INDICATING RISK OF CORONARY ARTERY DISEASE

A system for detection of frequency power for diagnosing coronary artery disease (CAD), comprising: an acoustic sensor to be placed on the chest of a patient to generate acoustic signals S: a memory adapted to store acoustic signals S; a control unit adapted to receive said acoustic signals S; the control unit comprising: an identification unit to identify diastolic or systolic periods in a predetermined time period and to generate a period signal S, a filtering unit adapted to apply a filter to said identified periods to generate a low frequency band signal Sindicating low frequency bands of identified periods; a calculation unit to estimate the power in said low frequency band of identified periods, to calculate a low frequency power measure and to generate a low frequency power measure signal S. The invention also relates to a stethoscope and a method for detection of low frequency power. 1. A system for detection of frequency power for diagnosing of coronary artery disease (CAD) , comprising:{'sub': 'A', 'an acoustic sensor adapted to be placed on the chest of a patient, and to generate acoustic signals S;'}{'sub': 'A', 'at least one memory adapted to store acoustic signals Sfrom the acoustic sensor; and'}{'sub': 'A', 'a control unit adapted to receive said acoustic signals S;'} [{'sub': A', 'P, 'an identification unit adapted to identify diastolic or systolic periods in a predetermined time period of the stored acoustic signals S, and to generate a period signal Sindicating said identified periods;'}, {'sub': 'LFB', 'a filtering unit adapted to apply at least one filter to said identified periods and to generate a low frequency band signal Sindicating low frequency bands of said identified periods; and'}, {'sub': 'LFP', 'a calculation unit adapted to estimate the power in said low frequency band of said identified periods, and that said calculation unit is adapted to normalize said estimated power over other, higher frequency band, said calculation unit is ...

Method and Apparatus for Indicating the Risk of an Emerging Ulcer

A method of monitoring at least one foot of a patient provides an open platform for receiving at least one foot. The open platform has at least one temperature sensor for generating a plurality of temperature data values after receipt of the at least one foot. The method also forms a thermogram of the sole of the at least one foot from the temperature data values, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. Finally, the method produces output information indicating the risk of an ulcer emerging on the foot as a function of whether the thermogram is determined to present the at least one prescribed pattern. 1. A method of monitoring at least one foot of a patient , the method comprising:providing an open platform for receiving at least one foot, the open platform having at least one temperature sensor, the at least one temperature sensor generating a plurality of temperature data values after receipt of the at least one foot;forming a thermogram of the sole of the at least one foot from the temperature data values;determining whether the thermogram presents at least one of a plurality of prescribed patterns, the prescribed patterns being determined at least in part by a comparison of the temperature(s) at one or more of: 1) the same portion of the same foot at different times, 2) corresponding portions of the patient's two feet, or 3) different portions of the same foot; andproducing output information indicating the risk of an ulcer emerging on the foot, producing being a function of whether the thermogram is determined to present the at least one prescribed pattern.2. The method as defined by wherein the plurality of temperature sensors are at discrete locations on the foot claim 1 , forming a thermogram comprising interpolating temperature data between at least two of the plurality of temperature sensors to produce approximate temperature readings at locations that are between the sensors.3. The method as ...

Method and Apparatus for Indicating the Emergence of an Ulcer

A method of monitoring a patient's foot forms a thermogram of the sole of at least one foot of the patient, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. The method also compares the thermogram against a prior thermogram of the same foot, and produces output information indicating the emergence of an ulcer on a given portion on the at least one foot as a function of 1) whether the thermogram is determined to present the at least one pattern, and 2) the comparison with the prior thermogram, which shows non-ulcerated tissue at the given location.

Method and Apparatus for Indicating the Emergence of a Pre-Ulcer and its Progression

A method of monitoring a patient's foot provides an open platform for receiving at least one foot. The platform has at least one temperature sensor for generating a plurality of temperature data values after receipt of the at least one foot. The method then forms a thermogram of the sole of the at least one foot from the temperature data, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. Next, the method produces output information indicating the emergence of a pre-ulcer or progression of a known pre-ulcer in the at least one foot as a function of whether the thermogram is determined to present the at least one pattern. 1. A method of monitoring a patient's foot , the method comprising:providing an open platform for receiving at least one foot, the open platform having at least one temperature sensor, the at least one temperature sensor generating a plurality of temperature data values after receipt of the at least one foot;forming a thermogram of the sole of the at least one foot from the temperature data;determining whether the thermogram presents at least one of a plurality of prescribed patterns; andproducing output information indicating the emergence of a pre-ulcer or progression of a known pre-ulcer in the at least one foot, producing being a function of whether the thermogram is determined to present the at least one pattern.2. The method as defined by further comprising:detecting a prescribed pattern on a portion of the at least one foot indicating the presence of a pre-ulcer on the portion; andcomparing the portion of the at least one foot with data from a previous thermogram of the portion of the same foot, the previous thermogram indicating that the portion of the at least one foot is pre-ulcer free.3. The method as defined by further comprising:detecting a prescribed pattern on a portion of the at least one foot indicating the presence of a given pre-ulcer on the portion; andcomparing the portion of the ...

Apparatus and method for predicting upcoming stage of carotid stenosis

An apparatus and a method predict an upcoming stage of carotid stenosis. The apparatus includes a receiving unit, a cluster determining unit, a risk factor score extracting unit, a prediction model storage unit, and a predicting unit. The method includes receiving a patient's medical test data relating to carotid stenosis; determining a cluster to which the patient's medical test data belong based on a gender of the patient; extracting from the patient's medical test data a risk factor score comprising a result of carotid stenosis ultrasonography; storing a plurality of prediction models used to predict an upcoming stage of carotid stenosis; and obtaining an outcome by applying a value indicating a stage of carotid stenosis corresponding to the result of carotid stenosis ultrasonography and the extracted risk factor score to the prediction model corresponding to the determined cluster among the plurality of prediction models.

PATIENT SUPPORT INTERFACE PRESSURE MONITORING SYSTEM

An interface pressure monitoring system includes an underlayment interposed between a patient support surface and a patient supported thereon and a processor. The underlayment includes pressure sensors such as, for example, an array of piezoelectric pressure sensors. The processor acquires pressure data from the underlayment, analyzes the data and stores the analyzed data for further processing, alerting and/or reporting. 1. A system for monitoring localized interface pressures produced between a surface and a patient supported thereon , said monitoring system comprising:an underlayment adapted to be interposed between a patient support surface and a patient resting adjacent said patient support surface, said underlayment comprising a plurality of pressure sensors; and acquire and map pressure data as measured by said pressure sensors;', 'store said mapped pressure data;', the supine position;', 'the prone position; and', 'a lateral position; and, 'analyze said stored pressure data for the determination of the body position of the patient from the group consisting of, 'determine, based upon whether the determined body position of the patient has remained unchanged, from one said body position to another said body position, over a length of time exceeding an established threshold value, whether repositioning of the patient should take place., 'a processor in electrical communication with said pressure sensors of said underlayment, said processor being adapted to2. The monitoring system as recited in claim 1 , wherein said pressure sensors comprise piezoelectric sensors.3. The monitoring system as recited in claim 2 , wherein said piezoelectric sensors are arranged in a sensor array.4. The monitoring system as recited in claim 1 , wherein said patient support surface comprises a mattress.5. The monitoring system as recited in claim 1 , wherein said processor is further adapted to transmit a signal indicating a need for caregiver intervention upon the determined body ...

Method and apparatus for processing of stroke ct scans

An automatic technique for stroke identification, localization, quantification and prediction, has the steps of receiving a CT scan, pre-processing it to extract the brain region corresponding to a brain volume of a subject who has suffered a stroke; identifying whether a hemorrhage is present in the brain volume and if so obtaining data characterizing the hemorrhage; otherwise identifying whether an infarct is present and if so obtaining data characterizing it; analyzing the results using a brain atlas; and, using the results of the analysis, obtaining at least one predictive value characterizing a prediction about the subject.

Methods, systems and devices for a clinical data reporting and surgical navigation

Three components are proposed, each having at its core a system for producing measurements of the relative motion of anatomical structures of mammals (the “measurement system”). The measurement system in this case would be comprised of an apparatus for imaging the joint of through a prescribed motion, and a process and mechanism for deriving quantitative measurement output data from the resulting images. The components of the present invention include: (1) a software device for reporting measurement output of the measurement system and for allowing users to interact with the measurement output data; (2) an apparatus and method for utilizing measurement output of the measurement system for therapeutic and surgical applications such as surgical navigation and patient positioning during a therapeutic procedure; and (3) an apparatus providing input image data for the measurement system that assists with the imaging of joints connecting anatomical regions that are in motion during operation.

Apparatuses and methods for diagnosing swallowing dysfunction

The present disclosure is directed to apparatuses and methods for diagnosing a swallowing dysfunction. The apparatuses may include a multi-parametric dysphagia analysis system in a plastic foil. The analysis systems may be smart sensing systems that are flexible, lightweight, and based on substrates having low-cost printed electronics technologies thereon. The methods may include measurement and classification of non-invasive parameters that may be indicative of a swallowing dysfunction or the probability of same. In a general embodiment, the methods include placing a sensor on a patient for measurement of at least one parameter associated with the patient's swallowing profile. The measured parameter is then analyzed and compared with several known normal and dysphagic swallowing profiles to provide an indication of the probability of an underlying swallowing dysfunction.

CONTOURED PROTRUSION FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS

A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector. 1. A noninvasive medical sensor configured to detect light attenuated by body tissue of a medical patient , the sensor comprising:a sensor housing comprising an upper shell and a lower shell pivotally connected together, the upper and lower shells each shaped to accept body tissue of a medical patient;one or more emitters disposed in the housing, the one or emitters configured to impinge light on the body tissue of the patient;one or more detectors disposed in the housing, the one or more detectors configured to receive the light after attenuation by the body tissue of the patient and to output one or more intensity signals responsive to the attenuated light; anda tissue thickness adjuster disposed in the housing, the tissue thickness adjuster positioned such that placement of the body tissue of the patient on the tissue thickness adjuster reduces a thickness of the body tissue and thereby increases a gain of the one or more intensity signals.2. The sensor of claim 1 , wherein the tissue thickness adjuster comprises a protrusion configured to deform the body tissue.3. The sensor of claim 2 , wherein the protrusion is a partially cylindrical protrusion.4. The sensor of claim 3 , wherein the partially cylindrical protrusion comprises a lens.5. The sensor of claim 4 , wherein the partially cylindrical protrusion ...

BODY WEIGHT MANAGEMENT DEVICE HAVING FUNCTION OF PREDICTING BODY WEIGHT VARIATION

A body weight management device includes a measurement unit that measures a body impedance of a measurement subject, an impedance change detection unit that detects a temporal change in the measured body impedance, a variation amount computation unit that computes a body impedance variation amount in a unit period, and a determination unit that makes determination about a trend for subsequent changes in the measurement subject's body weight, using the body impedance variation in the unit period, and an output unit that outputs a result of the determination. 1. A body weight management device comprising:a measurement unit that measures a body impedance of a measurement subject;an impedance change detection unit that detects a temporal change in the measured body impedance;a variation amount computation unit that computes a body impedance variation amount in a unit period, based on the temporal change in the body impedance;a determination unit that makes determination about a trend for subsequent changes in a measurement subject's body weight, using the body impedance variation amount in the unit period; andan output unit that outputs a result of the determination.2. The body weight management device according to claim 1 , further comprising:a body weight obtainment unit that obtains body weight data of the measurement subject;a body weight change detection unit that detects a temporal change in the body weight, based on the obtained body weight data; anda body weight variation amount computation unit that computes the body weight variation amount in the unit period, based on the temporal change in the body weight,wherein the determination unit makes determination about a trend for subsequent changes in the measurement subject's body weight, from a relationship betweenthe body impedance variation amount in the unit period and the body weight variation amount in the unit period.3. The body weight management device according to claim 2 , wherein the determination unit ...

PRESSURE SENSOR ASSEMBLY AND ASSOCIATED METHOD FOR PREVENTING THE DEVELOPMENT OF PRESSURE INJURIES

A pressure wound prevention system comprising at least one management device which comprises at least one user input apparatus, at least one output mechanism, at least one data input for connecting with a pressure sensor assembly and a processor configured to measure elapsed time, to receive pressure data from the data input and to present an output via the output mechanism. The system may be modular. A method for preventing the development of pressure wounds of a subject is also presented. 160-. (canceled)61. A pressure wound prevention system comprising:at least one sensor module comprising a plurality of pressure sensor elements; and at least one user input apparatus;', 'at least one output mechanism;', 'at least one data input connectable with the at least one sensor module; and', 'a processor configured to measure elapsed time, to receive pressure data from the data input, use the pressure data to calculate at least one risk index, compare the calculated risk index with at least one threshold value and to present an output via the output mechanism when the calculated risk index is greater than the at least one threshold value., 'at least one management module connectable with the sensor module, the at least one management module including62. The pressure wound prevention system of wherein the at least one sensor module comprises a docking station configured to connect to the at least one management module.63. The pressure wound prevention system of wherein the docking station includes a wireless communicator configured to communicate pressure data to the at least one management module.64. The pressure wound prevention system of wherein the at least one sensor module and the at least one management module each include at least one set of electrical contacts configured to connect with a corresponding set of electrical contacts on the other of the at least one sensor module and the at least one management module.65. The pressure wound prevention system of wherein ...

CONGENITAL HEART DISEASE MONITOR

A congenital heart disease monitor utilizes a sensor capable of emitting multiple wavelengths of optical radiation into a tissue site and detecting the optical radiation after attenuation by pulsatile blood flowing within the tissue site. A patient monitor is capable of receiving a sensor signal corresponding to the detected optical radiation and calculating at least one physiological parameter in response. The physiological parameter is measured at a baseline site and a comparison site and a difference in these measurements is calculated. A potential congenital heart disease condition in indicated according to the measured physiological parameter at each of the sites or the calculated difference in the measured physiological parameter between the sites or both. 117-. (canceled)18. A congenital heart disease monitor comprising:a display;a sensor configured to emit optical radiation having a plurality of wavelengths into a tissue site and to detect the optical radiation after attenuation by pulsatile blood flowing within the tissue site;a patient monitor configured to drive the sensor, receive a sensor signal corresponding to the detected optical radiation and to generate at least one of a visual output and an audio output responsive to the sensor signal; provide visual instructions to place the sensor on a first measurement site of a patient;', 'determine a first physiological measurement at the first measurement site;', 'provide visual instructions to move the sensor to a second physiological measurement site;', 'determine a second physiological measurement at the second measurement site; and', 'compare the measurements of the first and second measurement site as part of the determination of the indication of a congenital heart disease condition., 'one or more processors within the patient monitor programmed to derive a physiological parameter measurement from sensor data responsive to the sensor signal and determine and display an indication of a congenital heart ...

METHOD AND APPARATUS FOR DETECTING DISEASES ASSOCIATED WITH THE EYE

Disease may be detected, monitored, etc. by detecting metabolic dysfunction in a patient's eyes. In one embodiment of an apparatus, an excitation light is generated by an excitation light source to induce autofluorescence in an ocular tissue (e.g., retinal tissue), wherein the excitation light excites flavoprotein autofluorescence (FA) and minimizes the excitation of non-flavoprotein autofluorescence. At least a single image representing the induced ocular tissue autofluorescence is captured. The at least single image is intensified to increase the signal strength of the ocular tissue autofluorescence. The at least single image is analyzed to generate an indicator of whether a patient has one or more of eye damage, a disease that causes eye damage, or to generate an indicator of the progression of a disease, an indicator of the effectiveness of a treatment, a personalized treatment for a subject, etc. 1. A method comprising:measuring, in vivo and non-invasively, ocular flavoprotein fluorescence in ocular cells or ocular tissue with impaired electron transport or mitochondrial membrane instability; anddetermining from the measured ocular flavoprotein fluorescence ocular cells or ocular tissue that are in a pre-apoptotic state, wherein the level of ocular flavoprotein fluorescence indicates the functional status of mitochondria.2. The method of claim 1 , further comprising determining from the ocular flavoprotein fluorescence if the ocular cells or ocular tissue in the pre-apoptotic state are prone to apoptosis and undergo apoptosis.3. The method of claim 1 , further comprising determining from the ocular flavoprotein fluorescence if the ocular cells or ocular tissue in the pre-apoptotic state are prone to apoptosis but are rescued by endogenous intervention.4. The method of claim 1 , further comprising determining from the ocular flavoprotein fluorescence if the ocular cells or ocular tissue in the pre-apoptotic state are prone to apoptosis but are rescued by ...

PATIENT DETERIORATION DETECTION

A system (108) detects deterioration of a patient of a medical institution. A processor(152)receives attended physiological data for the patient from a user interface or a patient monitoring system (102) and obtains a baseline patient score from the attended physiological data and a scoring table. The scoring table is received from a memory (118). The processor (152) further receives physiological data, including at least one of unattended physiological data and attended physiological data, which includes measurements of one or more of the physiological parameters of the patient, from a patient monitoring system (102) for the patient. Scores of the physiological data measurements are compared to corresponding most recent attended physiological data measurements using the scoring table. A clinician is notified of patient deterioration if the score of one or more physiological data measurements has deteriorated as compared to the scores of the corresponding most recent attended physiological data measurements. 1. A deterioration detection system for detecting deterioration of a patient of a medical institution , said system comprising: receive attended physiological data for a patient, the attended physiological data including measurements of physiological parameters of the patient;', 'obtain a patient score for the patient from the attended physiological data and a scoring table;', 'receive physiological data, including at least one of unattended physiological data and attended physiological data, for the patient, the physiological data including measurements of one or more of the physiological parameters of the patient;', 'compare the measurements of the physiological data to corresponding measurements in most recent attended physiological data using the scoring table to determine any change in the patient score; and,', 'notify a clinician of patient deterioration in response to one or more physiological parameters of the physiological data deteriorating as compared ...

Automated Prevention and Control of Epileptic Seizures Using Biochemical And/or Electrical Signal Markers

Methods and medical device systems for preventing or abating seizures, making use of an association between the probability or likelihood of seizure occurrence and the concentrations or activity levels of one or more of putrescine, spermidine, spermine, or γγ-aminobutyric acid (GABA). The concentration or activity level of putrescine, spermidine, spermine, or GABA, or a substrate or enzyme for synthesis thereof, may be determined, and at least one further action may be performed. 1. A non-transitory computer readable program storage unit encoded with instructions that , when executed by a computer , perform a method , comprising:determining at least one of (i) a concentration of at least one polyamine selected from putrescine, spermidine, spermine, or γ-aminobutyric acid (GABA) in a brain of a patient, (ii) a concentration of a substrate for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, (iii) a concentration or an activity level of an enzyme for synthesis of putrescine, spermidine, spermine, or GABA in said brain of said patient, or (iv) a concentration of a metabolite of one of putrescine, spermidine, spermine, or GABA in said brain of said patient; andtaking a further action selected from:issuing a warning if said concentration or activity level is below a first reference value;indicating a lower probability or likelihood of an epileptic event if said concentration or activity level is above a second reference value;increasing said concentration if said concentration or activity level is below a third reference value; ormaintaining said concentration or activity level above a fourth reference value.2. The non-transitory computer readable program storage unit of , encoded with instructions that , when executed by a computer , perform the method of , wherein said increasing said concentration of said polyamine comprises activating an endogenous mechanism selected from increasing the concentration of at least one substrate for ...

Prediction and monitoring of clinical episodes

Apparatus and methods are provided including sensing at least one parameter of a subject while the subject sleeps. The parameter is analyzed, and a condition of the subject is determined at least in part responsively to the analysis. The subject is alerted to the condition only after the subject awakes. Other applications are also described.

Notification system of deviation from predefined conditions

The present invention includes a healthcare system for capturing and maintaining patient healthcare records and employing information in the records to proactively alert hospital workers to a condition that places patient health at risk.

Apparatuses And Methods For The Prevention Of Bodily Injuries

Apparatuses and methods for the prevention of bodily injuries through active monitoring of bodily postures, supporting a body while in or restricting a body from entering predetermined postures which heighten the body's susceptibility to injury, and alerting one or more entities (e.g., an apparatus user) of a body's susceptibility to injury is disclosed herein. In one embodiment, the method may include one or more operations including monitoring one or more bodily postures and/or bodily movements, storing data associated with bodily postures and/or bodily movements, determining a risk of injury associated with bodily postures and/or bodily movements, and alerting one or more entities when a risk of injury associated with bodily postures and/or bodily movements reaches a predetermined level. 1. A method for the prevention of bodily injuries , comprising:supporting a body while in or restricting the body from entering predetermined positions;monitoring bodily position;determining a risk of injury associated with bodily position;comparing the risk with a threshold level; andalerting one or more entities of the body's past, current, or expected future susceptibility to injury based on bodily position.2. The method of claim 1 , further comprising:transmitting data associated with bodily position to a data storage medium.3. The method of claim 1 , further comprising:tracking GPS coordinates;transmitting GPS coordinates to a data storage medium; anddetermining a position of the body from the GPS coordinates.4. A method for the prevention of bodily injuries claim 1 , comprising:supporting a body while in or restricting the body from entering predetermined positions;monitoring bodily position;determining a risk of injury associated with bodily position;storing data associated with bodily position; andtransmitting data associated with bodily position to a data storage medium.5. The method of claim 4 , further comprising:tracking GPS coordinates;transmitting GPS coordinates to ...

HEART FAILURE PATIENTS STRATIFICATION

A system, apparatus and method are provided to quantify a risk of worsening heart failure for subject using at least one physiological sensor circuit such as, for example, a heart sound sensor, a respiration sensor, a cardiac activity sensor, or other sensor circuit. A central tendency measurement of the at least one physiological sensor can be used to quantify the risk of worsening heart failure of the subject. 1. An apparatus comprising:at least a first physiological sensor circuit configured to generate a first physiological signal that is representative of cardiovascular function of a subject; [ determine a first physiological measurement using the first physiological sensor signal and determine a plurality of the first physiological measurements using a plurality of first physiological signals produced over a specified first time period; and', 'determine a central tendency measurement of the plurality of physiological measurements; and, 'a signal processing circuit configured to, 'a risk circuit configured to quantify a risk of worsening heart failure (WHF) for the subject using the determined central tendency measurement, including comparing the determined central tendency measurement to one or more criteria indicative of risk of WHF,, 'a control circuit communicatively coupled to the first physiological sensor circuit, wherein the control circuit includeswherein the control circuit is configured to generate an indication of risk of WHF according to a comparison of the determined central tendency measurement to the one or more criteria indicative of risk of WHF.2. The apparatus of claim 1 ,wherein the first physiological sensor circuit is configured to generate a first physiological signal type, and generate a first central tendency signal using a plurality of signals of the first physiological sensor signal type obtained for a number of cardiac cycles; and', 'determine the first physiological measurement using the first central tendency signal., 'wherein the ...

SYSTEM AND METHOD FOR QUANTITATIVELY ASSESSING DIABETIC CARDIAC AUTONOMIC NEUROPATHY IN TYPE I DIABETIC BIOLOGICAL SUBJECT

The present disclosure provides a method and an apparatus for identifying development of diabetic cardiovascular autonomic neuropathy (DCAN) in a biological subject. In one aspect, the method includes collecting data associated with heart rates of a biological subject, and processing the collected data to extract primary and secondary components of the collected data by performing a principal dynamic mode (PDM) analysis. A significant reduction of the primary or secondary component at a predetermined time period can be indicative of the DCAN development. 1. A method for identifying development of diabetic cardiovascular autonomic neuropathy (DCAN) in a biological subject , the method comprising:collecting data associated with heart rates of a biological subject; andprocessing the collected data to extract primary and secondary components of the collected data by performing a principal dynamic mode (PDM) analysis;determine whether there is a significant reduction of the primary or secondary component at a predetermined time period;wherein the significant reduction of the primary or secondary component at the predetermined time period is indicative of the DCAN development.2. The method of claim 1 , wherein the primary and secondary components respectively represent sympathetic and parasympathetic dynamics of an autonomic nervous system of the biological subject.3. The method of claim 1 , wherein collecting the data comprises monitoring pulsatile signals associated with the heart rates of the biological subject by detecting an optical property associated with a biological fluid of the biological subject using an imaging device of a portable communication device.4. The method of claim 1 , wherein collecting the data comprises monitoring pulsatile signals associated with the heart rates of the biological subject by using an electrocardiography (ECG) device.5. The method of claim 1 , wherein processing the collected data comprises using a computing device to:detrend the ...

System and method for monitoring glucose or other compositions in an individual

A system and method for modeling a blood glucose (BG) level of an individual is presented. A continuous glucose monitor (CGM) device is configured to monitor a blood glucose level of the individual. A processor is configured to receive CGM data of the individual from the CGM device, smooth the CGM data into a plurality of continuous curves, and generate an individual-level model of a BG profile of the individual using the plurality of continuous curves. The processor is configured to estimate the average blood glucose curve and inter-day variance-covariance of BG within the individual using the individual-level model, and generate a report based on the average blood glucose curve and inter-day variance-covariance of BG within the individual.

Sequential compression therapy compliance monitoring systems and methods

A system includes a sequential compression device (SCD) used by a patient as part of a sequential compression therapy (SCT) protocol. The system also includes a computer device that determines whether the SCD is in use in substantially real time in compliance with the protocol. The computer device initiates a notification to a caregiver if noncompliance with the SCT protocol is detected.

Monitoring volaemic condition in a human or animal subject

A method for processing data to monitor volaemic condition in a human or animal subject includes identifying one or more reference values for each of one or more haemodynamic variables; receiving haemodynamic data representing the one or more haemodynamic variables measured from the subject over time; for at least one of the one or more haemodynamic variables, comparing the haemodynamic data with the respective one or more reference values; and identifying the existence of abnormal volaemic condition in the subject when the comparison indicates a deviation from the one or more reference values for at least one of the haemodynamic variables. The method may be combined with a visual display of haemodynamic data in real time, ideally in conjunction with a visual indicator of ideal reference values.

METHOD AND APPARATUS FOR TRACKING A POSITION OF A TUMOR

Provided is a method and apparatus for tracking a tumor position, which changes by the movement of a body. According to various aspects, a location of a tumor position of a target organ may be estimated using images of one or more surrounding organs. 1. A method of tracking a tumor position , the method comprising:generating a target organ model and a surrounding organ model based on a medical image comprising anatomical information of a target organ having a tumor and a surrounding organ located on a periphery of the target organ;updating the surrounding organ model based on a real-time image of the target organ and the surrounding organ;updating the target organ model based on the updated surrounding organ model; andestimating a position of the tumor included in the target organ based on the updated target organ model.2. The method of claim 1 , wherein the updating of the target organ model comprises estimating a position and shape of the target organ.3. The method of claim 1 , wherein the updating of the target organ model comprises:extracting characteristics of the target organ from the real-time image; andestimating a position and a shape of the target organ based on the extracted characteristics of the target organ.4. The method of claim 1 , wherein the updating of the target organ model comprises estimating a position and shape of the target organ based on the extracted characteristics of the target organ and the updated surrounding organ model.5. The method of claim 1 , wherein the updating of the target organ model comprises estimating a position and shape of the target organ based on the extracted characteristics of the target organ and a respiratory phase of a target body.6. The method of claim 1 , wherein the generating of the target organ model and the surrounding organ model comprises:generating models showing shapes of the target organ and the surrounding organ; andmodeling movement of the generated models.7. The method of claim 1 , wherein the ...

NONINVASIVE SYSTEMS FOR AORTIC ANEURYSM EVALUATION

Hardware and software methodology are described for non-invasive approaches to aortic aneurysm evaluation using ultrasound, microwave, and/or other radiofrequency (RF) techniques. Embodiments can be used to diagnose AAA and other aortic aneurysm conditions by non-invasive measurement and computation of displacement-based wave intensity (DWI) and/or displacement-based reflected wave intensity (DRWI) along the aorta and by comparison of the results to baseline data for a given patent or a population sample catalogue. Deviation of DWI and/or DRWI from a normal condition can be used to assess the severity of the AAA or other aortic aneurysm and any associated rupture risk. 1. A system for non-invasive aortic aneurysm evaluation of a subject , comprising:at least one sensor, the at least one sensor adapted to produce a first data set that correlates to distension of a blood vessel and to produce a second data set that correlates to blood velocity within the vessel; andat least one processor, the at least one processor configured to convert the first data set to a measurement of blood vessel distention and the second data set to a measurement of blood velocity, to calculate from the distention and velocity measurements at least one of a displacement-based wave intensity (DWI) and a displacement-based reflected wave intensity (DRWI), and to compare at least one of the DWI and the DRWI to baseline data.2. The system of claim 1 , wherein the baseline data is from the subject.3. The system of claim 1 , wherein the baseline data is from a sample catalogue.4. The system of claim 1 , wherein the processor is further configured to output an indication of a presence of an aneurysm.5. The system of claim 4 , wherein the processor is further configured to output an indication of a severity of an aneurysm.6. The system of claim 4 , wherein the processor is further configured to output an indication of a risk of aneurysm rupture.7. The system of claim 1 , configured to calculate both ...

MONITORING, PREDICTING AND TREATING CLINICAL EPISODES

Apparatus and methods are provided for use with a subject who is undergoing respiration. A motion sensor senses motion of a subject. A breathing pattern analysis unit analyzes components of the sensed motion that result from the subject's respiration. The breathing pattern analysis unit includes double-movement-respiration-cycle-pattern-identification functionality that designates respiration cycles as being double-movement-respiration-cycles (DMRC's) by determining that the cycles define two subcycles. Double-movement-respiration-cycle-event-identification functionality of the breathing pattern analysis unit identifies a DMRC event by detecting that the subject has undergone a plurality of DMRC's. An output is generated that is indicative of the subject having used accessory muscles in breathing, in response to identification of the double-movement-respiration-cycle event. Other embodiments are also described. 1. Apparatus for use with a subject who is undergoing respiration , the apparatus comprising:a motion sensor configured to sense motion of a subject; double-movement-respiration-cycle-pattern-identification functionality that is configured to designate respiration cycles as being double-movement-respiration-cycles by determining that the cycles define two subcycles; and', 'double-movement-respiration-cycle-event-identification functionality configured to identify a double-movement-respiration-cycle event by detecting that the subject has undergone a plurality of double-movement-respiration-cycles; and', 'output-generation functionality configured to generate an output that is indicative of the subject having used accessory muscles in breathing, in response to identification of the double-movement-respiration-cycle event; and', 'a user interface configured to display the output., "a breathing pattern analysis unit that is configured to analyze components of the sensed motion that result from the subject's respiration, the breathing pattern analysis unit ...

SYSTEMS AND METHODS FOR DETECTING ISCHEMIC EVENTS

Embodiments of the present invention relate to implantable systems, and method for use therein, that can detect myocardial ischemic events. In accordance with specific embodiments of the present invention, short-term fluctuations in cardiac intervals that follow premature ventricular contractions (PVCs) are monitored. This allows myocardial ischemic events to be detected based on these monitored fluctuations. The cardiac intervals for which fluctuations are being monitored can be, for example, RR intervals. Alternatively, or additionally, short-term fluctuations in other types of cardiac intervals may be monitored. Such other cardiac intervals include, for example, PR intervals, PP intervals, QT intervals and RT intervals. 1. An implantable system , comprising:a monitor that monitors short-term fluctuations in cardiac intervals that follow premature ventricular contractions;a detector that detects ischemic events based on the monitored fluctuations, determines whether a patient is experiencing an ischemic event, and, when the patient is experiencing an ischemic event, at least one of the following: triggers myocardial ischemia therapy, transmits an alert that an action appropriate to the detection of myocardial ischemia should be taken, and stores a measure of myocardial ischemia burden.2. The system of claim 1 , wherein the monitor monitors cardiac intervals that both precede and follow each premature ventricular contraction claim 1 , such that cardiac intervals that precede the premature ventricular contraction can be used in calculating the short-term fluctuations in cardiac intervals that follow the premature ventricular contraction.3. The system of claim 1 , wherein the monitor monitors short-term fluctuations in cardiac intervals within beats that follow a premature ventricular contraction.4. The system of claim 1 , wherein the premature ventricular contractions are intrinsic claim 1 , induced or simulated claim 1 , or combinations thereof.5. The system of ...

Methods and systems for selectively filtering a physiological signal

A physiological monitoring system may determine physiological information, such as physiological rate information, from a physiological signal. The system may apply a digital filter to the physiological signal to assist in the determination of the physiological information. The system may determine a metric based on the physiological signal, and selectively apply the digital filter to the physiological signal based on the metric. The digital filter, which may include two or more filter coefficients, may correspond to a weighted sum of the physiological signal and a difference signal corresponding to the physiological signal. The filter coefficients may be adjustable, allowing selectivity in the characteristics of the digital filter between weighting the physiological signal and difference signal.

GLUCOSE PREDICTOR BASED ON REGULARIZATION NETWORKS WITH ADAPTIVELY CHOSEN KERNELS AND REGULARIZATION PARAMETERS

The invention relates to a method and a device for predicting a glycaemic profile of a subject. A multistage algorithm is employed comprising a prediction setting stage specifying a functional space for the prediction and a prediction execution stage specifying a predicted future glycaemic state of the subject in the functional space as a continuous function of time. 2. A device according to claim 1 , wherein the prediction setting stage specifies the functional space based on the information received by the input device.3. A device according to claim 1 , wherein the specified continuous function of time depends on a reproducing kernel and a regularization parameter claim 1 , and wherein the prediction setting stage is adapted to determine the reproducing kernel and an initial value of the regularisation parameter.4. A device according to claim 1 , wherein the prediction setting stage comprises:a labelling of data segments containing information received by the input device, anda determination of a kernel and an initial regularization parameter based on respective labels of the data segments, and wherein the prediction execution stage specifies a predicted glycaemic state by using the determined kernel and initial regularization parameter to construct the continuous function of time.5. A device according to claim 4 , wherein the labelling of data segments comprises a linear fitting claim 4 , and wherein the suggestion of a kernel and an initial regularization parameter is based on respective coefficients of the linear fit.6. A device according to claim 4 , wherein the continuous function of time is constructed by a regularized learning algorithm in a reproducing kernel Hilbert space.7. A device according to claim 6 , wherein the reproducing kernel Hilbert space is selected based on a data pool of training data segments claim 6 , each training data segment being indicative of a physiologic condition of a subject at respective points in time.8. A device according to ...

PREDICTING NEAR-TERM DETERIORATION OF HOSPITAL PATIENTS

Methods, systems, and computer storage media are provided for predicting a probability of acute deterioration for a specific patient. Various discrete measurements are taken regarding the patient's current health. Those measurements are used to determine a PPOD score, which is displayed for clinicians. 1. Computer storage media , not being a signal per se , storing computer-usable instructions that , when executed by one or more computing devices , cause the one or more computing devices to perform a method for determining a probability of acute deterioration for a particular patient , the method comprising:receiving patient information comprising a plurality physiological measurements for a patient in anatomically challenged and unchallenged positions;conditioning the patient information to create conditioned patient information; andbased on the conditioned patient information, determining a statistical probability of acute deterioration for the patient.2. The media of claim 1 , wherein the physiological measurements comprise systolic blood pressure (SBP) measurements and heart-rate measurements for the patient.3. The media of claim 2 , wherein the physiological measurements for the patient in anatomically challenged and unchallenged positions are derived from the patient in a supine position and a tilted position claim 2 , respectively.4. The media of further comprising selectively providing a notification based on the determined statistical probability of acute deterioration.5. The media of claim 1 , wherein the plurality of physiological measurements comprises a timeseries of measurements with timeseries intervals greater than 30 minutes.6. The media of claim 1 , wherein conditioning the patient information includes determining an index of deviation of the patient's current SBP from the patient's usual SBP.7. The media of claim 6 , wherein conditioning the patient information further includes determining a baroreceptor reflex sensitivity (BRS).8. The media of ...

CARDIOVASCULAR RISK EVALUATION APPARATUS

A cardiovascular risk evaluation apparatus includes a hypoxic acquisition unit for acquiring a measurement result that includes a blood oxygen saturation level measured in a hypoxic period in which the blood oxygen saturation level of a subject is lower than a threshold value, and a blood pressure measured when the blood oxygen saturation level was measured; a non-hypoxic acquisition unit for acquiring a measurement result that includes a blood oxygen saturation level measured in a non-hypoxic period of the blood oxygen saturation level of the subject, and a blood pressure measured when the blood oxygen saturation level was measured; and an indicator acquisition unit for acquiring a cardiovascular risk evaluation indicator for the subject based on the relationship between blood oxygen saturation level and blood pressure, which is based on the measurement results acquired by the hypoxic acquisition unit and the non-hypoxic acquisition unit. 1. A cardiovascular risk evaluation apparatus comprising:a hypoxic acquisition unit that acquires a measurement result that includes a blood oxygen saturation level that is measured in a hypoxic period in which the blood oxygen saturation level of a subject is lower than a threshold value, and a blood pressure that was measured when the blood oxygen saturation level was measured;a non-hypoxic acquisition unit that acquires a measurement result that includes a blood oxygen saturation level that is measured in a non-hypoxic period of the blood oxygen saturation level of the subject, and a blood pressure that was measured when the blood oxygen saturation level was measured;an indicator detection unit that acquires a cardiovascular risk evaluation indicator for the subject based on a relationship between blood oxygen saturation level and blood pressure that is based on the measurement result acquired by the hypoxic acquisition means and the measurement result acquired by the non-hypoxic acquisition means; anda display information ...

Feedback from Cloud or HCP to Payer or Patient via Meter or Cell Phone

Presented herein are one or more software applications to help a user manager their diabetes. Embodiments and descriptions of the various applications are provided below in conjunction with an analyte measurement device. 119-. (canceled)20. A method , comprising:displaying a chart having median glucose as a first axis and glucose variability as a second axis; anddisplaying an identifier on the chart corresponding to a median glucose value and a glucose variability value for sample data from a first patient, wherein the identifier represents a state of glucose control for the first patient.21. The method of claim 20 , wherein glucose variability is defined by the difference between the median glucose value and a predetermined percentile value of glucose.22. The method of claim 21 , wherein the predetermined percentage value is 10 percent.23. The method of claim 20 , comprising:displaying a graphical overlay representing a chronic clinical risk on the chart, wherein the graphical overlay derived representing retinopathy risk is based on eAG and median glucose values for a population of patients.24. The method of claim 23 , wherein the chronic clinical risk is retinopathy risk.25. The method of claim 24 , comprising:displaying a graphical overlay representing an acute risk on the chart, wherein the graphical overlay representing acute risk of hypoglycemia comprises one or more lines of hypoglycemia occurrences per a given time period.26. The method of claim 25 , wherein the acute risk is a risk of hypoglycemia.27. The method of claim 26 , comprising:directing patient treatment based on the position of the identifier representing the state of glucose control for the first patient with respect to the graphical overlays for retinopathy risk and/or acute risk of hypoglycemia.28. The method of claim 20 , comprising:displaying a graphical overlay for one or more clinical risks on the chart, wherein the graphical overly of the one or more clinical risks is associated with one ...

FEVER DETECTION APPARATUS

The invention relates to a fever detection apparatus for detecting fever of a living being. A heart rate providing unit () provides a heart rate value and a peripheral physiological value providing unit () provides a peripheral physiological value, wherein a heart rate characteristics determination unit () determines heart rate characteristics from the heart rate value and a peripheral characteristics determination unit () determines peripheral characteristics from the peripheral physiological value. A fever detection unit () detects fever depending on the heart rate characteristics and the peripheral characteristics. Since the heart rate characteristics and the peripheral characteristics are influenced by fever, the fever detection apparatus can be used to reliably and preferentially unobtrusively detect fever. 1. A fever detection apparatus for detecting fever of a living being , the fever detection apparatus comprising:a heart rate providing unit for providing a heart rate value being indicative of the heart rate of the living being measured over time,a peripheral physiological value providing unit providing a peripheral physiological value being indicative of a peripheral physiological property of the living being measured over time,a heart rate characteristics determination unit for determining heart rate characteristics from the heart rate value measured over time,a peripheral characteristics determination unit for determining peripheral characteristics from the peripheral physiological value measured over time, characterized bya fever detection unit for detecting fever depending on the heart rate characteristics and the peripheral characteristics.2. The fever detection apparatus as defined in claim 1 , wherein the peripheral physiological value providing unit is adapted to provide at least one of a skin temperature value being indicative of a skin temperature of the living being and a peripheral perfusion value being indicative of the blood perfusion in the ...

Multilead ecg template-derived residua for arrhythmia risk assessment

A method and system for predicting the onset of heart arrhythmias more accurately observes trends in abnormal or pathologic morphology of the electrocardiogram (ECG). A first set of ECG signals is monitored from a patient. A baseline measurement is generated from the monitored first set of ECG signals to contain nonpathologic ECG morphologies in each lead. A second set of ECG signals is monitored from the patient and the baseline measurement is subtracted from the second set of ECG signals on a beat-to-beat basis. Afterwards, a residuum signal is generated for each lead based on the subtraction. R-wave heterogeneity, T-wave heterogeneity, P-wave heterogeneity, or ST-segment heterogeneity or other indicators of arrhythmia risk or myocardial ischemia are quantified based on the generated residuum signals.

System and Method of Predicting Future Fractures

Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also include determining the effect of a candidate agent on any subject's risk of fracture. 1. A method for predicting fracture risk using electronic image data of a part of a skeleton of a target in a computer system , the method comprising:performing a sliding window analysis of the electronic image data;generating at least one bone structure parameter corresponding to at least a portion of the target;generating a parameter map from the at least one bone structure parameter to predict a fracture line;analyzing the at least one bone structure parameter along the predicted fracture line to predict a fracture load at which a fracture will occur; andpredicting a fracture risk by calculating a ratio between the fracture load and a peak impact force on the part of the skeleton of the target.2. The method of claim 1 , wherein the peak impact force is estimated.3. The method of claim 1 , wherein the peak impact force is calculated.4. The method of claim 1 , further including obtaining a body habitus of the target and using the body habitus to estimate or calculate the peak impact force. This patent application is a continuation of U.S. patent application Ser. No. 11/228,126, filed Sep. 16, 2005, now U.S. Pat. No. 8,600,124, which claims the benefit of U.S. Patent Application Ser. No. 60/610,447, filed Sep. 16, 2004, the disclosures of which are incorporated by reference herein in its entireties.1. Field of the InventionThis invention relates to using imaging methods for ...

Diagnostic, Prescriptive, And Data-Gathering System And Method For Macular Pigment Deficits And Other Eye Disorders

A macular health measurement and storage system comprises a plurality of macular-pigment measurement machine for measuring macular pigment density in humans, a plurality of computers each of which is associated with a corresponding one the macular-pigment measuring machines, and a central host. The plurality of macular-pigment measurement machines include a device for receiving macular pigment data from a patient, at least one data transfer port, and at least one processor that enables the transfer of the macular pigment data from the transfer port. The plurality of computers include a first port coupled to the data transfer port of the corresponding macular-pigment measurement machine for receiving the macular pigment data. Each of the computers includes a second port for transferring patient data. The central host is coupled to the second ports on each of the plurality of computers. The central host includes a storage device for storing the patient data.

Computerized Systems and Methods for Stability-Theoretic Prediction and Prevention of Falls

A system, methods, A system, methods and computer-readable media are provided for the automatic identification of patients according to near-term risk of sudden kinematic injury (falling). Embodiments of the invention are directed to event prediction, risk stratification, and optimization of the assessment, communication, and decision-making to prevent falling in humans, and in one embodiment take the form of a platform for wearable, mobile, unteathered monitoring devices with embedded decision support.

SYSTEM AND METHOD FOR DETECTING EMOTIONAL STATE OF PET

Disclosed is a system for detecting an emotional state of a companion animal, including: a state information collecting device comprising a microphone and sound sensor which collects a sound of the companion animal, a temperature sensor which collects a temperature of the companion animal, and an acceleration sensor which collects an activity of the companion animal, the state information collecting device being worn on a body of the companion animal; and a companion-animal emotion analysis server configured to extract characteristic information of sound information of the companion animal transmitted from the state information collecting device, select emotional state information of the companion animal corresponding to the extracted characteristic information from a database, and transmit the selected emotional state information of the companion animal through a wireless communication network to a portable terminal of an animal guardian. 1. A method for detecting an emotional state of a companion animal , the method comprising:(a) wearing a state information collecting device on a body of the companion animal, the state information collecting device comprising a microphone and sound sensor into which a companion-animal sound is input, a temperature detection sensor which detects a temperature of the companion animal, and a three-axis acceleration sensor which detects an activity of the companion animal;(b) storing sound information in the state information collecting device during a predetermined time when the companion-animal sound is generated;(c) transmitting the sound information, temperature information, and activity information of the companion animal detected in the microphone and sound sensor, the temperature detection sensor, and the three-axis acceleration sensor to a companion-animal emotion analysis server through wireless communication;(d) deducing emotion information of the companion animal by gathering the sound information, the temperature ...

ESTIMATION APPARATUS, ESTIMATION METHOD, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM

An estimation apparatus acquires stance phases of both feet and estimates a risk of abnormality of a lower limb on the basis of the difference between the stance phases of the both feet. 1. An estimation apparatus comprising:at least one memory configured to store instructions; andat least one processor configured to execute the instructions to:acquire stance phases of both feet; andestimate a risk of abnormality of a lower limb on the basis of a difference between the stance phases of the both feet.2. The estimation apparatus according to claim 1 , wherein the at least one processor is configured to execute the instructions to calculate the stance phases of the both feet on the basis of sensing information obtained from sensors provided in soles of shoes worn on the both feet.3. The estimation apparatus according to claim 2 , wherein the at least one processor is configured to execute the instructions to calculate the stance phases of the both feet on the basis of acceleration indicated by the sensing information.4. The estimation apparatus according to claim 2 , wherein the at least one processor is configured to execute the instructions to calculate the stance phases of the both feet on the basis of pressure values indicated by the sensing information.5. An estimation method comprising:acquiring stance phases for both feet, andestimating a risk of abnormality of a lower limb on the basis of a difference between the stance phases of the both feet.6. A non-transitory computer readable recording medium that records a program for causing a computer of an estimation apparatus to execute:acquiring stance phases of both feet; andestimating a risk of abnormality of a lower limb on the basis of a difference between the stance phases of the both feet. This application is based upon and claims the benefit of priority from Japanese Patent Application No. 2020-115936, filed Jul. 3, 2020, the disclosure of which is incorporated herein in its entirety by reference.The present ...

DETERMINATION APPARATUS, SENSOR APPARATUS, DETERMINATION METHOD, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM

A determination apparatus acquires a feature amount of a whipping motion of a foot and determines a gait disorder risk on the basis of the feature amount. 1. A determination apparatus comprising:at least one memory configured to store instructions; andat least one processor configured to execute the instructions to:acquire a feature amount of a whipping motion of a foot; anddetermine a gait disorder risk on the basis of the feature amount.2. The determination apparatus according to claim 1 , wherein the at least one processor is configured to calculate the feature amount on the basis of an acceleration or an angular velocity of the foot.3. The determination apparatus according to claim 2 , wherein the at least one processor is configured to calculate the feature amount in a whipping motion determination period from a pre-swing to an initial swing of any leg in a walking motion cycle of a person.4. The determination apparatus according to claim 1 , wherein the at least one processor is configured to determine the gait disorder risk on the basis of a comparison between the feature amount related to a user and a past feature amount related to the user.5. The determination apparatus according to claim 1 , wherein the at least one processor is configured to determine the gait disorder risk on the basis of a comparison between the feature amount related to one foot of a user and the feature amount related to the other foot of the user.6. The determination apparatus according to claim 1 , wherein the at least one processor is configured to determine the gait disorder risk on the basis of a comparison between the feature amount related to a user and a feature amount related to another user.7. The determination apparatus according to claim 2 , whereinthe acceleration or the angular velocity is measured by a sensor provided in a sole of a shoe attached to the foot, andthe feature amount is a rotation angle around a leg axis with a vicinity of an ankle of the foot as an origin ...

SYSTEMS AND METHODS FOR HEALTH DATA VISUALIZATION AND USER SUPPORT TOOLS FOR CONTINUOUS GLUCOSE MONITORING

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host. 1. A system comprising:a continuous analyte sensor configured to obtain glucose data of a host; a wireless transmitter configured to receive the glucose data from the continuous analyte sensor and transmit the glucose data to a processing module; andthe processing module further configured to receive insulin data of the host, the glucose data of the host, and event data of the host and to produce a graphical display on a mobile computing device,wherein the processing module further modifies the graphical display to display a visual indicating one or more relationships of the insulin data, the glucose data, the event data with each other or time, wherein the visual is scaled to not obscure the display of the insulin, glucose or event data.2. The system of claim 1 , wherein the event data includes one or more of insulin dosing claim 1 , carbohydrate intake claim 1 , or exercise.3. The system of claim 1 , wherein the insulin data includes an insulin on board value claim 1 , and the visual comprises a colored ring indicating the insulin on board and an estimated time remaining for the insulin on board.4. The system of claim 1 , wherein the visual comprises a trend graph of the glucose data and an interactive call out window associated with a region or a feature of the trend graph that is presented when a user selects the region or the feature of the trend graph on the graphical display claim 1 , wherein the presented call-out window comprises at least some of the insulin data or the event data.5. The system of claim 4 , wherein the presented call-out window is configured to display a graphical arrangement of the insulin ...

DIAGNOSIS TAILORING OF HEALTH AND DISEASE

The present invention relates generally and specifically to computerized devices capable of diagnosis tailoring for an individual, and capable of controlling effectors to deliver therapy or enhance performance also tailored to an individual. The invention integrates sensors which sense signals from measurable body systems together with external machines, to form adaptive digital networks over time of general health and health of specific body functions. The invention has applications in sleep and wakefulness, sleep-disordered breathing, other breathing disturbances, memory and cognition, monitoring and response to obesity or heart failure, monitoring and response to other conditions, and general enhancement of performance. 1. A method for diagnosis tailoring to improve the breathing-health of an individual , comprising:detecting one or more signals, directly or indirectly, from one or more sensors, the signals associated with breathing at a plurality of points in time, wherein signals that are not breaths are identified as breath-related and non-breath related components of breathing;tailoring a diagnosis of breathing-health to the individual based upon identifying one or more breaths from the one or more signals, and identifying at least one or more of (i) one or more quantitative indexes of health symptoms and (ii) one or more quantitative indexes of physical examination signs; wherein the diagnosis tailoring is determined using one or more of mathematical rules, mathematical weighting, machine learning, statistical correlation, and applying a threshold of breathing-health; andproviding a representation of the tailored diagnosis at the one or more points in time.2. The method of claim 1 , wherein the threshold of breathing-health is predetermined or dynamic.3. The method of claim 2 , wherein a threshold of breathing health can be tailored dynamically for the individual based upon one or more of recorded patterns in that individual claim 2 , recorded patterns in ...

DIAGNOSIS TAILORING OF HEALTH AND DISEASE

The present invention relates generally and specifically to computerized devices capable of diagnosis tailoring for an individual, and capable of controlling effectors to deliver therapy or enhance performance also tailored to an individual. The invention integrates sensors which sense signals from measurable body systems together with external machines, to form adaptive digital networks over time of general health and health of specific body functions. The invention has applications in sleep and wakefulness, sleep-disordered breathing, other breathing disturbances, memory and cognition, monitoring and response to obesity or heart failure, monitoring and response to other conditions, and general enhancement of performance. 1. (canceled)2. The method of claim 32 , wherein the threshold of breathing-health is predetermined or dynamic.3. The method of claim 2 , wherein a threshold of breathing health can be tailored dynamically for the individual based upon one or more of recorded patterns in that individual claim 2 , recorded patterns in other individuals claim 2 , patient history claim 2 , population database claim 2 , population characteristics claim 2 , machine learning claim 2 , and disease type.4. The method of claim 29 , wherein the one or more sensors is physically in contact with the body.5. The method of claim 29 , wherein the one or more sensors is not physically in contact with the body.6. The method of claim 29 , wherein the one or more signals are biological signals.7. The method of claim 29 , wherein the one of more indices of health are non-biological.8. The method of claim 29 , wherein the plurality of points in time comprise one or more days for repeated testing.9. The method of claim 6 , wherein the biological signal is selected from one or more of sounds from the airway associated with breathing claim 6 , sounds detectable on the body surface associated with breathing claim 6 , vibrations detectable on the body surface associated with breathing ...

Low Noise Sensing Circuit with Cascaded Reference

This disclosure provides cascaded reference circuits and low amplitude signal sensing circuits that are useful in applications where high sensitivity, low noise measurements are needed. Such embodiments may be especially useful in health and fitness wearable devices. Systems incorporating the circuits, as well as methods for using these circuits to determine quantities and qualities of a person's moods, such as how much and what kinds of stress they experience. The provided devices are useful on limbs and appendages, such as in a smart watch that is worn on the wrist. Methods are provided for using the devices of this disclosure to privately alert wearers to an increase in bad stress in the moment when they can take actions to reduce their stress and physiological stress responses. These devices are useful for measuring and increasing the effectiveness of relaxation techniques. As a result of using methods and devices of this disclosure, people are healthier, they make more response-able decisions, and relationships improve. 1. A circuit that provides a cascaded reference comprising:a first reference generator comprising: a first pair of resistive elements configured to inject a driven first reference containing a DC voltage and power supply noise to a second reference generator or to amplifying and filtering circuitry; andsaid second reference generator comprising: a second pair of resistive elements configured to inject a driven second reference containing a combined output of the first reference generator and an arbitrary input into a specimen or amplifying and filtering circuitry.2. The circuit of further comprising: a low amplitude signal sensing circuit including a sensing circuit configured to be electrically connected to said cascaded reference circuit through said specimen claim 1 , said sensing circuit comprising: 'electrical stimulus from said specimen, said stimulus comprising a low amplitude signal; and', 'one or more sensing electrodes configured to ...

Assembly, method and computer program product for influencing a biological process

The invention provides an assembly comprising: 1. An assembly comprising:a recording assembly for recording a time-based brain-related signal;a stimulus generator for providing a stimulus, anda computer assembly, functionally coupled to said recording assembly and to said stimulus generator, said computer assembly comprising:a memory for storing at least a data segment of said time-based brain-related signal during recording of said time-based brain-related signal, anda computer program which, when running on said computer assembly, functionally real-time performs:retrieving a most-recent data segment of said stored data segment of said time-based brain-related signal;fitting at least one curve to said retrieved most-recent data segment;predicting a future continuation of said most-recent data segment using said at least one curve fitted to said most-recent data segment;detecting a predefined pattern in said predicted future continuation for predicting occurrence of said predefined pattern, and defining a predicted event time of said predefined pattern, said predicted event time being in the future with respect to said most-recent data segment, andactuating said stimulus generator for providing a stimulus within a predefined event time window of said predicted event time.2. The assembly of claim 1 , wherein said prediction extending at least 0.5 seconds beyond the end time of said data segment claim 1 , in particular at least 0.5 seconds past a current time of the assembly.3. The assembly of claim 1 , wherein said stimulus generator is arranged for applying a sensory discernible stimulus claim 1 , in particular a sound or light stimulus that can be perceived by a human.4. The assembly of claim 1 , wherein said computer program is adapted for retrieving a most-recent data segment that has an end time that is less than 0.5 seconds from an assembly current time claim 1 , in particular less than 0.1 second claim 1 , more in particular less than 1 millisecond.5. The ...

SYSTEMS AND METHODS FOR DYNAMICALLY IDENTIFYING A PATIENT SUPPORT SURFACE AND PATIENT MONITORING

Various patient monitoring systems can include a sensor configured to collect three dimensional information. The systems can identify a location of a patient support surface based on the three dimensional information. The systems can set a two dimensional planar threshold based on the patient support surface. The systems can identify a patient location above the patient support surface based on the three dimensional information and compare the patient location to the two dimensional planar threshold. Exceeding the threshold can be indicative of a high risk of a patient fall. An alert can be generated based on the threshold being exceeded. The systems can repeat the identification of the patient support surface location and the setting of the threshold to account for changes in the patient area. 132-. (canceled)33. A patient monitoring system for monitoring a patient area , the system comprising:a sensor configured to output a plurality of frames, the plurality of frames containing three dimensional pixel information of the patient area;a user interface; and receive the three dimensional pixel information of the plurality of frames;', 'identify a location and dimensions of a patient support surface based on the three dimensional pixel information;', 'set at least one threshold that is extended above, below, or vertically beyond the location and dimensions of the patient support surface;', 'determine a repositioning of the patient support surface;', 'adjust the at least one threshold based on the repositioning of the patient support surface;', 'identify one or more patient locations based on the three dimensional pixel information;', 'compare the one or more patient locations to the at least one threshold; and', 'generate an output with the user interface based on the one or more patient locations traversing the at least one threshold., 'control circuitry configured to34. The patient monitoring system of claim 33 , wherein the control circuitry is configured to:detect ...