МИКРОФЛЮИДНЫЙ КАРТРИДЖ ДЛЯ ДЕТЕКЦИИ БИОМОЛЕКУЛ

Группа изобретений относится к молекулярно-биологическому диагностированию. Микрофлюидный картридж (100) для детекции биомолекул содержит камеру (140) детекции, микрочип (142) на основе комплементарной структуры металл-оксид-полупроводник (CMOS), имеющий сенсорную область (144), расположенную в камере (140) детекции, и контактную область (146), герметично отделенную от камеры (140) детекции. Камера (140) детекции выполнена с возможностью подачи раствора пробы через впускной канал (124) и вывода анализируемого раствора пробы через выпускной канал (126). Сенсорная область (144) микрочипа (142) содержит систему функционализованных тестовых участков (130) для электрохимической детекции биомолекул в растворе пробы. Каждый тестовый участок (130) сенсорной области (140) снабжен собственным сигма-дельта модулятором (132) для аналого-цифрового преобразования электрических сигналов, генерируемых на тестовых участках (130) при электрохимической детекции. Обеспечивается упрощение и сокращение времени ...

Systems and methods for detection of cells using engineered transduction particles

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Method for producing microcarriers

The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer (6) having a sandwich structure comprising a bottom layer (7), a top layer (8) and a insulating layer(9) located between said bottom and top layers (7, 8), (b) etching away the top layer (8) to delineate lateral walls (12) of bodies (11) of the microcarriers, (c) depositing a first active layer (13)at least on a top surface (14) of the bodies (11), (d) applying a continuous polymer layer (16) over the first active layer(13), (e) etching away the bottom layer (7) and the insulating layer (9), (f) removing the polymer layer (16) to release the microcarriers.

SPECIMEN CONTAINER LABEL FOR AUTOMATED CLINICAL LABORATORY PROCESSING SYSTEMS

A specimen collection container for automated viewing against a colored background, comprising an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein, wherein a material that forms the sidewall includes colorless indicia integrated with the material and having a surface enhancement feature for providing visual distinction from at least a portion of the sidewall.

Pipetting device with a liquid volume sensor and liquid processing system.

Die Erfindung betrifft eine Pipettiervorrichtung mit einer Röhre (1), welche an einem Ende eine Öffnung (3) zum Ansaugen bzw. Abgeben einer Probenflüssigkeit aufweist, und die am anderen Ende mit einem Druckerzeugungsmittel wirkverbindbar ist, wobei an der Pipettiervorrichtung eine erste Elektrode (5) ausgebildet ist, welche zusammen mit einer zweiten Elektrode (4´), die durch mindestens einen Teil der in der Röhre (1) aufnehmbaren Probenflüssigkeit (4´) gebildet wird, einen Messkondensator bildet, welcher mit einer Messeinheit wirkverbunden ist, welche ausgebildet ist, um in Abhängigkeit der Kapazität des Messkondensators ein Volumen der angesaugten bzw. abgegebenen Probenflüssigkeit (4´) zu bestimmen. Des Weiteren werden ein Flüssigkeitsbearbeitungssystem mit einer solchen Pipettiervorrichtung sowie ein Verfahren zur Bestimmung eines bearbeiteten Flüssigkeitsvolumens beim Pipettieren mit einer solchen Pipettiervorrichtung vorgeschlagen. Ferner werden Verwendungen von diesem Verfahren ...

Pipette tip comprising a volume measuring electrode and its preparation and pipetting device.

Die vorliegende Erfindung betrifft Pipettenspitzen (1) zum Anschliessen an eine Pipettenröhre (2) von einer Pipettiervorrichtung, welche zum Aufnehmen und Abgeben von Flüssigkeiten verwendet werden. Eine erfindungsgemässe Pipettenspitze (1) ist als langgestreckte Röhre geformt, welche einen Pipettenkörper (4) bildet, der an seinem einen Ende eine Öffnung (5) aufweist, und an seinem anderen Ende zum Anschliessen an die Pipettenröhre (2) ausgebildet ist, wobei die Pipettenspitze (1) dadurch gekennzeichnet ist, dass sie eine Elektrode (7) als Volumenmesselektrode eines Messkondensators aufweist. Des Weiteren betrifft die vorliegende Erfindung Pipettiervorrichtungen mit einer solchen Pipettenspitze (1), Verfahren zum Bestimmen des Volumens einer Probenflüssigkeit in einer solchen Pipettenspitze (1), Verfahren zum Erkennen einer solchen Pipettenspitze (1) an einer Pipettiervorrichtung, Verfahren zur Herstellung einer solchen Pipettenspitze (1), Verwendungen einer solchen Pipettenspitze (1) sowie ...

Pipette with pipette-pointed recognition unit and method for detecting a pipette tip at a pipetting device.

Die vorliegende Erfindung betrifft eine Pipettiervorrichtung mit einer auswechselbaren Pipettenspitze (2) zum Ansaugen und Abgeben von Flüssigkeitsvolumina für den Einsatz in automatisierten Laborgeräten/-anlagen. Es wird eine Pipettiervorrichtung mit einer Pipettenspitzenerkennungseinheit sowie ein Verfahren zur Erkennung einer Pipettenspitze (2) an einer solchen Pipettiervorrichtung angegeben. Eine Detektionseinheit (7) erkennt, ob eine Pipettenspitze (2) an der Pipettenröhre (1) angeschlossen ist bzw. bestimmt ein charakteristisches Merkmal der angeschlossenen Pipettenspitze (2). Dabei bildet die Pipettenspitze (2) zumindest einen Teil einer ersten Elektrode, wenn die Pipettenspitze (2) in elektrischer Wirkverbindung mit der Pipettenröhre (1) steht, und z.B. eine Pipettenspitzenhalterung (3), eine Auflage zum Absetzen der Pipettenspitzenhalterung (3) oder ein Arbeitstisch (5), über welchen die Pipettenröhre (1) bewegbar ist, bildet zumindest ein Teil einer zweiten Elektrode. Alternativ ...

Biopsy tissue sample cassettes and associated systems and methods

etiqueta para aplicação em um recipiente de coleta de amostra e recipiente de coleta de amostra

Method for producing microcarriers

The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer having a sandwich structure comprising a bottom layer, a top layer and an insulating layer located between said bottom and top layers, (b) etching away the top layer to delineate lateral walls of bodies of the microcarriers, (c) depositing a first active layer at least on a top surface of the bodies, (d) applying a continuous polymer layer over the first active layer, (e) etching away the bottom layer and the insulating layer, (f) removing the polymer layer to release the microcarriers.

NON-CONTACT OPTICAL ENCODING SCHEME FOR INTELLIGENT AUTOMATION PUCK

An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. The intelligent carriers can include one or more image sensors to observe the relative motion of the track as the carrier traverses it. The carriers can also observe position marks on the track surface to provide absolute position information, which can include additional data, such as routing instructions. Synchronization marks may be provided to correct errors in the observed trajectory.

PLATFORM FOR DISCOVERY AND ANALYSIS OF THERAPEUTIC AGENTS

Sampling device

A device 100 for use in separating biological samples into solids and liquids has a front cover 1 and back cover 2, folded closed via hinge 11. A separation membrane 6 can act as a filter. Absorption membrane 7 can retain liquid. On opening the device, the separation and absorption membranes 6, 7 bend, thereby applying a compressive force to the membranes 6, 7. A free end 13 of the laminate 6, 7 may be attached to a straining portion 5, which is in turn attached to a fixation point 3 on the front cover 1. On opening the device, the straining portion 5 may slide under anchor 4 to compress the laminate 6, 7. A manual actuator, e.g. pull cord, may also bend the filter 6 and absorbing layer 7 (figure 12). The device may have optical identification means, e.g., a barcode. >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> ...

A laboratory sample cassette

SPECIMEN CONTAINER LABEL FOR AUTOMATED CLINICAL LABORATORY PROCESSING SYSTEMS

A specimen collection container for automated viewing against a colored background, comprising an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein, wherein a material that forms the sidewall includes colorless indicia integrated with the material and having a surface enhancement feature for providing visual distinction from at least a portion of the sidewall.

SYSTEM Of SAMPLING OF LIQUID

L'invention concerne un dispositif d'échantillonnage de liquide (10) pour tester un liquide dans un récipient principal doté de moyens d'identification principaux, le dispositif comprenant un récipient d'échantillon incluant des moyens d'identification d'échantillon dont le traçage peut être assuré de manière non ambiguë en remontant aux moyens d'identification principaux, permettant ainsi l'authentification du liquide dans le récipient principal en testant l'échantillon.

IMPROVEMENTS WITH THE SYSTEMS OF TRANSFER ENTERS AN ENCLOSURE AND A CONTAINER.

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

SENSORS AND METHOD FOR VERIFICATION OF AGENTS - POWDER, LIQUID, GASEOUS OR OTHER AGENTS - IN A VESSEL

Agent verification can be performed by initially embedding definitive identification and parametric information regarding the vessel into a sensor set. The integrated sensor set, with a communication means, is incorporated into the vessel and/or its integral components to detect the current state of the vessel and its content. The information and sensor set can be normally passive or normally dormant, and can be activated by means of an external stimulus. Positive determination of the integrity of the vessel and its content is accomplished by interrogating the sensor set for detecting the current parameters and comparing the status of the vessel and its content against the initially embedded information using an external instrument. A match signifies a validation and the absent of a match signifies a non-valid condition. The method of providing indication of a valid or a non-valid condition can be accomplished by any means available, electronically or otherwise.

Specimen container label for automated clinical laboratory processing systems

A label and labeling system for identifying the volume of a specimen within a specimen collection container are disclosed. The system includes providing a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein. The specimen collection container also includes a label having a label body disposed over at least a portion of the sidewall, in visual alignment with a colored background. At least one of the sidewall of the specimen collection container and the label body have printing disposed thereon having a color that is substantially identical to the colored background against which the specimen collection container will be viewed. At least one of the sidewall of the specimen collection container and the label body may have colorless indicia having a surface enhancement feature for providing visual distinction.

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

AUTHENTICATABLE SAMPLE COLLECTION KIT FOR PLANT SAMPLE COLLECTION, AND USE THEREOF

ПЛАТФОРМА ДЛЯ ОБНАРУЖЕНИЯ И АНАЛИЗА ТЕРАПЕВТИЧЕСКИХ АГЕНТОВ

Изобретение относится к биотехнологии. Описан способ идентификации потенциальных агентов, включающий: (a) предоставление библиотеки потенциальных агентов, в которой каждый потенциальный агент присоединен к уникальному маркеру-нуклеиновой кислоте, имеющей последовательность маркера, где потенциальные агенты выбраны из группы, состоящей из белков, нуклеиновых кислот, клеток и небольших молекул, где небольшие молекулы выбраны из группы, состоящей из потенциальных ингибиторов ферментов, потенциальных антибиотиков, потенциальных противовирусных агентов, потенциальных пестицидов, потенциальных гормонов, потенциальных активаторов клеточной сигнализации, потенциальных ингибиторов клеточной сигнализации и потенциальных активаторов ферментов; (b) присоединение библиотеки потенциальных агентов к твердой подложке, включающей праймеры нуклеиновых кислот, посредством гибридизации маркеров-нуклеиновых кислот с праймерами нуклеиновых кислот с образованием массива потенциальных агентов; (c) приведение массива ...

ПЛАТФОРМА ДЛЯ ОБНАРУЖЕНИЯ И АНАЛИЗА ТЕРАПЕВТИЧЕСКИХ АГЕНТОВ

Verfahren zur Erkennung des Typs einer austauschbaren Kolben-Zylinder-Einheit für einen Dispenser

Die vorliegende Erfindung betrifft ein Verfahren zur Erkennung des Typs einer austauschbaren Kolben-Zylinder-Einheit (1) für einen Dispenser (2). Die Kolben-Zylinder-Einheit (1) weist mindestens einen den Typ der Kolben-Zylinder-Einheit (1) zumindest teilweise spezifizierenden, radial ausgerichteten Informationsträgerabschnitt (7) und mindestens einen den Typ der Kolben-Zylinder-Einheit (1) zumindest teilweise spezifizierenden, axial ausgerichteten Informationsträgerabschnitt (8) auf. Der Dispenser (2) weist eine Erfassungseinrichtung zum automatischen Identifizieren des Typs einer am Dispenser (2) angebrachten Kolben-Zylinder-Einheit (1) auf.Das erfindungsgemäße Verfahren umfasst die folgenden Verfahrensschritte:a) Lösbares Anbringen der Kolben-Zylinder-Einheit (1) am Dispenser (2) mittels einer zumindest im Wesentlichen in Axialrichtung (A) des Dispensers (2) verlaufenden Bewegung;b) Erfassen der Fertigstellung eines erfolgreichen Anbringens der Kolben-Zylinder-Einheit (1) am Dispenser ...

Microtome specimen carrier

Laboratory instrument industrial design customization for customer personalization

A customizable laboratory instrument comprising an interior space for receipt of test materials therein. An indented exterior surface of the laboratory instrument defines a boundary surface, a backing surface, and a sidewall. The backing surface is offset from the boundary surface a distance substantially equal to a depth of the sidewall. A panel having an edge is attachable to the sidewall such that a space is formed between the panel and backing surface for receipt of an object therein.

LABORATORY INSTRUMENT INDUSTRIAL DESIGN CUSTOMIZATION FOR CUSTOMER PERSONALIZATION

A customizable laboratory instrument comprising an interior space for receipt of test materials therein. An indented exterior surface of the laboratory instrument defines a boundary surface, a backing surface, and a sidewall. The backing surface is offset from the boundary surface a distance substantially equal to a depth of the sidewall. A panel having an edge is attachable to the sidewall such that a space is formed between the panel and backing surface for receipt of an object therein.

SPECIMEN CONTAINER LABEL FOR AUTOMATED CLINICAL LABORATORY PROCESSING SYSTEMS

A label and labeling system for identifying the volume of a specimen within a specimen collection container are disclosed. The system includes providing a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein. The specimen collection container also includes a label having a label body disposed over at least a portion of the sidewall, in visual alignment with a colored background. At least one of the sidewall of the specimen collection container and the label body have printing disposed thereon having a color that is substantially identical to the colored background against which the specimen collection container will be viewed. At least one of the sidewall of the specimen collection container and the label body may have colorless indicia having a surface enhancement feature for providing visual distinction.

Temporal Multiplexed Excitation for Miniaturized, Planar Fluorescence Activated Cell Sorting

A system for fluorescence activated cell sorting includes at least two excitation lasers and an objective that directs light from the at least two excitation lasers to a common point in an interrogation region of a fluidic channel. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. At least one modulator temporally multiplexes light from the at least two excitation lasers such that pulses of light from different lasers intersect the common point at different times. The system further includes at least one detector and at least one optical element that directs light emitted from the particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light are also described herein.

METHOD AND APPARATUS FOR PRINTING ON AN OBJECT HAVING A CURVED SURFACE

Platform for discovery and analysis of therapeutic agents

A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

Assay information management methods and devices

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

A cartridge, cartridge reader and method for preventing reuse of the cartridge

A disposable fluidic cartridge has a recess therein. A mechanically-actuated mechanism is disposed within the recess for effecting an operation of the fluidic cartridge. The cartridge further comprises a machine-readable identification code on a breakable label covering at least a portion of the recess such that the portion of the breakable label covering the recess may be broken upon insertion of a mechanical actuator into the recess to actuate the mechanically-actuated mechanism. This renders the identification code unreadable and prevents reuse of the cartridge.

PLATFORM FOR DISCOVERY AND ANALYSIS OF THERAPEUTIC AGENTS

A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

A CARTRIDGE, CARTRIDGE READER AND METHOD FOR PREVENTING REUSE OF THE CARTRIDGE

A disposable fluidic cartridge has a recess therein. A mechanically-actuated mechanism is disposed within the recess for effecting an operation of the fluidic cartridge. The cartridge further comprises a machine-readable identification code on a breakable label covering at least a portion of the recess such that the portion of the breakable label covering the recess may be broken upon insertion of a mechanical actuator into the recess to actuate the mechanically-actuated mechanism. This renders the identification code unreadable and prevents reuse of the cartridge.

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

Nanohybrid-driven Optical DNA Identification System

METHOD AND APPARATUS FOR SELF-CULTURING AUTOLOGOUS STEM CELLS

Provided is an autologous culture method of autologous stem cells according to an embodiment of the present disclosure, the autologous culture method including: (a) accommodating one's own stem cells collected by a medical institution and a first culture medium in a first culture container from the medical institution to a one's own culture device; (b) controlling the culture device to establish an environment suitable for culture of stem cells; (c) observing the stem cells cultured in the first culture container of the culture device; (d) replacing the first culture medium in the first culture container; (e) separating cultured stem cells from the first culture container; and (f) accommodating separated stem cells in a second culture container with a second culture medium. Accordingly, as an individual cultures one's own stem cells by oneself, costs may be remarkably reduced, a replacement of one's own stem cells with other's stem cells may be fundamentally prevented, and an environment ...

Methods and systems for labeling labware

The present invention includes a system for marking labware. The system includes an instruction set with markings to be applied to pieces of labware and the order in which the markings are to be applied to the labware. The system also includes a marking device that receives the instruction set and then places the non-toxic marks on the pieces of labware. The invention also includes methods tracking chain of custody of biological material in a facility. The methods include assigning a unique marking for biological materials, storing that marking in a database, applying a non-toxic marking to a piece(s) of labware and then scanning the marking.

A laboratory sample cassette

A laboratory sample cassette 1 comprises a main body 2 having a writing surface 3, and at least two protrusions 14 extending from the writing surface. Each said protrusion has substantially the same height from the writing surface. The protrusions may be rounded in profile with a height of 0.05-3 mm and base width of 0.1-3 mm, be adjacent to at least one edge of the writing surface and be configured to hold the writing surface substantially parallel to and facing a flat surface. The writing surface is preferably rectangular with a print area 30 for a thermal printer and is inclined relative to the main body of the cassette. The protrusions may comprise ribs that are spaced apart to define the print area. Preferably the cassette and protrusions are formed by injection moulding. A method for removing wax from a writing surface of a sample cassette is also disclosed, wherein the wax covered cassette is held with the protrusions against a flat heated surface to melt the wax and allow the molten ...

Sample tracking card

Double identification for sample tracking on a diagnostic device

A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument.

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The sample processing device and stand

RECOGNIZABLE CARRIER FOR OPTICAL MEASURING METHODS

Assay Wells with Hydrogel as a Well-Contents Separator and a Pigment-Based Temperature Indicator

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change ...

LIQUID BARCODE AND LIQUID BARCODE READER

СИСТЕМЫ И СПОСОБЫ ДЛЯ ОБНАРУЖЕНИЯ КЛЕТОК С ПРИМЕНЕНИЕМ СКОНСТРУИРОВАННЫХ ТРАНСДУКЦИОННЫХ ЧАСТИЦ

Reagent cartridge

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

Abstract Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Method and system for recovering products from an emulsion

The invention relates to a method for selecting and recovering products comprising the following steps: providing an emulsion (6) comprising a plurality of drops (4) contained in a carrier fluid (10), each drop comprising an internal fluid (8); measuring at least one physical parameter for a plurality of drops (4) of the emulsion (6); classifying at least one portion of the drops (4) of the emulsion in a class as a function of the measurements obtained during the measurement step; labelling at least one portion of the drops (4) classified as a function of the class of the drop (4); and selectively recovering the drop (4) or a portion of the drop (4) using the labelling of the drop or a portion of the drop (4). The emulsion (6) is provided in a two-dimensional chamber (22), the emulsion (6) being kept in the form of a single layer of drops (4) in the two-dimensional chamber (22) during the measurement step and the labelling step.

METHOD AND SYSTEM FOR RECOVERING PRODUCTS FROM AN EMULSION

Procédé de sélection et de récupération de produits comprenant les étapes suivantes: fourniture d'une émulsion (6) comprenant une pluralité de gouttes (4) contenues dans un fluide porteur (10), chaque goutte comprenant un fluide interne (8), mesure d'au moins un paramètre physique pour plusieurs gouttes (4) de l'émulsion (6), classement d'au moins une partie des gouttes (4) de l'émulsion dans une classe en fonction des mesures obtenues lors de l'étape de mesure, étiquetage d'au moins une partie des gouttes (4) classées en fonction de la classe de la goutte (4), récupération sélective de la goutte (4) ou d'une partie de la goutte (4) en utilisant l'étiquetage de la goutte ou d'une partie de la goutte (4). L'émulsion (6) est fournie dans une chambre bidimensionnelle (22), l'émulsion (6) étant maintenue sous forme d'une monocouche de gouttes (4) dans la chambre bidimensionnelle (22) au cours de l'étape de mesure et de l'étape d'étiquetage.

Assay information management methods and devices

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

LABORATORY INSTRUMENT INDUSTRIAL DESIGN CUSTOMIZATION FOR CUSTOMER PERSONALIZATION

Systems and methods for detection of cells using engineered transduction particles

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Apparatus for dispensing medicine, vitamins and/or samples

An apparatus for distributing medicines, vitamins and/or samples, including an organizer and dispensing units for medicines, vitamins and/or samples. The organizer includes seats in which to place the dispensing units. The apparatus includes an identification device connected to a data processing device and containing dispensing data on medicines, vitamins and/or samples, including detecting members controlled to a detecting state by detecting signals generated on the basis of dispensing data in the data processing device. The identification device is configured to be brought in connection with the organizer so that at least some of the detecting members are aligned with at least some of the seats of the organizer, wherein at least those dispensing units, which are aligned with at least one detecting member, can be identified by means of detecting signals generated on the basis of dispensing data in the data processing device.

Specimen container label for automated clinical laboratory processing systems

A label and labeling system for identifying the volume of a specimen within a specimen collection container are disclosed. The system includes providing a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein. The specimen collection container also includes a label having a label body disposed over at least a portion of the sidewall, in visual alignment with a colored background. At least one of the sidewall of the specimen collection container and the label body have printing disposed thereon having a color that is substantially identical to the colored background against which the specimen collection container will be viewed. At least one of the sidewall of the specimen collection container and the label body may have colorless indicia having a surface enhancement feature for providing visual distinction.

A device and method for delivering a laboratory sample carrier from a stack of sample carriers

A device (1 ) and method for delivering a laboratory sample carrier (2) from a stack (3) of sample carriers (2) includes providing means (4) for retaining the stack (3) of laboratory sample carriers (2), and an ejector mechanism (8) including a displaceable mechanism (27) comprising a carrier support portion (19) and a carrier transporting portion (20) which are hingeably interconnected. The stack (3) is supported by the carrier transporting portion (20) and the carrier transporting portion (20) is supported by a carrier transporting portion support (26) of the ejector mechanism (8) when the displaceable mechanism (27) is in a first carrier receiving position and configuration. The displaceable mechanism (27) is displaced from the first carrier receiving position and configuration to a second carrier release position and configuration by a displacement means (16, 17) of the ejector mechanism (8). This involves moving a lowermost carrier (2') from the bottom of the stack (3) in a carrier ...

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

PCR TUBE HOLDER

A PCR tube holder comprises an elongated strip body having a first portion and a second portion. One or more holes are defined in the first portion of the elongated strip body, the at least one hole configured to receive a single PCR tube. A writable zone in the second portion of the elongated strip body, the writable zone configured to receive ink thereon. A material of the elongated strip body is adapted to retain the ink through a PCR cycle. The material of the elongated strip body has a minimum flexural rigidity such that the elongated strip is adapted to support a PCR tube without folding.

SPECIMEN CONTAINER LABEL FOR AUTOMATED CLINICAL LABORATORY PROCESSING SYSTEMS

A label and labeling system for identifying the volume of a specimen within a specimen collection container are disclosed. The system includes providing a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein. The specimen collection container also includes a label having a label body disposed over at least a portion of the sidewall, in visual alignment with a colored background. At least one of the sidewall of the specimen collection container and the label body have printing disposed thereon having a color that is substantially identical to the colored background against which the specimen collection container will be viewed. At least one of the sidewall of the specimen collection container and the label body may have colorless indicia having a surface enhancement feature for providing visual distinction.

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

IMPROVEMENTS WITH THE SYSTEMS OF TRANSFER ENTERS AN ENCLOSURE AND A CONTAINER.

L'enceinte (2) comporte une paroi (5) ayant une ouverture (7) et une interface (8) de connexion, une porte (10), des moyens d'assemblage (12), des moyens de manoeuvre de la porte (10) et des moyens d'actionnement, de commande des moyens de manoeuvre, le conteneur (3) comporte une paroi (14) ayant une ouverture (16), une interface de connexion (9), une porte (18), des moyens d'assemblage (13) et des moyens de manoeuvre de la porte (18) associés fonctionnellement à la porte (10), et le système comporte en outre, fonctionnellement intégrés, des moyens marqueurs (19), portés par le conteneur (3), aptes à mémoriser des données, des moyens de lecture (20) de données à courte distance, fonctionnellement complémentaires des moyens marqueurs (19), des moyens de mémorisation (21) des données lues, des moyens de production d'un signal de sortie (22) fonction des données lues ou mémorisées, et des moyens de commande de l'ouverture de la première porte (10) et donc la seconde porte (18), responsifs ...

Device for storing samples, in particular biological samples for laboratory analysis

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

SLIDE AND MICROSCOPE SYSTEM USING THE SLIDE

A slide on which an observation object by a microscope is placed, is provided. A first mark indicating a reference line along a first direction and a second mark indicating a specific position on an extension of the reference line along the first direction are separately arranged in a vacant area between a label area used to arrange a label and a cover glass area used to arrange the observation object and a cover glass. A position reference is provided by the specific position on the extension of the reference line along the first direction.

SAMPLE CARRIER IDENTIFICATION

A sample carrier (102) includes a sample support region (104) that supports a sample to be processed by a sample carrier processing apparatus and storage and communications circuitry (106) that includes a wireless interface (502) that wirelessly communicates with a storage component reader of the sample processing apparatus when the sample carrier is loaded in the sample processing apparatus for processing. A sample carrier processing apparatus (100) includes a plurality of sample carrier receiving regions (116) respectively configured to receive individual sample carriers carrying samples to be processed by the sample carrier processing apparatus and a plurality of storage component readers (120), one for each of the plurality of sample carrier receiving regions and respectively configured to wirelessly communicate, one to one, with the sample carrier in a corresponding one of the sample carrier receiving regions.

Molecular code systems

The present invention relates to a method for protecting and. recovering nucleic acids. This method may be applied in a verification method of products using molecular code systems or it may be applied in a storage method for nucleic acids. The invention further provides specific particles, their use in secure marking; products suitable for such verification method, to processes for manufacturing such products and methods for reading the information.

Specimen collection device

A specimen collection device and a method of using the specimen collection device are disclosed herein. In some aspects, the specimen collection device allows for the individual collection of specimens via a removable specimen tray that can easily be swapped during a procedure. The specimen collection device includes a flexible sealing element for the continual use of suction during the procedure even when the specimen tray is not inserted.

APPARATUS, DEVICE AND METHOD FOR COLLECTING, SENSING AND ANALYZING SAMPLE FLUID

An apparatus for collecting a sample fluid includes a base part with sample well plate with cavity having plurality of holes fluidically connecting first side and second side of cavity. The cavity is configured to accommodate sample collection part of sample stick on first side of cavity. The base part has microfluidic plate configured to channelize flow of at least a part of sample fluid received via plurality of holes towards at least one sensor coupled to microfluidic plate; and plurality of electrical connectors connected to at least one sensor. Moreover, the apparatus has lid part coupled to base part, lid part having compressible region configured to receive first amount of external force thereon and exert pressure over sample collection part to enable flow of sample fluid towards at least one sensor.

System for collecting samples of a liquid

A device and method for delivering a laboratory sample carrier from a stack of sample carriers

A device and method for delivering a laboratory sample carrier from a stack of sample carriers

A device (1 ) and method for delivering a laboratory sample carrier (2) from a stack (3) of sample carriers (2) includes providing means (4) for retaining the stack (3) of laboratory sample carriers (2), and an ejector mechanism (8) including a displaceable mechanism (27) comprising a carrier support portion (19) and a carrier transporting portion (20) which are hingeably interconnected. The stack (3) is supported by the carrier transporting portion (20) and the carrier transporting portion (20) is supported by a carrier transporting portion support (26) of the ejector mechanism (8) when the displaceable mechanism (27) is in a first carrier receiving position and configuration. The displaceable mechanism (27) is displaced from the first carrier receiving position and configuration to a second carrier release position and configuration by a displacement means (16, 17) of the ejector mechanism (8). This involves moving a lowermost carrier (2') from the bottom of the stack (3) in a carrier ...

RECEPTACLE HOLDERS, SYSTEMS, AND METHODS FOR CAPACITIVE FLUID LEVEL DETECTION

A receptacle holder for supporting at least one fluid-containing receptacle includes a body and an RFID transponder. The body includes an electrically conductive portion defining a first recess configured to receive at least a first fluid-containing receptacle, and an electrically non-conductive portion attached to the electrically conductive portion. The RFID transponder is disposed on the electrically non-conductive portion of the body, and stores information about the receptacle holder. The receptacle holder can also include the first fluid-containing receptacle received within the first recess.

ADAPTABLE DETECTION APPARATUS

Described herein are an adaptable apparatus and methods for detecting the presence of a target substance in a liquid. For example, the adaptable apparatus can be a medallion that detects illicit drugs in a beverage. The adaptable apparatus comprises a detection unit comprising an indicator that is configured to display a signal upon the detection of an interaction with the target substance. In some examples, the adaptable apparatus can be attached to an implement.

Transparent object carrier having a marking

LIQUID SAMPLER SYSTEM

SELECTING METHOD AND PRODUCT RECOVERY AND SYSTEM THEREFOR

La présente invention concerne un procédé de sélection et de récupération de produits comprenant les étapes suivantes : - fourniture d'une émulsion (6) comprenant une pluralité de gouttes (4) contenues dans un fluide porteur (10), chaque goutte comprenant un fluide interne (8), - mesure d'au moins un paramètre physique pour plusieurs gouttes (4) de l'émulsion (6), - classement d'au moins une partie des gouttes (4) de l'émulsion dans une classe en fonction des mesures obtenues lors de l'étape de mesure, - étiquetage d'au moins une partie des gouttes (4) classées en fonction de la classe de la goutte (4), - récupération sélective de la goutte (4) ou d'une partie de la goutte (4) en utilisant l'étiquetage de la goutte ou d'une partie de la goutte (4).

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

DISPENSER GUIDES

The invention features devices, systems, and methods for introducing a sample (e.g., a biological sample, e.g., a blood sample) into a reaction vessel to maximize the effectiveness and/or reproducibility of introducing the sample (e.g., a biological sample, e.g., a blood sample).

Encoded particle having a grating with variations in the refractive index

Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 with a narrow band (single wavelength) or multiple wavelength source, in which case the code is represented by a spatial distribution of light or a wavelength spectrum, respectively. The code may be digital binary or may be other numerical bases. The micro-particles 8 can provide a large number of unique codes, e.g., greater than 67 million codes, and can withstand harsh environments. The micro-particles 8 are functionalized by coating them with a material/substance of interest, which are then used to perform multiplexed experiments involving chemical processes, e.g., DNA testing and combinatorial chemistry.

An improved cartridge, cartridge reader and method for preventing reuse

A disposable fluidic cartridge has a recess therein. A mechanically-actuated mechanism is disposed within the recess for effecting an operation of the fluidic cartridge. The cartridge further comprises a machine-readable identification code (bar code or QR code 199) on a breakable label 200 covering at least a portion of the recess such that the portion of the breakable label covering the recess may be broken upon insertion of a mechanical actuator into the recess to actuate the mechanically-actuated mechanism. This renders the identification code unreadable and prevents reuse of the cartridge.

An improved cartridge, cartridge reader and method for preventing reuse

INSTRUMENTS, DEVICES AND CONSUMABLES FOR USE IN A WORKFLOW OF A SMART MOLECULAR ANALYSIS SYSTEM

A system for performing a molecular analysis workflow includes a reaction holder or a reaction substrate, such as a multi-well reaction plate, with a reaction holder/substrate RFID tag, and/or a reagent container with a reagent container RFID tag, and an instrument and/or device that includes an RFID reader/writer operable to read and/or write information to and from the reaction holder/substrate RFID tag and/or the reagent container RFID tag. The reaction holder/substrate RFID tag and the reagent container RFID tag can be utilized separately or together to send and receive and store information, for example, for a workflow of a molecular analysis, such as a polymerase chain reaction (PCR).

BIOPSY TISSUE SAMPLE CASSETTE AND RELATED SYSTEMS AND METHODS

Tissue sample cassettes for receiving tissue samples include an upper tray including compartments separated by dividers, a lower tray coupled to the upper tray and having a central recess, and an absorbent material located in the recess of the lower tray. Related systems and methods for automated gross processing of tissue samples are also disclosed.

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

METHOD FOR PRODUCING MICROCARRIERS

The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer (6) having a sandwich structure comprising a bottom layer (7), a top layer (8) and a insulating layer(9) located between said bottom and top layers (7, 8), (b) etching away the top layer (8) to delineate lateral walls (12) of bodies (11) of the microcarriers, (c) depositing a first active layer (13)at least on a top surface (14) of the bodies (11), (d) applying a continuous polymer layer (16) over the first active layer(13), (e) etching away the bottom layer (7) and the insulating layer (9), (f) removing the polymer layer (16) to release the microcarriers.

SELECTING METHOD AND PRODUCT RECOVERY AND SYSTEM THEREFOR

liquid barcode and liquid barcode reader

조작된 형질 도입 입자를 이용하여 세포를 검출하기 위한 시스템 및 방법

... 조작된 형질 도입 입자를 이용하여 표적 세포(예컨대, 박테리아)를 검출 및/또는 식별하기 위한 시스템 및 방법이 본원에 기술된다. 일부 실시양태에서, 방법은 샘플 내에 형질 도입 입자의 양을 혼합하는 단계를 포함한다. 형질 도입 입자는 표적 세포와 연관된다. 형질 도입 입자는 비복제성이며, 표적 세포가 일련의 리포터 분자를 생성하게 하도록 제형된 핵산 분자를 포함하도록 조작된다. 샘플 및 형질 도입 입자는 표적 세포가 샘플 내에 존재할 때 상기 일련의 리포터 분자를 발현하도록 유지된다. 리포터 분자의 양과 연관된 신호가 수신된다. 일부 실시양태에서, 상기 신호의 크기는, 미리 결정된 양을 초과할 때 형질 도입 입자의 양으로부터 독립적이다.

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES

SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity. Fig. 138 ...

Systems and methods for detection of cells using engineered transduction particles

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Arrangement having a specimen plate and a transparent marking frame

Systems and methods for detection of cells using engineered transduction particles

Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.

Method and system for recovering products from an emulsion

The invention relates to a method for selecting and recovering products comprising the following steps: providing an emulsion (6) comprising a plurality of drops (4) contained in a carrier fluid (10), each drop comprising an internal fluid (8); measuring at least one physical parameter for a plurality of drops (4) of the emulsion (6); classifying at least one portion of the drops (4) of the emulsion in a class as a function of the measurements obtained during the measurement step; labelling at least one portion of the drops (4) classified as a function of the class of the drop (4); and selectively recovering the drop (4) or a portion of the drop (4) using the labelling of the drop or a portion of the drop (4). The emulsion (6) is provided in a two-dimensional chamber (22), the emulsion (6) being kept in the form of a single layer of drops (4) in the two-dimensional chamber (22) during the measurement step and the labelling step.

Adaptable detection apparatus

Described herein are an adaptable apparatus and methods for detecting the presence of a target substance in a liquid. For example, the adaptable apparatus can be a medallion that detects illicit drugs in a beverage. The adaptable apparatus comprises a detection unit comprising an indicator that is configured to display a signal upon the detection of an interaction with the target substance. In some examples, the adaptable apparatus can be attached to an implement.

High-throughput production of ingestible event markers

High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.

Liquid analysis system

A liquid analysis system for a photometric determination of an analyte in a liquid sample includes an analyzer comprising a photometer, an RFID parameter reading device and an identifier reading device, and a cuvette package comprising an RFID parameter transponder and a plurality of test cuvettes of one batch. Each test cuvette comprises a reagent. Batch identification and batch-specific reagent data are stored in the RFID parameter transponder. Each test cuvette comprises a batch-specific identifier including a batch identification. The batch identification is configured to be read by the identifier reading device.

Methods for placing, accepting, and filling orders for products and services

Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer.

Biosample plate with data storage and wireless communication means

Embodiments of the disclosure relate to a biosample plate that includes a memory component for storing information related to the biosample, biosample plate and biosample analysis data, and a wireless communication interface for transferring information to and from the biosample plate. The biosample plate may be used with an analyzing and data recording system such as an electromagnetic tape drive. The disclosed biosample plate facilitates the correlation between a large number of biosample plates and data as data remains with the corresponding biosamples both when the biosample plates are in use and when they are in storage. The wireless communication interface may comprise an antenna disposed in a biosample plate for data transmission to and from the biosample plate by radio signals.

Method of Pre-Treatment and Staining of a Biological Sample and Device for Support of a Biological Sample and Methods of Using Such Device

There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

RFID - Specimen Transport Puck Process Features and Porcess Method to Efficiently Wand, Rack, Transport, Track Specimens in the Laboratory

This invention is for the process method of an RFID Specimen Transport puck that can be used in the process of performing overall efficient wanding, racking, transporting and tracking of specimens throughout the entire lab. This puck design process can be used on a conveyor system, contains an RFID chip, can be used to wand specimens for tracking, can be used to rack specimens, can be used to transport specimens to laboratory areas and instruments, can be used to track specimen, is made of plastics, is small, has the ability to hold various tubes sizes, that has few pieces to assemble, that is low in cost, can be held in a rack carrying tray. By having all these process features in the one puck design, this ‘puck’ can be used in high volume and perform the overall wanding, racking, transporting, and tracking of specimens though out the entire laboratory.

System and method including analytical units

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

System and method including analytical units

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

BIOCHEMICAL ANALYSIS CARTRIDGE AND BIOCHEMICAL ANALYSIS APPARATUS

A biochemical analysis cartridge stores a plurality of dry analysis elements corresponding to a plurality of measurement items necessary for measurement of samples and supplies the dry analysis elements to a biochemical analysis apparatus. The biochemical analysis cartridge is equipped with a memory element that stores calibration curve data for all dry analysis elements which are within their effective lifetimes at the time of manufacture or shipment of the biochemical analysis cartridge. 1. A biochemical analysis cartridge that houses a plurality of dry analysis elements corresponding to a plurality of measurement items necessary to measure a sample and supplies the dry analysis elements to a biochemical analysis apparatus , wherein:the biochemical analysis cartridge comprises a memory element that stores calibration curve data for all dry analysis elements which are within their effective lifetimes at the time of manufacture or shipment of the biochemical analysis cartridge.2. A biochemical analysis cartridge as defined in claim 1 , wherein:the memory element is provided at a position at which the biochemical analysis apparatus is capable of reading out data therefrom.3. A biochemical analysis apparatus claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a calibration curve data readout section that reads out calibration curve data stored in the memory element of the biochemical cartridge defined in ;'}an identifying data readout section that reads out identifying data of the dry analysis elements loaded in the biochemical analysis cartridge; anda warning section that issues a warning in the case that the calibration curve data specified by the identifying data read out by the identifying data readout section is not within an effective period, based on the calibration curve data read out by the calibration curve data readout section. The present invention is related to a biochemical analysis apparatus for determining the concentrations of ...

Apparatus for marking histology embedding cassettes

A marking apparatus for marking histology embedding cassettes includes a marking device for marking plastic surfaces, a gripping means to grip and release a cassette, and a movement organ to rotate the gripping means with respect to a first rotation axis perpendicular to a second rotation axis. The first axis is arranged such that it is situated in an ideal plane that is parallel to and interposed between the ideal planes in which the perpendicular surfaces of a cassette, gripped by the gripping means, are located, so that, upon rotation with respect to the first axis the first and the second perpendicular surfaces can alternately be located in front of the marking device. The second axis being arranged with respect to the gripping means such that, upon rotation with respect to the second axis, the oblique surface of the cassette can be in front of the marking device.

Microvessels, microparticles, and methods of manufacturing and using the same

A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other.

SOURCE CONTROLLED DECODABLE MICROARRAY SYSTEM AND METHODS FOR USE

A system and methods for consumer use of a microarray product are provided. A method includes obtaining a microarray product and contacting the microarray product with a sample and performing bioassays. The method further includes obtaining a decoding information data package from a manufacturer of the microarray product for correlating bioassay signals from the bioassays with respective analytes, wherein the microarray product is obtained at a first time different and discrete from a second time that the decoding information data package is obtained. 1. A method for consumer use of a microarray product , the method comprising:obtaining a microarray product;contacting the microarray product with a sample and performing bioassays; andobtaining a decoding information data package from a manufacturer of the microarray product for correlating bioassay signals from the bioassays with respective analytes,wherein the step of obtaining the microarray product is performed at a first time and the step of obtaining the decoding information data package is performed at a second time, the first and second times being discrete times different from one another.2. The method in accordance with wherein the first time of obtaining the microarray product occurs before the second time of performing the step of obtaining the decoding information data package.3. The method in accordance with wherein the second time of performing the step of obtaining the decoding information data package occurs before the first time of obtaining the microarray product.4. The method in accordance with wherein the step of obtaining the microarray product comprises a customer obtaining the microarray product in a manner selected from over the counter and via delivery.5. The method in accordance with wherein the step of obtaining the microarray product comprises a customer obtaining the microarray product for a cost selected from for free and for a fee.6. The method in accordance with wherein the step of ...

Apparatus and Methods for Processing and Cataloging of Samples

A device for processing and cataloging of a sample, in a container having a label with identifying data, has a frame; a plurality of cameras mounted to the frame; and a controller system coupled to the cameras, the controller system including a controller and a non-transitory memory storing instructions, which, when executed by the controller, cause carrying out of computer processes that produce a catalog record output characterizing the sample, such record also including the identifying data.

Biological Sample Containment System and Label

A biological sample containment system and a label for a container that includes a first layer having a first readable information portion and a second layer removably attached to the first layer, the second layer having a second readable information portion, is disclosed. In one embodiment, the first layer and the second layer of the label are both formed of a thermosensitive material. In one embodiment, at least a part of the first readable information portion is identical to at least a part of the second readable information portion. The label of the present disclosure allows a portion of the label having readable information to be removed and adhered to a patient record, for example, while a portion of the label having identical readable information remains on the container.

Device and method for biological sample collection and inspection

A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.

REDUNDANT IDENTIFICATION FOR SAMPLE TRACKING ON A DIAGNOSTIC DEVICE

A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument. 1. A sample processing cartridge comprising:a substrate configured to be inserted into a sample processing instrument;a sample compartment supported on said substrate and configured to contain a fluid sample material;one or more process compartments supported on said substrate and configured to contain a process material, wherein said sample compartment is connected or connectable to at least one process compartment;a first machine-readable information tag mounted on or embedded in said substrate and encoded with cartridge-identifying information and configured to be read by a device that is external to a sample processing instrument; anda second machine-readable information tag mounted on or embedded in said substrate and encoded with cartridge-identifying information corresponding to the cartridge-identifying information encoded in said first machine-readable information tag and configured to be read by a device within a sample processing instrument.2. The sample processing cartridge of claim 1 , wherein said first machine-readable information tag comprises an optically-readable tag.3. The sample processing cartridge of claim 1 , wherein said first machine-readable information tag comprises a bar code.4. The sample processing cartridge of claim 1 , wherein said first machine readable information tag comprises a 1-D or a 2-D bar code.5. The ...

Modular Multiple-Column Chromatography Cartridge

A method for liquid chromatography comprises steps of: mixing a sample comprising a plurality of chemical constituents with a first solvent; transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge; chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column; transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent; chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; and transferring the separated individual constituents to a detector. 1mixing a sample comprising a plurality of chemical constituents with a first solvent;transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge;chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column;transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent;chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; andtransferring the separated individual constituents to a detector.. A method for liquid chromatography comprising: This application is a Divisional application of U.S. patent application Ser. No. 13/882,116, having a 371(c) date of May 2, 2013, which is the United States National Stage application, under 35 U.S.C. 371, of International Application PCT/US2011/058229 having an international filing date of Oct. 28, 2011, which claims the benefit of the ...

METHOD AND APPARATUS FOR CODING DIAGNOSTIC METERS

A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips. 1. A system for diagnostic testing comprising:a housing having a test media port and housing a diagnostic meter, wherein the diagnostic meter is a glucose meter;a plurality of test media compatible with the diagnostic meter, each test media of the plurality of test media having a first end and a second end, the first end having a width and a height, wherein a width and a height of the test media port is approximately equal to the width and the height of the first end such that the first end is insertable into the diagnostic meter through the test media port in the housing for performing a diagnostic test on a sample at the second end; and 'wherein at least one of the housing and the container comprises a top mount attachment configured to releasably attach the housing to the container.', 'a container having an open interior volume, the plurality of test media being housed in the open interior volume permitting contact between the plurality of test media,'}2. The system according to claim 1 , wherein the top mount attachment is configured to releasably mount the housing to the top end of the container.3. The system according to claim 1 , wherein the top mount attachment comprises at least one lock protruding from the housing and at least one corresponding protrusion protruding from at least a portion of a lip of the container claim 1 , each lock configured to slidably ...

METHOD FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES

A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark. 1. A method of reading machine-readable marks on a moveable support and objects of a sample instrument , the method comprising the steps of:(a) capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device;(b) determining whether a first fiducial machine-readable mark on the moveable support is in the first image;(c) determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and(d) associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.2. The method of claim 1 , further comprising the steps of:(e) capturing a second image of the moveable support as the moveable support moves from the first position to the second position using the image capture device;(f) determining whether a second fiducial machine- ...

Arrangement having a specimen plate and a transparent marking frame

The invention relates to an arrangement having a specimen plate (1) for freezing on a sample for processing in a microtome, which has an upper side (4) for freezing on the sample and a lower side (5), and having a transparent marking frame (6), having opaque regions forming a marking, which is arranged on the specimen plate (1); and to a method for assigning a sample after freezing onto that specimen plate; and to a method for identifying a sample that is frozen onto that specimen plate (1), the marking frame being arranged on the lower side (5) of the specimen plate (1) or so as to fit around the specimen plate (1).

Container Assembly and System for Detection Thereof

A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light. 1. A device for collecting a biological sample , comprising:a collection container having a first end, a second end, and a sidewall extending therebetween;at least one closure for sealing at least one of the first end and the second end; andone or more fluorescent compounds, wherein the one or more fluorescent compounds are disposed within the container.2. The device of claim 1 , wherein the one or more fluorescent compounds are molded into at least one of the container and the closure.3. The device of claim 1 , wherein the one or more fluorescent compounds are disposed on at least one of an outer surface of the collection container or an outer surface of the closure.4. The device of claim 1 , wherein the closure further comprises a stopper and a shield.5. The device of claim 4 , wherein the one or more fluorescent compounds are molded into the shield.6. The device of claim 4 , wherein the one or more fluorescent compounds are molded into the stopper.7. The device of claim 1 , wherein the closure further comprises a cap and a septum.8. A device for collecting a biological sample claim 1 , comprising:a collection container having a first end, a second end, and a sidewall extending therebetween ...

ASSAY INFORMATION MANAGEMENT METHODS AND DEVICES

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system. 188.-. (canceled)89. An assay system configured to use an assay cartridge in the conduct of an assay , said assay system comprising a reader adapted to perform the following operations:(i) reading cartridge lot identification information from a first consumable identifier associated with an assay consumable;(ii) reading lot specific parameters from an additional consumable identifier; and(iii) using said lot identification information and said lot specific parameters to adjust one or more operations performed by said assay system before, during and/or after the conduct of an assay by said system.90. The assay system of claim 89 , wherein said lot specific parameters are selected from the group consisting of (i) a revision level that determines schema used to interpret assay results and/or assay information; (ii) cartridge type; (iii) year of cartridge manufacture; (iv) cartridge lot number; (v) expiration date of cartridge and/or reagents used in said assay; (vi) a cross-talk correction matrix to account for chemical cross-reactivity; (vi) threshold values for assays to be conducted in said cartridge; (vii) a range for internal positive control(s) used in said assay; (viii) a ranges for each assay to be conducted in said cartridge for a positive control sample; and (ix) a software checksum.91. The assay system of claim 89 , wherein said first consumable identifier comprises non-volatile memory.92. The assay system of claim 91 , wherein said non-volatile memory is ...

Medical container with NFC Antenna

A pharmaceutical container may include a cylindrical hollow container body () defining a hollow chamber () to receive a pharmaceutical liquid, the container body () including a portion on a sidewall () of the container body (), wherein the portion has a longitudinal extension along the longitudinal axis of the container body () and a circumferential extension along the circumference of the container body (), thereby forming a window () through the sidewall () of the container body () into the hollow chamber (), the window () comprising two long edges () and two short edges (), and a Near Field Communication (NFC) antenna () arranged on the outer surface () of the sidewall () of the container, the antenna () including one or a plurality of nested antenna windings (), each of them surrounding an interior periphery () including a substantially longitudinal portion () arranged along the two long edges () of the window (), and a substantially circumferential portion () arranged mainly around the sidewall () of the container body () and at least partially along a first one of the two short edges () of the window () opposite to a second one of the two short edges () of the window (). 1. A pharmaceutical container , comprising:{'b': 100', '111', '100', '123', '121', '100', '123', '100', '100', '122', '121', '100', '111', '122', '124', '125, 'a cylindrical hollow container body () defining a hollow chamber () to receive a pharmaceutical liquid, the cylindrical hollow container body () comprising a portion() on a sidewall () of the cylindrical hollow container body (), wherein the portion () has a longitudinal extension along the longitudinal axis of the cylindrical hollow container body () and a circumferential extension along the circumference of the cylindrical hollow container body (), thereby forming a window ( through the sidewall () of the cylindrical hollow container body () into the hollow chamber (), the window () comprising two long edges () and two short edges ...

MASSIVE MICROFLUIDICS FOR MULTIPLEXED COUNTING

A microfluidics device includes an inlet, a plurality of parallelized microfluidic channels, a splitter and a plurality of detection electrodes. The inlet receives a fluidic sample including biological particles. The parallelized microfluidic channels include interaction zones for analysis of the biological particles. The splitter transmits the fluidic sample into the parallelized microfluidic channels. Detection electrodes can conduct the analysis. Each detection electrode is shared among the parallelized microfluidic channels. The detection electrodes are spatially encoded electrodes arranged on locations of each of the parallelized microfluidic channels. 1. A microfluidics device , comprising:an inlet for receiving a fluidic sample including biological particles;a plurality of parallelized microfluidic channels disposed across an interaction zone for transit-time analysis of the biological particles;a splitter for transmitting the fluidic sample into the parallelized microfluidic channels; anda plurality of detection electrodes configured to conduct the transit-time analysis, each detection electrode shared among the parallelized microfluidic channels.2. The microfluidics device of claim 1 , wherein the detection electrodes are spatially encoded electrodes arranged on locations of each of the parallelized microfluidic channels.3. The microfluidics device of claim 2 , wherein the arrangement of locations of the spatially encoded electrodes in each parallelized microfluidic channel represents an identification unique to the parallelized microfluidic channel.4. The microfluidics device of claim 3 , further comprising:a decoding component configured to decode the identification based on a matched-filtering scheme.5. The microfluidics device of claim 1 , further comprising:surface markers targeted to the biological particles disposed on walls of the parallelized microfluidic channels at the interaction zones, the target surface makers reduce flowing velocities of the ...

Storage Devices for RFID-Tracked Biological and Other Samples

A storage system for storing samples, such as frozen biological samples in RFID-tagged vials. The storage system has (i) a storage device having a device antenna and (ii) a plurality of storage components adapted to be stored within the storage device, each storage component having a component circuit. Each storage component is configured to store one or more samples. The storage device is configured to (i) transmit electrical power and downlink data signals wirelessly to each storage component via the device antenna and the corresponding component circuit and to (ii) receive uplink data signals from each storage component wirelessly via the corresponding component circuit and the device antenna such that a control system located outside of the dewar can identify any specified storage component stored within the storage device.

LABORATORY SPECIMEN TRAY

A laboratory specimen tray for the organization of medical and scientific specimens for improving continuity of case/patient identification and reduction in the mislabeling or mixing of specimens between patients is provided. The specimen tray may be an elongated body of material that forms various voids for securing various types of specimen containers and associated paperwork. An upper surface of the specimen tray provides a distinct demarcation, such as one of a plurality of colors, so that two specimens of the same type are never next to each other in a laboratory setting, further preventing the possibility of specimen/patient mix ups. This separation makes sure that a cassette during sectioning by the technologist is not accidentally cut and placed on the wrong patient slide. 1. A laboratory specimen tray device , comprising:an elongated body of material having opposing lower and upper surfaces;an elongated slot formed along the upper surface so as to extend substantially the full length thereof;a plurality of circular recesses formed along the upper surface;a plurality of rectangular cavities formed along the upper surface, each circular recess operatively aligns with one of the plurality of rectangular cavities, and wherein each rectangular cavity is dimensioned to accommodate a square tissue cassette; andan identification marking is provided along the upper surface.2. The device of claim 1 , wherein the upper surface is not coextensive with the lower surface claim 1 , forming an overhanging flange on each of the opposing ends of the elongated body.3. The device of claim 1 , wherein the identification marking is a color.4. The device of claim 1 , wherein each circular recess comprises at least one gripping circular recess claim 1 , wherein each gripping circular recess provides a circumferential grip insert extending into said gripping circular recess.5. (canceled)6. The device of claim 1 , wherein the plurality of circular recesses are aligned with each ...

SYSTEM AND METHOD FOR CONTROLLING ACCESS TO CONTENT OF CONTAINERS

System and methods for controlling access to content of at least one container, wherein the system is remotely connected to an external server, the system including: a lock unit, configured to lock a container and prevent access to the content therein, a unique readable tag, attachable to the container, and a key unit, wherein the key unit includes: a processor, connectable to the server via a communication channel, a detector, coupled to the processor, and adapted to read readable tags, and a key, coupled to the detector, and adapted to unlock the lock unit upon receipt, by the processor, of tag identification from the detector and also receipt of access authorization data, wherein the access authorization data is provided by the server upon confirmation of the tag identification data. 1. A system for controlling access to content of at least one container , wherein the system is remotely connected to an external server , the system comprising:a lock unit, configured to lock a container and prevent access to the content therein;a unique readable tag, attachable to the container; and a processor, connectable to the server via a communication channel;', 'a detector, coupled to the processor, and adapted to read readable tags; and', 'a key, coupled to the detector, and adapted to unlock the lock unit upon receipt, by the processor, of tag identification from the detector and also receipt of access authorization data,, 'a key unit, wherein the key unit compriseswherein the access authorization data is provided by the server upon confirmation of the tag identification data.2. The system of claim 1 , wherein the key unit further comprises a user interface unit to receive from the server the access authorization data for a locked container identified by the detector.3. The system of claim 1 , further comprising a memory unit claim 1 , coupled to the processor claim 1 , to store data that is indicative to each locked container claim 1 , wherein the stored data comprises ...

CLASSIFICATION OF BARCODE TAG CONDITIONS FROM TOP VIEW SAMPLE TUBE IMAGES FOR LABORATORY AUTOMATION

Embodiments are directed to classifying barcode tag conditions on sample tubes from top view images to streamline sample tube handling in advanced clinical laboratory automation systems. The classification of barcode tag conditions leads to the automatic detection of problematic barcode tags, allowing for a user to take necessary steps to fix the problematic barcode tags. A vision system is utilized to perform the automatic classification of barcode tag conditions on sample tubes from top view images. The classification of barcode tag conditions on sample tubes from top view images is based on the following factors: (1) a region-of-interest (ROI) extraction and rectification method based on sample tube detection; (2) a barcode tag condition classification method based on holistic features uniformly sampled from the rectified ROI; and (3) a problematic barcode tag area localization method based on pixel-based feature extraction. 1. A method of classifying barcode tag conditions on sample tubes held in a tube tray , the method comprising:acquiring, by an image capture system comprised of at least one camera, top view image sequences of the tube tray; and rectifying a region of interest (ROI) from each input image of the top view image sequences;', 'extracting features from the rectified ROI; and', 'inputting the extracted features from the rectified ROI into a classifier to determine the barcode tag condition, the barcode tag condition based upon a barcode tag condition category stored in the classifier., 'analyzing, by one or more processors in communication with the image capture system, the top view image sequences, the analyzing comprising, for each sample tube2. The method of claim 1 , wherein the analyzing by the one or more processors further comprises:if the determined barcode tag condition comprises a problematic identification, localizing a problematic area and issuing a warning via an output device in communication with the one or more processors.3. The ...

SYSTEMS AND METHODS FOR TAGGING AND ACOUSTICALLY CHARACTERIZING CONTAINERS

Embodiments of the present invention provide systems and methods for tagging and acoustically characterizing containers. 1providing the container, the container: originating from within a mold and comprising at least one vertical sidewall; and a bottom coupled to the at least one vertical sidewall wherein the bottom has an interior side, an exterior side, and a thickness and includes a plurality of recesses, grooves, or protrusions on the exterior side for acoustic characterization of the container;transmitting an acoustic signal toward the bottom;receiving a plurality of reflections of the acoustic signal, wherein the plurality of reflections comprises a first reflection from a first subset of the plurality of recesses, grooves, or protrusions a second reflection from a second subset of the plurality of recesses, grooves, or protrusions, the first reflection having a first time of flight and the second reflection having a second time of flight; andcharacterizing the container based on the first and second times of flight, wherein the characterizing comprises determining a characteristic of the container,wherein (a) the characteristic is associated with a location in the mold from which the container originates or (b) the mold is one of a plurality of molds and the characteristic is associated with the mold.. A method for acoustically characterizing a container configured to hold a fluid, the method comprising: This application is a continuation of U.S. patent application Ser. 16,705,807, filed Dec. 6, 2019, which is a continuation of U.S. patent application Ser. 15/289,692, filed Oct. 10, 2016, which claims the benefit of U.S. Provisional Patent Application No. 62/240,412, filed Oct. 12, 2015, and all entitled “Systems and Methods for Tagging and Acoustically Characterizing Containers,” the entire contents of all applications are incorporated by reference herein.This application relates to tagging containers, such as containers formed using injection molding. But ...

Resolving spatial arrays using deconvolution

Methods for determining a location of a feature on a spatial array include (a) providing an array of features on a substrate, where a feature of the array includes a barcoded oligonucleotide having, in a 5′ to 3′ direction, a spatial barcode, a cleavage domain, and a constant sequence; (b) hybridizing a priming oligonucleotide to the constant sequence; (c) extending the priming oligonucleotide using the barcoded oligonucleotide as a template; and (d) determining all or a portion of a sequence of the extended priming oligonucleotide corresponding to the spatial barcode, or a complement thereof, and a location of the extended priming oligonucleotide, and using the location of the extended priming oligonucleotide to determine the location of the feature on the spatial array.

Microfluidic Device for Image Multiplexing

The present invention relates to a microfluidic device for image multiplexing. The microfluidic device comprises a base structure comprising an optical window and a fluid well insert coupled to the base structure . The fluid well insert is configured to retain a microscope slide for mounting of a biological sample within the microfluidic device . The fluid well insert is also configured to provide a fluid to said biological sample . A fluid well insert lid coupled to the fluid well insert is also provided. 1. A microfluidic device for image multiplexing , the microfluidic device comprising:a base structure comprising an optical window;a fluid well insert coupled to the base structure and being configured to retain a microscope slide for mounting of a biological sample within the microfluidic device, said fluid well insert being further configured to provide a fluid to said biological sample; anda fluid well insert lid coupled to the fluid well insert.2. The microfluidic device of claim 1 , wherein the fluid well insert lid comprises an opaque cover material.3. The microfluidic device of claim 1 , wherein the fluid well insert lid further comprises a fluid input port and a fluid aspiration port.4. The microfluidic device of claim 1 , wherein the base structure further comprises at least one quick release coupling mechanism for releasably attaching the fluid well insert to the base structure.5. The microfluidic device of claim 4 , comprising a plurality of quick release coupling mechanisms each comprising a respective rotatable lug claim 4 , and wherein the rotatable lugs are configured to engage with a respective ledge portion provided on said fluid well insert.6. The microfluidic device of claim 5 , wherein the rotatable lugs are provided on respective spring clamps attached to the base structure.7. The microfluidic device of claim 1 , wherein the optical window is substantially transparent to electromagnetic radiation in at least one of the infrared claim 1 , near- ...

PIPETTE ACCESSORY FOR RELIABLE LIQUID HANDLING

An apparatus for limiting pipette motion, the apparatus comprising: (1) a stand for controlling spatial positions; (2) a mechanism for temporally coupling the pipette with the stand; the orientation or the movement of the pipette being restricted by the stand as predetermined for (a) limiting the insertion depth of the pipette tips into sample containers, (b) restricting unwanted movements or rotations of the pipette, or (c) maintaining the desired alignments of the pipette tips with the sample containers. Methods of limiting pipette motion or rotation are also provided.

Bodily fluid sample collection and transport

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.

CHAIN OF CUSTODY FORMS AND METHODS

A chain-of-custody form having integrated removable specimen seals and methods for using the form to identify a test sample collected from a donor and document the handling of the test sample. The form comprises a blank having a first portion and a second portion. The first portion comprises a first section having one or more spaces for recording demographic and testing information, and one or more indicia of the information to be recorded in one or more marked spaces; and a second section having a marked space for the donor to affix a signature and one or more indicia of the purpose of the space. An identifier that is unique to the form is recorded within the first portion and within the second portion. The identifier includes an specimen identification number or some other method of specimen identification such as a bar-code. 1. A form for recording a chain of custody , comprising:a single printable sheet that comprises at least a first portion and a second portion;one or more specimen seals within the second portion, each specimen seal being removable from the second portion and capable of being affixed to a specimen container so that the specimen container cannot be opened without either removing the specimen seal or visibly damaging the specimen seal; andan identifier that is unique to the form and is recorded at least once within the first portion and at least once upon each of the one or more specimen seals in the second portion.2. The form of claim 1 , wherein the identifier comprises a form control code that is unique to the printable sheet.3. The form of claim 2 , wherein the identifier is present in human-readable form.4. The form of claim 2 , wherein the identifier is present in machine-readable form.5. The form of claim 1 , comprising:a first section within the first portion, comprising one or more marked spaces for recording demographic information and test information and one or more indicia of the information to be recorded in the one or more marked ...

Storage System for Biological Samples and the Like

A storage system having racks and an outer container that receives the racks, each rack receiving a plurality of sample boxes, each box having a wireless ID tag. In certain embodiments, the storage system has reader electronics external to and distinct from the racks and that directly read the wireless ID tag of each box in at least one rack without relying on any reader electronics of any rack. In other embodiments, each rack has a set of rack reader electronics that read the wireless ID tag of each box in at least one rack, and the storage system has at least one removable reader access device removably connectable to the set of rack reader electronics of a rack in order to transmit the ID number of the wireless ID tag of each box in the rack outside of the outer container. 17001300. A storage system (e.g. , , ) comprising:a plurality of racks, each rack configured to receive a plurality of boxes, each box (i) having a wireless identification (ID) tag having an ID number and (ii) configured to receive one or more samples;an outer container configured to receive the plurality of racks; andreader electronics (i) external to and distinct from the racks and (ii) configured to directly read the ID number of the wireless ID tag of each box in at least one rack without relying on any reader electronics of any rack.2. The storage system of claim 1 , wherein each rack has no reader electronics.3. The storage system of claim 2 , wherein:at least one rack has a wireless ID tag; andthe reader electronics is configured to read the rack's wireless ID tag.4. The storage system of claim 2 , wherein:at least one rack has a sequence of one or more holes that represent an ID number for the rack, wherein the sequence is unique for the storage system; andthe reader electronics is configured to detect the sequence of one or more holes.5. The storage system of claim 2 , wherein:at least one rack has a sequence of one or more holes that represent a rack configuration for the rack; andthe ...

EQUIPMENT AND METHOD FOR THE AUTOMATED MANAGEMENT OF BIOLOGICAL SAMPLE JARS

The equipment item for automatically managing a plurality of biological samples placed in a respective sample jar includes a storage container for sample jars having a plurality of housings, an apparatus with a reader of encoded identification data affixed on the sample jars placed in the container, a device for determining data representative of the position of each sample jar within the container, and a device for rotating the container, and a computer processor connected to the apparatus. The container includes, in the immediate vicinity of each housing, a shape appearing recessed or raised, while the device for determining data representative of the position of each sample jar is defined by a detector for the shape. 1. An equipment item for automatically managing a plurality of biological sample , each sample being placed in a sample jar including being comprised of a bottom topped by a peripheral wall and closed by a lid , the equipment item comprising:storage container for sample jars having a plurality of housings with a shape complementary to a bottom of a sample jar; a case defining a cavity so as to accommodate at least one container,', 'means for reading encoded identification data affixed on the peripheral wall and/or the lid of the sample jars placed in the container,', 'means for determining data representative of the position of each sample jar within the container, and', 'means for rotating the container; and, 'one apparatus being comprised ofcomputer processing means connected to said apparatus by wired or wireless data transmission means and incorporating a software application,wherein said software application runs in order to record in memory means, for each jar in an associated manner, the identification data that it comprises, the data representative of position within the container and data relative to a history of the biological sample that it contains,wherein said software application runs in order to detect occurrence of a given event in ...

Devices, systems, and methods for performing optical assays

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

Storage System for Biological Samples and the Like

A storage system having racks and an outer container that receives the racks, each rack receiving a plurality of sample boxes, each box having a wireless ID tag. In certain embodiments, the storage system has reader electronics external to and distinct from the racks and that directly read the wireless ID tag of each box in at least one rack without relying on any reader electronics of any rack. In other embodiments, each rack has a set of rack reader electronics that read the wireless ID tag of each box in at least one rack, and the storage system has at least one removable reader access device removably connectable to the set of rack reader electronics of a rack in order to transmit the ID number of the wireless ID tag of each box in the rack outside of the outer container.

PORTABLE DNA ANALYSIS MACHINE

Aspects of the present disclosure relate to DNA amplification systems, e.g., PCR chips used to hold a testing solution and sample, and systems and methods for testing the sample including thermocycling and detection. The system can include a containment chip capable of holding a sample and reagents for amplifying a nucleic acid in the sample and containing a unique identifier used to choose a nucleic acid amplification protocol. The system can also include a nucleic acid detection component which may contain a light source, a light sensor, a temperature control unit and a processor. 1. A nucleic acid amplification system comprising:a containment chip capable of holding a first sample wherein the containment chip comprises at least one reagent for amplifying a nucleic acid in the sample and an identifier for uniquely identifying the containment chip, wherein the identifier is used to select a nucleic acid amplification protocol, a light source operably linked to the containment chip, wherein the light source provides light at the wavelength necessary to perform either absorption or fluorescence measurements of the sample;', 'a light sensor operably linked to the containment chip, wherein the light sensor measures either absorption or fluorescence from the containment chip;, 'a nucleic acid detection component comprisinga temperature control unit operably linked to the containment chip, wherein the temperature control unit measures the temperature of the sample, and adjusts the temperature of the containment chip; anda processor operably linked to the nucleic acid detection component and the temperature control unit, wherein the processor adjusts the light source, receives data from the light sensor, receives data from the temperature control unit, and adjusts the temperature, wherein the processer is operably connected to a database which contains the nucleic acid amplification protocol.2. The nucleic acid amplification system of wherein the nucleic acid detection ...

SYSTEM AND METHOD OF MARKING ARTICLES COATED WITH A LASER-SENSITIVE MATERIAL

A method for uniquely identifying tubes may include programming a motion of a laser relative to a tube pad printed with a mixture of ink and a laser sensitive material and exposing the laser-sensitive material to the laser to colorimetrically transform the material and reveal a unique identifier. A method of coating tubes includes plasma or flame treating the tube and mixing a laser-sensitive material with ink to form a mixture to pad print onto the tube. A system for identifying tubes coated with laser-sensitive material includes a laser mounted in translational relationship to a stage, a camera positioned to capture an image of a tube on a stage, a processor that receives the image and translates the laser relative to the stage in order to position the laser for marking the tube, and a laser controller to move the laser in order to mark the tube. 1. A tube with a laser-sensitive coating , comprising:a tube; anda coating applied on a portion of the tube comprising a mixture of ink and a laser-sensitive, color-changing material.2. The tube of claim 1 , wherein at least one of a top and a bottom of the tube is flat.3. The tube of claim 1 , wherein the tube is at least one of plasma- claim 1 , corona- claim 1 , or flame-treated prior to receiving the coating.4. The tube of claim 1 , wherein the coating is at least one of air-dried claim 1 , oven-dried claim 1 , and UV cured onto the tube.5. The tube of claim 1 , wherein the coating is applied to at least one of a curved side claim 1 , a top claim 1 , and a bottom of the tube.6. The tube of claim 1 , wherein the coating is marked using a COlaser to excite the laser-sensitive claim 1 , color-changing material.7. The tube of claim 1 , wherein the tube is molded or blown.8. The tube of claim 1 , wherein the ink is pad print ink or screen print ink.9. A tube with a laser-sensitive coating on an insert claim 1 , comprising:a tube; anda coating applied on an insert comprising a mixture of pad print ink and a laser-sensitive, ...

Test tube gripper, test tube labeling unit, and test tube preparing apparatus including the same

The present invention relates to a test tube preparation device which is compact, light and more mobile and improve the spatial layout of an installing unit, a transfer unit and a label attaching unit and the constitution of the units. According to an aspect, the invention may comprise a frame in which right and left installing units where a plurality of test tubes are vertically installed are provided on the upper part and at least one guide hole which allows the test tube to move by passing through the hole; a gripper transfer unit transfers the test tubes installed in the right and left installing units to the guide hole; a gripper pinches or separates the test tubes; and a labelling unit attaches a label to the waist of the test tube transferred through the guide hole.

INSTRUMENTS, DEVICES AND CONSUMABLES FOR USE IN A WORKFLOW OF A SMART MOLECULAR ANALYSIS SYSTEM

A system for performing a molecular analysis workflow includes a reaction holder or a reaction substrate, such as a multi-well reaction plate, with a reaction holder/substrate RFID tag, and/or a reagent container with a reagent container RFID tag, and an instrument and/or device that includes an RFID reader/writer operable to read and/or write information to and from the reaction holder/substrate RFID tag and/or the reagent container RFID tag. The reaction holder/substrate RFID tag and the reagent container RFID tag can be utilized separately or together to send and receive and store information, for example, for a workflow of a molecular analysis, such as a polymerase chain reaction (PCR). 1. A system for performing a molecular analysis , the system comprising:a reagent container comprising a reagent container RFID tag;the reagent container RFID tag storing and/or sharing information for a workflow for the molecular analysis,wherein the reagent container RFID tag includes information identifying a reagent within the reagent container, andwherein the reagent container RFID tag includes information directing application of the reagent within the reagent container to the sample as part of the workflow for the molecular analysis.2. The system of claim 1 , wherein the system is configured to perform polymerase chain reaction (PCR).34-. (canceled)5. The system of claim 1 , further comprising a reaction plate that comprises a plurality of reaction sites claim 1 , wherein the reagent container RFID tag and/or a reaction plate RFID tag includes an instruction for transfer of the reagent from the reagent container to a subset of the reaction sites.67-. (canceled)8. The system of claim 5 , wherein the reaction plate and/or the reagent container further comprise a temperature sensor wherein the temperature sensor is coupled to the reaction plate RFID and/or the reagent container RFID tag claim 5 , the reaction plate RFID tag and/or the reagent container RFID tag each capable ...

LIQUID HANDLING INSTRUMENT AND PIPETTING HEAD FOR AND METHOD OF ASPIRATING AND/OR DISPENSING LIQUIDS

A liquid handling instrument and pipetting head for and method of aspirating and/or dispensing liquids is disclosed. Namely, an automated liquid handling instrument is provided for aspirating and/or dispensing liquids from source media to destination media using at least one pipetting head and by using a positive displacement pipette tip, wherein the positive displacement pipette tip includes a pipette tip and a pipette plunger. A pipetting head of the liquid handling instrument includes an arrangement of plates, threaded rods, motors, timing (or drive) belts, and custom timing pulleys/nuts. The pipetting head further includes an arrangement of pipette plunger clamping mechanisms and pipette tip clamping mechanisms that feature zero-insertion force clamping mechanisms. 1. A liquid handling instrument , comprising:an instrument housing with an instrument deck;a pipetting head above the instrument deck; anda removable tray, the instrument deck holding the removable tray.2. The liquid handling instrument of claim 1 , wherein the removable tray includes handles.3. The liquid handling instrument of claim 2 , wherein the removable tray holds one or more microplates.4. The liquid handling instrument of claim 3 , further comprising a tip caddy atop one of the one or more microplates.5. The liquid handling instrument of claim 1 , wherein the removable tray has a unique identification number adapted for scanning or reading.6. The liquid handling instrument of claim 5 , wherein the unique identification number is a 2D barcode or a radio-frequency identification tag.7. The liquid handling instrument of claim 1 , further comprising a robotics instrumentation and a controller claim 1 , the robotics instrumentation adapted to control the movement of the pipetting head with respect to the instrument deck claim 1 , and the controller adapted to execute program instructions to the liquid handling instrument.8. The liquid handling instrument of claim 1 , further comprising one or ...

IDENTIFICATION OF BIOLOGICAL SAMPLES

A method for coding and identification of biological samples for in vitro fertilisation comprises the steps of applying to receptacles intended for unfertilised eggs and sperm, respectively, an identification code characteristic of the patient; placing unfertilised eggs and sperm, respectively, in the receptacles; storing, transporting and admixing the respective samples in receptacles which each carry the same code; and implanting the resulting embryo in the patient. The identification code may based on RFID technology, in which sample vessels () are codified by the application of an RFID tag (). 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. (canceled)23. (canceled)24. (canceled)25. (canceled)26. (canceled)27. (canceled)28. (canceled)29. (canceled)30. (canceled)31. (canceled)32. (canceled)33. (canceled)34. Apparatus for identification of biological samples for in vitro fertilisation , the apparatus comprising storage vessels associated with an identification code , the identification code being based on RFID technology , sample vessels being codified by the application of an RFID tag;the apparatus comprising:a surface defining a work area;a reader to read the RFID tag;an antenna for transmission of activation radiation and receiving signals emitted by the RFID tag, the antenna located below the surface;a resistor to dampen the magnetic field produced by said antenna sufficient to prevent the RFID tag being swamped and still allow communication between the antenna and the RFID tag;a transformer to provide power to the antenna, the transformer configured to minimise any impedance mismatch between the reader and the antenna; andan adjustable capacitor to tune to resonance the coupling between the antenna and the RFID tag over the ...

Medical Band Assembly With Detachable Flag Label

A medical band assembly for identifying a patient and items and/or samples related to the patient may have an elongated body that may be formed into a loop. The medical band assembly supports a flag label on one of its surfaces. The flag label has a pair of flag sections joined together by an intermediate support bridge. The flag label is separable from the medical band and attachable to an object to be labeled by wrapping the flag label around the object, such that the next extends around the object, and securing the flag sections together on the opposing side. 1. A medical band assembly comprising:a medical band having an elongated body with opposing surfaces bounded at their edges by a periphery, the medical band extending from a main body to a strap in which the strap is attachable to the main body to form a loop from the medical band;a flag label supported on one of the opposing surfaces of the main body of the medical band and being separable from the medical band for attachment to an object to be labeled, the flag label including a pair of flag sections joined to one another by an intermediate support bridge;wherein, when the flag label is separated from the medical band, the pair of flag sections are foldable onto one another to join a contacted pair of their surfaces together such that the intermediate support bridge is wrapable around the object to be labeled by the flag label.2. The medical band assembly of claim 1 , wherein the object is cylindrical in shape claim 1 , and wherein the intermediate support bridge wraps around the circumference of the object.3. The medical band assembly of claim 2 , wherein the object is a test tube.4. The medical band assembly of claim 1 , further comprising a transparent laminate shield attached to the main body of the medical band in which the transparent laminate shield is liftable from the main body to separate at least a portion of the transparent laminate shield from the main body.5. The medical band assembly of ...

NUCLEIC ACID DETECTION HOST AND NUCLEIC ACID DETECTION DEVICE

A nucleic acid detection host includes a host body, a detection kit installation area, a sample heating area, a sampling area, and an image collection unit. The detection kit installation area is configured to detachably install a nucleic acid detection kit. The sampling area is disposed above the detection kit installation area and is connected to the detection kit installation area. The sampling area is configured to add a detection solution into the nucleic acid detection kit. The image collection unit is configured to collect an image of the nucleic acid detection kit. A nucleic acid detection device including the nucleic acid detection host is also disclosed. The nucleic acid detection device has a simple structure, which is portable, flexible, and convenient, and can be used at home. 1. A nucleic acid detection host , comprising:a host body;a detection kit installation area;a sample heating area;a sampling area; andan image collection unit;wherein the detection kit installation area, the sample heating area, the sampling area, and the image collection unit are disposed on the host body, the detection kit installation area is configured to detachably install a nucleic acid detection kit therein, the sample heating area is configured to collect a detection solution and heat the detection solution, the sampling area is disposed above the detection kit installation area and connected to the detection kit installation area, the sampling area is configured to add the detection solution into the nucleic acid detection kit in the detection kit installation area, the image collection unit is disposed on a side of the detection kit installation area away from the sampling area, and is configured to collect an image of the nucleic acid detection kit.2. The nucleic acid detection host of claim 1 , wherein the detection kit installation area comprises a mounting groove claim 1 , an imaging port disposed on a surface of the mounting groove away form the sampling area claim ...

CLINICAL LABORATORY TEST APPARATUS AND SYSTEM

A clinical laboratory test apparatus of a health care information system includes a reading section that reads an optically readable code array, an extraction section that extracts, from a plurality of the code arrays read by the reading section, a rule that is common between the plurality of code arrays, a storage section that stores the rule extracted by the extraction section, and a determination section that determines authenticity of each of the code arrays read by the reading section based on the rule stored in the storage section. In testing a sample, in a case where it is determined by the determination section that the code array read by the reading section is true, the test is executed, and in a case where it is determined that the code array is false, the execution of the test is suspended. 1. A clinical laboratory test apparatus comprising:a reading section that reads an optically readable code array;an extraction section that extracts, from a plurality of the code arrays read by the reading section, a rule that is common between the plurality of code arrays;a storage section that stores the rule extracted by the extraction section; anda determination section that determines authenticity of each of the code arrays read by the reading section based on the rule stored in the storage section,wherein the rule comprises a total code number of the code array,wherein the determination section determines that the code array is true in a case where a total code number of the code array read by the reading section matches the total code number of the rule, and determines that the code array is false in a case where the total code number of the code array read by the reading section does not match the total code number of the rule, andwherein in testing a sample, in a case where the code array read by the reading section is determined by the determination section to be true, the test is executed, and in a case where the code array read by the reading section is ...

Temporal Multiplexed Excitation for Miniaturized, Planar Fluorescence Activated Cell Sorting

A system for fluorescence activated cell sorting includes at least two excitation lasers and an objective that directs light from the at least two excitation lasers to a common point in an interrogation region of a fluidic channel. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. At least one modulator temporally multiplexes light from the at least two excitation lasers such that pulses of light from different lasers intersect the common point at different times. The system further includes at least one detector and at least one optical element that directs light emitted from the particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light are also described herein. 1. A system comprising:at least two excitation lasers;an objective that directs light from the at least two excitation lasers to a common point in an interrogation region of a fluidic channel, wherein the fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region;at least one modulator that temporally multiplexes light from the at least two excitation lasers such that pulses of light from different lasers intersect the common point in the interrogation region of the fluidic channel at different times;at least one detector; andat least one optical element optically coupled to the objective and the at least one detector to direct light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one detector.2. The system of claim 1 , wherein the fluidic channel is defined in a planar microfluidic chip.3. The system of claim 1 , wherein the at least one modulator sequentially pulses the at least two excitation ...

EQUIPMENT FOR THE TRACEABILITY OF BIOLOGICAL SAMPLES

The equipment for the traceability of biological samples placed in cassettes provided with encoded identification data and intended to be stored within baskets, the general shape of which may vary from one basket to another includes at least one container to accommodate at least one basket, at least one apparatus for reading encoded data affixed on cassettes arranged in at least one basket placed in the container, a device for computerized processing of the data read by the apparatus for reading, and a device for identifying the shape of the basket placed in the container. 1. An equipment item for traceability of biological samples placed in inclusion cassettes provided with identification information comprised of encoded data and stored next to one another in housings arranged within baskets , the general shape of which may vary from one basket to another , said equipment item comprising:at least one container to accommodate at least one basket,at least one apparatus for reading encoded data affixed on cassettes arranged in at least one basket placed in the container, said apparatus being comprised of a bottom, a peripheral wall, an upper wall and with at least one opening for access to at least one inner cavity to accommodate the container and equipped with means for reading encoded data,means for computerized processing of the data read by the reading means, andmeans for identifying the shape of the basket placed in the container.2. The equipment item according to claim 1 , wherein the container is subdivided into several compartments having different shapes claim 1 , each configured to receive a basket of a given shape claim 1 , while the reading apparatus is comprised of a detection means for the presence claim 1 , or if applicable claim 1 , the absence of a basket in at least one of said compartments of said container and to send the corresponding information to means for controlling the means for reading encoded data.3. The equipment item according to claim 2 ...

Methods and Systems for Using RFID in Biological Field

Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents.

IDENTIFICATION OF BIOLOGICAL SAMPLES

A method for coding and identification of biological samples for in vitro fertilisation comprises the steps of applying to receptacles intended for unfertilised eggs and sperm, respectively, an identification code characteristic of the patient; placing unfertilised eggs and sperm, respectively, in the receptacles; storing, transporting and admixing the respective samples in receptacles which each carry the same code; and implanting the resulting embryo in the patient. The identification code may based on RFID technology, in which sample vessels () are codified by the application of an RFID tag (). 1. A method for coding and identification of biological samples for in vitro fertilisation , the method comprising the steps of applying to receptacles intended for unfertilised eggs and sperm , respectively , an identification code characteristic of the patient; placing unfertilised eggs and sperm , respectively , in the receptacles; storing , transporting and admixing the respective samples in receptacles which each carry the same code; and implanting the resulting embryo in the patient.2. A method according to claim 1 , in which the identification codes are computer-readable.3. A method according to claim 1 , in which the identification code is based on RFID technology claim 1 , sample vessels being codified by the application of an RFTD tag.4. A method according to claim 2 , in which information relating to the receptacles and samples stored therein is maintained in a database.5. A method according to claim 4 , in which the database is controlled by software which includes an anti-collision protocol to discriminate between data received from a plurality of vessels having different identification codes attached thereto.6. A method according to claim 3 , the method being carried out on a laboratory bench beneath which is located an antenna for transmission of activation radiation and receiving signals emitted by the RFID tag.7. A work station providing a warmed surface ...

Methods and Systems for Using RFID in Biological Field

Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents. 1. Apparatus for associating information with a biological reagent , the apparatus comprising:a carrier for supporting the biological reagent; andat least one RFID tag comprising a carrier RFID antenna coupled to the carrier, wherein the RFID tag is operable to be read by an RFID reader and wherein the RFID tag comprises identification information for the biological reagent.2. The apparatus of claim 1 , wherein the carrier comprises a microarray.3. The apparatus of claim 1 , wherein the carrier comprises a surface plasmon resonance array.4. The apparatus of claim 1 , wherein the carrier comprises a reaction plate.5. The apparatus of claim 1 , wherein the carrier comprises a tube.6. The apparatus of claim 1 , wherein the carrier comprises a tube carrier for holding a plurality of tubes.7. The apparatus of claim 1 , wherein the carrier comprises a microfluidic card.8. The apparatus of claim 1 , wherein the carrier RFID antenna is embedded in an interior portion of the carrier during a carrier manufacturing process.9. The apparatus of claim 1 , wherein the carrier RFID antenna is adhesively applied to at least part of an exterior portion of the carrier.10. The apparatus of claim 1 , further comprising:at least one instrument having an instrument RFID reader for reading the identification information; andat least one output interface that provides output information regarding an identification of the biological reagent while the instrument is performing operations in connection with the biological reagent.11. The apparatus of claim 10 , wherein the instrument comprises a non-transparent enclosure that substantially prevents optical scanning of a barcode on an object positioned within the instrument.12. Apparatus for associating information with a biological reagent claim 10 , the apparatus comprising:a carrier for supporting the ...

Test Strip Coding and Quality Measurement

A test strip and analytical apparatus have pin connections permitting the definition of geographic regions or of particular customers. A test strip made for use in a particular region or for a particular customer will have pin connections matching features of the apparatus made for use in that region or by that customer. Insertion of the strip into the apparatus does not merely turn on the apparatus, but provides the regional or customer coding. Analog switches within the apparatus allow coding of a larger number of distinct regions or customers than would otherwise be possible, all without degrading the quality of the measurements made of the fluid being tested. Conductive paths in the strips permit testing the strips during manufacture so as to detect quality lapses regarding the printing or deposition of the paths. 111-. (canceled)12. A method for use with a planar test strip elongated for a length along a first dimension parallel to a first axis and having a second dimension corresponding to the width of the strip , the strip having an electrochemical analysis cell at one axial end and a connection region at the other axial end , the strip made up of at least a first layer; the first layer having deposited thereupon at least one conductor extending from the connection region to the electrochemical cell , the conductor having a first portion which is not a conductive path for analysis and which does not make contact with sample in the electrochemical cell; the method comprising the steps of:applying first and second test probes to said first portion, said first and second test probes disposed axially or perpendicular to the axis and separated from one another along the length or width of the strip.13. The method of claim 12 , wherein the conductor has a second portion claim 12 , separate from the first conductive portion claim 12 , which is not a conductive path for analysis and which does not make contact with sample in the electrochemical cell claim 12 , the ...

Systems and Methods for Multianalyte Detection

Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery. 1133-. (canceled)134. A system comprising:a light source; a fluorescence detection module;', 'an absorbance reader; and', 'a cell-enumeration module;, 'a detector comprisinga platform configured for movement of a multiwell plate underneath the fluorescence detection module, absorbance reader, and/or the cell-enumeration module, the multiwell plate having a plurality of wells disposed therein that are configured to receive a liquid sample;a liquid handling device to transfer liquids to the wells of the multiwell plate; anda housing encapsulating each of the light source, detector, liquid handling device, and platform.135. The system of claim 134 , wherein the platform is configured to rotate the multiwell plate underneath each of the fluorescence detection module claim 134 , absorbance reader claim 134 , and the cell-enumeration module.136. The system of claim 134 , wherein the liquid handling device is a piezoelectric or acoustic liquid dispenser configured to transfer aqueous liquid from a liquid reservoir within the housing into a well of the multiwell plate.137. The system of further comprising the multiwell plate.138. The system of claim 137 , wherein the plurality of wells are organized in concentric circles around a center of the multiwell plate.139. The system of claim 138 , wherein the plurality of wells is arranged in a spokes-like arrangement.140. The system of claim 139 , wherein the ...

METHOD AND APPARATUS FOR CODING DIAGNOSTIC METERS

A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips. 1. A system for diagnostic testing comprising:an electronic meter for performing a diagnostic test on a sample applied to test media, the electronic meter comprising a housing having a test media port;a plurality of test media compatible with the electronic meter, each test media of the plurality of test media having a first end and a second end, the first end having a width and a height, wherein a width and a height of the test media port is approximately equal to the width and the height of the first end for insertion of the first end into the test media port; anda container having an open interior volume permitting contact between the plurality of test media housed therein;wherein at least one of the housing and the container comprises a top mount attachment configured to releasably attach the housing to the container.2. The system according to claim 1 , wherein the top mount attachment is configured to releasably mount the housing to the top end of the container.3. The system according to claim 1 , wherein the top mount attachment comprises at least one lock protruding from the housing and at least one corresponding protrusion protruding from at least a portion of a lip of the container claim 1 , each lock configured to slidably traverse at least a portion of each protrusion claim 1 , wherein in a first position claim 1 , each lock and each protrusion are ...

A MICROFLUIDIC DETECTION DEVICE WITH IMMOBILIZED BIOCHEMICAL ASSAYS, FABRICATION OF SAME AND METHOD OF ANALYSING A FLUID SAMPLE

The invention relates to a microfluidic chip with specifically shaped chambers to improve operability. The present invention further relates to a method of manufacturing a microfluidic chip, which has reagents embedded inside and which can perform analysis of multiple target analytes from a single test sample. Further, the invention relates to a simple analysis system that can be used by non-technical users by automating several stages of the process and providing the end user with simple feedback. 1. A microfluidic chip comprising:an inlet;at least one fluid path comprising at least one fluidic channel from the inlet to an outlet, said at least one fluidic path comprising a detection chamber and optionally a reaction chamber between the inlet and the detection chamber;said at least one fluidic path being enclosed and configured to allow a fluid sample dispensed onto the inlet to move through fluidic channels to at least one detection chamber surface due to capillary motion,characterised in thatthe outlet contains a vent to enable capillarity, said outlet being adjacent to the detection chamber and positioned substantially opposite to where the fluidic channel enters the detection chamber.2. The microfluidic chip of claim 1 , wherein the detection chamber surface is aligned with an inspection window claim 1 , and wherein the outlet and vent does not overlap with the inspection window.3. The microfluidic chip of or claim 1 , wherein the transitional zone between the fluidic channel and the detection chamber is filleted.4. The microfluidic chip of claim 3 , wherein the fillets have a curve with a radius of from 3 mm to 7 mm.5. A microfluidic chip comprising:an inlet;at least one fluid path comprising at least one fluidic channel from the inlet to a detection chamber, said at least one fluid path comprising a reaction chamber between the inlet and the detection chamber;characterised in thatthe reaction chamber is shaped with an aspect ratio of 3:2 or higher.6. The ...

Analytic plates with markable portions and methods of use

An analytic plate or other substrate having a permanent etchable, laserable, and/or developable marking surface coating (referred to herein as an “etchable coating” or as a “developable coating”) that is present on at least a portion of any side or surface thereof and is used to deposit a permanent indicium thereon, and a method of using the analytic plate or substrate.

Dual Barcode Labeling Facilitating Automated Decapping

A specimen collection assembly and method for detecting the same are disclosed. The specimen collection assembly includes a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior adapted to receive a biological specimen. The specimen collection container also includes first indicia containing information. The assembly further includes a cap having thereon second indicia, the cap being removably engagable with the open top end of the container. The second indicia contains the same information as the first indicia. 1. A method of detecting a specimen collection assembly comprising:providing a specimen collection assembly comprising a specimen collection container having an open top end, a closed bottom end, a sidewall extending therebetween defining an interior adapted for receiving a specimen therein, and a first indicia disposed on at least a portion of the sidewall; a cap removably engagable with the open top end of the specimen collection container; a second indicia disposed on at least a portion of the cap; and a specimen disposed within the interior of the specimen collection container;detecting the second indicia;removing the cap from the specimen collection container; andsubsequently detecting the first indicia.2. The method of claim 1 , further comprising:providing an automated processing system having at least one detector for detecting indicia in communication with a control unit having at least one processor therein and at least one analyzer;detecting, with the at least one detector, the second indicia; andsubsequently detecting, with the at least one detector, the first indicia.3. The method of claim 1 , wherein the first indicia and second indicia are machine-readable indicia.4. The method of claim 1 , wherein the first indicia and the second indicia comprise at least one of a matrix barcode claim 1 , RFID tag or linear barcode.5. The method of claim 1 , wherein the first ...

Kit, Apparatus and Method for a Portable Nucleic Acid Assay

The self-contained kit comprises methods for receiving and preparing the biological samples for the nucleic acid amplification and sensing the presence of the target assay. The kit consists of a self-heating pack to provide the heat for nucleic acid sample preparation and amplification processes. The change of the amplification is indicated through colorimetric or turbidity sensing and detected through a mobile phone camera and associated mobile application for photographic scanning of physical or chemical differences of the samples to produce the test results. 1. A kit for the sensing of biological samples comprising:a. a sampling swab;b. heat activation reagents;c. nucleic acid assay reagents;d. a first nucleic acid assay chamber containing the nucleic acid assay reagents;e. a second nucleic acid assay chamber containing control reaction reagents;f. a heating reaction chamber having an open end for receiving the first reaction chamber and the heat activation reagents; andg. an insulated housing for receiving the heating reaction chamber2. A kit according to claim 1 , further comprising a printed barcode identifying the type of nucleic acid assay.3. A kit according to claim 1 , further comprising a printed instructions and test chart for interpretation claim 1 , preferably which test chart comprises printed indications of positive and negative results.4. A kit according to claim 1 , further comprising a narrowing slot for squeezing out saliva from the sampling swab.5. A kit according to claim 1 , further comprising a printed QR code encoding a unique kit code for a given kit and a link to a mobile app or website.6. A kit according to claim 1 , wherein the first nucleic acid assay chamber further comprises a closing cap and wherein the nucleic acid assay reagents are located inside the closing cap and arranged to be released into the first nucleic acid assay chamber when the closing cap is turned to a closed position.7. A kit according to claim 1 , further ...

Assay Wells with Hydrogel as a Well-Contents Separator

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change 120-. (canceled)21. An assay device stable for shipment comprising:a plurality of wells which are a series of openings connected by first channels in a first surface of the body of the assay device, wherein said wells house assay reagents in solution, the wells include a gelatin hydrogel;at least one air gap in the first channels to separate fluids in the wells, wherein the gelled gelatin hydrogel prevents movement of the assay reagents from the wells into the air gap.22. The device of wherein the gelatin hydrogel is at least 150 Bloom.23. The device of wherein the gelatin hydrogel is less than 10% gelatin.24. The device of wherein the gelatin hydrogel is Bloom range 180-200.25. The device of wherein the gelatin hydrogel is at a concentration range of 1 to 4%.26. The device of wherein at least one of the wells also contains magnetic microbeads.27. The device of wherein second channels extending transverse to the first channels intersect the first channels.28. The device of wherein the second channels extend from the first surface through the body to its opposite surface.30. The device of wherein the wells are sealed using a plastic paraffin film covering substantially the first surface.31. The device of further including encoding the cartridge with a QR or other code.3229. The device of claim further including adhering a paper or polymer layer substantially covering said plastic paraffin film.33. The device of further including a QR or other ...

Assay Wells with Hydrogel as a Well-Contents Separator and a Pigment-Based Temperature Indicator

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change 120-. (canceled)21. An assay device stable for shipment comprising: a plurality of wells which are a series of openings connected with first channels in a first surface of the body of the assay device , wherein said wells house assay reagents in solution , the wells include a gelatin hydrogel of at least 150 Bloom and the wells are sealed using a plastic paraffin film covering substantially the first surface.22. The device of wherein the gelatin hydrogel is less than 10% gelatin.23. The device of wherein the gelatin hydrogel is Bloom range 180-200.24. The device of wherein the gelatin hydrogel is at a concentration range of 1 to 4%.25. The device of further including at least one air gap in the channels to separate fluids in the wells claim 21 , wherein the gelled gelatin hydrogel prevents movement of the assay reagents from the wells into the air gap.26. The device of wherein second channels extending transverse to the first channels intersect the first channels.27. The device of wherein the second channels extend from the first surface through the body to its opposite surface.28. The device of wherein the plastic paraffin film is adhered to substantially flat portions of said first surface.29. The device of further including encoding the cartridge with a QR or other code.30. The device of further including adhering a paper or polymer layer substantially covering said plastic paraffin film.31. The device of further including a QR or other ...

CONTAINER FOR BIOLOGICAL PRESERVATION AT LOW TEMPERATURE

A container is provided in the present disclosure. The container includes at least one outer wall that is made of a low temperature tolerant material where the at least one outer wall is arranged to substantially form the container with an opening end; a tube that is situated inside the at least one outer wall, where the tube and the at least one outer wall are substantially thermally insulated, and the tube is open at one end that is on a same side of the opening end of the container; and a container cover being shaped substantially to match the at least one outer wall, where the container over is capable of covering the opening end of the container. 1. A container , comprising:at least one outer wall that is made of a low temperature tolerant material, wherein the at least one outer wall is arranged to substantially form the container with an opening end;a tube that is situated inside the at least one outer wall, wherein the tube and the at least one outer wall are substantially thermally insulated, and the tube is open at one end that is on a same side of the opening end of the container; anda container cover being shaped substantially to match the at least one outer wall, wherein the container over is capable of covering the opening end of the container, and when the opening end of the container is covered by the container cover, the container cover substantially seals the tube and substantially thermally insulate the tube such that the container is capable of being placed in a low temperature environment.2. The container of claim 1 , wherein the low temperature environment has a temperature that is below or equal to −80° C.3. The container of claim 1 , wherein the at least one outer wall is substantially squarely shaped by four side walls claim 1 , and each of the four side walls is shaped substantially rectangularly and has about a same size.4. The container of claim 3 , wherein more than one containers are capable of bundling together to form a substantially ...

CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS

Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part. 1. A cartridge for the detection of the presence , absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences , characterized in that the cartridge comprises a generic part and one or more separate application-specific parts , which are connectable to the generic part.2. A cartridge according to claim 1 , wherein one of the one or more specific parts is a PCR body having one or more thermocycling chambers and comprising a number of primers.3. A cartridge according to claim 2 , wherein at least one primer is arranged in each one of the one or more thermocycling chambers.4. A cartridge according to claim 2 , wherein at least one of the number of primers is spotted on the PCR body.5. A cartridge according to claim 2 , wherein the PCR body is disc-shaped.6. A cartridge according to claim 2 , wherein the PCR body comprises one or more thermal masses.7. A cartridge according to claim 1 , wherein one of the one or more application-specific parts is a detection device.8. A cartridge according to claim 2 , wherein the detection device is selected on the basis of the primers in the PCR body.9. A cartridge according to claim 1 , wherein one of the one or more application-specific parts is a sample introduction device configured to prepare a sample to a specific state.10. A cartridge according to claim 9 , wherein the sample introduction device is a pre-lysis device configured to prepare a sample to a specific state.11. A cartridge according to claim 1 , wherein at least one of the one or more application-specific parts is connectable on the main body with a click-fit connection.12. A cartridge according to claim 1 , ...

Sample tube and method

A sample tube includes a barcode split into components at the bottom of the sample tube. Each barcode component stores less than the full data output from the barcode, but the components combine to full data output. Redundant diagonal components provide for error checking. A center region between the barcode components supports an electrical circuit or an optical or acoustic window. The sample tube may have a sidewall with a substantially cylindrical open end and non-cylindrical end closed with a bottom, the non-cylindrical end orienting the sample tube in a rack. Additional non-cylindrical surfaces are provided to orient the sample tube relative to complementary surfaces at a gripper. The sample tube of a particular application is positioned in an acoustic dispensing system where acoustic waves are transmitted through a center window for surveying and dispensing.

BIOLOGICAL SAMPLE PROCESSING

Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge front at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge. 146-. (canceled)47. A method for processing a biological sample , the method comprising:receiving a sample vessel containing the sample;retrieving information from an information storage unit associated with the sample;using said information for selecting at least one cartridge from at least two or more different cartridges, each configured for use with a sample processing device;using the automated robotic system to load the cartridge and the sample vessel onto a robotic transport assembly for operably coupling a cartridge assembly location with a sample processing location of the sample processing device.48. The method of wherein retrieving comprises using optical scanning to obtain information from the information storage unit.49. The method of wherein retrieving comprises using electromagnetic techniques to obtain information from the information storage unit.50. The method of wherein the information storage unit comprises a bar code.51. The method of wherein the information storage unit comprises a QR code.52. The method of wherein the information storage unit comprises a radiofrequency-based storage unit.53. The method of further comprising communicating the information from to an external server.54. The method of wherein the information comprises information regarding components to be included in the cartridge. ...

Labeling Method for Medical Samples

An method for labeling and sealing medical samples prevents tampering, saves time, and reduces user error in matching medical samples to patients. The label has two portions, one portion being detachable and each portion having a barcode containing the patient's information as well as areas for the patient's signature, and/or the label also acts as a tamper strip for the sample container, and/or the patient's information is embedded or pre-printed on the sample container, as well as a label to do the same. 1. A method of labeling and sealing a container for medical samples comprising the steps of:a) supplying a patient a sample cup including an attached label comprising a detachable portion and a tamper strip portion, wherein the detachable portion is detachable from the attached label, and wherein both the detachable portion and the temper strip portion comprise a barcode for storing patient information;b) instructing the patient to initial the detachable portion and the tamper strip portion, and to remove the detachable portion;c) scanning the patient information into a digital records system; andd) sealing the sample cup with the tamper strip portion.2. A method of labeling and sealing a container for medical samples comprising the steps of:a) supplying a patient a sample cup comprising a pre-attached a mechanism for storing patient information;b) scanning the patient's information into a digital records system using the mechanism on the label; andc) sealing the sample cup with a tamper strip.3. The method of claim 2 , further comprising tracking the status of the medical sample by means of a computer system program that is coupled to a wireless data collection system.4. The method of claim 3 , wherein the computer system program further includes and communicates with a computer application that is accessible on a user's personal mobile device.5. The method of claim 4 , wherein the computer application informs the patient of the status of the sample testing ...

Method for fixing a histological sample

The disclosure relates to a method for fixing a histological sample, in which a target fixing time for the sample is defined and the sample is exposed to the action of a fixative, the exposure start time being stored in a memory associated with the sample. The sample is no longer exposed to the fixative when an action time of the fixative on the sample is equal to or greater than the target fixing time.

POSITIVE DISPLACEMENT PIPETTE SYRINGE IDENTIFICATION SYSTEM

Described are exemplary embodiments of a syringe identification system for use with a positive displacement pipette, such as a handheld powered positive displacement pipette. An exemplary syringe identification system may include a sensor, such as a color sensor, that is located at or near a distal end of the pipette and arranged such that the sensor is operative to read an identifying marking(s) on a syringe that has been installed to the pipette. The sensor may be a color sensor having an illumination source and configured to read a color code on the syringe. The color code may be usable to identify the syringe to the pipette. 1. A syringe identification system for use with a handheld positive displacement pipette , comprising:a color sensor located along a distal end of the pipette;a controller in communication with the color sensor and configured to receive data signals therefrom; anda colored marking placed on a syringe at a location that will reside within a field of view of the color sensor when the syringe is installed to pipette;wherein the color sensor is operable to detect the color of the colored marking on the syringe and to provide detected color data to the controller; andwherein the controller is programmed to use the detected color data received from the color sensor to identify the syringe installed to the pipette.2. The syringe identification system of claim 1 , wherein the controller is a component of the pipette.3. The syringe identification system of claim 2 , wherein the controller is further programmed to automatically set or adjust one or more operating parameters of the pipette based on the identified syringe.4. The syringe identification system of claim 1 , wherein the syringe includes a syringe retention element at a proximal end thereof claim 1 , and the colored marking is located on the syringe retention element.5. The syringe identification system of claim 4 , wherein the syringe retention element includes a chamfered shoulder and the ...

APPARATUS AND METHOD FOR PRINTING AND CONTROLLING EMBEDDING CASSETTES

Apparatus and method for printing and controlling embedding cassettes The present invention is directed to an embedding cassette printer comprising: at least one hub for feeding at least one printing position; conveyor means to transport the cassettes from the hub to the at least one printing position; at least one printing head (); at least one mean () to verify the correctness and the readability of the print job; release means () to discard the cassette if the print job is not correct or readable, or to convoy it to make it available to an operator. The present invention is also directed to a system for tracing embedding cassettes, which system comprises a printer as above defined and a storage facility, wherein the storage facility comprises verification means which reads the information printed on the cassette and saves it, wherein the system is capable of comparing the content of the database with the data of the printer and, if a cassette which was printed is not stored within a predetermined period of time, alerts the user of the missing cassettes. The invention is also directed to a method for using the above defined printer which method comprises the following steps: submit a cassette to a print job on at least one face of the cassette, preferably the slanted face; submit the print job to verification of the readability and correctness thereof by a verification mean (); if the print job is readable and correct, release the cassette; if the print job is not readable or incorrect, discard the cassette and proceed with printing a new cassette with the identical information of the discarded cassette. 1. Embedding cassette printer comprising:a. at least one hub for feeding at least one printing position;b. conveyor means to transport the cassettes from the hub to the at least one printing position;{'b': '110', 'c. at least one printing head ();'}{'b': '120', 'd. at least one mean () to verify the correctness and the readability of the print job;'}{'b': '140', ' ...

TISSUE CONTAINER, AND DEVICE AND METHOD FOR PROVIDIING SUCH A TISSUE CONTAINER WITH DATA

The invention relates to a container for containing tissue, comprising at least one receiving space for tissue and at least one information surface for arranging data, wherein the information can be arranged by means of a laser. The invention also comprises a device provided with a laser for arranging information on such a container. The invention moreover also comprises a method for arranging information on such a container using a laser. 1. A method for arranging data on a container for containing tissue material derived from humans , animals or plants , said container comprising at least one receiving space for tissue , the receiving space comprising a plurality of fluid-access recesses in the form of a grating , through which fluids from outside the container can come into contact with the tissue material within the receiving space and leave the receiving space , and at least one information surface for arranging said data , the data comprising at least the source of the tissue sample , wherein the entire container is manufactured from an electromagnetic radiation colorable material ,the method comprising the steps of positioning the information surface of the container and an electromagnetic radiation source relative to each other, and arranging said data on the information surface by selective activation of said electromagnetic radiation colorable material by said electromagnetic radiation source,wherein the electromagnetic radiation colorable material comprises a radiation-absorbing pigment that makes is possible to absorb the electromagnetic radiation efficiently resulting in an accelerated coloring of the electromagnetic radiation colorable material, andwherein the positioning of the electromagnetic radiation source is controlled from a database comprising said data, andwherein the data is arranged such as to be non-erasable when exposed to repeated chemical treatments with chemicals for fixing and coloring tissue cells.2. The method as claimed in claim 1 , ...

Sample Collection Device

A sampling device having a lower portion with a sample container. A cap is moveably attached with the lower portion and includes a cutting edge configured for cutting a leaf. When the cap is attached to the lower portion with a leaf there between, a leaf sample is deposited into the sample container of the lower portion. The cap includes a vent in fluid communication with the sample container such that the leaf sample is dried. A detachable label can extend from the lower portion. 111-. (canceled)12. A method for sampling a leaf of a plant using a sampling device system , the method comprising:obtaining a plurality of sampling devices, each sampling device comprising a dead space opening configured to receive a first pipette and a vent configured to receive a second pipette, the vent being in fluid communication with a sample container;arranging the plurality of sampling devices in first and second sampling device arrays;positioning the plurality of sampling devices adjacent to an array of pipettes, the array of pipettes comprising a first plurality of pipettes and a second plurality of pipettes arranged in alternating rows;moving the array of pipettes such that the first plurality of pipettes move into the vents of the first sampling device array and the second plurality of pipettes lower into the dead space openings of the first sampling device array;withdrawing fluid from the vents of the first sampling device array using the first plurality of pipettes;moving the array of pipettes such that the first plurality of pipettes moving into the dead space openings of the second sampling device array and the second plurality of pipettes lower into the vents of the second sampling device array;withdrawing fluid from the vents of the second sampling device array using the second plurality of pipettes.13. The method of claim 12 , wherein each sampling device comprises:a lower portion comprising a sample container and an elongated bore adjacent to the sample container;a cap ...

Assay Wells with Hydrogel as a Well-Contents Separator and a Pigment-Based Temperature Indicator

In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change

METHOD AND SYSTEM FOR RECOVERING PRODUCTS FROM AN EMULSION

The present invention relates to a method for selecting and recovering products, comprising the following steps: 1. A method for selecting and recovering products comprising the following steps:providing an emulsion comprising a plurality of drops contained in a carrier fluid, each drop comprising an internal fluid,measuring at least one physical parameter for several drops of the emulsion,classifying at least some of the drops of the emulsion in a class based on measurements obtained during the measuring step,tagging at least some of the classified drops based on the class of the drop, andselectively recovering the drop or part of the drop using the tag of the drop or part of the drop.2. The method according to claim 1 , wherein a plurality of drops are classified simultaneously during the classification step and the recovery step includes sorting the drops after tagging each classified drop.3. The method according to claim 1 , wherein the measuring step comprises measuring at least one parameter reiterated at different successive moments on the same drops claim 1 , preferably for a kinetic reaction monitoring within each drop.4. The method according to claim 1 , wherein for each drop of a plurality of drops claim 1 , the measuring step comprises measuring several distinct parameters on the same drop.5. The method according to claim 1 , wherein the internal fluid of each drop comprises a signal reagent claim 1 , the tagging step comprising a step for optical activation of the signal reagent depending on the classification of the drop.6. The method according to claim 5 , wherein a plurality of drops are classified during the classification step in a plurality of classes claim 5 , the tagging step consisting of illuminating each drop from a class with preset illumination conditions claim 5 , the signal reagent being able to emit a light signal claim 5 , advantageously fluorescence claim 5 , after its activation claim 5 , the drops being sorted based on their light ...

SMARTBOX AND USES THEREOF

Systems, devices and methods are disclosed for collecting laboratory specimens from laboratory specimen boxes once a specimen has been placed inside a box. 1. A laboratory specimen box comprisinga detection system to detect a laboratory specimen placed inside the box,an interface connection system connected to the detection system and to an internet, anda battery or power source to power the interface connection system and optionally the detection system, wherein the detection system is configured to alert a specimen collection service via the interface connection system when a laboratory specimen is placed inside the box.2. The box of claim 1 , wherein the box is constructed of plastic or metal.3. The box of claim 1 , wherein the detection system comprises one or more of a scale system claim 1 , an optical detection system claim 1 , a light beam claim 1 , a bar code reader for reading a bar code on the laboratory specimen claim 1 , and a push button.4. A system for collecting laboratory specimens from laboratory specimen boxes claim 1 , the system comprising a plurality of the laboratory specimen boxes of connected via an internet to a specimen collection service claim 1 , wherein each individual specimen box is identified within the system and wherein the system is configured to notify the collection service when a laboratory specimen is placed inside a specified box.5. A method for collecting laboratory specimens from laboratory specimen boxes claim 5 , the method comprising receiving a notification from the system of that a laboratory specimen has been placed within a specified specimen box and dispatching a courier to collect the laboratory specimen from the specimen box. This application claims the benefit of U.S. Provisional Patent Application No. 62/572,693, filed Oct. 16, 2017, the contents of which are herein incorporated by reference.Laboratory boxes are used across geographies to hold lab specimens for collection. Couriers affiliated with collection ...

PLATFORM FOR DISCOVERY AND ANALYSIS OF THERAPEUTIC AGENTS

A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent. 1. A method of characterizing candidate agents , comprising(a) providing a library of candidate agents, wherein each candidate agent is attached to a nucleic acid tag haying a tag sequence;(b) conflicting the library of candidate agents with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed comprising individual features on the solid support that each attach to an individual candidate agent from the library;(c) contacting the array of candidate agents with a screening agent, wherein one or more candidate agents in the array react with the screening agent;(d) detecting the array during or after the contacting of the array with the screening agent, thereby determining that at least one candidate agent in the array reacts with the screening agent;(e) sequencing the nucleic acid tags on the array to determine the tag sequence that is attached to each of the candidate agents; and(f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.2. The method of claim 1 , wherein the ...

TECHNIQUES FOR ENSURING IDENTIFICATION AND CHAIN OF CUSTODY INFORMATION OF DRIED SAMPLES

Techniques for use with dried sample portions include a device having sample areas, identification areas and detachable portions. Each sample area includes one of the dried sample portions of the sample. Each identification area includes information stored therein which identifies the sample from which the dried sample portions stored on the sample areas of the device are obtained. Each detachable portion includes one of the sample areas and includes one of the identification areas. Also described is a method for processing dried sample portions of a sample. A card is received that includes a plurality of detachable portions. Each detachable portion includes a sample area with a dried sample portion and an identification area including information that identifies the sample. A first detachable portion is detached to process a dried sample portion included in the first detachable portion. 1. A device for storing dried sample portions of a sample comprising:a plurality of sample areas, wherein each of said plurality of sample areas include one of the dried sample portions of the sample;a plurality of identification areas, wherein each of said plurality of identification areas includes information stored therein which identifies the sample from which the dried sample portions stored on the plurality of sample areas of the device are obtained; anda plurality of detachable portions, wherein each of said plurality of detachable portions includes one of the plurality of sample areas and includes one of the plurality of identification areas.2. The device of claim 1 , wherein each of said plurality of identification areas includes a radio-frequency identification tag including the information stored thereon.3. The device of wherein the information stored in each of the plurality of identification areas is encoded as any of machine-readable information and human-readable information in said each identification area.4. The device of claim 3 , wherein each of the plurality of ...

Dual Barcode Labeling Facilitating Automated Decapping

A specimen collection assembly and method for detecting the same are disclosed. The specimen collection assembly includes a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior adapted to receive a biological specimen. The specimen collection container also includes first indicia containing information. The assembly further includes a cap having thereon second indicia, the cap being removably engagable with the open top end of the container. The second indicia contains the same information as the first indicia. 1. A specimen collection assembly comprising:a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior adapted for receiving a specimen therein;a cap removably engagable with the open top end of the specimen collection container;a first indicia disposed on at least a portion of the sidewall, the first indicia comprising information; anda second indicia disposed on at least a portion of the cap, wherein the second indicia comprises the same information as the first indicia.2. The specimen collection assembly of claim 1 , wherein the first indicia and the second indicia are identical.3. The specimen collection assembly of claim 1 , wherein the cap is opaque.4. The specimen collection assembly of claim 1 , wherein the cap claim 1 , when engaged with the open top end of the specimen collection container claim 1 , at least partially obscures the first indicia.5. The specimen collection assembly of claim 1 , wherein the cap claim 1 , when engaged with the open top end of the specimen collection container claim 1 , fully obscures the first indicia.6. The specimen collection assembly of claim 1 , wherein the first indicia and the second indicia comprise at least one of a matrix barcode claim 1 , RFID tag or linear barcode.7. The specimen collection assembly of claim 1 , wherein the first indicia and the second ...

DIAGNOSTIC TEST DEVICE WITH PATTERNED MATERIAL SPOTS

A test device is configured for diagnostic testing and includes an optical readable medium, in turn including a pattern of spots of material arranged on a surface of the device. Several patterns may be provided. The patterns accordingly formed may be human and/or machine readable. They may notably encode security information, e.g., indicating whether the device has already been used. The spots may notably be inkjet spotted. In addition, a method is provided for decoding information encoded in a pattern of such a test device. In embodiments, liquid is introduced in the device, which comprises additional spots having a substantially different solubility than spots forming the actual pattern. Thus, the additional spots get solubilized in and flushed by the liquid as the latter wets them, and an initially hidden pattern may be read, which is formed of the remaining spots (not solubilized). Encoding methods are also provided. 1. A test device configured for diagnostic testing , the device comprising:a liquid inlet;a flow path extending from said liquid inlet;an optical readable medium, the medium comprising a pattern of spots of material arranged on a surface of the device, within the flow path, wherein the spots are arranged according to a bi-dimensional lattice and are located at positions corresponding to a subset of cells of the lattice, so as to form the pattern, wherein each cell of the subset of cells comprises one of the spots of material,wherein the spots are of a first material and the device further comprises additional spots of a second material, wherein the spots and the additional spots are identical in appearance before exposure to a liquid to be used for the diagnostic testing, the first material and the second material have a substantially different solubility in the liquid to be used for the diagnostic testing, and the additional spots are located at positions corresponding to other cells of the lattice, distinct from the subset of cells,wherein after ...

REDUNDANT IDENTIFICATION FOR SAMPLE TRACKING ON A DIAGNOSTIC DEVICE

A sample-containing device configured to be placed into a sample processing instrument for performing a process on a sample contained in the device includes redundant identification features, such as machine-readable tags. A first machine-readable information tag is read before the device is placed in the instrument, and a second machine-readable information tag is read after the device is in the instrument. Information read from the two tags is compared to determine if there is proper correspondence between the information read from the tags to ensure that the correct sample processing device was placed in the instrument. 1. A sample processing cartridge comprising:a substrate configured to be inserted into a sample processing instrument;a sample compartment supported on said substrate and configured to contain a fluid sample material;one or more process compartments supported on said substrate and configured to contain a process material, wherein said sample compartment is connected or connectable to at least one process compartment;a first machine-readable information tag mounted on or embedded in said substrate and encoded with cartridge-identifying information and configured to be read by a device that is external to a sample processing instrument; anda second machine-readable information tag mounted on or embedded in said substrate and encoded with cartridge-identifying information corresponding to the cartridge-identifying information encoded in said first machine-readable information tag and configured to be read by a device within a sample processing instrument.2. The sample processing cartridge of claim 1 , wherein said first machine-readable information tag comprises an optically-readable tag.3. The sample processing cartridge of claim 1 , wherein said first machine-readable information tag comprises a bar code.4. The sample processing cartridge of claim 1 , wherein said first machine readable information tag comprises a 1-D or a 2-D bar code.5. The ...

Specimen Container Label for Automated Clinical Laboratory Processing Systems

A label and labeling system for identifying the volume of a specimen within a specimen collection container are disclosed. The system includes providing a specimen collection container having an open top end, a closed bottom end, and a sidewall extending therebetween forming an interior adapted for receiving a specimen therein. The specimen collection container also includes a label having a label body disposed over at least a portion of the sidewall, in visual alignment with a colored background. At least one of the sidewall of the specimen collection container and the label body have printing disposed thereon having a color that is substantially identical to the colored background against which the specimen collection container will be viewed. At least one of the sidewall of the specimen collection container and the label body may have colorless indicia having a surface enhancement feature for providing visual distinction. 1. A specimen collection container for automated viewing against a colored background , comprising:an open top end;a closed bottom end; anda sidewall extending therebetween forming an interior adapted for receiving a specimen therein, wherein the sidewall includes colorless indicia having a surface enhancement feature for providing visual distinction from at least a portion of the sidewall.2. The specimen collection container of claim 1 , wherein the colorless indicia comprises at least one fill line.3. The specimen collection container of claim 1 , further comprising a label disposed on a portion of the sidewall claim 1 , at least a portion of the label aligned with the sidewall including colorless indicia.4. The specimen collection container of claim 3 , wherein the colorless indicia comprises at least one fill line and the label comprises at least one fill line aligned with the colorless indicia.5. A method for viewing a specimen within a specimen collection container claim 3 , comprising: an open top end;', 'a closed bottom end;', 'a ...

ASSEMBLY FOR STORING AND TRANSPORTING TISSUE SAMPLES IMMERSED IN A FLUID

A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted. 1. An assembly for storing and transporting biological samples immersed in a fixative solution , the assembly comprising:a cap comprising a first chamber prefilled with a volume of a fixative solution;a sample container comprising a second chamber for holding the biological sample; when the valve is in the open configuration, one or more channel(s) is formed between the first and second chamber permitting fixative solution to flow from the first chamber to the second chamber, and allow air to be vented in exchange;', 'when the valve is in the closed configuration, the valve creates a barrier between the first chamber and the second chamber that prevents flow of the fixative solution from the second chamber to the first chamber;', 'the valve is configured to switch from the closed configuration to the open configuration upon application of a first force; and', 'the valve is configured to default back to the closed configuration upon removal of the first force;, 'a valve situated between the first chamber and the second chamber and adapted to switch between a closed configuration and an open configuration, wherein movement of the actuator from the disengaged position to the engaged position requires application of a second force on the actuator by the operator;', 'movement of the actuator from the disengaged position to the engaged position applies the first force to the valve; and', 'removal of the second force from the actuator releases the first force from the valve., 'an actuator moveable between a disengaged ...

ANALYTIC PLATES WITH MARKABLE PORTIONS AND METHODS OF USE

An analytic plate or other substrate having a permanent etchable, laserable, and/or developable marking surface coating (referred to herein as an “etchable coating” or as a “developable coating”) that is present on at least a portion of any side or surface thereof and is used to deposit a permanent indicium thereon, and a method of using the analytic plate or substrate. 1. A method , comprising:obtaining a microscope slide having a first surface and a second surface;positioning a biological sample on the first surface of the microscope slide;affixing a coverslip to the first surface of the microscope slide to cover the biological sample, the coverslip having a first surface, a second surface, and a transparent or invisible developable coating associated with at least one of the first surface and the second surface, the transparent or invisible developable coating being developable by exposure to a photoactivating wavelength or an activating heat;selecting at least one location on the biological specimen; andexposing the transparent or invisible developable coating to the photoactivating wavelength or the activating heat to develop a portion of the transparent or invisible developable coating into an indicium that identifies the at least one selected location on the biological sample.2. The method of claim 1 , wherein the exposed portion of the transparent or invisible developable coating becomes darker in comparison to the unexposed portions of the transparent or invisible developable coating.3. The method of claim 1 , wherein the exposed portion of the transparent or invisible developable coating becomes opaque in comparison to the unexposed portions of the transparent or invisible developable coating.4. The method of claim 1 , wherein the exposed portion of the transparent or invisible developable coating becomes a different color in comparison to the unexposed portions of the transparent or invisible developable coating.5. The method of claim 1 , wherein the ...

Non-contact optical encoding scheme for intelligent automation puck

An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. The intelligent carriers can include one or more image sensors to observe the relative motion of the track as the carrier traverses it. The carriers can also observe position marks on the track surface to provide absolute position information, which can include additional data, such as routing instructions. Synchronization marks may be provided to correct errors in the observed trajectory.

METHOD FOR DETERMINING THE POSITION OF A ROBOTIC ARM IN A LIQUID HANDLING SYSTEM, AND A CORRESPONDING LIQUID HANDLING SYSTEM

The present invention relates to a method for determining the position of a robotic arm in an automatic liquid handling system in which a measurement probe with a first electrode is arranged on the robotic arm and, together with a second electrode formed by at least part of a working area or at least part of a container or container carrier forms a measurement capacitor that is operatively connected to a measurement unit for measuring an impedance, in particular a capacitance of the measurement capacitor. The method involves moving the measurement probe along a first path, detecting a first change in the impedance, in particular in the capacitance of the measurement capacitor at a first point on the first path, and defining at least one first reference spatial coordinate for a control unit of the robotic arm on the basis of the first point on the first path. 14123114453116454231113. Method for position determination of a robot arm () in an automatic liquid handling system () comprising a substantially horizontally aligned worksurface () for the placement of containers () or container carriers () and at least one robot arm () having a drive , for example , a pipetting robot () having at least one pipette () for aspirating and/or dispensing liquid samples or a logistics robot having at least one gripper finger for moving the containers () or container carriers () , and a control unit () which is operationally connected to the robot arm () , wherein a measuring probe (′) having a first electrode is arranged on the robot arm () , which , together with a second electrode , which is formed by at least a part of the worksurface () or at least a part of the container () or container carrier () forms a measuring capacitor , which is operationally connected to a measuring unit () for measuring an impedance , in particular a capacitance (C) , of the measuring capacitor , wherein the method has the following steps:{'b': 5', '1', '2', '3', '11, 'a) moving the measuring probe (′) ...

SYSTEM AND METHOD FOR FLEXIBLY REPRESENTING AND PROCESSING ASSAY PLATES

A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects. 111.-. (canceled)12. A method of controlling an instrument to process an assay plate , the assay plate having associated geometry data that includes one or more predefined points of interest , the method employing a computerized set of instructions implementing a tree of one or more multi-dimensional coordinate space objects , wherein the tree has a root coordinate space and each coordinate space object has a plurality of subspaces , each of the subspaces being anchored in the coordinate space object at a predefined subspace anchor point and wherein one or more of the plurality of subspaces may contain one or more of the predefined points of interest , the method comprising:ascertaining the point of interest;resolving the point of interest to the root coordinate space;instructing the instrument to move to the ascertained point of interest by traversing the tree of coordinate spaces.1318.-. (canceled) This application claims the benefit of U.S. Provisional Application No. 60/363,459, filed Mar. 11, 2002.The present invention relates generally to software architecture and design; more particularly, to a system and method for flexibly representing and processing assay plates.Microtiter plates are used in many chemical, ...

Barcode scanning of bulk sample containers

An apparatus is provided for scanning and decoding barcodes in a tray or other container containing multiple items, such as tissue samples, that are identified with discrete barcodes. The apparatus includes an imager, a lighting system, and a processor. The imager is configured to capture images within a selectable field of view. At least a portion of a bulk sample container, which is configured to carry a plurality of sample/tissue containers, is positioned within the field of view. The lighting system is configured to evenly light the field of view. The processor is configured to receive the captured images from the imager. The processor is further configured to analyze a first image of the captured images and to detect and decode the barcodes present in the first image.

PACKAGING FOR ASSAYS AND RELATED METHODS

The disclosure relates to a package for an assay kit, comprising an insert that provides for convenient, e.g. one step, scanning of reagent and other assay kit information from assay kit reagent containers that are disposed within the insert. The disclosure also describes methods of preparing such an insert and of assembling the assay kit. 1. A package for a particular assay kit comprising:a tray having assay product information on an outer sidewall;an insert disposed within the tray, the insert configured or adapted to hold a plurality of assay kit reagent containers comprising the same or different reagents, wherein each assay kit reagent container has a container bottom, wherein all or a subset of each assay kit reagent container bottom comprises a product code that is readable by a human, a machine, or both and identifies the reagent within that particular container, wherein the insert comprises an upper surface, a bottom surface, and a plurality of through holes extending through the insert from the upper surface to the bottom surface, and wherein each of the plurality of through holes is shaped to individually hold a respective assay kit reagent container such that the product code located on each container bottom is readable through the respective through hole at the bottom surface of the insert.210.-. (canceled)11. A loaded insert comprising:an insert comprising an upper surface, a bottom surface, and a plurality of through holes extending from the upper surface of the member to the bottom surface of the insert; anda plurality of assay kit reagent containers comprising the same or different reagents, each of the plurality of assay kit reagent containers disposed within a respective through hole of the plurality of through holes, wherein all or a subset of the plurality of assay kit reagent containers has a container bottom on which is located a product code identifying the reagent within that particular container, and wherein the product code is readable by ...

Reagent Storage Device for Storing a Target-Specific Reagent

A target specific PCR component reagent storage device is configured to enable customization of a universal reagent cartridge. The reagent storage cartridge may exhibit a generally tubular geometry and includes a reagent storage section and a remaining section with a break-off region therebetween. The reagent section is configured to store a lyophilized, target-specific reagent therein. The break-off region exhibits a lower structural integrity than the remainder of the reagent storage device such that the reagent storage section breaks-off from the remaining section when the reagent storage section is pressed against a port in a universal reagent cartridge that includes multiple predetermined reagents, such that the lyophilized, target-specific reagent enters the reagent cartridge via the port to customize the universal reagent cartridge with the target-specific reagent. 114-. (canceled)15. A reagent storage device , comprising:a tubular member including opposed first and second open ends;a break-off region situated a predetermined distance from the first open end, the break-off region dividing the tubular member into a reagent storage section between the first open end and the break-off region, and a remaining section between the break-off region and the second open end;wherein the reagent storage section is configured to store a lyophilized, target-specific reagent therein;wherein the break-off region exhibits a lower structural integrity than the reagent storage section and the remaining section of the reagent storage device, such that the reagent storage section breaks-off from the remaining section at the break-off region when the tubular member is bent about the break-off region.16. The reagent storage device of claim 15 , wherein the break-off region of the reagent storage device is configured such that the reagent storage section breaks-off from the remaining section at the break-off region when the reagent storage section is pressed against a port in a ...

SMART SAMPLE CONTAINER FOR COMPLEX SAMPLE EVALUATION WORKFLOWS

Systems and methods for using smart sample containers to manage complex sample evaluation workflows, are disclosed. An example method for using a smart sample container configured to manage a sample evaluation workflow according to the present invention comprises, obtaining a sample evaluation workflow for the one or more samples, receiving interactions with external devices, and based on the sample evaluation workflow, and causing the external devices to perform actions to advance the sample evaluation workflow. The smart sample container may further modify the sample evaluation workflow based on results of actions performed by the sample evaluation workflow and/or store information relating to the results of such actions. In this way, the smart sample containers are able to dynamically drive the evaluation of a sample through its sample evaluation workflow. 1. A method for smart sample container configured to manage a sample evaluation workflow across multiple devices , the smart sample container comprising:obtaining a sample evaluation workflow for the one or more samples;receiving an interaction from an external device; andbased on the sample evaluation workflow, causing the external device to perform an action to advance the sample evaluation workflow.2. The method of claim 1 , wherein the sample evaluation workflow corresponds to a collection of one or more steps that need to be taken to evaluate the sample.3. The method of claim 1 , wherein the external device comprises at least one of:a microscopy system;a dual beam microscopy system;a sample container transportation system;a vitrification system; anda sample preparation system;4. The method of claim 1 , wherein the sample evaluation workflow further comprises at least one of external device settings claim 1 , external device requirements claim 1 , sample evaluation requirements claim 1 , and sample information.5. The method claim 1 , wherein the sample evaluation workflow further comprises:a sample type;a ...

CARTRIDGE, CARTRIDGE READER AND METHOD FOR PREVENTING REUSE OF THE CARTRIDGE

A disposable fluidic cartridge has a recess therein. A mechanically-actuated mechanism is disposed within the recess for effecting an operation of the fluidic cartridge. The cartridge further comprises a machine-readable identification code on a breakable label covering at least a portion of the recess such that the portion of the breakable label covering the recess may be broken upon insertion of a mechanical actuator into the recess to actuate the mechanically-actuated mechanism. This renders the identification code unreadable and prevents reuse of the cartridge. 1. A cartridge reader configured to receive a disposable fluidic cartridge having a recess , a mechanically-actuatable mechanism disposed within the recess for effecting an operation of the fluidic cartridge , and a machine-readable identification code on a breakable label covering at least a portion of the recess , the reader comprising:a sensor for detecting the identification code of a disposable cartridge inserted into the cartridge reader; anda mechanical actuator configured extend into the recess to actuate the mechanically-actuatable mechanism and break the portion of the breakable label covering the recess thereby rendering the identification code unreadable and preventing reuse of the cartridge; wherein:the reader is configured only to extend the mechanical actuator into a recess of a cartridge inserted into the reader only if the sensor detects an identification code on the cartridge.2. The cartridge reader of claim 1 , wherein the mechanical actuator is a foot configured to break the portion of the breakable label covering the recess and collapse a collapsible chamber located within the recess of the cartridge.3. The cartridge reader of claim 2 , wherein the collapsible chamber contains a liquid component.4. The cartridge reader of claim 2 , wherein the cartridge reader is configured to perform a diagnostic test on a sample in a disposable cartridge inserted into the reader.5. The cartridge ...

Sample Collection Device and Methods for Nucleic Acid Preservation

The present application generally relates to methods and compositions for biological sample collection, including a sample collection device directed to the use of a flammable solvent-free based composition for preservation, stabilization, and transportation of nucleic acids from biological samples for long-term room temperature storage. 1. A device for preserving nucleic acids from a biological sample in a subject comprising:(a) a main body forming a central portion of the device and having a sample collection element rigidly fixed thereto and extending coaxially therefrom;(b) a first container removably engaged with the main body to form a first sealed cavity that contains the sample collection element, the first container also being at least substantially coaxial with the main body and forming a first end of the device; and,(c) a second container removably engaged with the main body to form a second sealed cavity, the second container also being at least substantially coaxial with the main body, forming a second end of the device, and having a partition disposed within the second sealed cavity and traversing the entire cross-sectional area of the second container to form a first compartment and a second compartment within the second sealed cavity;wherein the first compartment is proximal to the main body comparative to the second compartment and the second compartment is distal to the main body comparative to the first compartment,wherein the first compartment contains a first preservative that is operatively coupled to the interior surface of the second container,wherein the second compartment contains a quantity of a second preservative, andwherein the partition prohibits the quantity of the second preservative from entering the first compartment.2. The device of claim 1 , wherein the biological sample is saliva.3. The device of claim 1 , wherein the sample collection element is a brush.4. The device of claim 1 , wherein the interior surface of the second ...

PLATFORM FOR DISCOVERY AND ANALYSIS OF THERAPEUTIC AGENTS

A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent. 1. A method of characterizing candidate agents , comprising(a) providing a library of candidate agents, wherein each candidate agent is attached to a nucleic acid tag having a tag sequence;(b) contacting the library of candidate agents with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed comprising individual features on the solid support that each attach to an individual candidate agent from the library;(c) contacting the array of candidate agents with a screening agent, wherein one or more candidate agents in the array react with the screening agent;(d) detecting the array during or after the contacting of the array with the screening agent, thereby determining that at least one candidate agent in the array reacts with the screening agent;(e) sequencing the nucleic acid tags on the array to determine the tag sequence that is attached to each of the candidate agents; and(f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.2. The method of claim 1 , wherein the ...

Method for producing microcarriers and for performing biological assays

The method according to the invention consists in providing a wafer having a bottom layer, a top first sacrificial layer and an insulating layer, structuring the first sacrificial layer to form a three dimensional structure onto which a first structural layer is deposited to define a corresponding three dimensional structure on the bottom surface of the first structural layer. The method consists also in forming a second three dimensional structure on the upper surface of the first structural layer.

PLATE MAPPING FOR A COMPLIANCE AND PREVENTION SYSTEM

A computer program product is provided. The computer program product includes processor executable code for an integration tracking engine. The processor executable code is stored on a non-transitory computer readable medium. The processor executable code is executed by a processor to cause the integration tracking engine to receive a scan of a code on a vial containing a sample. The code at least identifying a user profile associated to the sample and the vial. The integration tracking engine also automatically assigns a position for the vial within a plate map for a plate well, provides the position through a user interface to guide placement of the vial within the plate well, and associates sample data corresponding to the vial and the position within the plate well to a user profile to enable continuous tacking of the sample. 1. A computer program product comprising processor executable code for an integration tracking engine , the processor executable code being stored on a non-transitory computer readable medium , the processor executable code being executed by at least one processor to cause the integration tracking engine to perform:receiving a scan of a code on a vial containing a sample, the code at least identifying a user profile associated to the sample and the vial;automatically assigning a position for the vial within a plate map for a plate well;providing the position through a user interface to guide placement of the vial within the plate well; andassociating sample data corresponding to the vial and the position within the plate well to a user profile to enable continuous tacking of the sample.2. The computer program product of claim 1 , wherein the integration tracking engine associates the sample data claim 1 , the position claim 1 , a placement time claim 1 , and a lab technician identify to maintain a chain of custody of the sample.3. The computer program product of claim 1 , wherein the plate well comprises a plurality of slots arranged in ...

BIOLOGICAL REACTION APPARATUS WITH DRAINING MECHANISM

A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means. 1. An apparatus comprising:a controller;a robotic arm;a dispensing mechanism, mounted on the robotic arm, configured to dispense fluids;a plurality of individual tray receiving ports disposed under the robotic arm;a plurality of slide trays, each of the plurality of slide trays comprises a sliding mechanism such that said respective single slide tray is fitted to slide into a respective individual tray receiving port of the plurality of individual tray receiving ports, wherein each slide tray comprises a plurality of slide receiving sections;a plurality of slides, a single slide of the plurality of slides placed on each slide receiving section of the plurality of slide receiving sections of each slide tray;a plurality of covers, each cover mounted on a slide of the plurality of slides, wherein each cover comprises a cavity on a side facing the corresponding slide thereby forming a reaction chamber between each slide and its corresponding cover; anda rack receiving zone comprising a reagent rack which includes a plurality of reagent containers,wherein the controller comprises non-transient memory including a program to control the dispensing mechanism of the robotic arm to dispense fluid onto a slide of one of the slide trays independently of dispensing fluid onto another slide of another one of the slide trays,wherein the sliding mechanism is rails that extend along a longitudinal side of the sliding tray, andwherein each of the ...

ENCODED MEDIA FOR DISPENSING LOCATION

An apparatus includes a media that includes an encoded pattern to indicate a location of each of a plurality of dispensing locations on a receiving area for a pipette dispenser. The encoded pattern is employed to guide the pipette dispenser to dispense a volume to a selected dispensing location from the plurality of dispensing locations based on a predetermined dispensing location on the receiving area. 1. An apparatus , comprising:a media that includes an encoded pattern to indicate a location of each of a plurality of dispensing locations on a receiving area for a pipette dispenser, the encoded pattern is employed to guide the pipette dispenser to dispense a volume to a selected dispensing location from the plurality of dispensing locations based on a predetermined dispensing location on the receiving area.2. The apparatus of claim 1 , wherein the media is at least one of a paper material claim 1 , a metallic material claim 1 , and a plastic material that includes the encoded pattern.3. The apparatus of claim 1 , wherein the encoded pattern encodes an X and a Y location for each of the dispensing locations on the receiving area.4. The apparatus of claim 3 , wherein the media further comprises a metallic portion to provide a Z direction that indicates a depth with respect to a distance between the pipette dispenser and the receiving area.5. The apparatus of claim 1 , wherein the media is located on top of the receiving area claim 1 , beneath the receiving area claim 1 , or integrated within the receiving area to provide the encoded pattern claim 1 , the receiving area includes a well plate or a petri dish.6. The apparatus of claim 1 , wherein the encoded pattern is illuminated by at least one of an infrared source and a visible light source.7. The apparatus of claim 1 , wherein encoded pattern indicates an amount of the volume to dispense to the selected dispensing location.8. An apparatus claim 1 , comprising:a pipette dispenser to distribute a predetermined ...

PIPETTE TIP FOR AN AUTOMATED PIPETTING DEVICE

The invention concerns pipette tips for connecting to a pipette tube of a pipetting device are used for taking up and discharging fluids. The pipette tip is in the shape of an elongated tube forming a pipette body that has an opening at one end and is designed for connecting to the pipette tube at the other end. The pipette tip has a first electrode as a volume measuring electrode of a measuring capacitor and a second electrode as an immersion detector electrode. The first electrode is located on an outer surface of the pipette body or is embedded in the pipette body, and the second electrode is located at least partially on an inner surface of the pipette body. 112314521710744104. Pipette tip () for connection to a pipette tube () of a pipetting device () , wherein the pipette tip () is formed as an elongated tube forming a pipette body () having at one first end thereof an opening () for aspirating and/or dispensing liquids and being adapted at the other end thereof for connection to the pipette tube () , wherein the pipette tip () has a first electrode () as volume measuring electrode of a measuring capacitor , and a second electrode () as immersion detection electrode , wherein the first electrode () is disposed on an outer surface of the pipette body () or is embedded in the pipette body () , and the second electrode () is disposed at least partially on an inner surface of the pipette body ().21710. Pipette tip () according to claim 1 , wherein the first electrode () and second electrode () are electrically conductive claim 1 , and the second electrode at least partially galvanically contacts the liquid at the inner surface of the pipette body.314. Pipette tip () according to claim 1 , wherein the pipette body () comprises an electrically non-conductive material claim 1 , in particular a non-conductive plastic claim 1 , such as for example non-conductive polypropylene claim 1 , which acts in particular at least as a part of a dielectric of the measuring ...

SYSTEM AND METHOD OF MARKING ARTICLES COATED WITH A LASER-SENSITIVE MATERIAL

A method for uniquely identifying tubes may include programming a motion of a laser relative to a tube pad printed with a mixture of ink and a laser sensitive material and exposing the laser-sensitive material to the laser to colorimetrically transform the material and reveal a unique identifier. A method of coating tubes includes plasma or flame treating the tube and mixing a laser-sensitive material with ink to form a mixture to pad print onto the tube. A system for identifying tubes coated with laser-sensitive material includes a laser mounted in translational relationship to a stage, a camera positioned to capture an image of a tube on a stage, a processor that receives the image and translates the laser relative to the stage in order to position the laser for marking the tube, and a laser controller to move the laser in order to mark the tube. 1. A marking system for a tube with a laser-sensitive coating , comprising:a tube; anda coating applied on a portion of the tube comprising a mixture of ink and a laser-sensitive, color-changing material; anda laser marking system configured to trace a pattern of a desired mark on the tube, thereby applying the desired mark, wherein the laser marking system is further configured to apply the desired mark at a consistent position on the tube.2. The marking system of claim 1 , wherein at least one of a top and a bottom of the tube is flat.3. The marking system of claim 1 , wherein the tube is at least one of plasma- claim 1 , corona- claim 1 , or flame-treated prior to receiving the coating.4. The marking system of claim 1 , wherein the coating is at least one of air-dried claim 1 , oven-dried claim 1 , and UV cured onto the tube.5. The marking system of claim 1 , wherein the coating is applied to at least one of a curved side claim 1 , a top claim 1 , and a bottom of the tube.6. The marking system of claim 1 , wherein the coating is marked using a COlaser to excite the laser-sensitive claim 1 , color-changing material.7. ...

Resolving spatial arrays using deconvolution

Methods for determining a location of a feature on an array include: (a) providing a first array with a first plurality of features immobilized on a first substrate; (b) providing a second array with a second plurality of features immobilized on a second substrate; (c) aligning the first array with the second array; (d) hybridizing a first barcoded oligonucleotide of the first array to a second barcoded oligonucleotide of the second array, thereby producing a combined nucleic acid that includes first and second spatial barcodes; (e) determining all or a portion of the sequence of the combined nucleic acid; and (f) identifying the second barcoded oligonucleotide associated with the first barcoded oligonucleotide in the combined nucleic acid, and determining the location of a second feature in the second array.

Test Tube with Identification Device and Corresponding Production Method

A test tube, suitable to be immersed in a cryogenic fluid, comprises a containing body having a perimeter wall that defines a containing compartment, a bottom wall, disposed inside the latter to close it at the lower part, and a housing seating, inside the perimeter wall and outside the containing compartment. A support element for an identification code is suitable to be inserted into the housing seating, with at least a free surface facing toward the outside of the housing seating on the opposite side with respect to the bottom wall. In correspondence to said housing seating, mechanical constraint means are provided in cooperation with said perimeter wall of the containing body and with a peripheral portion of the free surface of the support element, in order to constrain the latter in a defined axial position with respect to the containing body. 1. Test tube , suitable to be immersed in a cryogenic fluid , comprising a containing body having a perimeter wall that defines a containing compartment , a bottom wall , disposed inside said containing compartment to close it at the lower part , and a housing seating , inside said perimeter wall and outside said containing compartment , into which housing seating a support element for an identification code is suitable to be inserted , said support element having at least a free surface facing toward the outside of said housing seating on the opposite side with respect to said bottom wall , wherein discharge means to discharge said cryogenic fluid are provided between said bottom wall and said support element and cooperate with said housing seating to connect the latter with the outside of said test tube and expel said cryogenic fluid from said housing seating , and in that in correspondence to said housing seating for said support element , mechanical constraint means are provided , in cooperation with said perimeter wall of said containing body and with a peripheral portion of said free surface of said support element ...