05-02-2015 дата публикации
Номер: US20150037884A1
Принадлежит:
A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies such as rotator cuff injuries, periodontal disease and hernia. 1. A three-dimensional tissue comprising a biocompatible scaffold, a bioabsorbable material encasing or layered with the scaffold, and an extracellular matrix. This application is a continuation of U.S. application Ser. No. 11/890,989 filed Aug. 9, 2007, now U.S. Pat. No. 8,864,844, which is a continuation of International Application PCT/US05/16393 filed May 11, 2005, which claims priority to U.S. Provisional Patent Application No. 60/570,204 filed May 11, 2004, the entire disclosure of each of which is incorporated herein by this reference.A structure useful as an implantable device made totally or in part from biocompatible materials and mammalian cells and/or mammalian cell products is provided.Many complex tissues in the adult mammal fail to regenerate following injury or disease. For example, a critical sized defect in bone will fail to regenerate. Ligaments do not regenerate if destroyed by disease or injury such as the dental ligament in periodontal disease. Dermal ulcers in the elderly, diabetic, or individuals with venous stasis pathology can become chronic wounds that fail to heal. One approach to repair damage of this sort is referred to as Tissue Engineering wherein cells on matrices are used to affect tissue repair that would not occur without such an intervention. Tissue scaffolds are known in the art, see for example U.S. Pat. No. 6,451,060, 5,830,708, 6,284,284, 6,143,293, 6,306,169, 6,319,712, 6,228,117, and 5,916,585, and PCT and U.S. Patent Applications WO 99/03979, WO 01/03750, WO 01/85226, and US2003/0023316.U.S. Pat. No. 4,963,489 discloses a living ...
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