Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 33. Отображено 33.
08-01-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING MIDDLE EAST RESPIRATORY SYNDROME-CORONAVIRUS INFECTION

Номер: KR1020180002504A
Автор: CHOI, SANG DUN, PRASANNAVENKATESH, SHIN, HYEON JUN, SHAH MASAUD
Принадлежит:

The present invention relates to a composition comprising a compound having papain-like protease inhibitory activity of Middle East respiratory syndrome-coronavirus (MERS-CoV) as an active ingredient. The compound is an inhibitor of papain-like protease which plays an important role in transcription and replication of MERS-CoV, and can be usefully used as a pharmaceutical composition for preventing or treating MERS-CoV infection or a health food for preventing or alleviating MERS-CoV infection. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 1
07-08-2017 дата публикации

CASING ROTATOR

Номер: KR1020170090234A
Автор: CHOI, SANG DON, LEE, SANG SIK, LEE, SANG TAE, SONG, SU DONG, LIM, JONG KYU
Принадлежит:

The present invention relates to a casing rotator and, specifically, to a casing rotator capable of returning rotation to an initial position in a case that the casing rotator rotates at a predetermined angle or greater in an opposite direction of a casing by influence of torque during a rotation work of the casing. According to the present invention, the casing rotator includes a casing chuck, a chuck driver, a track, a track driver, a position sensor, a hydraulic pump, and a valve. The casing chuck holds the casing. The chuck driver rotates the casing chuck. The track is mounted on the casing chuck to move the casing chuck. The track driver can operate the track. The position sensor is mounted on a casing rotator main body to measure a rotation angle of the casing chuck. The hydraulic pump generates oil pressure to drive the chuck driver and the track driver. The valve guides the oil pressure generated in the hydraulic pump to the chuck driver or the track driver. Also, the valve guides ...

Подробнее
Номер записи: 2
01-06-2017 дата публикации

WARM KEEPING CONTAINER FOR BEVERAGE BOTTLE

Номер: KR1020170060444A
Автор: CHOI, SANG DON
Принадлежит:

The present invention relates to a warm keeping container allowing the body of a beverage bottle embedded therein to be sealed to prevent the beverage bottle from being in direct contact with outer air. The warm keeping container comprises: an insulation container, which is a container having an opened upper part and has an opening part formed on a lower part thereof and allows the beverage bottle to be inserted thereinto; a sealing body assembled to the opening part to seal the opening part and having the upper surface to be in contact with the bottom surface of the beverage bottle; and an upper sealing material in contact with an upper end of the beverage bottle inserted into the insulation container while enclosing the upper end to seal the upper part of the insulation container. Thus, the warm keeping container is able to block heat transfer between the beverage bottle and the outer air. Without a need to input the beverage bottle to be stored in the warm keeping container for a beverage ...

Подробнее
Номер записи: 3
13-10-2017 дата публикации

GROUND EXCAVATING AND STIRRING DEVICE

Номер: KR1020170114147A
Автор: CHOI, SANG DON, LEE, SANG SIK, LEE, SANG TAE, SONG, SU DONG, LIM, JONG KYU
Принадлежит:

The present invention relates to a ground excavating and stirring device and, specifically, to a ground excavating and stirring device capable of stability against collapse by reducing a gravity center. According to the present invention, the ground excavating and stirring device includes a base machine, a leader, a kelly-bar, and an excavation unit. The leader is mounted on the base machine. The kelly-bar is mounted on the leader. The excavation unit includes: a swivel; an excavation rod connected to a lower end of the swivel; a hose connected to the swivel to supply cement to the swivel; and a reel mounted on the leader to wind the hose. The excavation unit is mounted on the lower part of the kelly-bar in order for the excavation rod to rotate by the rotation of the kelly-bar. Also, the swivel includes a connection coupling, a body, and a housing. The connection coupling is connected to the kelly-bar to integrally rotate. The body includes an inflow groove, a first through hole, and a ...

Подробнее
Номер записи: 4
16-10-2017 дата публикации

GROUND EXCAVATING AND STIRRING DEVICE

Номер: KR1020170114486A
Автор: CHOI, SANG DON, LEE, SANG SIK, LEE, SANG TAE, SONG, SU DONG, LIM, JONG KYU
Принадлежит:

The present invention relates to a ground excavating and stirring device and, specifically, to a ground excavating and stirring device capable of excavating the ground by improving stability against collapse and changing a center distance of multi-axis. According to the present invention, the ground excavating and stirring device includes a base machine, a leader, a clamping guide, and a driving unit. The clamping guide is mounted on the leader to hold an excavation rod. The driving unit includes a driver frame and a hydraulic driver unit. The driver frame is mounted on the leader to vertically slide along the leader. The hydraulic driver unit is mounted on the driver frame to rotate the excavation rod. The hydraulic driver unit includes a unit frame, a hydraulic motor, a wedge groove body unit, a wedge, an upper rotor, a bearing housing, and a hydraulic cylinder. The unit frame is mounted on the driver frame. The hydraulic motor is mounted on the unit frame. The wedge groove body unit ...

Подробнее
Номер записи: 5
06-03-2018 дата публикации

케이싱 로테이터

Номер: KR0101834768B1
Автор: 최상돈, 이상식, 이상태, 송수동, 임종규
Принадлежит: (주)부마씨이

... 본 발명은 케이싱 로테이터에 대한 것으로서, 더욱 상세하게는 케이싱의 회전작업 중 케이싱 로테이터가 토크의 영향으로 케이싱과 반대방향으로 일정한 각도 이상 회전한 경우 그 회전을 원래의 위치로 복귀시킬 수 있는 케이싱 로테이터에 대한 것이다. 본 발명에 따른 케이싱 로테이터는 케이싱 척과, 척드라이버와, 트랙과, 트랙드라이버와, 위치센서와, 유압펌프와, 밸브를 포함한다. 상기 케이싱 척은 케이싱을 파지한다. 상기 척드라이버는 상기 케이싱 척을 회전시킨다. 상기 트랙은 상기 케이싱 척을 이동시킬 수 있도록 상기 케이싱 척에 장착된다. 상기 트랙드라이버는 상기 트랙을 구동시킬 수 있다. 상기 위치센서는 상기 케이싱 척의 회전각도를 측정하기 위하여 상기 케이싱 로테이터 본체에 장착된다. 상기 유압펌프는 상기 척드라이버 및 상기 트랙드라이버를 구동시킬 수 있는 유압을 발생시킨다. 상기 밸브는 상기 유압펌프에서 발생된 유압을 상기 척드라이버 또는 상기 트랙드라이버로 안내한다. 또한, 상기의 케이싱 로테이터에 있어서, 상기 밸브는 상기 위치센서에서 측정된 회전각도가 일정 크기 이상이면 상기 트랙으로 상기 케이싱 척을 원래의 위치로 회전시킬 수 있도록 상기 유압펌프에서 발생된 유압을 상기 트랙드라이버로 안내시키는 것이 바람직하다.

Подробнее
Номер записи: 6
29-09-2017 дата публикации

음료수병 보온 용기

Номер: KR0101783025B1
Автор: 최상돈
Принадлежит: 최상돈

... 본 발명은 음료수병이 외기와 직접 접촉이 차단되도록 음료수병이 내장되어 음료수병의 몸체를 밀봉시키는 보온용기에 관한 것으로서, 상부가 개방되고 하부에 개구부가 형성되는 통체로서 내부에 음료수 병이 삽입되는 단열용기와; 상기 개구부에 조립되어 개구부를 밀봉시키며, 상면은 상기 음료수 병 저면에 접촉되는 밀봉체; 및 상기 단열용기에 삽입되는 음료수 병의 선단부를 감싸며 접촉되어 단열용기의 상부를 밀폐시키는 상부밀봉재로 구성되어 음료수병과 외부 공기와의 직접적인 열전달을 차단시켜 줄 수 있는 한편, 음료수병 보온용기에 보관될 음료수병을 별도의 용기에 넣어서 냉장고에 넣어 냉각시킬 필요 없이 음료수병 보온용기 내부에 음료수병이 장착된 상태에서 곧바로 냉장고에 넣어서 온도를 조절시킬 수 있게 됨으로써 냉장고에서 꺼내어 곧바로 휴대 가능한 음료수병 보온용기를 제공하고자 한다.

Подробнее
Номер записи: 7
30-03-2023 дата публикации

CXCR4와 상호작용하여 줄기세포 이동을 유도하는 신규한 펩타이드

Номер: KR102515415B1
Автор: 박용두, 이강곤, 최상돈
Принадлежит: 고려대학교 산학협력단, 아주대학교산학협력단

... 서열번호 1 내지 3의 아미노산 서열로 이루어진 줄기세포 이동용 펩타이드는 CRCX4 수용체에 대한 친화도가 우수하여 줄기세포의 이동을 유도하기 위해 사용될 수 있다.

Подробнее
Номер записи: 8
12-06-2017 дата публикации

신규한 TLR2 길항제

Номер: KR0101745524B1
Автор: 최상돈, 듀라이 프라산나벤카테시, 아첵 아스마
Принадлежит: 아주대학교산학협력단

... 본 발명은 신규한 작은 분자인 TLR2 길항제에 관한 것으로, 구체적으로는 19개의 신규한 TLR2 길항제, 상기 길항제를 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물 및 TLR4 조절자에 관한 것이다. 본 발명에 따른 신규한 TLR2 길항제는 분자량이 작아 경구적 생체이용률이 높으므로 경구 투여제로서 효과적으로 사용될 수 있으며, IL-8 분비를 효과적으로 저해하고 생체 내에서 독성을 유발하지 않으므로 염증성 질환의 예방 또는 치료용 약학적 조성물에 유용하게 사용될 수 있다. 또한 본 발명에 따른 신규한 TLR2 길항제는 TLR4의 조절자로 이용될 수 있다.

Подробнее
Номер записи: 9
04-09-2015 дата публикации

DRUG SCREENING METHOD FOR BLOCKING INTERFERON REGULATORY FACTOR-3 INHIBITORY ACTIVITY OF HUMAN PAPILLOMA VIRUS TYPE 16 E6 AND PHARMACEUTICAL COMPOSITION HAVING SAME DRUG AS ACTIVE INGREDIENT FOR TREATING OR PREVENTING UTERINE CANCER

Номер: KR1020150101690A
Автор: CHOI, SANG DUN
Принадлежит:

The present invention relates to a drug screening method for blocking an interferon regulatory factor-3 (IRF-3) inhibitory activity of human papillomavirus (HPV) type 16 E6 and a pharmaceutical composition having the drug as an active ingredient for treating or preventing a uterine cancer. HPV 16 E6 inhibits an IFR-3 transition activity and thus inhibiting an antiviral response in HPV 16-infected cells. The drug composition can be helpfully used as a candidate for treating or preventing a uterine cancer by selecting drugs capable of inhibiting binding between HPV 16 E6 and IFR-3 through a pharmacophore-based simulation screening. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 10
07-12-2016 дата публикации

NOVEL TOLL-LIKE RECEPTOR 4 ANTAGONIST

Номер: KR1020160140031A
Автор: CHOI, SANG DUN, YOO, TAE HYEON, PARK, SEOL HEE
Принадлежит:

The present invention relates to a peptide capable of inhibiting a toll-like receptor 4 (TLR4) signal transduction pathway, a TLR4 antagonist including the peptide, and a composition for preventing or treating inflammatory disease and autoimmune disease including the peptide. According to the present invention, the peptide inhibits the TLR4 signal transduction pathway induced by lipopolysaccharide (LPS), and also exhibits inhibitory effects on activation of NFκB and mitogen-activated protein kinases (MAPKs) as well as secretion of interleukin-6 (IL-6), NO, and reactive oxygen species (ROS). Thus, the peptide can be useful for compositions for preventing or treating inflammatory disease and autoimmune disease caused by the TLR4 signal transduction pathway. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 11
03-07-2014 дата публикации

PLASMA REACTOR AND PLASMA IGNITION METHOD USING SAME

Номер: WO2014104753A1
Автор: Choi, Sang-Don
Принадлежит:

One aspect of the present invention relates to a plasma reactor and a plasma ignition method using the same. The plasma reactor of the present invention comprises: a magnetic core having a primary winding of a transformer; an alternative current power supply source for supplying alternative current power to the primary winding of the transformer wound around a magnetic core; a plasma chamber body provided with the magnetic core and enables induction of electromotive force by directly inducing a voltage through the magnetic core; and a floating chamber connected to the plasma chamber body through an insulating region and receiving the induced electromotive force, and a large voltage difference is generated between the plasma chamber body and the floating chamber according to a phase change of the alternative current power supplied from the alternative current power supply source so as to enable easy plasma ignition and to supply the plasma to a process chamber. The plasma reactor and the ...

Подробнее
Номер записи: 12
09-07-2020 дата публикации

PEPTIDE INHIBITORY OF TLR4 SIGNALING AND USE THEREOF

Номер: WO2020141704A1
Автор: CHOI, Sangdun, ACHEK, Asma
Принадлежит:

The present invention relates to a peptide that inhibits toll-like receptor 4 (TLR4) signaling and, more particularly, to a peptide that binds to the TIR domain of TLR4 to suppress the secretion of pre-inflammatory cytokines and inhibit the activation of NF-κB and MAPKs, a fusion peptide in which the peptide is fused to a cell-penetrating peptide, a TLR4 antagonist comprising the peptide or fusion peptide, and a composition comprising the peptide or fusion peptide for preventing or treating an autoimmune disease or an inflammatory disease. The peptide according to the present invention exhibits an inhibitory effect on TLR4 and TLR3 signaling, blocks MyD88- and TRIF-dependent TLR4-signaling pathway in various humans and murine cell lines, and has substantial disease relieving effects in rheumatoid arthritis, psoriasis, and systemic lupus erythematosus mouse models. Thus, the peptide can be used as a therapeutic agent for immune-related diseases requiring the negative control of TLR for the ...

Подробнее
Номер записи: 13
31-12-2018 дата публикации

중동호흡기증후군 코로나바이러스 감염증 예방 또는 치료용 조성물

Номер: KR0101934199B1
Автор: 최상돈, 프라산나벤카테쉬, 신현준, 사 마사우드
Принадлежит: 아주대학교산학협력단

... 본 발명은 중동호흡기증후군 코로나바이러스(middle east respiratory syndrome-coronavirus, MERS-CoV)의 파파인 유사 단백질 분해효소(papain-like protease) 억제 활성을 갖는 화합물을 유효성분으로 포함하는 조성물에 관한 것으로, 상기 화합물은 중동호흡기증후군 코로나바이러스의 전사와 복제에 중요한 역할을 하는 파파인 유사 단백질 분해효소의 억제제로서 중동호흡기증후군 코로나바이러스의 예방 또는 치료용 약학 조성물, 또는 중동호흡기증후군 코로나바이러스 예방 또는 개선용 건강식품으로 유용하게 활용될 수 있다.

Подробнее
Номер записи: 14
07-05-2020 дата публикации

COMPOSITION COMPRISING TLR INHIBITING PEPTIDE FOR PREVENTING OR TREATING LUPUS

Номер: WO2020091513A1
Автор: CHOI, Sangdun, KWON, Hyuk Kwon, SHIN, Hyeon Jun, GUI, Xiangai, SUH, Chang Hee
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a peptide inhibiting the toll-like receptor (TLR) signaling pathway as an active ingredient for preventing or treating lupus. The pharmaceutical composition according to the present invention effectively regulates factors associated with lupus symptoms in a lupus mouse model and as such, is effective for preventing or treating lupus.

Подробнее
Номер записи: 15
26-03-2020 дата публикации

TLR4 ANTAGONISTIC PEPTIDE

Номер: WO2019209030A9
Автор: CHOI, Sangdun, ACHEK, Asma, SHAH, Masaud
Принадлежит:

The present invention relates to a peptide inhibiting the TLR4 signaling pathway, a TLR4 antagonist comprising the peptide, and a pharmaceutical composition, comprising the peptide, for treatment of autoimmune disease or inflammatory disease. The peptide according to the present invention exhibits an excellent effect of suppressing the secretion of inflammatory cytokines and the activation of NF-kB and MAPKs by inhibiting the TLR4 signaling pathway and thus is useful for a pharmaceutical composition for prevention or treatment of autoimmune diseases and inflammatory diseases mediated through the TLR4 signaling pathway.

Подробнее
Номер записи: 16
12-06-2017 дата публикации

신규한 TLR4 길항제

Номер: KR0101745520B1
Автор: 최상돈, 유태현, 박설희
Принадлежит: 아주대학교산학협력단

... 본 발명은 TLR4 신호전달 경로를 억제하는 펩타이드, 상기 펩타이드를 포함하는 TLR4 길항제, 상기 펩타이드를 포함하는 자가면역 질환 및 염증성 질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 펩타이드는 리포폴리사카라이드(LPS)에 의해 유도되는 TLR4 신호전달 경로를 억제함으로써 인터루킨-6(IL-6), NO 및 ROS의 분비와 NFκB와 MAPKs의 활성화를 억제하는 효과가 우수한바, TLR4 신호전달 경로에 의해 발생하는 자가면역 질환 및 염증성 질환의 예방 또는 치료용 조성물로 유용하게 활용할 수 있다.

Подробнее
Номер записи: 17
18-01-2019 дата публикации

지반굴착교반장치

Номер: KR0101940058B1
Автор: 최상돈, 이상식, 이상태, 송수동, 임종규
Принадлежит: (주)부마씨이

... 본 발명은 지반굴착교반장치에 대한 것으로서, 더욱 상세하게는 전도안전성을 개선하고 다축의 축간 거리를 변형하여 지반을 굴착할 수 있는 지반굴착교반장치에 대한 것이다. 본 발명에 따른 지반굴착교반장치는 베이스머신과, 리더와, 클램핑가이드 및 구동수단을 포함한다. 상기 클램핑가이드는 굴착로드를 파지할 수 있도록 상기 리더에 장착된다. 상기 구동수단은 드라이버프레임과 유압드라이버유닛을 구비한다. 상기 드라이버프레임은 상기 리더를 따라 상하로 슬라이딩을 할 수 있게 상기 리더에 장착된다. 상기 유압드라이버유닛은 상기 굴착로드를 회전시킬 수 있도록 상기 드라이버프레임에 장착된다. 이를 위하여 상기 유압드라이버유닛은 유닛프레임과, 유압모터와, 웨지홈몸체부와, 웨지와, 상부회전체와, 베어링하우징과, 유압실린더를 구비한다. 상기 유닛프레임은 상기 드라이버프레임에 장착된다. 상기 유압모터는 상기 유닛프레임에 장착된다. 상기 웨지홈몸체부는 상기 유압모터에 의해 감속기 및 기어 조합을 거쳐 회전될 수 있고, 상기 굴착로드가 삽입되며 웨지홈이 형성되어 상기 유닛프레임에 축방향으로는 구속되고 반경방향으로는 회전할 수 있게 장착된다. 상기 웨지는 상기 웨지홈에 삽입되어 상기 굴착로드를 파지할 수 있다. 상기 상부회전체는 상기 굴착로드가 삽입되며 상기 웨지가 결합된다. 상기 베어링하우징은 상기 상부회전체를 축방향으로는 구속시키고 반경방향으로는 회전할 수 있도록 상기 상부회전체에 결합된다. 상기 유압실린더는 일단은 상기 베어링하우징에 결합되고 타단은 상기 유닛프레임에 결합되어 상기 웨지가 상기 웨지홈에 삽입되어 상기 굴착로드를 파지할 수 있도록 신축가능하다.

Подробнее
Номер записи: 18
08-11-2018 дата публикации

PEPTIDE FOR TOLL-LIKE RECEPTOR (TLR) INHIBITION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: WO2018203613A1
Автор: CHOI, Sang Dun, KWON, Hyuk Kwon, SHIN, Hyeon Jun, GUI, Xiang Ai
Принадлежит:

The present invention relates to a fusion polypeptide that inhibits TLR1/2, TLR2/6, TLR7, TLR8 and TLR9 signaling pathways as well as Toll-like receptor 4 (TLR4) and TLR3, and a pharmaceutical composition for preventing or treating TLR pathway mediated diseases. The fusion peptide of the present invention has an excellent effect of inhibiting TLR4 and various TLR pathways and can be effectively used in preventing and treating various TLR pathway mediated diseases caused by the signaling pathways, such as autoimmune diseases, inflammatory diseases and degenerative neurological diseases, by inhibiting the TLR mediated immune responses.

Подробнее
Номер записи: 19
08-12-2016 дата публикации

NOVEL TLR4 ANTAGONIST

Номер: WO2016195159A1
Автор: CHOI, Sang Dun, YOO, Tae Hyeon, PARK, Seol Hee
Принадлежит:

The present invention relates to a peptide for inhibiting a TLR4 signaling pathway, a TLR4 antagonist comprising the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. More specifically, the present invention relates to a peptide which binds to a TLR4/MD2 composite to inhibit the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs, a TLR4 antagonist comprising the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. The peptide according to the present invention has an excellent effect of inhibiting the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs by inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS), and thus can be favorably used as a composition for preventing or treating autoimmune diseases and inflammatory diseases occurring by the TLR4 signaling pathway.

Подробнее
Номер записи: 20
27-02-2019 дата публикации

역순환 굴반 기능을 구비한 케이싱 로테이터

Номер: KR0101923636B1
Автор: 이상태, 이상식, 송수동, 임종규, 최상돈
Принадлежит: (주)부마씨이

... 본 발명은 역순환 굴반 기능을 구비한 케이싱 로테이터에 대한 것으로서, 더욱 상세하게는 암반을 파쇄하는 역순환 굴반기 기능을 수행할 수 있는 케이싱 로테이터에 대한 것이다. 본 발명에 따른 케이싱 로테이터는 케이싱과, 복수의 드릴로드파이프와, 키플레이트와, 로테이터조립수단을 포함한다. 상기 드릴로드파이프는 일렬로 조립되며 상기 케이싱에 삽입되어 스위벨의 하부에 결합된다. 상기 키플레이트는 상기 드릴로드파이프의 일단에 탈부착할 수 있게 결합된다. 상기 로테이터조립수단은 구동모터의 구동속도를 감속하여 전달하는 감속기어부와, 내부에 상기 케이싱이 삽입될 수 있는 관통공이 형성되고 상기 감속기어부로 회전할 수 있게 상기 감속기어부에 결합되는 클램프바디와, 상기 클램프바디의 관통공의 일측에 삽입되어 상기 케이싱을 파지할 수 있는 케이싱파지부, 상기 클램프바디의 관통공의 타측에 삽입되어 상기 키플레이트를 파지할 수 있는 파이프파지부를 구비한다. 본 발명에 의하면 케이싱 로테이터가 역순환 굴반 기능을 구비하므로 별도의 역순환 굴반기가 필요하지 아니한다. 그래서 케이싱 로테이트 작업과, 토사배출 및 암반굴착을 하나의 장비로 처리할 수 있다. 그래서 작업시간이 단축되며, 별도의 장비 구입이 필요하지 아니하므로 초기 투입비용이 적게 든다. 또한, 현장에서 소음발생을 획기적으로 줄이고, 토사배출 처리의 일관화를 도모하여 작업 효율을 높일 수 있다.

Подробнее
Номер записи: 21
07-12-2016 дата публикации

NOVEL TLR2 ANTAGONISTS

Номер: KR1020160140325A
Автор: CHOI, SANG DUN, DURAI PRASANNAVENKATESH, ACHEK ASMA
Принадлежит:

The present invention relates to novel small molecules, TLR2 antagonists. Particularly, the present invention relates to 19 novel TLR2 antanonists, and a pharmaceutical composition for preventing or treating inflammatory diseases and TLR4 regulator comprising the antagonists. The novel TLR2 antagonists according to the present invention have a low molecular weight and high bio-availability, and thus can be used as an agent for oral administration effectively. In addition, the novel TLR2 antagonists effectively inhibit secretion of IL-8 and cause no toxicity in vivo, and thus are useful for a pharmaceutical composition for preventing or treating inflammatory diseases. Further, the novel TLR2 antagonists according to the present invention may be used as TLR4 regulators. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 22
28-11-2019 дата публикации

SMALL MOLECULE ANTAGONIST COMPOUND TAC5 SERIES HAVING TOLL-LIKE RECEPTOR 3/7/8/9 INHIBITORY FUNCTION

Номер: WO2019225920A1
Автор: CHOI, Sangdon, KIM, Eunha
Принадлежит:

The present invention relates to a small molecule antagonist compound having a toll-like receptor 3/7/8/9 inhibitory function and TLR7, TLR8, TLR9 and TLR3 inhibitors comprising same. A novel compound expressed by TAC5 and TAC5-a, TAC5-c, TAC5-d or TAC5-e which are derivatives thereof not only prevents TNFα secretion, NFkB activation, IkB degradation and MAPKs phosphorylation induced by poly(I:C) (TLR3 agonist), IMQ (TLR7 agonist), CL075 (TLR7/8 agonist), R848 (TLR7/8 agonist), TL8 (TLR8 agonist) or CpG ODN (TLR9 agonist), but also inhibits generation of inflammatory cytokine, and thus is highly advantageous for preventive or therapeutic use for TLR3/7/8/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus, psoriasis and the like.

Подробнее
Номер записи: 23
29-03-2023 дата публикации

엔도솜 톨-유사 수용체를 제어하는 신규 소분자 화합물 및 이를 이용한 자가면역질환 치료제

Номер: KR102513463B1
Автор: 최상돈, 서창희, 정의석, 최양선, 백욱영, 최케빈재석, 임춘영, 이두현, 김남희, 이승연, 김효지, 김상균, 오유진, 김소영, 한예리
Принадлежит: 주식회사 에스앤케이테라퓨틱스

... 본 발명은 엔도솜 톨-유사 수용체(Toll-like receptor; TLR) 억제 기능이 있는 길항성 소분자 화합물에 관한 것으로, 더욱 상세하게는 톨-유사 수용체 3/7/8/9 신호전달 경로를 억제하는 소분자 화합물과 이를 포함하는 톨-유사 수용체 억제용 조성물 및 자가면역질환, 염증성질환 또는 바이러스질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 신규 화합물은 Poly I:C(TLR3 작용제), 이미퀴모드(Imiquimod; TLR7 작용제), TL8-506(TLR8 작용제) 또는 ODN2395(TLR9 작용제)에 의해 유도된 TNF-α의 분비를 차단할 뿐만 아니라, 염증성 사이토카인의 생성을 억제함으로써 전신홍반루푸스 동물 모델에서 매우 유의미한 결과를 도출했다. 이는 TLR3, TLR7, TLR8 또는 TLR9 관련 자가면역질환, 염증성질환 및 바이러스질환의 예방 또는 치료에도 유용함을 시사한다.

Подробнее
Номер записи: 24
12-09-2013 дата публикации

ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) FOR TOXICITY PREDICTION AND AS THERAPEUTIC TARGET

Номер: WO2013133472A1
Автор: CHOI, Sang Dun
Принадлежит:

The present invention relates to activating transcription factor 3 (ATF3) used for predicting toxicity or as a therapeutic target, and, more specifically, the ATF3 of the present invention features markedly increased expression in cells treated with doxorubicin and cisplatin which are anticancer chemotherapy agents or with cyclosporine which is an immunosuppressant having toxic adverse effects, and thus the present invention can be used for predicting the toxicity of an anticancer agent or immunosuppressant or else a toxic substance or as a therapeutic target therefor. Consequently, the ATF3 can be used as a marker for predicting toxicity due to anticancer agents, immunosuppressants, drugs or toxic substances in various human organs, notably the kidneys, and can be used as a target for developing anticancer therapy agents, immunosuppressants and other drugs able to prevent cytotoxic adverse reactions by suppressing ATF3 since it has been confirmed that suppression of ATF3 expression alleviates ...

Подробнее
Номер записи: 25
08-12-2016 дата публикации

NOVEL TLR2 ANTAGONISTS

Номер: WO2016195194A2
Автор: CHOI, Sang Dun, DURAI, Prasannavenkatesh, ACHEK, Asma
Принадлежит:

The present invention relates to TLR2 antagonists, which are small novel molecules, and, particularly, to: 19 novel TLR2 antagonists; a pharmaceutical composition, containing the antagonists, for preventing or treating inflammatory diseases; and a TLR4 modulator, containing the antagonists. The novel TLR2 antagonists according to the present invention can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present invention can be used as a TLR4 modulator.

Подробнее
Номер записи: 26
08-12-2016 дата публикации

NOVEL TLR2 ANTAGONISTS

Номер: WO2016195194A3
Автор: CHOI, Sang Dun, DURAI, Prasannavenkatesh, ACHEK, Asma
Принадлежит:

The present invention relates to TLR2 antagonists, which are small novel molecules, and, particularly, to: 19 novel TLR2 antagonists; a pharmaceutical composition, containing the antagonists, for preventing or treating inflammatory diseases; and a TLR4 modulator, containing the antagonists. The novel TLR2 antagonists according to the present invention can be effectively used as a preparation for oral administration by having low molecular weight and high oral bioavailability, and can be useful in pharmaceutical compositions for preventing or treating inflammatory diseases since the secretion of IL-8 is effectively inhibited and in vivo cytotoxicity is not induced. In addition, the novel TLR2 antagonists according to the present invention can be used as a TLR4 modulator.

Подробнее
Номер записи: 27
10-10-2016 дата публикации

CASING ROTATOR INCLUDING REVERSE CIRCULATION EXCAVATION FUNCTION

Номер: KR1020160116497A
Автор: LEE, SANG TAE, LEE, SANG SIK, SONG, SU DONG, LIM, JONG KYU, CHOI, SANG DON
Принадлежит:

The present invention relates to a casing rotator including a reverse circulation excavation function and, more specifically, relates to a casing rotator capable of performing a reverse circulation excavation function to crush bedrock. According to the present invention, the casing rotator comprises: a casing, a plurality of drill rod pipes, a key plate, and a rotator assembly unit. The drill rod pipe is assembled in a row and is inserted into the casing to be connected to a lower part of a swivel. The key plate is connected to an end of the drill rod pipe to be detached. The rotator assembly unit comprises: a decelerating gear unit decelerating and transmitting a driving speed of a driving motor; a clamp body having a through hole in which the casing is able to be inserted, wherein the clamp body is connected to the decelerating gear unit to rotate by the decelerating gear unit; a casing holding unit holding the casing by being inserted into one side of the through hole of the clamp body ...

Подробнее
Номер записи: 28
21-04-2016 дата публикации

METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS USING PHYSICOCHEMICAL NANOSTRUCTURE

Номер: KR1020160043463A
Автор: CHOI, SANG DUN, KIM, JAE HO, KWON, HYUK KWON, LEE, JAE HYEOK, SHIN, HYEON JUN
Принадлежит:

The present invention relates to a method for producing induced pluripotent stem cells (iPS cell) using a physicochemical nanostructure and, more specifically, to a method for producing induced pluripotent stem cells by dedifferentiating mammal cells including somatic cells or adult stem cells by physicochemical stimulation of a nanostructure, to induced pluripotent stem cells produced using the method, and to a cell therapeutic agent including the induced pluripotent stem cells. The method for producing induced pluripotent stem cells by dedifferentiating mammal cells including somatic cells or adult stem cells using the nanostructure uses physicochemical stimulation present in the nanostructure ithout the introduction of a foreign transcription factor, and thus can safely and effectively produce the induced pluripotent stem cells. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 29
31-10-2019 дата публикации

TLR4 ANTAGONISTIC PEPTIDE

Номер: WO2019209030A1
Автор: CHOI, Sangdun, ACHEK, Asma, SHAH, Masaud
Принадлежит:

The present invention relates to a peptide inhibiting the TLR4 signaling pathway, a TLR4 antagonist comprising the peptide, and a pharmaceutical composition, comprising the peptide, for treatment of autoimmune disease or inflammatory disease. The peptide according to the present invention exhibits an excellent effect of suppressing the secretion of inflammatory cytokines and the activation of NF-kB and MAPKs by inhibiting the TLR4 signaling pathway and thus is useful for a pharmaceutical composition for prevention or treatment of autoimmune diseases and inflammatory diseases mediated through the TLR4 signaling pathway.

Подробнее
Номер записи: 30
30-05-2017 дата публикации

DUAL THERMOKEEPING CONTAINER

Номер: KR101741162B1
Автор: CHOE, SANG DON
Принадлежит: CHOE, SANG DON

The present invention relates to a thermokeeping container having a dual wall for blocking a direct contact with external air. The thermokeeping container comprises: an external container having a first suctioning hole formed at the top end thereof, and having an opening part formed at the bottom thereof; an internal container having a second suctioning hole formed at the top end thereof, inserted as a container body into the opening part of the external container, and having an outer circumferential surface of the second suctioning hole formed to be closely placed on the inner circumferential surface of the first suctioning hole; a sealing body assembled with the opening part, sealing the opening part, and having a top surface coming in contact with the bottom surface of the internal container; and an insertion cover inserted into the second suctioning hole of the internal container, and sealing the second suctioning hole. Direct heat transfer between a food and external air is blocked ...

Подробнее
Номер записи: 31
07-03-2013 дата публикации

CAPRIC ACID HAVING INHIBITING EFFECT ON OSTEOCLAST FORMATION AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2013032096A1
Автор: CHOI, Sang Dun
Принадлежит:

The present invention provides an osteoclast formation-inhibiting agent containing capric acid as an active ingredient, and a pharmaceutical composition containing capric acid as an active ingredient for preventing or treating diseases due to bone loss. The capric acid, according to the present invention, inhibits the formation of an osteoclast by inhibiting the expression of MCP-1 and the expression of iNOS by means of STAT3(Ser727) activity in a RAW264.7 cell that is LPS-treated. Also, the capric acid according to the present invention reduces the expression of LPS-derived TRAP, which is an osteoclast differentiation marker. The pharmaceutical composition containing the capric acid, according to the present invention, is useful in treating various diseases that are induced from bone loss, wherein the diseases can be selected from a group consisting of osteoporosis, arthritis, and periodontitis. In addition, the pharmaceutical composition containing the capric acid, according to the present ...

Подробнее
Номер записи: 32
20-06-2017 дата публикации

SPEED REDUCER WITH BRAKE AND CLUTCH

Номер: KR101748324B1
Автор: LEE, SANG SIK, LIM, JONG KYU, CHOI, SANG DON, BAE, MYOUNG HO
Принадлежит: BUMA CE CO., LTD.

The present invention relates to a speed reducer, and more specifically, to a speed reducer, which has a brake and a clutch, and is capable of reducing the speed at two speed ratios. According to the present invention, the speed reducer comprises: a housing; an input shaft; a first gear; a first ring gear; a plurality of first intermediate gears; a first input shaft; a power output means; a clutch means; and a brake means. The input shaft is inserted into one side of the housing. The first gear is combined with one end of the input shaft in the housing. The first ring gear is mounted in the housing to wrap around the first gear and to rotate around the central axis of the first gear. The first intermediate gears are mounted in the first ringer to be engaged with the first ring gear and the first gear. One end of the first output shaft is combined with the central axis of the first intermediate gears to rotate around the central axis of the input shaft. The power output means is mounted ...

Подробнее
Номер записи: 33