Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 108. Отображено 100.
12-11-2015 дата публикации

PRODUCING METHOD OF PUERARIA THUNBERGIANA DRINK

Номер: KR101568756B1
Автор: CHOI, EUN KYEONG
Принадлежит: CHOI, EUN KYEONG

The present invention relates to a producing method of a Pueraria thunbergiana drink and, more specifically, to a producing method of a Pueraria thunbergiana drink. The drink can preserve and take original nutrition of Pueraria thunbergiana and leaves of Triticum aestivum L. by mixing a fresh Pueraria thunbergiana extract extracted from Pueraria thunbergiana and the leaves of Triticum aestivum L. into a Pueraria thunbergiana crude liquid, of which general taste is delicate and soft due to disappearing exciting smell or taste by ripening and aftertaste is also simple by the leaves of Triticum aestivum L. unusually cultivated and processed. COPYRIGHT KIPO 2016 (AA) Wheat leaves water cultivating step (BB) Wheat leaves processing step (CC) Pueraria thunbergiana extraction step (DD) Pueraria thunbergiana raw solution extraction step (EE) Inserting and heating step ...

Подробнее
Номер записи: 1
29-11-2016 дата публикации

이동 단말기 및 이것의 메시지 리스트 디스플레이 방법

Номер: KR0101680663B1
Автор: 유선, 최은경
Принадлежит: 엘지전자 주식회사

... 본 발명은, 상대방 기반 메시지 리스트에 포함된 복수의 상대방들 중 적어도 두 개의 상대방들을 하나의 그룹으로 구성하고, 상기 상대방 기반 메시지 리스트 상에서 상기 구성된 그룹을 하나의 상대방으로서 디스플레이할 수 있는 이동 단말기 및 이것의 메시지 리스트 디스플레이 방법에 관한 것이다.

Подробнее
Номер записи: 2
13-03-2018 дата публикации

SYSTEM AND METHOD FOR RECOGNIZING FINGER LANGUAGE

Номер: KR1020180026711A
Автор: KIM YOUNGHO, SEONGJUNG KIM, HANSOO LEE, SOONJAE AHN, KIM JONG MAN, JO MIN, EUNKYOUNG CHOI
Принадлежит:

The present invention relates to a system and a method for recognizing a finger language, wherein the system for recognizing a finger language includes: an acquisition portion for acquiring an electromyography (EMG) signal from a sensor measuring device worn on a user′s upper arm; an extracting portion for extracting a muscle activation section from the EMG signal; a calculation portion for calculating a characteristic vector of a finger language operation taken by the user by performing signal processing in the muscle activation section; a searching portion for searching for a signal corresponding to the characteristic vector in a database; and an output portion for outputting a text corresponding to the searched signal. COPYRIGHT KIPO 2018 (110) Acquisition portion (120) Extraction portion (130) Calculation portion (140) Search portion (150) Output portion ...

Подробнее
Номер записи: 3
27-11-2017 дата публикации

BIOMARKER COMPOSITION FOR PREDICTING PROGNOSIS OF RADIOTHERAPY AND DIAGNOSING RADIATION-RESISTANT CANCER CONTAINING LRP-1 AS ACTIVE INGREDIENT

Номер: KR1020170129620A
Автор: CHOI, EUN KYUNG, JEONG, SEONG YUN, SONG, SI YEOL, LEE, KYOUNG JIN
Принадлежит:

The present invention relates to a biomarker composition for diagnosing radiation-resistant cancer containing low density lipoprotein receptor-related protein (LRP)-1 as an active ingredient, and a method for diagnosing radiation-resistant cancer using the same. An investigation has been conducted on LRP-1 which is a binding protein to which a specific peptide sequence specifically targeting radiation-resistant colorectal cancer tissues actually binds, and LRP-1 can possibly function as a factor associated with resistance to radiotherapy for cancer based on the investigation. COPYRIGHT KIPO 2017 (AA) Radiation resistant case (BB) Radiation sensitive case ...

Подробнее
Номер записи: 4
23-11-2017 дата публикации

BIOMARKER COMPOSITION COMPRISING LRP-1 AS ACTIVE INGREDIENT, FOR DIAGNOSIS OF RADIATION-RESISTANT CANCER OR PREDICTION OF RADIATION THERAPY PROGNOSIS

Номер: WO2017200263A1
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Kyoung Jin
Принадлежит:

The present invention relates to a biomarker composition comprising LRP-1 as an active ingredient, for the diagnosis of radiation-resistant cancer, and a method for diagnosing a radiation-resistant cancer using the same. The present invention identifies LRP-1, a binding partner protein to which a specific peptide sequence that specifically targets radiation-resistant colon cancer tissues actually binds, and having such basis, has suggested the possibility of a radiation therapy resistance-related factor for cancer.

Подробнее
Номер записи: 5
01-04-2016 дата публикации

METHOD FOR DISPLAYING DATA AND MOBILE TERMINAL THEREOF

Номер: KR0101608532B1
Автор: 서경혜, 김준희, 이선정, 최은경, 박혜경, 김경락, 유지혜
Принадлежит: 엘지전자 주식회사

... 본 발명은, 복수의 아이템을 포함한 아이템 리스트를 상기 이동 통신 단말기의 터치스크린에 표시하는 단계와, 제 1 포인팅 장치가 상기 복수의 아이템 중 적어도 하나에 터치앤 홀드되면, 이 선택된 아이템의 제 1 프리뷰 화면이 상기 터치스크린 상에 표시되는 단계; 및 상기 제 1 포인팅 장치가 홀드된 상태에서, 제 2 포인팅 장치에 의해 프리킹 신호가 발생되면, 상기 제 1 프리뷰 화면이 차순위 아이템의 제 2 프리뷰 화면으로 변경되어 표시되는 단계를 포함하는, 이동 통신 단말기에서의 데이터 표시방법 및 이를 적용한 이동 통신 단말기에 관한 것이다.

Подробнее
Номер записи: 6
12-02-2019 дата публикации

표시 장치 및 그것의 구동 방법

Номер: KR1020190014298A
Автор: 최은경, 양진욱
Принадлежит:

... 표시 장치는 감마 데이터들을 생성하는 데이터 처리부를 포함하고, 상기 데이터 처리부는 순차적으로 화소들 각각을 기준 화소로 설정하고, 상기 기준 화소에 제공되기 위한 기준 계조값과 상기 기준 화소에 인접한 비교 화소들에 제공되기 위한 비교 계조값들의 차이값들을 계산하고, 상기 차이값들을 임계값과 비교하고, 상기 비교 결과에 따라 복수 개의 계조 등급들 중 상기 기준 계조값이 속하는 계조 등급의 값을 카운팅 시키고, 상기 계조 등급들에 축적된 값들의 분포 비율들에 기초하여 상기 감마 데이터들을 가변시켜 출력한다.

Подробнее
Номер записи: 7
21-12-2017 дата публикации

BIOMARKER COMPRISING NCKAP1 AS EFFECTIVE INGREDIENT FOR DIAGNOSING COLORECTAL CANCER OR FOR PREDICTING METASTASIS AND PROGNOSIS OF COLORECTAL CANCER

Номер: WO2017217807A2
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Jae Hee
Принадлежит:

The present invention relates to a biomarker composition comprising NCK-Associated Protein 1 (NCKAP1) as an effective ingredient for diagnosis of colorectal cancer or for prediction of the metastasis and prognosis of colorectal cancer. In brief, new colorectal cancer target candidates were excavated by massive gene expression analysis in bloods of human colorectal cancer tissue-transplanted mouse models, and were experimentally assayed by downregulatng the expression of the target candidate genes in a colorectal cancer cell line. Through the experiment, the overexpression of NCKAP1 in blood and tissues of colorectal cancer patients, and the suppression of cancer cell migration, infiltration, and metastasis upon the downregulation of NCKAP1 were observed, with the consequent possibility confirmation of NCKAP1 for use as a novel colorectal cancer target. Therefore, effective use can be made of an expression level of NCKAP1 in colorectal cancer diagnosis, and of a NCKAP1 gene expression inhibitor ...

Подробнее
Номер записи: 8
14-06-2018 дата публикации

웨이퍼 레벨 패키지 형성방법

Номер: KR0101867489B1
Автор: 김상원, 김종윤, 최은경, 한상욱, 홍지석
Принадлежит: 삼성전자주식회사

... 웨이퍼 레벨 패키지 형성방법이 제공된다. 본 발명의 일부 실시예에 따른 웨이퍼 레벨 패키지 형성방법은, 복수의 제1 반도체 칩을 포함하는 웨이퍼를 준비하는 단계; 상기 웨이퍼 상에 복수의 제2 반도체 칩을 실장하는 단계; 상기 웨이퍼를 하부 금형 상에 배치하고, 상기 웨이퍼 상면의 가장자리를 모두 감싸도록 상부 금형을 배치하는 단계; 몰딩 부재를 상기 웨이퍼 상에 디스펜싱(dispensing) 하는 단계; 및 플런저(plunger)로 상기 몰딩 부재를 압축하여 상기 제2 반도체 칩의 상부면이 노출되는 웨이퍼 레벨 패키지를 형성하는 단계;를 포함한다.

Подробнее
Номер записи: 9
27-12-2018 дата публикации

반도체 패키지 및 반도체 패키지의 제조 방법

Номер: KR0101932495B1
Автор: 김상원, 최광철, 송현정, 조차제, 최은경, 홍지석
Принадлежит: 삼성전자주식회사

... 반도체 패키지는 제1 반도체 칩, 제2 반도체 칩 및 밀봉 부재를 포함한다. 상기 제1 반도체 칩은 제1 면 및 상기 제1 면에 반대하는 제2 면을 가지며 상기 제2 면으로부터 소정의 깊이를 갖는 개구부가 형성된 기판, 및 상기 제1 면으로부터 상기 기판의 두께 방향으로 연장하고 상기 개구부의 저면을 통해 일단부가 노출된 다수개의 관통 전극들을 포함한다. 상기 제2 반도체 칩은 상기 개구부 내에 수용되고 상기 개구부의 저면 상에 실장된다. 상기 밀봉 부재는 상기 개구부 내에서 상기 제2 반도체 칩을 덮는다.

Подробнее
Номер записи: 10
09-11-2017 дата публикации

대장암 표적용 펩타이드 및 이의 의학적 용도

Номер: KR0101795140B1
Автор: 최은경, 정성윤, 송시열, 이경진, 최진향, 박재숙, 박석순, 이재희
Принадлежит: 울산대학교 산학협력단

... 본 발명은 대장암 표적용 펩타이드 및 이를 이용한 방사선 반응성에 따른 대장암 예후 진단용 조성물 및 약물전달 용도에 관한 것으로서, 암 발병환자 개개인의 유전적 차이로 인해 치료 반응성이 달라 환자별 치료사례가 달라짐에 따라 치료 시 문제점을 염두에 두고, 환자 개인별 맞춤형 진단 및 치료를 구현하고자 이를 표적할 수 있는 기능성 펩타이드를 발굴하였다. 실제 환자의 암 미세환경과 유사한 동물모델을 구축하여 방사선 조사한 개체군과 그의 대조군으로 방사선을 조사하지 않은 개체군으로 구분하고, 각 개체군에 특이적으로 결합하는 펩타이드를 스크리닝하여 선별된 펩타이드에 대해 각각의 표적효율을 검증하였다. 이를 통해 최종적으로 방사선 치료 반응성을 예측하기 위한 영상진단 기술 개발 및 그에 따른 맞춤형 표적 치료제 개발에 활용될 수 있다.

Подробнее
Номер записи: 11
21-02-2018 дата публикации

MOBILE TERMINAL AND METHOD FOR CONTROLLING SAME

Номер: KR1020180018150A
Автор: CHOI, YOO JIN, CHOI, EUN KYUNG, SHIN, WOOK
Принадлежит:

Disclosed are a mobile terminal and a method for controlling the same. According to an embodiment of the present invention, the mobile terminal comprises: a display unit: a user input unit for detecting a touch input and including a menu key executing cancellation of a command input; and a control unit for limiting realization of a second work screen which was displayed prior to a first work screen, and displaying a third work screen different from the first and second work screens when a touch degree on the menu key exceeds standard pressure while the first work screen is displayed on the display unit. Here, the third work screen corresponds to one of previous works executed before the second work screen was displayed or a status in which one or more input values set in the first screen are restored. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 12
15-02-2016 дата публикации

MOBILE TERMINAL AND CONTROL METHOD THEREOF

Номер: KR1020160016181A
Автор: YOON, SUNG HYE, CHOI, EUN KYUNG, CHOI, JIN HAE, PARK, WON JOO, SUH, MEE OHK
Принадлежит:

The present invention relates to a mobile terminal capable of being interconnected with a wearable device. The mobile terminal includes: a display unit; a near field communications module connecting the wearable device and near field wireless communications; and a control unit entering a screen connection mode with the wearable device, when a pre-determined gesture is inputted, allowing an operation screen of the wearable device to be displayed on the display unit, and remotely controlling the operation screen of the wearable device in response to the touch input through the display unit. COPYRIGHT KIPO 2016 (AA) Start (B1,B2,B3,B4) No (C1,C2,C3,C4) Yes (DD) End (S310) Connecting a wearable device and short distance wireless communications (S320) Is the input of a predetermined gesture received? (S330) Entering a screen interworking mode (S340) Displaying an operation screen and an expansion menu of the wearable device (S350) Is relative location change with the wearable device detected ...

Подробнее
Номер записи: 13
20-04-2018 дата публикации

상지 재활훈련 장치 및 방법

Номер: KR0101850992B1
Автор: 양길태, 전호준, 고득호, 지종균, 이성희, 김영호, 최은경, 안순재, 유제성, 신이수, 김종만, 조민, 임명준
Принадлежит: 주식회사 시드테크, 연세대학교 원주산학협력단, 대한민국(국립재활원장)

... 본원은 상지 재활훈련 장치 및 방법에 관한 것으로서, 본원의 일 실시예에 따른 상지 재활훈련 장치는 피검자의 환측 부위에 대한 재활훈련을 위하여, 제1 컨트롤러로부터 입력받은 운동모드 정보를 포함하는 운동 설정 정보를 수신하는 운동모드 수신부, 상기 운동 설정 정보에 기초하여 상기 피검자의 생체 관련 데이터를 수신하는 데이터 수신부, 상기 운동 설정 정보 중 운동모드의 종류에 기초하여 상기 데이터가 미리 정의된 기준 조건을 충족하는지의 여부를 판단하는 판단부, 및 상기 판단 결과에 따라, 상지 재활 장치를 상기 운동 설정 정보에 기초하여 동작시키는 제어부를 포함할 수 있다.

Подробнее
Номер записи: 14
16-06-2015 дата публикации

ADMINISTRATION CONTROL SYSTEM OF WATER TREATMENT PLANT USING MOBILE DEVICE AND OPERATING METHOD THEREOF

Номер: KR1020150066345A
Автор: CHOI, EUN KYOUNG, KANG, GUM YUNG, RYU, CHOL, LEE, SEONG KYU
Принадлежит:

The present invention relates to an administration control system of a water treatment plant using a mobile device and an operating method thereof, by which a mobile device is connected to a water treatment plant administration sever only when an external module is attached to the mobile device, and the external module provides a double security function with a user authentication means, through which outside hacking can be fundamentally blocked. That is, the present invention is characterized by comprising: the administration control system of the water treatment plant using the mobile device, comprising: the external module configured to be capable of performing an administration and control of the water treatment plant using the mobile device in an administration server, and attached to an interface mounted in the mobile device, wherein the mobile device is controlled to be connected to the administration server and is administrated by generating an OTP based on standard time information ...

Подробнее
Номер записи: 15
01-05-2014 дата публикации

OIL-IN-WATER FORM ORGANOGEL COSMETIC COMPOSITION HAVING VARIABLE TRANSPARENCY

Номер: WO2014065536A1
Автор: YOO, Hyun-Oh, KIM, Jong-Chul, KWAK, Jae-Hoon, CHOI, Eun-Kyoung, PARK, Dong-Kyun
Принадлежит:

The present invention relates to an oil-in-water form organogel cosmetic composition having variable transparency. More particularly, the oil-in-water (O/W) form organogel cosmetic composition comprising an oil phase part and a water phase part according to the present invention, said cosmetic composition comprises: 0.05 to 50 wt% of an oil phase part and 50 to 99.95 wt% of a water phase part, based on the total weight; and is characterized in that the difference between the refractive index of the water phase part and the oil phase part is 0.03 to 0.16. The present invention not only has i) outstanding formulation stability depending on the temperature and time, but ii) also becomes transparent from an opaque white color by adjusting the content of a component contained in the water phase part and the oil phase part when applied to the skin so as to allow the optimal application time in order to be easily identified. Therefore, the present invention can be usefully applied to the development ...

Подробнее
Номер записи: 16
29-08-2016 дата публикации

p34의 발현 억제제 또는 활성 억제제를 유효성분으로 포함하는 암의 치료 또는 전이 억제용 조성물

Номер: KR0101652010B1
Автор: 김태원, 진동훈, 홍승우, 문재희, 신재식, 김진선, 정경아, 이정신, 최은경, 이재련, 홍용상, 김규표, 남기엽, 김봉철
Принадлежит: 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 본 발명은 p34의 발현 억제제 또는 활성 억제제를 유효성분으로 포함하는 암의 치료 또는 전이 억제용 조성물에 관한 것이다. 본 발명에 따르면, p34 단백질의 넉다운(knock-down)은 PTEN의 모노-유비퀴틴화를 일으켜 PTEN의 핵국재화(nuclear localization)를 촉진시키는 결과, 종양의 생존, 증식, 침습성 및 전이성과 관련된 Akt 경로를 억제하므로 PTEN 및 NEDD4-1을 동시 발현하는 다양한 암 세포의 종양발생성 및 집락 형성능을 현저하게 감소시키는 효과가 있다. 따라서 본 발명의 p34 유전자의 발현 억제제 또는 p34 단백질의 활성 억제제는 암의 치료제 또는 전이 억제제로서 유용하게 사용될 수 있다.

Подробнее
Номер записи: 17
04-01-2018 дата публикации

반도체 패키지

Номер: KR0101814022B1
Автор: 홍지석, 최광철, 김상원, 송현정, 최은경
Принадлежит: 삼성전자주식회사

... 반도체 패키지를 제공한다. 반도체 패키지는, 제1 반도체 소자, 제1 반도체 소자와 이격되어 마주하는 제2 반도체 소자, 제1 및 제2 반도체 소자들을 전기적으로 연결하는 연결 구조물들 및 연결 구조물들을 보호하며 제1 및 제2 반도체 소자들 사이를 접착시키는 보호 구조물을 포함한다. 보호 구조물은, 평면적으로 볼 때 상기 연결 구조물들을 완전히 감싸는 제1 물질막 및 제1 물질막을 감싸는 제2 물질막을 포함한다.

Подробнее
Номер записи: 18
18-07-2019 дата публикации

BIOMARKER COMPOSITION FOR DIAGNOSING RADIATION-RESISTANT CANCER OR FOR PREDICTING PROGNOSIS OF RADIATION THERAPY CONTAINING PMVK AS ACTIVE INGREDIENT

Номер: WO2019103456A3
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, PARK, Yun-Yong, PARK, Seok Soon, JU, Eun Jin, KO, Eun Jung
Принадлежит:

The present invention relates to a biomarker composition for diagnosing radiation-resistant cancer containing PMVK as an active ingredient, and a method for diagnosing radiation-resistant cancer using the same, wherein when the PMVK was knocked down, it was confirmed that the survival rate of cancer cells decreases in the radiation treatment, and on the basis of this, it was suggested that it is possible to use the PMVK as a radiation therapy resistance-related factor for cancer, whereby the PMVK can be utilized as a novel target that can enhance the radiation therapy effect on human cancer cells.

Подробнее
Номер записи: 19
24-05-2017 дата публикации

METHOD FOR PRODUCING ALCOHOL FROM CARBON DIOXIDE USING SLURRY REACTOR

Номер: KR1020170057072A
Автор: KIM, HAK JOO, JEONG, SOON KWAN, KANG, SEONG PIL, PARK, KI TAE, YOUN, MIN HYE, CHOI, EUM KYUNG, SONG, KYOUNG HO
Принадлежит:

According to the present invention, a method for producing alcohol, comprises: a first step of preparing a slurry reactor having a slurry containing a catalyst for producing a first alcohol and water from carbon dioxide; a second step of injecting carbon dioxide-containing gas and hydrogen gas into the slurry reactor; a third step of performing an exothermic reaction which generates a first alcohol containing a second alcohol of C2 to C4, and water from carbon dioxide by the catalyst in the slurry reactor in the presence of the second alcohol of C2 to C4, which is a heat dispersion medium; a fourth step of discharging first alcohol containing gas which is a reaction product from the slurry reactor and then cooling the same; and a fifth step of recycling, to the slurry reactor as the heat dispersion medium, a part or all of the second alcohol of C2 to C4 condensed in the fourth step. According to the present invention, when the alcohol of C2 to C4 which is a part of the reaction product ...

Подробнее
Номер записи: 20
27-12-2017 дата публикации

BIOMARKER COMPOSITION FOR DIAGNOSING COLON CANCER OR PREDICTING PROGNOSIS OF COLON CANCER METASTASIS, COMPRISING NCKAP1 AS ACTIVE INGREDIENT

Номер: KR1020170141951A
Автор: CHOI, EUN KYUNG, JEONG, SEONG YUN, SONG, SI YEOL, LEE, JAE HEE
Принадлежит:

The present invention relates to a biomarker composition for diagnosing colon cancer or predicting prognosis of colon cancer metastasis, the biomarker composition comprising NCK-associated protein 1 (NCKAP1) as an active ingredient. Specifically, a novel colon cancer target candidate has been discovered through a mass gene expression analysis in blood of a human body colon cancer tissue transplantation mouse model, and experimental verification thereon has been performed through the inhibition of target candidate gene expression in colon cancer cell lines. As a result, it has been observed that NCKAP1 is overexpressed in blood and tissues of colon cancer patients, and that migration, invasion and metastasis of cancer cells by the inhibition of NCKAP1 are inhibited. Also, the possibility of NCKAP1 as a new colon cancer target has been confirmed. Therefore, a colon cancer diagnosis and gene expression inhibitor using the expression level of NCKAP1 can be effectively used as an active ingredient ...

Подробнее
Номер записи: 21
07-09-2015 дата публикации

PRIMER SET FOR AMPLIFYING MUTANT GENES RELATED TO LUNG CANCER AND KIT INCLUDING PROBE COMPLEMENTARY TO MUTANT GENES FOR DIAGNOSING LUNG CANCER

Номер: KR1020150102468A
Автор: LEE, JUNG SHIN, CHOI, EUN KYUNG, JANG, SE JIN, SUH YOUNG AH, CHUN, SUNG MIN
Принадлежит:

The present invention relates to: a primer set capable of amplifying genes of epidermal growth factor receptor (EGFR), Kirsten ras (KRAS), B type Raf kinase (BRAF) and phosphoinositide-3-kinase catalytic-alpha polypeptide (PIK3CA); a kit for diagnosing lung cancer including a probe complementary to the genetic mutation; and a method for diagnosing lung cancer using the same. According to the present invention, a kit for diagnosing lung cancer has higher susceptibility than a sequence analysis method which has been conventionally used, and can confirm DNA mutation of 113 simultaneously, thereby outstandingly reducing the amount of clinical samples used, and predicting effects of reducing costs, manpower and the time required. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 22
30-05-2018 дата публикации

BIOMARKER COMPOSITION INCLUDING TTP AS ACTIVE INGREDIENT FOR DIAGNOSING MENOPAUSE-INDUCED INSULIN RESISTANCE OR PREDICTING TREATMENT PROGNOSIS

Номер: KR1020180057295A
Автор: CHOI, HYE SEON, CHOI, EUN KYEONG
Принадлежит:

The present invention relates to a biomarker composition for diagnosing menopause-induced insulin resistance or predicting a treatment prognosis, wherein the biomarker composition comprises tristetraprolin (TTP) or a gene for encoding the same as an active ingredient. It has been confirmed that the expression amount of the TTP is significantly reduced in a patient exhibiting insulin resistance induced by menopause, and thus the possibility of the TTP as a novel target of menopause-induced insulin resistance has been demonstrated. Therefore, it is possible to easily diagnose menopause-induced insulin resistance or predict a treatment prognosis thereof by using the expression level of TTP. A TTP gene or a protein expression enhancer can be useful as an active ingredient for a composition for preventing or treating menopause-induced insulin resistance. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 23
06-07-2018 дата публикации

지화 인식 시스템 및 방법

Номер: KR0101875472B1
Автор: 김영호, 김성중, 이한수, 안순재, 김종만, 조민, 최은경
Принадлежит: 연세대학교 원주산학협력단

... 지화 인식 시스템에 관한 것이며, 지화 인식 시스템은 사용자의 상완 부위에 착용된 센서 측정 기기로부터 근전도 신호를 획득하는 획득부, 근전도 신호에서 근활성 구간을 추출하는 추출부, 근활성 구간에 신호처리를 수행함으로써, 사용자가 취한 지화 동작의 특성 벡터를 산출하는 산출부, 데이터베이스 내에서 특성 벡터에 대응되는 신호를 검색하는 검색부, 및 검색된 신호에 대응하는 텍스트를 출력하는 출력부를 포함할 수 있다.

Подробнее
Номер записи: 24
27-05-2016 дата публикации

COLORECTAL CANCER TARGETING PEPTIDE AND MEDICAL USE OF SAME

Номер: KR1020160059944A
Автор: CHOI, EUN KYUNG, JEONG, SEONG YUN, SONG, SI YEOL, LEE, KYOUNG JIN, CHOI, JIN HYANG, PARK, JAE SOOK, PARK, SEOK SOON, LEE, JAE HEE
Принадлежит:

The present invention relates to a colorectal cancer targeting peptide, a composition for diagnosing colorectal cancer prognosis according to radiation reactivity by using the same, and a drug delivery use. By considering a treatment problem in which there are different kinds of treatment reactivity and treatment cases differ by patients due to genetic difference between individual cancer patients, a functional peptide capable of targeting the same has been developed to ensure individual patient-customized diagnosis and treatment. An animal model which is similar to a cancer micro-environment of an actual patient is constructed, and is divided into a radiation-irradiated individual group and an individual group, provided as a control group thereof, to which radiation is not irradiated. Target efficiency has been verified with respect a peptide sorted by screening peptides specifically bonding to each of the individual group. Accordingly, the colorectal cancer targeting peptide may be finally ...

Подробнее
Номер записи: 25
01-06-2017 дата публикации

Claudin 7을 포함하는 방사선 반응성 위암 진단용 바이오마커 조성물

Номер: KR0101741898B1
Автор: 최은경, 정성윤, 송시열, 이경진
Принадлежит: 울산대학교 산학협력단

... 본 발명은 Claudin 7을 포함하는 방사선 반응성 위암 진단용 바이오마커 조성물 및 이를 이용한 방사선 반응성 위암 진단 방법에 관한 것으로서, 특히 실제 암환자와 가장 유사한 동물모델인 실제 환자 위암조직을 이식한 동물모델에서 방사선을 조사하였을 때, 방사선을 조사한 위암조직에서 과발현되는 Claudin 7은 방사선 반응성 위암 진단에 이용될 수 있으며, 차후 방사선 치료 모니터링용 조영제 및 방사선 치료 효과 증진용 약물 전달체 개발 등에 활용될 수 있다.

Подробнее
Номер записи: 26
11-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSITIVITY OF PARP INHIBITOR AND USAGE THEREOF

Номер: KR1020160014565A
Автор: KIM, TAE WON, JIN, DONG HOON, HONG, SEUNG WOO, MOON, JAI HEE, SHIN, JAE SIK, HWANG, IH YEON, KIM, JEONG HEE, LEE, HA REUM, CHOI, EUN KYOUNG, KIM, SEUNG MI, JUNG, SOO A, HA, SEUNG HEE, LEE, DAE HEE, LEE, EUN YOUNG, LEE, SEUL, LEE, JUNG SHIN, CHOI, EUN KYUNG, LEE, JAE LYUN, HONG, YONG SANG, KIM, KYU PYO, KIM, JEONG EUN, PARK, SEONG JOON, KIM, BONG CHOEL
Принадлежит:

The present invention relates to a novel biomarker for predicting the sensitivity of a poly ADP ribose polymerase (PARP) inhibitor and the usage thereof. More particularly, the present invention provides: a biomarker for predicting the sensitivity of a PARP inhibitor containing DNA-dependent protein kinase (DNA-PK) or p53 genes; a composition for predicting the sensitivity of the PARP inhibitor containing medications for measuring the expression level of genes in the biomarker or the expression level of protein in the genes; a kit for predicting the sensitivity of the PARP inhibitor containing the composition; a method of predicting the sensitivity of the PARP inhibitor; a sensitivity promotor for the PARP inhibitor; and a pharmaceutical composition for treating or preventing cancer, including the sensitivity promotor and the PARP inhibitor as active components. An effect of predicting the sensitivity of the PARP inhibitor is great, so the present invention can be usefully utilized as a ...

Подробнее
Номер записи: 27
22-03-2023 дата публикации

전압 안정화를 위한 2조 병렬 인버터의 협조 제어 구조를 갖는 단상 독립형 인버터

Номер: KR20230040003A
Автор: 박성준, 김수연, 최은경
Принадлежит:

... 본 발명은 2조 병렬 인버터의 협력 제어 구조를 갖는 단상 독립형 인버터에 관한 것으로, 더욱 상세하게 출력 전압을 제어하는 메인 인버터부와 출력 전류를 제어하는 댐핑 인버터부를 병렬 구조로 연결함으로써, 공진 현상과 부하 탈락시 출력 전압의 진동을 최소화할 수 있고 고신뢰성을 갖는 2조 병렬 인버터의 협력 제어 구조를 갖는 단상 독립형 인버터에 관한 것이다.

Подробнее
Номер записи: 28
03-08-2017 дата публикации

SIGN LANGUAGE RECOGNITION SYSTEM AND METHOD

Номер: WO2017131318A1
Автор: KIM, Young Ho, KIM, Seong Jung, LEE, Han Soo, KIM, Jong Man, JO, Min, CHOI, Eun Kyoung, AHN, Soon Jae, JEONG, Young Jae
Принадлежит:

The present invention relates to a sign language recognition system, and the sign language recognition system can comprise: an acquisition unit for acquiring an electromyographic signal of a user from a sensor measurement device worn on an arm part of the user; an extraction unit for extracting a muscle activation period from the electromyographic signal in order to sense a sign language motion made by the user; a calculation unit for calculating a first characteristics vector by performing signal processing on the muscle activation period; a search unit for searching for a signal corresponding to the first characteristics vector in a database; and an output unit for outputting text corresponding to the searched for signal.

Подробнее
Номер записи: 29
09-01-2020 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF PRION DISEASE

Номер: WO2020009522A1
Автор: KIM, Dong Yeon, SHIN, Jae Soo, CHO, Dae Jin, LEE, Gong Yeal, KIM, Hong Youb, LEE, Hea Un, AHN, Choong Am, SONG, Song Ei, PARK, Jong Seong, KANG, Soung Young, KIM, Yong Sun, CHOI, Eun Kyoung, CHOI, Yeong Gon, PARK, Jeong Ho
Принадлежит:

The present invention relates to a pharmaceutical composition for the prevention or treatment of a prion disease which is one of the neurodegenerative diseases, the composition comprising, as an active ingredient, radotinib or a pharmaceutically acceptable salt thereof.

Подробнее
Номер записи: 30
29-11-2018 дата публикации

COMPRESSION TYPE BOLT ANCHOR HAVING THREE-STAGE WATERPROOF FUNCTION

Номер: KR101923419B1
Автор: CHOI, EUN GYEONG
Принадлежит: CHOI, EUN GYEONG

The present invention relates to a compression type bolt anchor having a three-stage waterproof function, which is used for preventing sagging of a rebar and blocking leaked water when a lining is formed. According to the present invention, the compression type bolt anchor having a three-stage waterproof function comprises: a packing (10) made of an elastic material and installed to allow a sheet contact surface to come in contact with the outer surface of a waterproof sheet (203); a packing cap (20) including a tubular cap circumferential wall part (21), and a cap bottom surface part (22) formed to seal one opening of the cap circumferential wall part (21) and having a cap through-hole (22a) formed in a center; a rebar support bolt (31); a compressing nut (32) screw-coupled to the rebar support bolt (31); a terminal rebar supporter (33) coupled to a terminal of the rebar support bolt (31); and a packing support pipe part (40) installed on a raw base to allow a terminal of a support pipe ...

Подробнее
Номер записи: 31
22-09-2016 дата публикации

METHOD FOR ISOLATING NUCLEIC ACID FROM FFPE TISSUE

Номер: KR1020160110806A
Автор: JANG, SE JIN, CHUN, SUNG MIN, KIM, TAE IM, LEE, JUNG SHIN, CHOI, EUN KYUNG
Принадлежит:

The present invention relates to a method for isolating nucleic acid from a sample comprising formalin-fixed and paraffin-embedded (FFPE) tissue fragments, to a kit for isolating nucleic acid, and to a dissolving buffer solution for isolating nucleic acid. The method for isolating nucleic acid comprises the following steps: (a) adding salts, a solution including polyethylene glycol (PEG), and magnetic beads in a sample produced and isolated by dissolving FFPE tissue fragments; and (b) obtaining the magnetic beads and isolating nucleic acid from the same. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 32
26-05-2016 дата публикации

PEPTIDES FOR TARGETING GASTRIC CANCER, AND MEDICAL USE THEREOF

Номер: WO2016080633A1
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Kyoung Jin, SHIN, Seol Hwa, JU, Eun Jin
Принадлежит:

The present invention relates to peptides for targeting gastric cancer, a composition for gastric cancer diagnosis based on irradiation or non-irradiation using same, and a drug delivery use thereof. The functional peptides capable of targeting cancer have been discovered so as to implement customized diagnosis and treatment for individual patients in consideration of problems during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients having cancer. After establishing animal models similar to the cancer microenvironments of actual patients and dividing into an irradiated population and a non-irradiated population as a control group, targeting efficiency has been tested for respective peptides selected by screening peptides specifically binding to the respective populations. As such, the present invention can finally be used in the technical development of image diagnosis for ...

Подробнее
Номер записи: 33
26-05-2017 дата публикации

UPPER LIMB REHABILITATION APPARATUS AND METHOD THEREFOR

Номер: KR1020170058208A
Автор: YANG, GIL TAE, CHEON, HO JUN, GO, DUK HO, JI, JONG KYUN, LEE, SUNG HEE, KIM, YOUNG HO, CHOI, EUN KYOUNG, AHN, SOON JAE, RYU, JE SEONG, SHIN, I SU, KIM, JONG MAN, JO, MIN, LIM, MYUNG JOON
Принадлежит:

The present invention relates to an upper limb rehabilitation apparatus and a method therefor. According to an embodiment of the present invention, in an attempt to conduct rehabilitation training on an affected portion of an examinee, the upper limb rehabilitation apparatus comprises: an exercise mode receiving part receiving exercise setting information including exercise mode information input from a first controller; a data receiving part receiving data associated with body of the examinee based on the exercise setting information; a determination part determining whether the data satisfies a predetermined criterion based on the types of exercise mode among the exercise setting information; and a control part operating the rehabilitation apparatus based on the exercise setting information depending on the determined outcome. COPYRIGHT KIPO 2017 (120) Exercise mode receiving part (130) Data receiving part (140) Determination part (150) Control part (160) Electromyogram signal measurement ...

Подробнее
Номер записи: 34
06-09-2017 дата публикации

PARP 및 탄키라제 동시 저해제에 대한 감수성 결정 방법

Номер: KR0101775356B1
Автор: 김태원, 진동훈, 홍승우, 문재희, 신재식, 김정희, 황이연, 최은경, 김승미, 정수아, 이대희, 이은영, 이정신, 홍용상, 김규표, 김정은, 김봉철
Принадлежит: 재단법인 아산사회복지재단

... 본 발명은 PARP(Poly ADP Ribose Polymerase) 및 탄키라제(tankyrase) 동시 저해제에 대한 감수성 결정 방법에 관한 것이다. 본 발명에 따르면, PARP 및 탄키라제 동시 저해제에 대한 감수성을 갖는 환자군을 분류함으로써 대장암 치료 효과를 극대화 할 수 있다.

Подробнее
Номер записи: 35
22-10-2015 дата публикации

METHOD AND DEVICE FOR DETECTING INFINITESIMAL PATHOGENIC PRION PROTEIN

Номер: WO2015160007A1
Автор: PARK, Young Jae, PARK, Jeong Ho, CHOI, Eun Kyoung, KIM, Yong Sun
Принадлежит:

The present invention relates to a method for infinitesimal diagnosis of a transmissible spongiform encephalopathy (also known as prion disease) which uses an improved ultrasonic apparatus and, more specifically, improves detection ability by amplifying an infinitesimal pathogenic prion protein by applying electricity to an improved ultrasonic apparatus. It has been confirmed that the ultrasonic apparatus of the present invention improves amplification of a pathogenic prion protein by improving the existing protein misfolding cyclic amplification (PMCA) function, and can detect more minute amounts compared to the existing PMCA condition by modifying the upper cross section of a vial and a horn made of a glass material to be a curved surface in order to increase cavitation.

Подробнее
Номер записи: 36
06-03-2018 дата публикации

시트룰린화 미엘린 염기성 단백질에 대한 모노클론 항체 및 이를 이용한 신경 퇴행성 질환 진단 킷트

Номер: KR0101834724B1
Автор: 최은경, 김용선, 장병기
Принадлежит: 한림대학교 산학협력단

... 해결하려는 과제: CJD, 스크래피 질환 등의 프리온 질환에서 발생하는 MBP 시트룰린화를 탐지할 수 있는 모노클론 항체를 제공하는 것. 해결수단: 본 발명은 시트룰린화 MBP 단백질에 특이적으로 결합하고, 비시트룰린화 MBP 단백질에는 실질적으로 반응하지 않는 모노클론 항체 및 그의 항원 결합 단편을 제공한다.

Подробнее
Номер записи: 37
11-10-2018 дата публикации

반도체 패키지 및 그 제조 방법

Номер: KR0101906408B1
Автор: 김원근, 송현정, 최은경, 장혜영
Принадлежит: 삼성전자주식회사

... 본 발명의 기술적 사상은 반도체 패키지 공정에서 핸들링이 용이하고 워피지 발생 문제를 해결할 수 있는 반도체 패키지 및 그 제조 방법을 제공한다. 그 반도체 패키지는 적어도 하나의 반도체 칩이 내부 밀봉재에 의해 밀봉된 내부 패키지; 상기 내부 패키지가 실장되는 외부 기판; 및 상기 내부 패키지를 밀봉하는 외부 밀봉재;를 포함하고, 상기 내부 밀봉재와 외부 밀봉재는 서로 다른 모듈러스(Young's modulus)를 갖는다.

Подробнее
Номер записи: 38
21-12-2017 дата публикации

BIOMARKER COMPRISING NCKAP1 AS EFFECTIVE INGREDIENT FOR DIAGNOSING COLORECTAL CANCER OR FOR PREDICTING METASTASIS AND PROGNOSIS OF COLORECTAL CANCER

Номер: WO2017217807A3
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Jae Hee
Принадлежит:

The present invention relates to a biomarker composition comprising NCK-Associated Protein 1 (NCKAP1) as an effective ingredient for diagnosis of colorectal cancer or for prediction of the metastasis and prognosis of colorectal cancer. In brief, new colorectal cancer target candidates were excavated by massive gene expression analysis in bloods of human colorectal cancer tissue-transplanted mouse models, and were experimentally assayed by downregulatng the expression of the target candidate genes in a colorectal cancer cell line. Through the experiment, the overexpression of NCKAP1 in blood and tissues of colorectal cancer patients, and the suppression of cancer cell migration, infiltration, and metastasis upon the downregulation of NCKAP1 were observed, with the consequent possibility confirmation of NCKAP1 for use as a novel colorectal cancer target. Therefore, effective use can be made of an expression level of NCKAP1 in colorectal cancer diagnosis, and of a NCKAP1 gene expression inhibitor ...

Подробнее
Номер записи: 39
07-09-2015 дата публикации

SUPERSENSITIVE METHOD FOR AMPLIFYING MUTATION AND PRIMER THEREFOR

Номер: KR1020150102455A
Автор: LEE, JUNG SHIN, CHOI, EUN KYUNG, JANG, SE JIN, SUH YOUNG AH, CHUN, SUNG MIN, KIM, TAE IM
Принадлежит:

The present invention relates to a supersensitive method for amplifying mutation and a primer therefor and, specifically, to a primer for amplifying mutation or single nucleotide polymorphism (SNP), comprising a complementary base sequence on mutation or SNP at a 3′ terminal end, and comprising a template base sequence and a miss-matched base sequence in a direction of a 5′ terminal end from the base sequence. According to the present invention, a primer for amplifying mutation or SNP and a method for amplifying mutation or SNP using the same are capable of selectively and intensively amplifying only genes having a specific base sequence with one gene amplification reaction, and specifically amplifying a mutant gene or SNP present at extremely low concentrations. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 40
27-05-2016 дата публикации

GASTRIC CANCER TARGETING PEPTIDE AND MEDICAL USE OF SAME

Номер: KR1020160059945A
Автор: CHOI, EUN KYUNG, JEONG, SEONG YUN, SONG, SI YEOL, LEE, KYOUNG JIN, SHIN, SEOL HWA, JU, EUN JIN
Принадлежит:

The present invention relates to a gastric cancer targeting peptide, a composition for diagnosing gastric cancer according to irradiation of radiation by using the same, and a drug delivery use. By considering a treatment problem in which there are different kinds of treatment reactivity and treatment cases differ by patients due to genetic difference between individual cancer patients, a functional peptide capable of targeting the same has been developed to ensure individual patient-customized diagnosis and treatment. An animal model which is similar to a cancer micro-environment of an actual patient is constructed, and is divided into a radiation-irradiated individual group and an individual group, provided as a control group thereof, to which radiation is not irradiated. Target efficiency has been verified with respect a peptide sorted by screening peptides specifically bonding to each of the individual group. Accordingly, the colorectal cancer targeting peptide may be finally utilized ...

Подробнее
Номер записи: 41
29-05-2015 дата публикации

SEMICONDUCTOR PACKAGE HAVING HEAT SPREADER

Номер: KR1020150058940A
Автор: CHOI, EUN KYOUNG, HAN, SANG UK, CHO, TAE JE
Принадлежит:

The present invention includes a substrate, a first semiconductor chip on the substrate, and a second semiconductor chip on the first semiconductor chip. A heat spreader can be formed on the first semiconductor chip. A heat transfer material layer which touches the first semiconductor chip and the heat spreader and covers the sides of the second semiconductor chip can be formed. Heat generated from the first semiconductor chip can be discharged through the heat transfer material layer and the heat spreader. Structural stability can be secured by dispersing thermal stress based on a difference of thermal expansion coefficient between the substrate and the first semiconductor chip. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 42
22-09-2016 дата публикации

METHOD FOR ISOLATING CIRCULATING CELL-FREE NUCLEIC ACID

Номер: KR1020160110902A
Автор: LEE, JUNG SHIN, CHOI, EUN KYUNG, JANG, SE JIN, CHUN, SUNG MIN, KIM, TAE IM, LEE, JI YOUNG, KIM, YU JIN
Принадлежит:

The present invention relates to a method for isolating circulating cell-free nucleic acid from a sample including the circulating cell-free nucleic acid, to a kit for isolating circulating cell-free nucleic acid, and to a dissolving buffer solution for isolating circulating cell-free nucleic acid. The method for isolating circulating cell-free nucleic acid from a sample including the circulating cell-free nucleic acid comprises the steps of: adding a solution including slats and polyethylene glycol (PEG) and magnetic beads into an isolated sample including circulating cell-free nucleic acid; and obtaining and isolating the magnetic beads from the sample in which the magnetic beads are added, and isolating the circulating cell-free nucleic acid therefrom. COPYRIGHT KIPO 2016 (AA) Unit : ng ...

Подробнее
Номер записи: 43
10-08-2016 дата публикации

SEMICONDUCTOR PACKAGE

Номер: KR1020160094768A
Автор: CHOI, EUN KYOUNG, JO, CHA JEA, HAN, SANG UK, CHO, TAE JE
Принадлежит:

The present invention provides a semiconductor package including a marking pattern on the side surface of the semiconductor package. The semiconductor package includes an upper surface, a lower surface, and a side surface. The marking pattern including information on a semiconductor chip is formed on the side surface of the semiconductor package. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 44
15-09-2016 дата публикации

METHOD OF SEPARATING CIRCULATING CELL-FREE NUCLEIC ACID

Номер: WO2016144137A1
Автор: LEE, Jung Shin, CHOI, Eun Kyung, JANG, Se Jin, CHUN, Sung Min, KIM, Tae Im, LEE, Ji Young, KIM, Yu Jin
Принадлежит:

The present invention relates to: a method of separating circulating cell-free nucleic acid from a sample including circulating cell-free nucleic acid; a circulating cell-free nucleic acid separating kit; and a dissolving buffer solution for separating circulating cell-free nucleic acid.

Подробнее
Номер записи: 45
25-08-2015 дата публикации

METHOD FOR DRIVING ORGANIC LIGHT EMITTING DISPLAY APPARATUS, AND ORGANIC LIGHT EMITTING DISPLAY APPARATUS

Номер: KR1020150096546A
Автор: PARK, JI EUN, LEE, DONG WON, CHOE, EUN GYEONG, WHANG, HEE CHUL
Принадлежит:

A method for driving an organic light emitting display apparatus in a digital driving method comprises the steps of: receiving input data; converting the input data into mapped data based on random data mapping information; selecting one sub-frame pattern among multiple sub-frame patterns, which are different from each other, based on the random data mapping information; and displaying an image according to the mapped data by using the selected sub-frame pattern. Therefore, the occurrence of dynamic false contour can be reduced. COPYRIGHT KIPO 2015 (AA) Start (S110) Receive input data (S130) Convert input data into mapped data based on random data mapping information (S150) Select one of the sub-frame patterns based on random data mapping information (S170) Display an image corresponding to mapped data using a selected sub-frame pattern (SBB) End ...

Подробнее
Номер записи: 46
11-03-2016 дата публикации

BIOMARKER FOR PREDICTING SENSITIVITY TO PROTEIN KINASE INHIBITOR AND USE OF SAME

Номер: KR1020160028399A
Автор: KIM, TAE WON, JIN, DONG HOON, HONG, SEUNG WOO, MOON, JAI HEE, SHIN, JAE SIK, LEE, HA REUM, CHOI, EUN KYOUNG, KIM, SEUNG MI, JUNG, SOO A, HA, SEUNG HEE, JUNG, HA NA, LEE, DAE HEE, JUNG, SEANG HWAN, LEE, JUNG SHIN, CHOI, EUN KYUNG, LEE, JAE LYUN, HONG, YONG SANG, KIM, KYU PYO, KIM, JEONG EUN, PARK, SEONG JOON, KIM, BONG CHOEL
Принадлежит:

The present invention relates to a biomarker for predicting sensitivity to a protein kinase inhibitor, and a use of the same. Provided are a marker, a composition, a kit, and a method for predicting sensitivity for a protein kinase inhibitor. According to the present invention, the biomarker excellently predicts sensitivity to a protein kinase inhibitor, thereby being used in cancer treatment. The biomarker for predicting sensitivity to a protein kinase inhibitor comprises active Recepteur d′origine nantais (RON). COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 47
04-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO PARP INHIBITOR, AND USE THEREOF

Номер: WO2016018089A1
Автор: KIM, Tae Won, JIN, Dong Hoon, HONG, Seung Woo, MOON, Jai Hee, SHIN, Jae Sik, HWANG, Ih Yeon, KIM, Jeong Hee, LEE, Ha Reum, CHOI, Eun Kyoung, KIM, Seung Mi, JUNG, Soo A, HA, Seung Hee, LEE, Dae Hee, LEE, Eun Young, LEE, Seul, LEE, Jung Shin, CHOI, Eun Kyung, LEE, Jae Lyun, HONG, Yong Sang, KIM, Kyu Pyo, KIM, Jeong Eun, PARK, Seong Joon, KIM, Bong Choel
Принадлежит:

The present invention relates to a novel biomarker for predicting sensitivity to a poly ADP ribose polymerase (PARP) inhibitor, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the PARP inhibitor, the biomarker comprising the p53 gene and/or the DNA-dependent protein kinase (DNA-PK) gene; a composition for predicting sensitivity to the PARP inhibitor, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression of the protein of the gene; a kit for predicting sensitivity to the PARP inhibitor, the kit comprising the composition; a method for predicting sensitivity to the PARP inhibitor; a sensitivity enhancer for enhancing the sensitivity of a subject to the PARP inhibitor; and a pharmaceutical composition for preventing or treating cancer, the pharmaceutical composition comprising, as active ingredients, the sensitivity enhancer ...

Подробнее
Номер записи: 48
06-01-2017 дата публикации

위암 표적용 펩타이드 및 이의 의학적 용도

Номер: KR0101693431B1
Автор: 최은경, 정성윤, 송시열, 이경진, 신설화, 주은진
Принадлежит: 울산대학교 산학협력단

... 본 발명은 위암 표적용 펩타이드 및 이를 이용한 방사선 조사 여부에 따른 위암 진단용 조성물 및 약물전달 용도에 관한 것으로서, 암 발병환자 개개인의 유전적 차이로 인해 치료 반응성이 달라 환자별 치료사례가 달라짐에 따라 치료 시 문제점을 염두에 두고, 환자 개인별 맞춤형 진단 및 치료를 구현하고자 이를 표적할 수 있는 기능성 펩타이드를 발굴하였다. 실제 환자의 암 미세환경과 유사한 동물모델을 구축하여 방사선 조사한 개체군과 그의 대조군으로 방사선을 조사하지 않은 개체군으로 구분하고, 각 개체군에 특이적으로 결합하는 펩타이드를 스크리닝하여 선별된 펩타이드에 대해 각각의 표적효율을 검증하였다. 이를 통해 최종적으로 방사선 치료 반응성을 예측하기 위한 영상진단 기술 개발 및 그에 따른 맞춤형 표적 치료제 개발에 활용될 수 있다.

Подробнее
Номер записи: 49
21-06-2017 дата публикации

불멸화 신경줄기세포를 유효성분으로 포함하는 뇌경색 또는 뇌졸중 예방 및 치료용 약제학적 조성물

Номер: KR0101749410B1
Автор: 김윤배, 김지현, 신경하, 최은경
Принадлежит: 충북대학교 산학협력단

... 본 발명은 불멸화 신경줄기세포, 이의 배양액 또는 이의 추출물의 뇌경색(뇌졸증) 치료 용도에 관한 것이다. 본 발명에 따른 불멸화 신경줄기세포로서, 특히 콜린 아세틸트랜스퍼라아제 유전자가 도입된 형질전환 불멸화 신경줄기세포는 뇌경색 동물모델에 적용하는 경우 뇌경색의 부피를 효과적으로 감소시키고; 뇌 조직 내 지질과산화물 및 일산화탄소와 같은 염증유발물질의 억제하며; 뇌 조직 내 염증성 사이토카인의 발현을 억제하고; 뇌 보호 효과가 우수하므로, 궁극적으로 뇌경색 또는 뇌졸증을 예방 및 치료할 수 있는 약학적 조성물로 유용하게 사용할 수 있다.

Подробнее
Номер записи: 50
23-11-2016 дата публикации

적층 패키지, 반도체 패키지 및 적층 패키지의 제조 방법

Номер: KR0101678539B1
Автор: 이충선, 김정환, 임윤혁, 황지환, 김현철, 최광철, 최은경, 민태홍
Принадлежит: 삼성전자 주식회사

... 본 발명은 3차원 시스템-인-패키지(SIP)에 사용될 수 있는 적층 패키지에 관한 것이다. 적층 패키지는 제 1 반도체 칩, 제 2 반도체 칩 및 지지 부재를 포함한다. 제 1 반도체 칩은 관통 전극을 구비한다. 제 2 반도체 칩은 제 1 반도체 칩의 상면 상에 적층되며, 제 1 반도체 칩의 관통 전극을 통해 제 1 반도체 칩과 전기적으로 연결된다. 지지 부재는 제 2 반도체 칩의 테두리로부터 이격하여 상기 제 1 반도체 칩의 상면 상에 부착된다.

Подробнее
Номер записи: 51
20-04-2017 дата публикации

FFPE 조직에서 핵산의 분리 방법

Номер: KR0101728096B1
Автор: 장세진, 천성민, 김태임, 이정신, 최은경
Принадлежит: 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 본 발명은 FFPE(formalin-fixed, paraffin-embedded) 조직 절편을 포함하는 시료로부터 핵산을 분리하는 방법, 핵산 분리 키트 및 핵산 분리를 위한 용해 완충액에 관한 것이다.

Подробнее
Номер записи: 52
13-12-2016 дата публикации

ELECTRONIC FRAME USING ELECTRONIC TAG

Номер: KR1020160142553A
Автор: CHOI, EUN KYUNG
Принадлежит:

The present invention relates to an electronic frame using an electronic tag. According to an embodiment of the present invention, the electronic frame using an electronic tag comprises: a photo mounting unit which includes two plates connected though a hinge by connecting one sides thereof, wherein a photo or a picture is mounted on one surface thereof; the electronic tag which is formed on the other surface of the photo mounting tag and transmits additional information on the photo or the picture as an electric signal; and an electronic tag accommodation unit which is pivotably connected to the other side of the photo mounting unit and has one surface to which the electronic tag is attached. Therefore, the additional information on the photo can be provided by using the electronic tag and the additional information can be provided as an image though a user terminal. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 53
19-10-2017 дата публикации

SYSTEM AND METHOD FOR RECOGNIZING SIGN LANGUAGE

Номер: KR1020170116332A
Автор: KIM, YOUNG HO, KIM, SEONG JUNG, LEE, HAN SOO, JEONG, YOUNG JAE, CHOI, EUN KYOUNG, KIM, JONG MAN, JO, MIN
Принадлежит:

The present invention relates to a sign language recognition system which is easy to carry without limiting an operation of everyday life. The sign language recognition system comprises: an acquisition unit for acquiring an inertia signal and an electromyographic signal of a user from a sensor measurement device worn on an arm part of the user; an extraction unit for extracting a muscle activation period from the electromyographic signal, and extracting a motion period of the arm part from the inertia signal in order to sense a sign language motion made by the user; a calculation unit for calculating a first characteristics vector by performing signal processing on the muscle activation period, and calculating a second characteristics vector by performing the signal processing on the motion period; a search unit for searching a signal corresponding to an integrated characteristics vector in a database based on the integrated characteristics vector integrating the first and second characteristics ...

Подробнее
Номер записи: 54
05-03-2018 дата публикации

FLEXIBLE DISPLAY DEVICE

Номер: KR1020180021540A
Автор: CHOI, EUN KYUNG, SHIN, WOOK, CHOI, YOO JIN
Принадлежит:

A flexible display device according to an embodiment of the present invention includes a flexible display part including a front display and a rear display for displaying content information, and a control part for displaying association information related to a selected content item on the rear display when the content item included in the content information is selected through a pointing point in the bent state of the flexible display part. It is possible to quickly provide information which a user wants. COPYRIGHT KIPO 2018 (S501) Displaying content information on a front surface of a display part (S503) Detecting a display is bent (S505) Is a content item included in the content information displayed on a front surface selected through a pointing point of the bent display? (S507) Displaying association information related to a selected content item on a rear surface of a bent display part (S509) Is an empty area on the front surface selected through the pointing point of the bent display ...

Подробнее
Номер записи: 55
07-10-2015 дата публикации

Mobile Terminal And Method Of Setting Items Using The Same

Номер: KR0101558207B1
Автор: 김준희, 최은경, 박혜경, 서경혜, 이선정, 유지혜
Принадлежит: 엘지전자 주식회사

... 본 발명은 이동 단말기 및 이동 단말기의 아이템 설정 방법을 제공한다. 본 발명은, 복수의 아이템들을 포함하는 그래픽사용자인터페이스에서, 아이템의 위치를 편리하게 설정할 수 있는 이동 단말기 및 이동 단말기의 아이템 설정 방법을 제공한다.

Подробнее
Номер записи: 56
28-08-2015 дата публикации

SOIL COMPOSITION FOR GREENING, MANUFACTURING METHOD THEREOF, AND REVEGETATION METHOD USING SAME

Номер: KR101548006B1
Автор: ROH, CHAN GEE, CHOI, EUN KYOUNG, LEE, KYUNG HWAN, KIM, JONG SIL, CHOI, BONG KIL, KIM, HYEONG KYU, SIM, SE YOUNG
Принадлежит: KUNHWA CO., LTD., YES ONE CORPORATION

The present invention relates to a soil composition for greening, a manufacturing method thereof, and a revegetation method using the same, for improving soil in a tree planting area such as a seashore landfill, a landfill, a park, a green area, a line of trees, a unproductive land, etc. The soil composition is capable of inducing early rooting of a tree root in soil in the tree planting area and improving environment for growth and development of trees by comprising 7 wt% of cocopeat, 50 wt% of leaf mold, 20 wt% of bottom ash, 10 wt% of peat-moss, 5 wt% of vermiculite, 5 wt% of a rooting compound, and 3 wt% of a microbial agent (VK81) 3. COPYRIGHT KIPO 2015 (S10) Preparing a raw material (S20) Producing a first mixture (S30) Producing a second mixture (S40) Selecting (S50) Measuring (S60) Packaging ...

Подробнее
Номер записи: 57
04-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT, AND USE THEREOF

Номер: WO2016018087A1
Автор: KIM, Tae Won, JIN, Dong Hoon, HONG, Seung Woo, MOON, Jai Hee, SHIN, Jae Sik, HWANG, Ih Yeon, KIM, Jeong Hee, LEE, Ha Reum, CHOI, Eun Kyoung, KIM, Seung Mi, JUNG, Soo A, HA, Seung Hee, LEE, Dae Hee, LEE, Eun Young, LEE, Seul, LEE, Jung Shin, CHOI, Eun Kyung, LEE, Jae Lyun, HONG, Yong Sang, KIM, Kyu Pyo, KIM, Jeong Eun, PARK, Seong Joon, KIM, Bong Choel
Принадлежит:

The present invention relates to a novel biomarker for predicting sensitivity to an epidermal growth factor receptor (EGFR)-targeting agent, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the EGFR-targeting agent, the biomarker comprising the Recepteur d'Origine Nantais (RON) gene; a composition for predicting sensitivity to the EGFR-targeting agent, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression or activity of the protein of the gene; a composition for enhancing sensitivity to the EGFR-targeting agent, the composition comprising, as an active ingredient, an inhibitor inhibiting the expression of the gene, or the expression or activity of the protein of the gene; a kit for predicting sensitivity to the EGFR-targeting agent, the kit comprising the compositions; and a method for predicting sensitivity to the EGFR-targeting ...

Подробнее
Номер записи: 58
26-10-2016 дата публикации

METHOD AND DEVICE FOR DETECTING FALL

Номер: KR1020160123642A
Автор: KIM, YOUNG HO, AHN, SOON JAE, SHIN, I SU, RYU, JE SEONG, CHOI, EUN KYOUNG, KIM, JONG MAN, CHA, BAEK DONG
Принадлежит:

A method for detecting a fall comprises: a step of measuring first to third acceleration corresponding to a user from a fall detection device; a step of measuring a first to a third angular velocity corresponding to the user; a step of determining an acceleration value for the user based on at least one among the first to the third acceleration; a step of determining an angular velocity value for the user based on at least one among the first and the second angular velocity; a step of determining an angle value for the user based on at least one among the first to the third acceleration; a step of detecting a fall of the user based on at least one among the acceleration value, the angular velocity value, and the angle value; and a step of outputting information corresponding to the detected fall. COPYRIGHT KIPO 2016 (10) Acceleration measurement unit (11) Angular velocity measurement unit (20) Acceleration value determination unit (21) Angular velocity value determination unit (22) Angle ...

Подробнее
Номер записи: 59
31-05-2018 дата публикации

단백질 키나제 억제제에 대한 감수성 예측용 바이오 마커 및 이의 용도

Номер: KR0101862719B1
Автор: 김태원, 진동훈, 홍승우, 문재희, 신재식, 이하름, 최은경, 김승미, 정수아, 하승희, 정하나, 이대희, 정승환, 이정신, 이재련, 홍용상, 김규표, 김정은, 박성준, 김봉철
Принадлежит: 웰마커바이오 주식회사

... 본 발명은 단백질 키나제 억제제에 대한 감수성 예측용 바이오 마커 및 이의 용도에 관한 것으로, 단백질 키나제 억제제에 대한 감수성 예측용 마커, 조성물, 키트 및 예측 방법을 제공한다. 본 발명에 따르면, 단백질 키나제 억제제에 대한 감수성 예측 효과가 우수하므로, 본 발명은 암 치료에 유용하게 이용될 수 있다.

Подробнее
Номер записи: 60
15-06-2017 дата публикации

AIRBAG GAS INJECTION DEVICE

Номер: KR101747671B1
Автор: KIM, YOUNG HO, RYU, JE SEONG, AHN, SOON JAE, CHOI, EUN KYOUNG, JO, MIN, LEE, KYU DAE, SONG, JAE HOON
Принадлежит: UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS

An airbag gas injection device is disclosed. According to the present invention, the airbag gas injection device comprises: a sensor unit detecting an external shock; a burst unit bursting a sphere in accordance with detection of the sensor unit; an inflator having a moving path in which the burst sphere is moved and a firing pin arranged in a dead end of the moving path; and a cartridge having compressed gas expanding an airbag. With a blow of the burst sphere and the firing pin, a cover of the cartridge is broken to discharge the compressed gas. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 61
30-06-2016 дата публикации

MOBILE TERMINAL AND METHOD FOR CONTROLLING SAME

Номер: KR1020160076263A
Автор: CHOI, EUN KYUNG, LEE, JI YOUN, SUH, MEE OHK, CHOI, JIN HAE
Принадлежит:

The present invention relates to a mobile terminal and a method for controlling the same, which can easily and conveniently check an event generated from the mobile terminal even in a state in which a display unit of the mobile terminal is turned off. The mobile terminal of the present invention comprises: the display unit divided into a plurality of touch areas; a memory for storing applications mapped to the respective touch areas; a sensing unit for sensing a first touch input applied to a first touch area among the divided touch areas when the display unit is turned off; a control unit for detecting an event generated through a first application mapped to the first touch area among the applications based on the first touch input and generating a first vibration pattern corresponding to the detected event; and a haptic module for generating vibration according to the first vibration pattern. COPYRIGHT KIPO 2016 (AA) Start (BB) End (S11) Turn off a display unit of a mobile terminal (S12 ...

Подробнее
Номер записи: 62
04-04-2017 дата публикации

DEGRADATION COMPENSATION DEVICE AND DISPLAY DEVICE INCLUDING SAME

Номер: KR1020170036938A
Автор: CHOE, EUN GYEONG
Принадлежит:

A degradation compensation device comprises: a degradation determination unit for determining whether pixels connected to sensing lines are degraded through the sensing lines; a sensing unit for setting a first area including at least one pixel connected to a sensing line in which degradation is detected and a second area including pixels adjacent to the first area, and sensing first sensing data of the first area and second sensing data of the second area; a degradation calculation unit for determining whether the first area is degraded based on the first sensing data and the second sensing data, and calculating a degradation compensation amount of the first area; a luminance calculation unit for calculating a luminance compensation amount that compensates luminance of the first area based on the degradation compensation amount; a color difference calculation unit for calculating a color difference compensation amount that compensates color difference of the first area based on the degradation ...

Подробнее
Номер записи: 63
02-07-2018 дата публикации

수화 인식 시스템 및 방법

Номер: KR0101873031B1
Автор: 김영호, 김성중, 이한수, 정영재, 최은경, 김종만, 조민
Принадлежит: 연세대학교 원주산학협력단

... 수화 인식 시스템에 관한 것이며, 수화 인식 시스템은 사용자의 팔 부위에 착용된 센서 측정 기기로부터 상기 사용자의 근전도 신호 및 관성 신호를 획득하는 획득부, 상기 사용자가 취한 수화 동작을 감지하기 위해, 상기 근전도 신호에서 근활성 구간을 추출하고, 상기 관성 신호에서 상기 팔 부위의 움직임 구간을 추출하는 추출부, 상기 근활성 구간에 신호처리를 수행함으로써 제1 특성 벡터를 산출하고, 상기 움직임 구간에 신호처리를 수행함으로써 제2 특성 벡터를 산출하는 산출부, 상기 제1 특성 벡터와 상기 제2 특성 벡터를 통합한 통합 특성 벡터에 기초하여, 데이터베이스 내에서 상기 통합 특성 벡터에 대응되는 신호를 검색하는 검색부 및 상기 검색된 신호에 대응하는 텍스트를 출력하는 출력부를 포함할 수 있다.

Подробнее
Номер записи: 64
24-05-2017 дата публикации

CATALYST FOR SYNTHESIZING ALCOHOL, PRODUCTION METHOD THEREOF, AND USE THEREOF

Номер: KR1020170057168A
Автор: KIM, HAK JOO, JEONG, SOON KWAN, KANG, SEONG PIL, PARK, KI TAE, YOUN, MIN HYE, SONG, KYOUNG HO, CHOI, EUM KYUNG
Принадлежит:

The present invention relates to a catalyst comprising: a particle containing copper oxide (CuO) and zinc oxide (ZnO); and a porous coating layer containing metal aluminium oxyhydroxide formed on a surface of the particle. The present invention further relates to a production method thereof, and a use thereof. The catalyst of the present invention prevents sintering of copper which is an activation site for the catalyst, thereby increasing stability of the catalyst and consistently maintaining activities. Additionally, the catalyst is reduced at a relatively low temperature. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 65
21-02-2018 дата публикации

CITRULLINATED MYELIN BASIC PROTEIN MONOCLONAL ANTIBODIES AND DIAGNOSTIC KIT FOR NEURODEGENERATIVE DISEASES USING SAME

Номер: KR1020180017929A
Автор: CHOI, EUN KYOUNG, KIM, YONG SUN, JANG, BYUNG KI
Принадлежит:

The present invention provides a monoclonal antibody capable of detecting MBP citrullination occurring in neurodegenerative diseases such as CJD, scrapie disease, prion disease, Alzheimer′s and the like. The present invention provides a monoclonal antibody and an antigen-binding fragment thereof which specifically bind to the citrullinated MBP protein and do not substantially react with the non-citrullinated MBP protein. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 66
07-07-2011 дата публикации

POLYMER NANOPARTICLE INJECTION FORMULATION COMPOSITION CONTAINING RAPAMYCIN WITH IMPROVED WATER SOLUBILITY, PREPARATION METHOD THEREOF, AND ANTICANCER COMPOSITION FOR COMBINED USE WITH RADIOTHERAPY

Номер: WO2011081430A3
Автор: KANG, Hye Won, SEO, Min Hyo, LEE, Sa Won, KIM, Bong Oh, CHOI, Eun Kyung, JEONG, Seong Yun, WOO, Ha Na
Принадлежит:

The present invention relates to a polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, and more specifically, to an injection formulation composition containing rapamycin wherein water solubility is improved by solubilizing rapamycin having low water solubility with polymer nanoparticles, a preparation method thereof, and an anticancer composition for a combined use with radiotherapy.

Подробнее
Номер записи: 67
04-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO MET INHIBITOR, AND USE THEREOF

Номер: WO2016018088A1
Автор: KIM, Tae Won, JIN, Dong Hoon, HONG, Seung Woo, MOON, Jai Hee, SHIN, Jae Sik, HWANG, Ih Yeon, KIM, Jeong Hee, LEE, Ha Reum, CHOI, Eun Kyoung, KIM, Seung Mi, JUNG, Soo A, HA, Seung Hee, LEE, Dae Hee, LEE, Eun Young, LEE, Seul, LEE, Jung Shin, CHOI, Eun Kyung, LEE, Jae Lyun, HONG, Yong Sang, KIM, Kyu Pyo, KIM, Jeong Eun, PARK, Seong Joon, KIM, Bong Choel
Принадлежит:

The present invention relates to a novel biomarker for predicting sensitivity to an MET inhibitor, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the MET inhibitor, the biomarker comprising the Immunoglobulin Superfamily member 1 (IGSF1, NM_001555.2) gene; a composition for predicting sensitivity to the MET inhibitor, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression of the protein of the gene; a pharmaceutical composition for treating diseases related to the dysregulation of the MET signaling pathway, the pharmaceutical composition comprising, as an active ingredient, an inhibitor inhibiting the expression of the gene in the biomarker, or the expression or activity of the protein of the gene; a kit for predicting sensitivity to the MET inhibitor, the kit comprising the compositions; and a method for predicting sensitivity ...

Подробнее
Номер записи: 68
08-06-2015 дата публикации

WATCH-TYPE MOBILE TERMINAL AND METHOD FOR CONTROLLING SAME

Номер: KR1020150062761A
Автор: LEE, SUN JUNG, CHOI, EUN KYUNG, HAN, MI RAN, JUNG, EUN SOO
Принадлежит:

The present invention relates to a mobile terminal and, more specifically, to a watch-type mobile terminal formed to be wearable on the wrist and a method for controlling the same. The watch-type mobile terminal formed to be wearable on the wrist according to an embodiment of the present invention comprises: a body disposed on the wrist; a display unit mounted on the body to output watch information and enabling a touch input; a situation information unit for collecting situation information of surroundings based on the body; and a control unit for applying the collected situation information to the watch information outputted to the display unit. COPYRIGHT KIPO 2015 (AA) Start (BB) End (S410) Output watch information on a display unit (S420) Collect situation information of surroundings of a watch-type mobile terminal formed to be wearable on the wrist (S430) Apply the collected situation information to the watch information outputted to the display unit ...

Подробнее
Номер записи: 69
02-04-2018 дата публикации

PARP 저해제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도

Номер: KR0101844541B1
Автор: 김태원, 진동훈, 홍승우, 문재희, 신재식, 황이연, 김정희, 이하름, 최은경, 김승미, 정수아, 하승희, 이대희, 이은영, 이슬, 이정신, 이재련, 홍용상, 김규표, 김정은, 박성준, 김봉철
Принадлежит: 재단법인 아산사회복지재단

... 본 발명은 PARP 저해제에 대한 감수성을 예측하기 위한 신규한 바이오 마커 및 이의 용도에 관한 것으로, 보다 상세하게는, p53 유전자 및/또는 DNA-PK(DNA-dependent protein kinase) 유전자를 포함하는, PARP(poly ADP ribose polymerase) 저해제에 대한 감수성 예측용 바이오 마커; 상기 바이오 마커의 유전자 발현 수준; 또는 상기 유전자의 단백질의 발현 수준을 측정하는 제제를 포함하는, PARP 저해제에 대한 감수성 예측용 조성물; 상기 조성물을 포함하는 PARP 저해제에 대한 감수성 예측용 키트; PARP 저해제에 대한 감수성 예측 방법; 대상의 PARP 저해제에 대한 감수성 증진제; 및 상기 감수성 증진제 및 PARP 저해제를 유효성분으로 포함하는, 암의 예방 또는 치료용 약학적 조성물을 제공한다. 본 발명에 따르면, PARP 저해제에 대한 감수성 예측 효과가 우수하므로, 본 발명은 대장암 치료에 유용하게 이용될 수 있다.

Подробнее
Номер записи: 70
18-04-2013 дата публикации

EMULSIFIED HYDROGEL COMPOSITION AND A PRODUCTION METHOD THEREFOR

Номер: WO2013055041A1
Автор: KIM, Sung Jang, PARK, Hyoung-Il, CHO, Jae Han, CHOI, Eun Kyoung, KWAK, Jae hoon, LIM, Jae Min, LIM, Hyun Jun, KIM, Jai Hyun, KIM, Min Seok, YANG, Jin A, YOO, Hyun Oh, KIM, Jong Chul
Принадлежит:

The present invention relates to an emulsified hydrogel composition and to a production method therefor, wherein, by incorporating between 20 and 30 percent by weight of a gelling solution and an emulsion obtained by mixing between 45 and 60 percent by weight of an aqueous component and between 15 and 30 percent by weight of an oil component, it is possible to simultaneously provide the skin with an aqueous fraction and an oil fraction, and it is possible to enhance functionality due to the inclusion of a high content of a dermatologically active component dissolved in the oil component.

Подробнее
Номер записи: 71
10-11-2016 дата публикации

환자유래 일차배양 암세포의 배양방법 및 일차배양 암세포를 이용하여 제작된 암 환자와 동일한 이종 이식 동물모델의 구축 방법

Номер: KR0101674468B1
Автор: 설향숙, 장세진, 이정신, 최은경, 서영아, 정성윤
Принадлежит: 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 종양세포의 일차 배양 방법 및 이를 이용하여 제작된 암 환자와 동일한 이종 이식 동물모델의 구축에 관한 것이다. 본 발명의 암 조직을 바로 이식하지 않고 종양세포를 배양 후 이식하는 방법은, 적은 양의 세포에서 많은 양의 세포로 증식 및 유지가 가능하며, 언제든지 종양세포를 배양할 수 있는 이점이 있다. 또한, 본 발명의 이종 이식 동물모델은 항암제를 스크리닝하는데 유용하게 사용될 수 있고, 짧은 시간에 환자 맞춤형 항암제를 선별할 수 있어, 새로운 치료법을 개발하는데 유용하게 사용될 수 있다.

Подробнее
Номер записи: 72
11-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSIBILITY TO MET INHIBITOR, AND USES THEREOF

Номер: KR1020160014564A
Автор: KIM, TAE WON, JIN, DONG HOON, HONG, SEUNG WOO, MOON, JAI HEE, SHIN, JAE SIK, HWANG, IH YEON, KIM, JEONG HEE, LEE, HA REUM, CHOI, EUN KYOUNG, KIM, SEUNG MI, JUNG, SOO A, HA, SEUNG HEE, LEE, DAE HEE, LEE, EUN YOUNG, LEE, SEUL, LEE, JUNG SHIN, CHOI, EUN KYUNG, LEE, JAE LYUN, HONG, YONG SANG, KIM, KYU PYO, KIM, JEONG EUN, PARK, SEONG JOON, KIM, BONG CHOEL
Принадлежит:

The present invention relates to a novel biomarker for predicting sensibility to an MET inhibitor, and uses thereof. Particularly, an objective of the present invention is to provide: a biomarker for predicting sensibility to an MET inhibitor containing immunoglobulin superfamily member 1 (IGSF1, NM_001555.2) genes; a sensibility predicting composition capable of sensing the sensibility of an MET inhibitor, containing a product for measuring the expression level of the genes of the biomarker or protein thereof; a pharmaceutical composition for curing diseases related to adjusting malfunctions in the path of transmitting signals of MET, containing an inhibitor which inhibits the expression or activeness of protein of the genes or the expression of the genes of the biomarker as an active component; a sensitivity predicting kit for an MET inhibitor containing the composition; and a method of predicting sensitivity to an MET inhibitor. The present invention is excellent in predicting the sensibility ...

Подробнее
Номер записи: 73
21-12-2017 дата публикации

BIOMARKER COMPRISING NCKAP1 AS EFFECTIVE INGREDIENT FOR DIAGNOSING COLORECTAL CANCER OR FOR PREDICTING METASTASIS AND PROGNOSIS OF COLORECTAL CANCER

Номер: WO2017217807A9
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Jae Hee
Принадлежит:

The present invention relates to a biomarker composition comprising NCK-Associated Protein 1 (NCKAP1) as an effective ingredient for diagnosis of colorectal cancer or for prediction of the metastasis and prognosis of colorectal cancer. In brief, new colorectal cancer target candidates were excavated by massive gene expression analysis in bloods of human colorectal cancer tissue-transplanted mouse models, and were experimentally assayed by downregulatng the expression of the target candidate genes in a colorectal cancer cell line. Through the experiment, the overexpression of NCKAP1 in blood and tissues of colorectal cancer patients, and the suppression of cancer cell migration, infiltration, and metastasis upon the downregulation of NCKAP1 were observed, with the consequent possibility confirmation of NCKAP1 for use as a novel colorectal cancer target. Therefore, effective use can be made of an expression level of NCKAP1 in colorectal cancer diagnosis, and of a NCKAP1 gene expression inhibitor ...

Подробнее
Номер записи: 74
07-07-2011 дата публикации

POLYMER NANOPARTICLE INJECTION FORMULATION COMPOSITION CONTAINING RAPAMYCIN WITH IMPROVED WATER SOLUBILITY, PREPARATION METHOD THEREOF, AND ANTICANCER COMPOSITION FOR COMBINED USE WITH RADIOTHERAPY

Номер: KR2011081430A2
Автор: KANG, Hye Won, SEO, Min Hyo, LEE, Sa Won, KIM, Bong Oh, CHOI, Eun Kyung, JEONG, Seong Yun, WOO, Ha Na
Принадлежит:

The present invention relates to a polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, and more specifically, to an injection formulation composition containing rapamycin wherein water solubility is improved by solubilizing rapamycin having low water solubility with polymer nanoparticles, a preparation method thereof, and an anticancer composition for a combined use with radiotherapy.

Подробнее
Номер записи: 75
20-04-2017 дата публикации

폐암관련 돌연변이 증폭용 프라이머 세트, 및 상기 돌연변이에 상보적인 프로브를 포함하는, 폐암 진단용 키트

Номер: KR0101720050B1
Автор: 이정신, 최은경, 장세진, 서영아, 천성민
Принадлежит: 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 본 발명은 EGFR, KRAS, BRAF 및 PIK3CA 유전자를 증폭할 수 있는 프라이머 세트; 및 상기 유전자의 돌연변이에 상보적인 프로브를 포함하는, 폐암 진단용 키트 및 이를 이용하여 폐암을 진단하는 방법에 관한 것이다. 본 발명에 따른 폐암 진단용 키트를 이용하는 경우, 종래 사용하는 서열분석법보다 매우 높은 감도로, 113의 DNA 돌연변이를 동시에 확인 할 수 있는 바, 임상 시료 사용량이 현저히 감소되며, 비용, 인력 및 소요 시간 감소 효과가 예상된다.

Подробнее
Номер записи: 76
02-10-2014 дата публикации

COMPOSITION FOR TREATMENT OR METASTASIS SUPPRESSION OF CANCERS WHICH INCLUDES P34 EXPRESSION INHIBITOR OR ACTIVITY INHIBITOR AS ACTIVE INGREDIENT

Номер: WO2014157965A1
Автор: KIM, Tae Won, JIN, Dong Hoon, HONG, Seung Woo, MOON, Jai Hee, SHIN, Jae Sik, KIM, Jin Sun, JUNG, Kyung Ah, LEE, Jung Shin, CHOI, Eun Kyung, LEE, Jae Lyun, HONG, Yong Sang, KIM, Kyu Pyo, NAM, Ky Youb, KIM, Bong Cheol
Принадлежит:

The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumours is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumour forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

Подробнее
Номер записи: 77
17-03-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CEREBRAL INFARCTION AND STROKE COMPRISING IMMORTALIZED NEURAL STEM CELLS AS ACTIVE INGREDIENTS

Номер: KR1020170030216A
Автор: KIM, YUN BAE, KIM, JI HYUN, SHIN, KYUNG HA, CHOI, EHN KYOUNG
Принадлежит:

The present invention relates to immortalized neural stem cells, a use of a culture medium thereof or an extract thereof for treating cerebral infarction (stroke). The immortalized neural stem cells of the present invention, in particular, transgenic and immortalized neural stem cells in which choline acetyltransferase gene were introduced, effectively reduce the volume of the cerebral infarction when applied to a cerebral infarction animal model; inhibit an inflammation-inducing substance such as a lipid peroxide and a carbon monoxide in brain tissue; inhibit the expression of inflammatory cytokines in the brain tissue; and are excellent in protecting the brain. Ultimately, the present invention can be usefully used as the pharmaceutical composition capable of preventing and treating cerebral infarction or stroke. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 78
22-05-2014 дата публикации

STICKY HYDROGEL COSMETIC COMPOSITION

Номер: WO2014077519A1
Автор: YOO, Hyun-Oh, KIM, Jong-Chul, YANG, Jin-A, CHOI, Eun-Kyoung, KIM, Min-Seok
Принадлежит:

The present invention relates to a sticky hydrogel cosmetic composition. According to the present invention, the sticky hydrogel cosmetic composition containing 0.1 to 1 wt% of sodium polyacrylate having an Na substitution degree of at least 50% as a hydrophilic polymer forms hydrogel containing a sufficient amount of a sticky mucilaginous substance while having excellent stability in formulation. Therefore, the present invention has excellent adhesiveness when applied to the skin, thereby allowing the absorption of moisture and ingredients into the skin to be maximized. Thus, the present invention can be widely used for the development of various cosmetics such as a mask pack.

Подробнее
Номер записи: 79
11-02-2016 дата публикации

NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT AND USE THEREOF

Номер: KR1020160014563A
Автор: KIM, TAE WON, JIN, DONG HOON, HONG, SEUNG WOO, MOON, JAI HEE, SHIN, JAE SIK, HWANG, IH YEON, KIM, JEONG HEE, LEE, HA REUM, CHOI, EUN KYOUNG, KIM, SEUNG MI, JUNG, SOO A, HA, SEUNG HEE, LEE, DAE HEE, LEE, EUN YOUNG, LEE, SEUL, LEE, JUNG SHIN, CHOI, EUN KYUNG, LEE, JAE LYUN, HONG, YONG SANG, KIM, KYU PYO, KIM, JEONG EUN, PARK, SEONG JOON, KIM, BONG CHOEL
Принадлежит:

The present invention relates to a novel biomarker for predicting sensitivity to an epidermal growth factor receptor (EGRF)-targeting agent, and use thereof. More specifically, the present invention provides: the biomarker for predicting sensitivity to the (EGRF)-targeting agent; a composition for predicting sensitivity to the (EGRF)-targeting agent which includes an agent for measuring a level of gene expression of the biomarker, expression of protein of the genes, or an activity level of the gene; a composition for increasing sensitivity to the (EGRF)-targeting agent which includes an agent for suppressing expression of the gene, expression of the protein of the gene, or activity of the gene; a kit for predicting sensitivity to the (EGRF)-targeting agent including the composition; and a method for predicting sensitivity to the (EGRF)-targeting agent. According to the present invention, the biomarker of the present invention has an excellent effect of predicting sensitivity to the (EGRF ...

Подробнее
Номер записи: 80
25-05-2018 дата публикации

PACKING PAPER FOR EASY FOOD PACKAGE AND FORMING APPARATUS THEREOF

Номер: KR1020180055102A
Автор: CHAE, EN KYUNG
Принадлежит:

The present invention relates to a packing paper capable of easily packing food and a forming apparatus for forming the packing paper with a release tape attached to one side thereof. The packing paper includes a release tape attached to the packing paper by an adhesive solution which is fed onto an inside of the packing paper by an adhesive feeding unit. The forming device includes a first winder wound by the packing paper; a second winder wound by the release tape; a first transfer roller for transferring the packing paper from the first winder; a second transfer roller for transferring the release paper from the second winder; an adhesive feeding unit for feeding an adhesive solution onto an inside of the packing paper; a rod connected to the adhesive feeding unit to guide movement of the adhesive feeding unit; a sealing pressing/cutting unit for momentarily stopping the packing paper or pressing and cutting the release tape; a paper feeding roller for transferring the packing paper ...

Подробнее
Номер записи: 81
02-06-2015 дата публикации

APPARATUS FOR DECOCTING SOLID EXTRACT

Номер: KR101525075B1
Автор: CHOI, EUN KYEONG
Принадлежит: CHOI, EUN KYEONG

The present invention relates to an apparatus for decocting a solid extract allowing to continuously heat a pottery unit which is made of ceramic and accommodates a solid extract and continuously decoct the solid extract accommodated in the pottery unit so as to extract an extract containing a large amount of beneficial components, the apparatus comprising: a burner unit which generates heat; and a pottery unit which is disposed in an upper part of the burner unit and heated by the heat provided from the burner unit, and which accommodates water and a solid extract in space for decocting, wherein the apparatus is configured to extract an extract containing components included in a solid extract. The pottery unit includes a heating container which is made of a ceramic material and secures the space for decocting; and a cover which covers an inlet formed in the space for decocting of the heating container, wherein tray elements for arranging trays are arranged in the space for decocting of ...

Подробнее
Номер записи: 82
25-05-2018 дата публикации

TERMINAL AND CONTROL METHOD THEREOF

Номер: KR1020180055351A
Автор: CHOI, EUN KYUNG, JOO, GO EUN, JANG, HYUNG TAE, YOON, SUNG HYE, CHOI, YOO JIN
Принадлежит:

The present invention relates to a terminal and an operating method thereof. The terminal executes at least one task. The terminal displays information about the at least one task which is executed and a soft key in a first region and displays a function indicator related to the information displayed in the first region in a second region which is a partial region of the display unit. Accordingly, the present invention can provide a control user interface for the task which is executed, to a user. COPYRIGHT KIPO 2018 (S210) Execute at least one task (S220) Display information about a soft key and at least one task being executed in a first region (S230) Display a function indicator associated with the information displayed in the first region in a second region (S240) Obtain a selection input for selecting at least one function indicator displayed in the second region (S250) Perform the function corresponding to the selected function indicator ...

Подробнее
Номер записи: 83
31-05-2019 дата публикации

BIOMARKER COMPOSITION FOR DIAGNOSING RADIATION-RESISTANT CANCER OR FOR PREDICTING PROGNOSIS OF RADIATION THERAPY CONTAINING PMVK AS ACTIVE INGREDIENT

Номер: WO2019103456A2
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, PARK, Yun-Yong, PARK, Seok Soon, JU, Eun Jin, KO, Eun Jung
Принадлежит:

The present invention relates to a biomarker composition for diagnosing radiation-resistant cancer containing PMVK as an active ingredient, and a method for diagnosing radiation-resistant cancer using the same, wherein when the PMVK was knocked down, it was confirmed that the survival rate of cancer cells decreases in the radiation treatment, and on the basis of this, it was suggested that it is possible to use the PMVK as a radiation therapy resistance-related factor for cancer, whereby the PMVK can be utilized as a novel target that can enhance the radiation therapy effect on human cancer cells.

Подробнее
Номер записи: 84
13-06-2019 дата публикации

COMPOSITION COMPRISING STEM CELL-DERIVED EXOSOME CONTAINING CULTURE AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING ARTHRITIS

Номер: WO2019112177A1
Автор: KANG, Myung Hee, CHOI, Ehn Kyoung, SEO, Da Woom
Принадлежит:

The present invention relates to a composition of a stem cell-derived exosome-containing culture for preventing or treating arthritis and, more particularly, to a pharmaceutical composition comprising a stem cell-derived exosome-containing culture as an effective ingredient for preventing or treating arthritis, wherein the stem cell-derived exosome-containing culture is obtained by treating a stem cell culture with TNF-α and incubating the stem cell culture in the condition of a 1-8 % oxygen concentration. Containing a large amount of exosomes containing functional effective ingredients such as a cartilage regeneration promoting factor, etc., the stem cell-derived exosome-containing culture according to the present invention was found to have a far higher therapeutic effect on arthritis, compared to conventional stem cell transplantation methods for treatment of arthritis and the application of cultures obtained in general stem cell culturing conditions. Hence, the stem cell-derived exosome-containing ...

Подробнее
Номер записи: 85
31-05-2018 дата публикации

이동 단말기 및 그 제어방법

Номер: KR0101850825B1
Автор: 최은경, 김나영, 이정민
Принадлежит: 엘지전자 주식회사

... 이동 단말기 및 그 제어방법이 개시된다. 본 발명의 이동 단말기 및 그 제어방법은, 근거리 통신 모듈; 및 일정 거리 이내에 위치한 적어도 하나의 제1 단말과 상기 근거리 통신 모듈을 이용한 제1 통신 링크를 형성하고, 상기 제1 통신 링크를 통하여 획득한 데이터에 기초하여 제1 동작 모드를 활성화하고, 상기 활성화한 제1 동작 모드에 포함된 적어도 하나의 기능을 실행하는 제어부를 포함하는 것을 특징으로 한다. 본 발명에 의하면, 근거리 통신 모듈을 이용한 통신 링크를 통하여 획득한 데이터로 이동 단말기가 특정 동작 모드에서 작동하도록 손쉽게 설정할 수 있다.

Подробнее
Номер записи: 86
21-02-2018 дата публикации

MOBILE TERMINAL AND CONTROLLING METHOD THEREOF

Номер: KR1020180017738A
Автор: CHOI, YOO JIN, CHOI, EUN KYUNG, SHIN, WOOK
Принадлежит:

The present invention provides a mobile terminal which enables a user to apply various different user inputs only with one touch input, and a controlling method thereof. The mobile terminal comprises: a display part displaying image information; a memory storing a plurality of content having mutually related attributes by dividing the plurality of content according to a type of each content and intensity of the corresponding touch pressure; a touch detection part detecting a touch input applied on the display part and the intensity of the touch pressure applied from the touch input; and a control part generating data including second content corresponding to the intensity of the touch pressure detected from the touch input among the plurality of content, when the touch input is applied to first content displayed on the display part among the plurality of content. COPYRIGHT KIPO 2018 (AA) Start (BB) End (S300) Recognizing first content on which a force touch is sensed (S302) Sensing pressure ...

Подробнее
Номер записи: 87
08-12-2016 дата публикации

BIOMARKER COMPOSITION COMPRISING CLAUDIN 7 FOR DIAGNOSING RADIORESPONSIVE STOMACH CANCER

Номер: KR1020160141075A
Автор: CHOI, EUN KYUNG, JEONG, SEONG YUN, SONG, SI YEOL, LEE, KYOUNG JIN
Принадлежит:

The present invention relates to a biomarker composition comprising claudin 7 for diagnosing radioresponsive stomach cancer, and to a method for diagnosing radioresponsive stomach cancer using the same. Particularly, when radiation is emitted to an animal model having a stomach cancer tissue of a real patient which is an animal model most similar to the real patient with cancer, claudin 7 is overly expressed in stomach cancer tissue exposed to the radiation. Thus, claudin 7 can be used for diagnosing radioresponsive stomach cancer, and can be utilized for developing a contrast medium for monitoring radiation therapy, and for developing a drug carrier for enhancing efficacy of the radiation therapy. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 88
16-03-2016 дата публикации

DEHUMIDIFIER

Номер: KR1020160029976A
Автор: KIM, HYUNG GEUK, LEE, SANG JUN, SHIN, SEUNG KYU, CHOI, EUN KYOUNG
Принадлежит:

The present invention provides a dehumidifier comprising: a housing which is in a hollow cylinder shape with opened upper and lower portions, and which provides a housing hole formed to penetrate from an inner side thereof to an outer side thereof; a support block which has a plate shape and couples to the housing hole; a plurality of dehumidifying plates which has a plate shape, of which the outside couples to the inner surface of the support block, and of which the inside extends into the housing; and an endothermic surface and a heating surface, wherein the endothermic surface includes a Peltier element coupling to the outer surface of the support block and a cooling block coupling to a heating surface of the Peltier element. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 89
06-02-2020 дата публикации

DISPLAY PANEL AND DISPLAY APPARATUS

Номер: WO2020027443A1
Автор: YANG, Jin-Wook, KIM, Soon-Dong, YOON, Chang-Noh, CHOE, Eun-Gyeong
Принадлежит:

A display panel comprises: a first pixel group including subpixels which are connected to a first scan line and are arranged in a first subpixel column to an N-th subpixel column (N is an even number greater than or equal to 2); a second pixel group including subpixels which are connected to the first scan line and are arranged in an (N+1)-th subpixel column to a 2N-th subpixel column; a third pixel group including subpixels which are connected to a second scan line adjacent to the first scan line and are arranged in the first subpixel column to the N-th subpixel column; and a fourth pixel group including subpixels which are connected to the second scan line and are arranged in the (N+1)-th subpixel column to the 2N-th subpixel column. For a first scan-on time for driving of the first scan line, the first pixel group and the second pixel group are sequentially driven; for a first part of a second scan-on time for driving of the second scan line, (N-1) consecutive subpixels among the subpixels ...

Подробнее
Номер записи: 90
10-03-2016 дата публикации

BIOMARKER FOR PREDICTING SENSITIVITY TO PROTEIN KINASE INHIBITOR AND USE THEREOF

Номер: WO2016036172A1
Автор: KIM, Tae Won, JIN, Dong Hoon, HONG, Seung Woo, MOON, Jai Hee, SHIN, Jae Sik, LEE, Ha Reum, CHOI, Eun Kyoung, KIM, Seung Mi, JUNG, Soo A, HA, Seung Hee, JUNG, Ha Na, LEE, Dae Hee, JUNG, Seang Hwan, LEE, Jung Shin, CHOI, Eun Kyung, LEE, Jae Lyun, HONG, Yong Sang, KIM, Kyu Pyo, KIM, Jeong Eun, PARK, Seong Joon, KIM, Bong Choel
Принадлежит:

The present invention relates to a biomarker for predicting sensitivity to a protein kinase inhibitor and a use thereof, and provides a marker for predicting sensitivity to a protein kinase inhibitor, a composition, a kit, and a prediction method. According to the present invention, an effect of predicting sensitivity to a protein kinase inhibitor is excellent, and thus the present invention can be useful for cancer treatment.

Подробнее
Номер записи: 91
25-01-2018 дата публикации

MET 저해제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도

Номер: KR0101811731B1
Автор: 김태원, 진동훈, 홍승우, 문재희, 신재식, 황이연, 김정희, 이하름, 최은경, 김승미, 정수아, 하승희, 이대희, 이은영, 이슬, 이정신, 이재련, 홍용상, 김규표, 김정은, 박성준, 김봉철
Принадлежит: 재단법인 아산사회복지재단

... 본 발명은 MET 저해제에 대한 감수성 예측용 신규한 바이오 마커 및 이의 용도에 관한 것으로, 보다 상세하게는, IGSF1(Immunoglobulin Superfamily member 1, NM_001555.2) 유전자를 포함하는 MET 저해제에 대한 감수성 예측용 바이오 마커; 상기 바이오 마커 유전자 발현 수준 또는 이의 단백질의 발현 수준을 측정하는 제제를 포함하는 MET 저해제에 대한 감수성 예측용 조성물; 상기 바이오 마커 유전자의 발현 또는 상기 유전자의 단백질의 발현 또는 활성을 억제하는 억제제를 유효성분으로 포함하는 MET 신호전달 경로의 조절이상과 관련된 질환의 치료용 약학적 조성물; 상기 조성물을 포함하는 MET 저해제에 대한 감수성 예측용 키트; 및 MET 저해제에 대한 감수성 예측 방법을 제공한다. 본 발명에 따르면, 본 발명은 위암 또는 폐암에서의 MET 저해제제에 대한 감수성 예측 효과가 우수하므로, 본 발명은 위암 또는 폐암 치료에 유용하게 이용될 수 있다.

Подробнее
Номер записи: 92
10-12-2018 дата публикации

METHOD FOR STIMULATING SECRETION OF EXOSOMES FROM STEM CELLS AND FUNCTIONAL COSMETIC COMPOSITION COMPRISING STEM CELL-DERIVED EXOSOMES AS ACTIVE INGREDIENT

Номер: KR1020180131158A
Автор: KIM, YUN BAE, CHOI, EHN KYOUNG, SEO, DA WOOM
Принадлежит:

The present invention relates to a method for stimulating secretion of exosomes from stem cells and a functional cosmetic composition comprising stem cell-derived exosomes as an active ingredient. Specifically, the present invention relates to a method for mass-producing exosomes from stem cells, a method for increasing secretion of the exosomes from the stem cells, and a functional cosmetic composition comprising the stem cell-derived exosomes as an active ingredient, wherein the method for mass-producing exosomes from stem cells comprise a step of treating a stem cell culture medium with TNF-α and culturing the same under condition with 1-8% of oxygen concentration. COPYRIGHT KIPO 2019 ...

Подробнее
Номер записи: 93
26-05-2016 дата публикации

PEPTIDES FOR TARGETING COLORECTAL CANCER, AND MEDICAL USE THEREOF

Номер: WO2016080632A1
Автор: CHOI, Eun Kyung, JEONG, Seong-Yun, SONG, Si Yeol, LEE, Kyoung Jin, CHOI, Jinhyang, PARK, Jaesook, PARK, Seok Soon, LEE, Jae Hee
Принадлежит:

The present invention relates to peptides for targeting colorectal cancer, a composition for colorectal cancer prognosis diagnosis based on radioresponsiveness using same, and a drug delivery use thereof. The functional peptides capable of targeting cancer have been discovered so as to implement customized diagnosis and treatment for individual patients in consideration of problems during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients having cancer. After establishing animal models similar to the cancer microenvironments of actual patients and dividing into an irradiated population and a non-irradiated population as a control group, targeting efficiency has been tested for respective peptides selected by screening peptides specifically binding to the respective populations. As such, the present invention can finally be used in the technical development of image diagnosis ...

Подробнее
Номер записи: 94
11-04-2013 дата публикации

HYDROGEL COMPOSITION FOR A MASK BASE AND METHOD FOR MANUFACTURING A HYDROGEL USING SAME

Номер: WO2013051795A1
Автор: YOO, Hyun Oh, KIM, Jong Chul, YANG, Jin A, CHOI, Eun Kyoung, LIM, Jae Min
Принадлежит:

The present invention relates to a hydrogel composition and to a method for manufacturing a hydrogel using same. The hydrogel composition comprises 0.1 to 10 wt% of a cross-linking agent, 0.2 to 6 wt% of a gelling polymer, 0.5 to 20 wt% of a polyhydric alcohol, and 70 to 90 wt% of purified water. The shape of the hydrogel may be retained without a supporter. The hydrogel may not be untied but may be stable even when impregnated into cosmetics or pharmaceuticals. In addition, the cosmetics or the pharmaceuticals may be delivered uniformly to the skin.

Подробнее
Номер записи: 95
14-04-2017 дата публикации

신규한 피리도피리미딘 유도체 및 이의 용도

Номер: KR0101727211B1
Автор: 이길남, 임철수, 조한원, 서정법, 교르코스, 알버트 찰스, 조석영, 최은경, 김청수, 황정진
Принадлежит: 주식회사 씨엠지제약, 의료법인 성광의료재단

... 본 발명은 화학식 I로 표시되는 신규한 치환된 피리도피리미딘 또는 이의 약학적으로 허용가능한 염, 용매화물, 다형체, 에스테르, 호변이성질체 또는 프로드럭, 및 이러한 화합물을 포함하는 조성물을 제공한다. 이러한 화합물은 염증성 질환, 암, 심혈관 질환, 알레르기, 천식 및 자가면역 장애의 치료를 위한 포스포이노시타이드 3'OH 키나제 패밀리 (PI3K)의 억제제로서 사용될 수 있다.

Подробнее
Номер записи: 96
04-12-2018 дата публикации

NCKAP1을 유효성분으로 포함하는 대장암 진단 또는 대장암 전이 예후 예측용 바이오마커 조성물

Номер: KR0101925125B1
Автор: 최은경, 정성윤, 송시열, 이재희
Принадлежит: 울산대학교 산학협력단, 재단법인 아산사회복지재단

... 본 발명은 NCKAP1(NCK-Associated Protein 1)을 유효성분으로 포함하는 대장암 진단 또는 대장암 전이 예후 예측용 바이오마커 조성물에 관한 것으로서, 구체적으로 인체 대장암 조직 이식 마우스 모델의 혈액에서 대량 유전자 발현 분석을 통해 신규한 대장암 표적 후보를 발굴하였고, 이를 대장암 세포주 내 표적 후보 유전자 발현 억제를 통해 실험적 검증을 하였다. 이를 통해 대장암 환자 혈액 및 조직에서 NCKAP1이 과발현되고, NCKAP1의 억제에 의한 암세포의 이동, 침윤 및 전이가 저해됨을 관찰하고, 신규한 대장암 표적으로서 NCKAP1의 가능성을 확인하였다. 따라서 NCKAP1의 발현 수준을 이용한 대장암 진단과 유전자 발현 억제제를 암의 치료 또는 암 전이 억제용 약학적 조성물의 유효성분으로 유용하게 이용할 수 있다.

Подробнее
Номер записи: 97
24-03-2023 дата публикации

휴대 단말기용 받침대

Номер: KR20230041165A
Автор: 최은경
Принадлежит:

... 본 발명은 휴대 단말기의 위치를 사용자가 원하는 위치에 용이하게 맞출 수 있고, 휴대 단말기를 그 맞춘 위치에 길이 변화 없이 정지된 상태로 유지할 수 있으며, 휴대시에는 휴대 단말기와 함께 용이하게 휴대할 수 있는 휴대 단말기용 받침대를 제공하는 것이 그 기술적 과제이다. 이를 위해, 본 발명의 휴대 단말기용 받침대는, 휴대 단말기 또는 상기 휴대 단말기의 케이스 등의 피장착부에 구비되어 상기 휴대 단말기를 받치는 휴대 단말기용 받침대로, 상기 피장착부에 구비되기 위한 고정부; 길이 방향으로 인입되거나 인출되면서 길이가 신축되는 신축부; 상기 고정부와 상기 신축부 사이에 구비되며 상기 고정부를 상대적으로 회전시키는 회전부; 및 상기 신축부의 말단에 구비되는 말단 지지부;를 포함하고, 상기 신축부는, 상기 회전부 또는 상기 말단 지지부에 일단부가 구비되는 제1 미끄럼 부재; 상기 제1 미끄럼 부재가 인입출되도록 인입출용 수용부를 가지는 제2 미끄럼 부재; 및 상기 제1 미끄럼 부재가 상기 제2 미끄럼 부재로부터 인출된 상태에서 상기 제1 미끄럼 부재의 이동을 정지시키는 이동 멈춤부;를 포함한다.

Подробнее
Номер записи: 98
15-09-2016 дата публикации

METHOD FOR SEPARATING NUCLEIC ACIDS FROM FEPE TISSUE

Номер: WO2016144136A1
Автор: JANG, Se Jin, CHUN, Sung Min, KIM, Tae Im, LEE, Jung Shin, CHOI, Eun Kyung
Принадлежит:

The present invention relates to: a method for separating nucleic acids from a sample containing formalin-fixed, paraffin-embedded (FFPE) tissue sections; a nucleic acid separation kit; and a lysis buffer for separating nucleic acids.

Подробнее
Номер записи: 99
16-01-2017 дата публикации

METHOD FOR DETERMINING SUSCEPTIBILITY TO DUAL INHIBITOR AGAINST PARP AND TANKYRASE

Номер: KR1020170005627A
Автор: KIM, TAE WON, JIN, DONG HOON, HONG, SEUNG WOO, MOON, JAI HEE, SHIN, JAE SIK, KIM, JEONG HEE, HWANG, IH YEON, CHOI, EUN KYOUNG, KIM, SEUNG MI, JUNG, SOO A, LEE, DAE HEE, LEE, EUN YOUNG, LEE, JUNG SHIN, CHOI, EUN KYUNG, HONG, YONG SANG, KIM, KYU PYO, KIM, JEONG EUN, KIM, BONG CHOEL
Принадлежит:

The present invention relates to a method for determining susceptibility to a dual inhibitor against poly(ADP-ribose) polymerase (PARP) and tankyrase. According to the present invention, a patient group having susceptibility to a dual inhibitor against PARP and tankyrase is classified, so the colorectal cancer treatment effect can be maximized. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 100