FLAMEPROOF, WEATHERPROOF ENCLOSURES FOR ELECTRICAL EQUIPMENT

The invention provides for flameproof, weatherproof enclosures for electrical equipment for use in hazardous areas where flammable gases or other substances are or may be present in quantities sufficient to produce explosive or ignitable mixtures during normal operation of the electrical equipment. The enclosure which is of sufficient thickness and mechanical strength to withstand the internal ignition of explosive gases is sealed for weathertightness and is provided with a metallic flametrap having a replaceable filter element therein of metallic foil or mesh structure to provide for cooling and deionizing products of combustion as they pass from within the enclosure to atmosphere through the flametrap. The outer end of the flametrap is sealed by a bursting disc of predetermined burating strength which seals the flametrap against the weather. A translucent portion may be formed in the enclosure. The filter element may be in the form of alternate planar strips of metallic foil and crimped ...

Apparatus and method for measuring turbine temperature

A temperature sensing device for a turbine of an engine and a method for measuring the temperature of the turbine are disclosed. The turbine includes a turbine stage coupled to a rotatable shaft and an outer casing. First and second sensor holders are disposed between the rotatable shaft and the outer casing, and first and second temperature sensors disposed on the first and second sensor holders, respectively. Each of the first and second sensor holders has only one temperature sensor disposed thereon, the first and second temperature sensors are disposed at first and second distances from the rotatable shaft respectively, and the first and second distances are different.

APPARATUS AND METHOD FOR MEASURING TURBINE TEMPERATURE

A temperature sensing device for a turbine of an engine and a method for measuring the temperature of the turbine are disclosed. The turbine includes a turbine stage coupled to a rotatable shaft and an outer casing. First and second sensor holders are disposed between the rotatable shaft and the outer casing, and first and second temperature sensors disposed on the first and second sensor holders, respectively. Each of the first and second sensor holders has only one temperature sensor disposed thereon, the first and second temperature sensors are disposed at first and second distances from the rotatable shaft respectively, and the first and second distances are different. 1. A temperature sensing device for measuring temperature in a turbine of an engine , wherein the turbine includes a turbine stage coupled to a rotatable shaft and an outer casing , comprising:first and second sensor holders disposed between the rotatable shaft and the outer casing;a first temperature sensor disposed on the first sensor holder at a first radial distance from the rotatable shaft; anda second temperature sensor disposed on the second sensor holder at a second radial distance from the rotatable shaft;wherein each of the first and second sensor holders has only one temperature sensor disposed thereon, and the first and second distances are different.2. The temperature sensing device of claim 1 , including a third sensor holder disposed between the rotatable shaft and the outer casing claim 1 , wherein the third sensor holder is free of a temperature sensor.3. The temperature sensing device of claim 1 , further including a ring that encircles the rotatable shaft claim 1 , and the first and second sensor holders are secured to the ring.4. The temperature sensing device of claim 3 , wherein first and second sensor holders are secured to the casing.5. The temperature sensing device of claim 1 , wherein the first and second sensor holders are cantilevered from the outer casing.6. The ...

FLAMEPROOF, WEATHERPROOF ENCLOSURES FOR ELECTRICAL EQUIPMENT

Infusor system for delivery of medication to a body cavity

An infusor system (10) comprises a delivery tube (12) with one of the ends couplable to a supply (37, 38) of liquid medication. A dispenser head (14) is coupled to the other end of the delivery tube (12) and medication is directed therethrough. The dispenser head is configured to be placed within a body cavity of a patient such that a contact surface contacts a portion of a mucous membrane (32) in the body, and is operable for directing medication from the delivery tube (12) to the contact surface and on to the mucous membrane (32). In a preferred embodiment of the invention, the dispenser head (14) includes a portion of compressible foam which is configured to fit within the rectal cavity (30) of a patient. The dispenser head (14) channels medication to the rectal mucous membrane (32) to be absorbed thereby. Unique methods of utilizing the infusor system to administer medication to a patient are set forth herein.

Improvements in or relating to thermal storage space heaters

... 1,097,820. Thermal storage space heaters. ANDREW CHALMERS & MITCHELL Ltd. Aug. 17, 1964 [May 18, 1963], No. 19865/63. Heading F4U. In a thermal storage heater in which heat storage blocks 1 are heated by electric heating elements, an air duct 2 is arranged in proximity to the heat storage blocks with its ends open to the exterior of the heater and in which is situated a shutter 5 for controlling the flow of air through said duct. The shutter 5 is biased by a spring to its open position and is closed by an electricallyoperated actuating mechanism in opposition to said spring. The electrically-operated means may be in the form of a solenoid coil 7 and a slidable armature 8 connected to a bell crank lever 9 which operates the shutter 5. The solenoid coil 7 is electrically in circuit with the heating elements so that the shutter is closed when the storage blocks are accumulating heat. A switch or time-switch may be used to control the period during which the storage blocks receive heat from ...

FLAMEPROOF, WEATHERPROOF ENCLOSURES FOR ELECTRICAL EQUIPMENT

AUSSERAXIAL-ABTASTENDES, RECHNERGESTÜTZTES ELEKTRONENSTRAHL-TOMOGRAPHIESYSTEM

Cancer Therapeutic

Methods for the delivery of a siNA to a cell via a liposome are provided. In certain embodiments, the siNA may bind to a nucleotide sequence encoding ZNF306 protein. These methods may be used to treat a disease, such as cancer. One example of a composition is a composition comprising a siNA component that binds to a nucleotide sequence encoding ZNF306 protein and a lipid component. One example of a method is a method of treating cancer.

AUSSERAXIAL-ABTASTENDES, RECHNERGESTÜTZTES ELEKTRONENSTRAHL-TOMOGRAPHIESYSTEM

Engine degradation management via multi-engine mechanical power control

A multi-engine power system is described that includes at least a first engine and a second engine configured to jointly provided mechanical power to the multi-engine power system. The multi-engine power system further includes a controller configured to estimate a deterioration factor of the first engine. The controller is further configured to adjust, based on the deterioration factor of the first engine, a first amount of mechanical power being provided by the first engine to increase a service time of the first engine, and adjust, based on the first amount of mechanical power being provided by the first engine, a second amount of mechanical power being provided by the second engine to compensate for the adjustment to the first amount of mechanical power.

GAS TURBINE ENGINE WITH REVERSIBLE HEAT EXCHANGER

A gas turbine engine system includes a gas turbine engine having a fan bypass duct, a heat exchanger system, and a flow transfer unit configured to selectively allow or preclude flow between the fan bypass duct and the heat exchanger system. A controller is coupled to and configured to vary the state of one or more of a fan exit nozzle, a heat exchanger exit nozzle, and a flow control valve controlling flow between the fan bypass duct and the heat exchanger system.

ENGINE DEGRADATION MANAGEMENT VIA MULTI-ENGINE MECHANICAL POWER CONTROL

A multi-engine power system is described that includes at least a first engine and a second engine configured to jointly provided mechanical power to the multi-engine power system. The multi-engine power system further includes a controller configured to estimate a deterioration factor of the first engine. The controller is further configured to adjust, based on the deterioration factor of the first engine, a first amount of mechanical power being provided by the first engine to increase a service time of the first engine, and adjust, based on the first amount of mechanical power being provided by the first engine, a second amount of mechanical power being provided by the second engine to compensate for the adjustment to the first amount of mechanical power. 1. An engine controller comprising:at least one processor; and monitor one or more operating parameters of each of a first engine and a second engine from two or more engines that are configured to jointly provide mechanical power to a multi-engine power system;', 'estimate a deterioration factor of the first engine based on the one or more operating parameters of the first engine, wherein the first engine is configured to supply mechanical power to a first propulsor or a first generator;', 'estimate a deterioration factor of the second engine based on the one or more operating parameters of the second engine, wherein the second engine is configured to supply mechanical power to a second propulsor or a second generator, different from the first propulsor or the first generator;', 'adjust, based on the deterioration factor of the first engine, a first amount of mechanical power being provided by the first engine to extend a service time of the first engine; and', 'adjust, based on the deterioration factor of the second engine, a second amount of mechanical power being provided by the second engine to at least partially compensate for the adjustment to the first amount of mechanical power., 'a memory storing ...

Method and system for providing remote access to baggage scanned images

A remote access security network is provided that comprises a local terminal receiving scan data representative of objects scanned during a security check. An enterprise server communicates with the local terminal. The enterprise server processes the scan data to form a displayable image and provides remote access to the displayable image upon request. A remote terminal located remote from the enterprise server and remote from the local terminal communicates with the enterprise server over a high-speed connection to provide remote review of the displayable image at the remote terminal associated with the scan data obtained at the local terminal. The enterprise server may include a passenger information interface configured to access a passenger information database having passenger information. The enterprise server may include a conferencing module for establishing a video conference between multiple remote terminals to permit operators of the multiple remote terminals to view simultaneously ...

PORTABLE BACKSCATTER ADVANCED IMAGING TECHNOLOGY SCANNER WITH AUTOMATED TARGET RECOGNITION

A portable backscatter advanced imaging technology scanner with automated threat or target recognition including: a floor assembly having a cantilever drive assembly for rotating the floor assembly, the floor assembly being able to be partitioned into multiple parts for reassembly; at least one x-ray tube oriented towards selected sides of a test subject; a detector assembly oriented on the circumference of the floor assembly, the detector assembly being able to partitioned into multiple parts for reassembly; a storage unit to store images from detected scattered photons on the detector assembly; and a processing unit to detect, identify and classify concealed objects on the test subject. 1. A portable scanning detection system , comprising:a floor assembly having a cantilever drive assembly for rotating the floor assembly, the floor assembly being able to be partitioned into multiple parts for reassembly;at least one x-ray tube oriented towards selected sides of a test subject;a detector assembly oriented on the circumference of the floor assembly, the detector assembly being able to partitioned into multiple parts for reassembly;a storage unit to store images from detected scattered photons on the detector assembly; anda processing unit to detect, identify and classify concealed objects on the test subject.2. The portable scanning detection system of claim 1 , wherein the at least one x-ray tube is positioned within the detector assembly.3. The portable scanning detection system of claim 1 , wherein the at least one x-ray tube comprises a top x-ray tube oriented on the top portion of the detector assembly and a bottom x-ray tube positioned below the floor assembly.4. The portable scanning detection system of claim 1 , wherein the at least one x-ray tube emits backscatter x-rays and further wherein the detector screen comprises at least one dual energy backscatter plastic detectors screen having photo multiplier tubes claim 1 , the screens being arranged in a ...

DUAL ENERGY BACKSCATTER X-RAY SHOE SCANNING DEVICE

Dual-energy backscatter x-ray shoe scanning including: pre-processing input image information received from a shoe scanning device and image calibration data received from a database to output an atomic number image; detecting at least one suspect region based off the atomic number image; identifying the at least one detected suspect region as an object class using a changeable list of attributes; and classifying the object class according to a changeable list of categories. 1. A shoe scanning device , comprising:at least one x-ray tube oriented towards selected sides of a test subject;at least one detector screen oriented towards the selected sides of a test subject and configured to detect scattered photons from x-rays emitted by the at least one x-ray tube;a storage unit to store images from the detected scattered photons on the at least one detector screen; anda processing unit having software to detect, identify and classify concealed objects in a selected area of the test subject.2. The shoe scanning device of claim 1 , further comprisinga region to place the selected area of the test subject, and wherein the selected area of the test subject is a footwear area.3. The shoe scanning device of claim 1 , wherein the at least one detector screen comprises at least one dual energy detector screen arranged in a cascade to capture both low and high energy photons independently.4. The shoe scanning device of claim 1 , wherein the at least one detector screen comprises a front screen claim 1 , a right screen claim 1 , a left screen and a bottom base detector screen claim 1 , and each of the at least one x-ray tube collects four images claim 1 , which are a high energy image claim 1 , a low energy image claim 1 , a transmission image and a scatter image.5. The shoe scanning device of claim 1 , wherein the processing unit comprises:a database to store image calibration data;a pre-processing unit to receive image data from the storage unit and image calibration data from ...

SPLIT SPIN CENTRIFUGATION OF TEST ELEMENTS

High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion. 1. A testing apparatus , comprising:a) a plurality of centrifuges configured for the centrifugation of plurality of sample receptacles;b) one or more drive mechanisms, said drive mechanisms connected to said sample centrifuges;c) at least one transfer mechanism configured for the loading or unloading of said sample centrifuges, and d) a control mechanism interfaced with said drive mechanisms and said at least one transfer mechanism, said control mechanism configured for the staggered operation of said centrifuges, wherein said staggered operation comprises the steps of:i. creating a plurality of smaller secondary batches from a primary batch of test samples, wherein said primary batch typically requires centrifugation for a time period equal to t in a primary centrifuge and the number of secondary batches is equal to y, which is at least 2;ii. loading the test samples of said secondary batches into x number of separate secondary centrifuges, in which x is at least 2;iii. staggering the operation of said x number of secondary centrifuges by a time period t/xy in relation to one another over a total centrifugation cycle for each secondary centrifuge that is equal to time period t;iv. pausing the operation of each of said staggered secondary centrifuges;v. at least one of loading new test samples and unloading completed test samples from each of said paused secondary centrifuges during said pausing step; andvi. resuming ...

Vendor and scanner independent common workstation for security

A vendor and scanner independent common workstation (CW) for security, as discussed above, including the abilities to: plug into any existing, past or future scanners; utilize expedited bag-check, bag-search and remote monitor/view features; and scroll the display of the CW so that the “re-scan” operation may not necessarily be performed on the CW display, for instance.

DYNAMIC BEAM APERATURE CONTROL TO REDUCE RADIATION DOSE USING COLLIMATOR

A computed tomography (CT) apparatus including: an X-ray source configured to direct X-rays toward a detector assembly; a dynamic beam collimator fixed in space and configured to dynamically limit an X-ray beam directed toward an object of interest, the dynamic beam collimator including a plurality of leaflets to block a cone beam of X-rays impinging upon the dynamic beam collimator, wherein a subset of the plurality of leaflets opens and closes to block or allow a portion of the cone beam of X-rays to reduce or increase a solid angle of the cone beam, wherein the cone beam of X-rays with the reduced solid angle is directed toward a predetermined portion of the object of interest; and the detector assembly configured to detect the directed cone beam of X-rays on a side opposite to the X-ray source. 1. A computed tomography (CT) apparatus to perform a CT scan with a reduced radiation , the apparatus comprising:an X-ray source configured to direct a cone beam of X-rays toward a detector assembly with an object of interest situated between the X-ray source and the detector assembly;a dynamic beam collimator fixed in space and configured to dynamically limit the X-ray beam directed toward the object of interest, the dynamic beam collimator comprising a plurality of leaflets to block the cone beam of X-rays impinging upon the dynamic beam collimator,wherein a subset of the plurality of leaflets opens and closes to block or allow a portion of the cone beam of X-rays to reduce or increase a solid angle of the cone beam,wherein the cone beam of X-rays with the reduced solid angle is directed toward a predetermined portion of the object of interest; andthe detector assembly configured to detect the directed cone beam of X-rays on a side opposite to the X-ray source after the cone beam of X-ray beams the reduced solid angle passes through the object of interest.2. The apparatus of claim 1 , wherein the X-ray source comprises:an electron gun to generate an electron beam;a beam ...

SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN URINE

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples. 1. An optical cup or cuvette for holding a processed fluid sample and for use in an optical analysis , comprising:a container having an open portion through which a light travels for the optical analysis of the fluid sample, said container including a reflective surface for enhancing the optical analysis, said container having sidewalls that are continuously tapered along their length,and wherein during optical analysis, the light is directed downwardly through the open portion of the container and into the fluid sample, wherein the tapered sidewalls are configured to assist with the optical analysis and the reflective surface of the container reflects fluorescent emissions back in an upwardly direction out of the fluid sample and through the open portion of the container to an optical collection unit for optical analysis.2. The optical cup or cuvette of claim 1 , wherein the fluid sample is urine.3. The optical cup or cuvette of claim 1 , wherein the light comprises ultra violet (UV) light.4. ...

HER3 ANTIGEN-BINDING MOLECULES

HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules. 1. An antigen-binding molecule , optionally isolated , which is capable of binding to HER3 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:43', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:46', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:51; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:91', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:94', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:99., '(ii) a light chain variable (VL) region incorporating the following CDRs2. The antigen-binding molecule according to any one of to , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:45', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:48; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:88', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:92', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:95., '(ii) a light chain variable (VL) region incorporating the following CDRs3. The antigen-binding molecule according to or , wherein the antigen-binding molecule comprises:a VH region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:36; anda VL region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:83.4. An antigen-binding molecule , optionally isolated , comprising (i) an antigen-binding molecule according to any one of to , and (ii) an antigen-binding molecule capable of binding to an antigen other than ...

TUMOR TRACING DEVICE WITH MULTIPLE SCAN TUBES

A system for tracking tumors during radiotherapy for interleaving treatment pulses with imaging pulses is disclosed. The system includes a plurality of multisource scanning eBeam X-ray tubes, each having multiple focal spots. The X-ray tubes are configured to emit X-rays in a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the different focal spots. This is done such that the X-rays can be emitted to the plurality of different locations without substantially moving the X-ray tube or the target. The system further includes multiple imager panels configured to act as targets and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process outputs from the imager panels to construct a unified three-dimensional image that takes information from each of the different imager panels. 1. A system for tracking biological features during radiotherapy , the system comprising:a first multisource scanning eBeam X-ray tube having a plurality of focal spots, the first X-ray tube being configured to emit X-rays in a plurality of different locations on a first target by sequentially emitting the X-rays to the focal spots in the plurality of focal spots, such that the X-rays can be emitted to the plurality of different locations without substantially moving the first X-ray tube or the first target;a first imager panel configured to act as the first target for the first X-ray tube, the first imager panel receiving the X-rays from the focal spots of the first X-ray tube;a second multisource scanning eBeam X-ray tube having a plurality of focal spots, the second X-ray tube being configured to emit X-rays in a plurality of different locations on a second target by sequentially emitting the X-rays to the focal spots in the plurality of focal spots;a second imager panel configured to act as the second target for the second X-ray tube, ...

SYSTEM AND METHOD FOR MEDICAL INSTRUMENT NAVIGATION AND TARGETING

Certain aspects relate to systems and techniques for medical instrument navigation and targeting. In one aspect, a system includes a medical instrument having an elongate body and at least one sensor, a display, a processor, and a memory storing a model of a mapped portion of a luminal network and a position of a target with respect to the model. The processor may be configured to: determine, based on data from the at least one sensor, a position and orientation of a distal end of the medical instrument with respect to the model, and cause, on at least a portion of the display, a rendering of the model, the position of the target, and the position and orientation of the distal end of the medical instrument. The rendering may be based on a viewpoint directed at the target and different from a viewpoint of the medical instrument 1. A system , comprising:a medical instrument having an elongate body and at least one sensor;a display;a processor; and determine, based on data from the at least one sensor, a position and orientation of a distal end of the medical instrument with respect to the model, and', 'cause, on at least a portion of the display, a rendering of the model, the position of the target, and the position and orientation of the distal end of the medical instrument, wherein the rendering is based on a viewpoint directed at the target and different from a viewpoint of the medical instrument., 'a memory storing a model of a mapped portion of a luminal network and a position of a target with respect to the model, the memory further storing computer-executable instructions to cause the processor to2. The system of claim 1 , further comprising a user input element claim 1 , wherein the memory further stores computer-executable instructions to cause the processor to:receive, via the user input element, a first type of user interaction with the user input element,generate a first type of rendering instruction based on the first type of user interaction with the ...

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

MEDICATION INJECTOR APPARATUS WITH DRIVE ASSEMBLY THAT FACILITATES RESET

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. ( ...

Calibration of electrode-to-muscle mapping for functional electrical stimulation

A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns.

TREATMENT AND PREVENTION OF CANCER USING HER3 ANTIGEN-BINDING MOLECULES

Methods for treating or preventing a cancer in a subject are disclosed, wherein the cancer comprises cells having a mutation resulting in increased expression of a ligand for HER3, wherein the method comprises administering a therapeutically or prophylactically effective amount of an antigen-binding molecule which is capable of binding to HER3 to the subject. 116-. (canceled)17. A method of treating a cancer in a subject , wherein the cancer comprises cells having a mutation resulting in increased expression of a ligand for HER3 , wherein the method comprises administering a therapeutically or prophylactically effective amount of an antigen-binding molecule which is capable of binding to HER3 to the subject , and wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:43', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:46', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:51; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:91', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:94', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:99., '(ii) a light chain variable (VL) region incorporating the following CDRs18. The method according to claim 17 , wherein the ligand for HER3 comprises an amino acid sequence having at least 60% sequence identity to the EGF-like domain of an NRG.19. The method according to claim 17 , wherein the mutation results in increased expression of the EGF-like domain of an NRG at the cell surface.20. The method according to claim 17 , wherein the cancer comprises cells having an NRG gene fusion.21. The method according to claim 20 , wherein the NRG gene fusion is selected from CLU-NRG1 claim 20 , CD74-NRG1 claim 20 , DOC4-NRG1 claim 20 , SLC3A2-NRG1 claim 20 , RBPMS-NRG1 claim 20 , WRN-NRG1 claim 20 , SDC4-NRG1 claim 20 , RAB2IL1-NRG1 claim 20 , VAMP2-NRG1 claim 20 , KIF13B-NRG1 claim 20 , THAP7-NRG1 claim ...

System for Conducting the Identification of Bacteria in Urine

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples. 16-. (canceled)7. A sample processor for preparing fluid samples used for conducting the identification and quantification of micro-organisms in the urine samples , comprising:a) a rotatable table; andb) a magazine supported by the rotatable table adapted to contain cartridges and containing a plurality of cartridges for holding a plurality of disposable components including an optical cup or cuvette.810-. (canceled)11. The sample processor of claim 7 , wherein the fluid sample is urine.12. (canceled)13. The sample processor of claim 7 , further comprising a rotatable gripper.14. The sample processor of claim 7 , further comprising a movable fluid transfer arm for diluting the dissolved material in the fluid samples and for transferring the diluted fluid urine to the optical cup or cuvette of each cartridge.15. The sample processor of claim 7 , further comprising a syringe pump dispenser fluid system for delivering clean fluid to the fluid samples for the dilution of the dissolved materials in ...

CD47 ANTIGEN-BINDING MOLECULES

CD47 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the CD47 antigen-binding molecules. 139.-. (canceled)40. An antigen-binding molecule which binds to CD47 , comprising: HC-CDR1 having the amino acid sequence of SEQ ID NO:169', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:170', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:26; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:171', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:172', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:173., '(ii) a light chain variable (VL) region incorporating the following CDRs42. The antigen-binding molecule according to claim 40 , wherein the antigen-binding molecule comprises:a VH region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:132, 23, 39, 178, 127, 129, 130 or 131; anda VL region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:128, 31, 44, 179, 133, 134, 135 or 136.44. The antigen-binding molecule according to claim 40 , wherein the antigen-binding molecule inhibits interaction between CD47 and SIRPα.45. The antigen-binding molecule according to claim 40 , wherein the antigen-binding molecule is a multispecific antigen-binding molecule claim 40 , and further comprises an antigen-binding domain specific for a target antigen other than CD47.46. A nucleic acid claim 40 , or a plurality of nucleic acids claim 40 , encoding an antigen-binding molecule which binds to CD47 claim 40 , comprising: HC-CDR1 having the amino acid sequence of SEQ ID NO:169', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:170', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:26; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC- ...

MEDICATION INJECTOR APPARATUS WITH DRIVE ASSEMBLY THAT FACILITATES RESET

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting. 161-. (canceled)62. A medication injector apparatus comprising:a housing;a fluid container mounted ...

SYSTEM AND METHOD FOR MEDICAL INSTRUMENT NAVIGATION AND TARGETING

Certain aspects relate to systems and techniques for medical instrument navigation and targeting. In one aspect, a system includes a medical instrument having an elongate body and at least one sensor, a display, a processor, and a memory storing a model of a mapped portion of a luminal network and a position of a target with respect to the model. The processor may be configured to: determine, based on data from the at least one sensor, a position and orientation of a distal end of the medical instrument with respect to the model, and cause, on at least a portion of the display, a rendering of the model, the position of the target, and the position and orientation of the distal end of the medical instrument. The rendering may be based on a viewpoint directed at the target and different from a viewpoint of the medical instrument 1. A system , comprising:a medical instrument having an elongate body and at least one sensor;a display;a processor; and determine, based on data from the at least one sensor, a position and orientation of a distal end of the medical instrument with respect to the model, and', 'cause, on at least a portion of the display, a rendering of the model, the position of the target, and the position and orientation of the distal end of the medical instrument, wherein the rendering is based on a viewpoint directed at the target and different from a viewpoint of the medical instrument., 'a memory storing a model of a mapped portion of a luminal network and a position of a target with respect to the model, the memory further storing computer-executable instructions to cause the processor to2. The system of claim 1 , further comprising a user input element claim 1 , wherein the memory further stores computer-executable instructions to cause the processor to:receive, via the user input element, a first type of user interaction with the user input element,generate a first type of rendering instruction based on the first type of user interaction with the ...

DYNAMIC BEAM APERTURE CONTROL TO REDUCE RADIATION DOSE USING COLLIMATOR

A computed tomography (CT) apparatus to perform a CT scan with a reduced radiation, including: an X-ray source to direct a cone beam of X-rays toward a detector assembly with an object of interest situated between the source and the detector assembly; a multi-leaf collimator fixed with respect to the X-ray source and configured to dynamically limit the cone beam of X-rays directed toward the object of interest, the multi-leaf collimator comprising a plurality of leaflets to block impinging cone beam of X-rays; and the detector assembly to detect the directed X-ray beam on a side opposite to the X-ray source after the X-ray beam with the reduced solid angle passes through the object of interest. 16.-. (canceled)7. A computed tomography (CT) apparatus to perform a CT scan with a reduced radiation , the apparatus comprising:an X-ray source configured to direct a cone beam of X-rays toward a detector assembly with an object of interest situated between the source and the detector assembly;a multi-leaf collimator fixed with respect to the X-ray source and configured to dynamically limit the cone beam of X-rays directed toward the object of interest, the multi-leaf collimator comprising a plurality of leaflets to block impinging cone beam of X-rays,wherein a subset of the plurality of leaflets opens and closes to block or allow that portion of the cone beam of X-rays to reduce or increase a solid angle of the cone beam;wherein the X-ray beam with the reduced solid angle is directed towards a predetermined portion of the object of interest; andthe detector assembly configured to detect the directed X-ray beam on a side opposite to the X-ray source after the X-ray beam with the reduced solid angle passes through the object of interest.8. The apparatus of claim 7 , wherein the X-ray source claim 7 , the multi-leaf collimator claim 7 , and the detector assembly are fixed on a rotating gantry configured to rotate about the object of interest while the cone beam of X-rays with ...

PROCESS AND AUTOINJECTOR DEVICE FOR INJECTIONS WITH INCREASED PATIENT COMFORT

The invention provides methods and apparatus for injecting a medicine, especially a highly viscous medicine. Conventional methods and apparatus for injecting viscous medicines suffers from a variety of problems such as excessive force during the initial needle insertion and initial injection. In an inventive method, during the initial phase of the injection, energy is stored in a torsion spring that is subsequently released during a later stage of the injection. The present invention also provides for an improved autoinjector; especially via the use of a combination compression and torsion spring that powers the injection through controlling force applied to plunger via a screw flange or nut having pins that ride in a prescribed path down the length of the autoinjector. 1. A method of injecting a medicament from a syringe , comprising:providing a driving force that moves a plunger down a syringe from a distal position toward a proximal position;wherein a torsion spring is attached at a distal end to a first surface and at a proximal end to a second surface;wherein the second surface moves with the plunger;wherein an early stage movement of the plunger toward the proximal position twists the torsion spring to store energy in the spring;and, subsequently, at a later stage, as the driving force continues to move the plunger toward the proximal position, and the second surface moves with the plunger,the torsion spring rotates through a prescribed path to modify the driving force moving the plunger toward the proximal position.2. The method of wherein the torsion spring is a combination torsion and compression spring.3. The method of wherein the combination torsion and compression spring is the only source of providing the driving force.4. The method of claim any of the preceding claims wherein claim 2 , during the later stage claim 2 , the torsion spring is untwisted to enhance the driving force.5. The method of any of the preceding claims wherein claim 2 , once ...

INLET GUIDE VANE DRAW HEAT EXCHANGER SYSTEM

A system includes a housing for a gas turbine engine, and a fan disposed in the housing to rotate coaxially with a gas turbine included in the housing. The system also includes an inlet guide vane disposed in the housing in axial alignment with the fan and configured to have an open position where a first flow of air is received by the fan through the inlet guide vane, and a closed position where airflow through the inlet guide vane is obstructed. The system further includes a heat exchanger disposed in a supply passage in fluid communication with a second flow of air received by the fan. The second flow of air is received by the fan via the supply passage with the inlet guide vane in the open position or in the closed position. 1. A system comprising:a housing for a gas turbine engine;a fan disposed in the housing to rotate coaxially with a gas turbine included in the housing;an inlet guide vane disposed in the housing in axial alignment with the fan and configured to have an open position where a first flow of air is received by the fan through the inlet guide vane, and a closed position where airflow through the inlet guide vane is obstructed; anda heat exchanger disposed in a supply passage in fluid communication with a second flow of air received by the fan, the second flow of air received by the fan via the supply passage with the inlet guide vane in the open position or in the closed position.2. The system of claim 1 , wherein the second flow of air through the supply passage is induced by a differential pressure between an inlet of the supply passage and the fan claim 1 , the differential pressure created by rotation of the fan.3. The system of claim 1 , further comprising a plenum at least partially surrounding a part of the housing and in fluid communication with the fan claim 1 , the supply passage also in fluid communication with the plenum such that the second flow of air is circumferentially supplied to the fan by the plenum.4. The system of claim 3 , ...

System for Conducting the Identification of Bacteria in Urine

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples. 116-. (canceled)17. A method for processing a fluid sample in preparation for the identification and quantification of micro-organisms in the fluid sample , the steps comprising:a) obtaining a fluid sample;b) passing the fluid sample through a filter;c) obtaining a sample of the filtered fluid sample and placing it into a centrifuge tube; 1) centrifuging the sample of step c);', '2) decanting a portion of the fluid in the centrifuge tube of step 1);', '3) replacing the decanted solution of step 2) with a saline solution; and, 'd) obtaining a dilution of the dissolved material in the fluid sample while retaining bacteria in the fluid sample by performing the following stepse) transferring the final solution of step 4) into an optical cup or cuvette for analysis.18. The method of claim 17 , wherein the fluid sample is urine.19. The method of claim 17 , wherein step d) results in about a 1 claim 17 ,000 claim 17 ,000:1 dilution.20. The method of claim 17 , wherein the sample of step (d)(1) is ...

Ebeam tomosynthesis for radiation therapy tumor tracking

A system for tracking tumors during radiotherapy for interleaving treatment pulses with imaging pulses is disclosed. The system includes a multisource scanning eBeam X-ray tube having a plurality of focal spots. The X-ray tube is configured to emit X-rays in a plurality of different locations on a target by sequentially emitting the X-rays to the focal spots in the plurality of focal spots. This is done such that the X-rays can be emitted to the plurality of different locations without substantially moving the X-ray tube or the target. The system further includes an imager panel configured to act as the target and configured to receive the X-rays from the focal spots of the X-ray tube. The system further includes a tomosynthesis reconstruction module configured to process output from the imager panel to construct an image.

CALIBRATION OF ELECTRODE-TO-MUSCLE MAPPING FOR FUNCTIONAL ELECTRICAL STIMULATION

A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns. 1. A functional electrical stimulation (FES) system comprising:an FES device configured for connection with an associated body part and including electrodes arranged to apply functional electrical stimulation to the associated body part and further including sensors to measure a position of the associated body part; and for each proposal of a current pool of proposals, applying the proposal comprising an electrode energization pattern to the electrodes of the FES device and receiving sensor readings from the sensors of the FES device with the associated body part positioned by the applying of the proposal and generating an error metric for the proposal with respect to the movement using an error function corresponding to the movement that depends on the sensor readings, and', 'generating an updated pool of proposals for a next iteration of the iterative calibration method by modifying the proposals of the current pool of proposals based on the generated error metrics,, 'an electronic processor programmed to ...

EXTRACTION AND CLASSIFICATION OF 3-D OBJECTS

Automatic threat detection of volumetric computed tomography (CT) data, including: extracting at least one 3-D object from the volumetric CT data; constructing a feature vector for each of the at least one 3-D objects; and classifying each 3-D object as one of a threat or benign object using the feature vector and a set of truth threat and benign objects. 1. A method for automatic threat detection of volumetric computed tomography (CT) data , the method comprising:extracting at least one 3-D object from the volumetric CT data;constructing a feature vector for each of the at least one 3-D objects; andclassifying each 3-D object as one of a threat or benign object using the feature vector and a set of truth threat and benign objects.2. The method of claim 1 , wherein the volumetric CT data is obtained from a CT scan of the baggage.3. The method of claim 1 , wherein extracting at least one 3-D object comprises:pre-processing the volumetric CT data;sequentially applying a segmentation and carving technique on the pre-processed data to generate segmented data; andpost-processing the segmented data.4. The method of claim 3 , wherein pre-processing comprisescompensating for artifacts in the volumetric CT data using an edge-preserving bilateral filter or a Total Variation minimization filter.5. The method of claim 3 , wherein the segmentation and carving technique compriseslabelling the at least one 3-D object with a connected component labeling (CCL) processing using the symmetric region growing (SRG) with connectivity strength that varies across the volume.6. The method of claim 3 , wherein the post-processing comprises:splitting merged 3-D objects; andmerging split 3-D objects.7. The method of claim 3 , wherein the post-processing comprises:reducing a dimensionality of the at least one 3-D object using simple linear clustering; andsplitting merged 3-D objects and merging split 3-D objects.8. The method of claim 7 , wherein splitting the merged 3-D objects comprises: ...

VISTA ANTIGEN-BINDING MOLECULES

VISTA antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules. 1. An antigen-binding molecule , optionally isolated , which is capable of binding to VISTA and inhibiting VISTA-mediated signalling , independently of Fc-mediated function.2. The antigen-binding molecule according to claim 1 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:305', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:306', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:307; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:308', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:43., '(ii) a light chain variable (VL) region incorporating the following CDRs3. The antigen-binding molecule according to or claim 1 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:290', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:291', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:278; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:309', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:43., '(ii) a light chain variable (VL) region incorporating the following CDRs4. The antigen-binding molecule according to any one of to claim 1 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:290', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:291', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:278; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:41 ...

ENGINEERED FC

Antigen-binding molecules comprising an Fc region comprising a polypeptide having: (i) C at the position corresponding to position 242, and C at the position corresponding to position 334, and (ii) one or more of: A at the position corresponding to position 236, D at the position corresponding to position 239, E at the position corresponding to position 332, L at the position corresponding to position 330, K at the position corresponding to position 345, and G at the position corresponding to position 430 are disclosed. Also discloses are constituent polypeptides of such Fc regions, nucleic acids encoding such antigen- binding molecules and polypeptides, compositions comprising such antigen-binding molecules, polypeptides and nucleic acids, and methods using the same. 1. An antigen-binding molecule , optionally isolated , comprising an Fc region , the Fc region comprising a polypeptide having: (i) C at the position corresponding to position 242 , and C at the position corresponding to position 334 , and (ii) one or more of: A at the position corresponding to position 236 , D at the position corresponding to position 239 , E at the position corresponding to position 332 , L at the position corresponding to position 330 , K at the position corresponding to position 345 , and G at the position corresponding to position 430.2. The antigen binding molecule according to claim 1 , wherein the Fc region comprises a polypeptide having: (i) C at the position corresponding to position 242 claim 1 , and C at the position corresponding to position 334 claim 1 , and (ii) A at the position corresponding to position 236 claim 1 , D at the position corresponding to position 239 claim 1 , E at the position corresponding to position 332 claim 1 , and L at the position corresponding to position 330;or A at the position corresponding to position 236, D at the position corresponding to position 239, and E at the position corresponding to position 332; or A at the position corresponding ...

Vista antigen-binding molecules

V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules.

HER3 ANTIGEN-BINDING MOLECULES

HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules. 144.-. (canceled)45. An antigen-binding molecule which binds to HER3 , comprising: HC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:45', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:48; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:88', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:92', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:95., '(ii) a light chain variable (VL) region incorporating the following CDRs46. The antigen-binding molecule according to claim 45 , wherein the antigen-binding molecule comprises:a VH region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:36; anda VL region comprising an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:83.47. The antigen-binding molecule according to claim 45 , wherein the antigen-binding molecule further comprises an Fc region.48. A method of treating or preventing a cancer in a subject claim 45 , the method comprising administering to a subject a therapeutically or prophylactically effective amount of an antigen-binding molecule which binds to HER3 claim 45 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:45', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:48; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:88', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:92', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:95., '(ii) a light chain variable (VL) ...

ENGINE DEGREDATION MANAGEMENT VIA MULTI-ENGINE MECHANICAL POWER CONTROL

A multi-engine power system is described that includes at least a first engine and a second engine configured to jointly provided mechanical power to the multi-engine power system. The multi-engine power system further includes a controller configured to estimate a deterioration factor of the first engine. The controller is further configured to adjust, based on the deterioration factor of the first engine, a first amount of mechanical power being provided by the first engine to increase a service time of the first engine, and adjust, based on the first amount of mechanical power being provided by the first engine, a second amount of mechanical power being provided by the second engine to compensate for the adjustment to the first amount of mechanical power. 1. An engine controller comprising:at least one processor; and estimate a deterioration factor of a first engine from two or more engines that are configured to jointly provide mechanical power to a multi-engine power system;', 'adjust, based on the deterioration factor of the first engine, a first amount of mechanical power being provided by the first engine to extend a service time of the first engine; and', 'adjust, based on the first amount of mechanical power being provided by the first engine, a second amount of mechanical power being provided by a second engine from the two or more engines to compensate for the adjustment to the first amount of mechanical power., 'a memory storing instructions that, when executed, cause the at least one processor to2. The engine controller of claim 1 , wherein the instructions claim 1 , when executed claim 1 , further cause the at least one processor to adjust the first amount of mechanical power being provided by the first engine to adjust a rate of change of the deterioration factor of the first engine.3. The engine controller of claim 2 , wherein the instructions claim 2 , when executed claim 2 , further cause the at least one processor to:decrease the first amount of ...

HER3 ANTIGEN-BINDING MOLECULES

HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules. 123-. (canceled)24. An antigen-binding molecule comprising a heavy chain variable (VH) region and a light chain variable (VL) region , wherein the antigen-binding molecule specifically binds to HER3 , and wherein binding to HER3 comprises contact with one or more amino acid residues of the region of HER3 shown in SEQ ID NO:229.25. The antigen-binding molecule according to claim 24 , wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:43', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:46', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:51; and, 'a VH region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:91', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:94', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:99., 'a VL region incorporating the following CDRs26. The antigen-binding molecule according to claim 24 , wherein the antigen-binding molecule comprises: [ HC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:44', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:47; and, 'a VH region having the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:88', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:92', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:95; or, 'a VL region having the following CDRs], '(a)'} [ HC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:44', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:47; and, 'a VH region having the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:89', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:92', 'LC-CDR3 having the amino acid sequence of SEQ ID ...

VISTA ANTIGEN-BINDING MOLECULES

VISTA antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules. 134-. (canceled)35. An antigen-binding molecule comprising a heavy chain variable (VH) region and a light chain variable (VL) region , wherein the antigen-binding molecule specifically binds to human VISTA and mouse VISTA , and wherein the antigen-binding molecule inhibits VISTA-mediated signalling independently of Fc-mediated function.36. The antigen-binding molecule according to wherein the antigen-binding molecule comprises: HC-CDR1 having the amino acid sequence of SEQ ID NO:305', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:306', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:307; and, 'a VH region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:308', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:43., 'a VL region incorporating the following CDRs37. The antigen-binding molecule according to claim 35 , wherein the antigen-binding molecule comprises: [ HC-CDR1 having the amino acid sequence of SEQ ID NO:290', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:291', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:278; and, 'a VH region having the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:309', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:43; or, 'a VL region having the following CDRs], '(a)'} [ HC-CDR1 having the amino acid sequence of SEQ ID NO:290', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:291', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:278; and, 'a VH region having the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:41', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:295', 'LC-CDR3 having the amino acid sequence ...

DYNAMIC BEAM APERTURE CONTROL TO REDUCE RADIATION DOSE USING COLLIMATOR

An apparatus to perform a CT scan of an object of interest with a reduced radiation dose including: an X-ray source configured to circularly rotate about the object of interest, the X-ray source configured to generate an X-ray beam; a detector assembly configured to move in tandem with the X-ray source on the opposite side of the X-ray source with respect to the object of interest, wherein the detector assembly is fixed with respect to the X-ray source and configured to detect the X-ray beam on a side of the object of interest opposite to the X-ray source after the X-ray beam passes through the object of interest; a 6-DOF collimator coupled to the X-ray source and comprising a plate with a hole disposed within the plate, wherein an aperture of the X-ray beam is dynamically adjusted by controlling a 3-D pose of the plate. 1. A computed tomography (CT) apparatus to perform a CT scan of an object of interest with a reduced radiation dose , the apparatus comprising:an X-ray source configured to circularly rotate about the object of interest, the X-ray source configured to generate an X-ray beam;a detector assembly configured to move in tandem with the X-ray source on the opposite side of the X-ray source with respect to the object of interest,wherein the detector assembly is fixed with respect to the X-ray source and configured to detect the X-ray beam on a side of the object of interest opposite to the X-ray source after the X-ray beam passes through the object of interest;a six degree-of-freedom (6-DOF) collimator coupled to the X-ray source and comprising a plate with a hole disposed within the plate,wherein an aperture of the X-ray beam is dynamically adjusted by controlling a three-dimensional (3-D) pose of the plate.2. The apparatus of claim 1 , wherein the X-ray beam is a cone beam.3. The apparatus of claim 1 , wherein the plate is configured as a circular plate.4. The apparatus of claim 3 , wherein the hole is positioned at the center of the circular plate.5. ...

KILOVOLTAGE RADIATION THERAPY

Apparatus and methods to deliver kV X-rays toward a target lesion within a body including: a treatment anode configured to receive electron beams and output the kV X-rays through a specially-designed collimator; an electron beam source configured to generate and direct the electron beams toward the treatment anode; and at least one magnet configured to steer and scan the electron beams along the treatment anode to prevent overheating of the treatment anode. The components are mounted on a gantry that rotates about the target lesion to distribute the dose delivered over a large volume of healthy tissue while substantially maximizing the dose delivered to the target lesion. 1. An apparatus for delivering kV X-rays toward a target lesion within a body , the apparatus comprising:a treatment anode configured to receive electron beams and output the kV X-rays;an electron beam source configured to generate and direct the electron beams toward the treatment anode; andat least one magnet configured to steer and scan the electron beams along the treatment anode to prevent overheating of the treatment anode.2. The apparatus of claim 1 , further comprisinga collimator configured to receive the kV X-rays from the treatment anode and block out all of the kV X-rays not directed to a convergence point centered at the target lesion.3. The apparatus of claim 2 , further comprisinga gantry configured to mount and rotate the electron beam source, the at least one magnet, the treatment anode, and the collimator about an axis that includes the target lesion.4. The apparatus of claim 2 , wherein the kV X-rays output from the collimator are in a plane substantially perpendicular to the electron beams steered and scanned onto the treatment anode.5. The apparatus of claim 2 , further comprisinga plurality of imaging anodes configured to provide real-time images of the target lesion,wherein the real-time images enable tracking of the target lesion and adjustment of the collimator to move the ...

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

CD47 ANTIGEN-BINDING MOLECULES

CD47 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the CD47 antigen-binding molecules. 139-. (canceled)40. An antigen-binding molecule which binds to CD47 , comprising: HC-CDR1 having the amino acid sequence of SEQ ID NO:169', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:170', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:26; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs LC-CDR1 having the amino acid sequence of SEQ ID NO:171', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:172', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:173., '(ii) a light chain variable (VL) region incorporating the following CDRs41. The antigen-binding molecule according to claim 40 , wherein the antigen-binding molecule comprises: [ HC-CDR1 having the amino acid sequence of SEQ ID NO:137', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:138', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:26; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:32', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:33', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:34;, '(ii) a light chain variable (VL) region incorporating the following CDRs], '(a)'}or [ HC-CDR1 having the amino acid sequence of SEQ ID NO:24', 'HC-CDR2 having the amino acid sequence of SEQ ID NO:25', 'HC-CDR3 having the amino acid sequence of SEQ ID NO:26; and, '(i) a heavy chain variable (VH) region incorporating the following CDRs, LC-CDR1 having the amino acid sequence of SEQ ID NO:32', 'LC-CDR2 having the amino acid sequence of SEQ ID NO:33', 'LC-CDR3 having the amino acid sequence of SEQ ID NO:34;, '(ii) a light chain variable (VL) region incorporating the following CDRs], '(b)'}or [ HC-CDR1 having the amino acid sequence of SEQ ID NO:24', 'HC-CDR2 having the amino acid ...

Diluent wells produced in card format for immunodiagnostic testing

An immunodiagnostic test card includes a flat planar member and at least one dilution chamber that is supported by the flat planar member. The at least one dilution chamber can be disposed adjacent chambers used for testing a patient sample that are provided on the immunodiagnostic test card or can be provided separately.

Rotating X-ray tube with external bearings

X-ray tube includes a rotatable envelope in which is mounted an electron gun at one end and a target anode at the other end. A fixed means for deflecting the electron beam from the electron gun is provided to deflect the electron beam on a fixed path as the envelope of the x-ray tube rotates about an axis. The electron beam being confined to a fixed path results in the electron beam striking various positions of the target anode to provide for improved heat dissipation. The electron beam is deflected along the fixed path using magnetic deflection means including magnetic deflection coils positioned external of the envelope to provide a deflection field transverse to the electron beam. The target anode is cooled by directing a cooling fluid on an external side of the target anode.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus

DRUG INSPECTOR'S DEVICE WITH DRIVING SYSTEM EASY TO EFFECT

Μία ιατρική συσκευή εγχυτή όπως μία πένα έγχυσης. Η πένα έγχυσης (20) περιλαμβάνει ένα επιδεκτικό επαναφοράς, σύστημα οδήγησης εμβόλου φυσιγγίου και μπορεί να περιλαμβάνει ένα σύστημα μηχανισμού ηχητικής ένδειξης έγχυσης που έχει ένα κολάρο διατεταγμένο ομοαξονικά επάνω σε ένα χιτώνιο οδήγησης και το οποίο ταλαντώνεται αξονικά επάνω στο χιτώνιο οδήγησης που περιστρέφεται κατά τη χορήγηση φαρμάκου για παροχή ενός ακουστικού ήχου ένδειξης που υποδεικνύει τη χρήση έγχυσης της πένας. Η πένα έγχυσης μπορεί να περιλαμβάνει επίσης έναν επιδεκτικό δοσολογίας ποσοτικό αναγνωριστή που χρησιμοποιεί μία περιστροφική μήτρα και έναν αισθητήρα για ηλεκτρική ανίχνευση της διάταξης του μηχανισμού καθορισμού δόσης της πένας, ο οποίος αναγνωριστής μπορεί να είναι μέρος ενός συστήματος ένδειξης θεραπευτικής δόσης που χρησιμοποιεί έναν αναγνωστήρα φυσιγγίου για αναγνώριση μίας συγκέντρωσης φαρμάκου έτσι ώστε να επιτρέπεται ένας αυτόματος προσδιορισμός μίας θεραπευτικής δόσης. A medical injector such as an injection pen. The injection pen (20) comprises a resilient, cartridge plunger drive system and may comprise a sound-injection mechanism system having a collar coaxially arranged on a drive sleeve and which oscillates axially on the driving spin sleeve. drug for providing an acoustic signal indicating the use of a pen injection. The injection pen may also include a dosing quantitative identifier employing a rotary die and a sensor for electrically detecting the device of the pen dosing device, which identifier may be part of a therapeutic dose indication system using a cartridge reader for identification of a drug concentration so as to permit an automatic determination of a therapeutic dose.

MEDICAMENT INJECTION DEVICE WITH RESERVATION OF SIMILAR DRIVE ARRANGEMENT

Device for injecting drugs

MEDICATION INJECTOR DEVICE WITH MOTOR ASSEMBLY THAT FACILITATES THE REARME.

Un conjunto motriz de pistón con cartucho, rearmable de un mecanismo de inyección de dosis de un aparato (20) inyector de medicación, incluyendo el aparato una base (26) reutilizable y un conjunto (24) con cartucho que puede montarse en la base (26), teniendo la base (26) un elemento (135) motriz giratorio del mecanismo de inyección de dosis dentro de un alojamiento de base, teniendo el conjunto (24) con cartucho un cartucho (22) lleno de medicamento con un pistón (34) móvil en un extremo y una salida en el otro extremo, comprendiendo el conjunto motriz: una tuerca (60) enchavetada al alojamiento de base para ser, tanto móvil con respecto al él entre las posiciones axiales primera y segunda, como para fijarse giratoriamente con respecto a él en las posiciones axiales primera y segunda, incluyendo dicha tuerca (60) una abertura (81, 82) roscada internamente; un tornillo (120) que incluye un extremo (121) distal enganchado al pistón y un roscado (124) externo en enganche roscado con dicha abertura roscada internamente de dicha tuerca; un embrague (100) motriz conectado a dicha tuerca (60) para retenerse axialmente y moverse giratoriamente con respecto a ella, enchavetado dicho embrague (100) motriz a dicho tornillo (120) para fijarse giratoriamente y moverse axialmente con respecto a él; situada dicha tuerca (60) dentro del alojamiento de base para ser móvil axialmente desde dicha primera posición axial hasta dicha segunda posición axial mediante el enganche con el conjunto (24) con cartucho durante el montaje del conjunto (24) con cartucho a la base (26) reutilizable, en la que: dicho embrague (100) motriz está en enganche de transmisión de momento de torsión con el elemento (135) motriz giratorio cuando dicha tuerca (60) está dispuesta en dicha segunda posición axial, por lo que el giro del elemento (135) motriz durante el funcionamiento del mecanismo de inyección de dosis hace girar dicho embrague (100) motriz y, por tanto, dicho tornillo (120), para producir el ...

Medication injector apparatus with drive assembly that facilitates reset

Process and autoinjector device for injections with increased patient comfort

The invention provides methods and apparatus for injecting a medicine, especially a highly viscous medicine. Conventional methods and apparatus for injecting viscous medicines suffers from a variety of problems such as excessive force during the initial needle insertion and initial injection. In an inventive method, during the initial phase of the injection, energy is stored in a torsion spring that is subsequently released during a later stage of the injection. The present invention also provides for an improved autoinjector; especially via the use of a combination compression and torsion spring that powers the injection through controlling force applied to plunger via a screw flange or nut having pins that ride in a prescribed path down the length of the autoinjector.

Medication injector apparatus with drive assembly that facilitates reset

Drug injector device with drive that facilitates resetting

Medication injector apparatus

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen includes a doseable quantity identifier that uses a rotational matrix (500) and a sensor (502) for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus

Medication injector apparatus with drive assembly that facilitates reset

The invention relates to a medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. The injection pen also may include an injection clicker assembly. The injection pen also may include a doseable quantity identifier. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

Medication injector apparatus

Medication injector apparatus

Un identificador de la cantidad dosificable para un aparato inyector de medicamentos (620) que tiene unmecanismo de ajuste de la dosis (680, 690, 695) accionable para seleccionar un volumen de medicina a administrardesde un cartucho 5 sujeto (632), que comprende: una matriz rotacional (800) dispuesta sobre un primer componente del aparato; un sensor (805, 806) para detectar eléctricamente la matriz rotacional, dicho sensor dispuesto sobre un segundocomponente del aparato que experimenta movimiento rotacional con respecto al primer componente durante elaccionamiento del mecanismo de ajuste de la dosis; con lo cual datos de dicha matriz rotacional detectables por dicho sensor de la matriz son de este modoindicativos de una disposición del mecanismo de ajuste de la dosis; un controlador (867) en circuito con dicho sensor que interpreta datos de dicha matriz rotacional detectados pordicho sensor para determinar una cantidad de medicina a administrar desde el cartucho durante la inyección; yuna pantalla visible (871) que muestra la cantidad de medicina a administrar según lo determinado por dichocontrolador; caracterizado por que dicho identificador de la cantidad dosificable incluye, además, dicha matriz que incluyeuna pluralidad de filas y una pluralidad de columnas, en el que dicho sensor incluye una pluralidad de contactoseléctricos (810, 811, 812, 816, 817, 818), cada uno de dichos contactos alineado con una fila diferente de dichamatriz, en el que dichos datos de la matriz están en forma de presencia o ausencia de un material conductor dela electricidad en intersecciones de dichas filas y columnas de dicha matriz, y en el que dicha pluralidad decontactos eléctricos y dicha matriz rotacional están configurados de forma cooperativa de modo que, cuando losprimer y segundo componentes están desplazados rotacionalmente de forma respectiva desde una primeraposición rotacional, un cambio en los datos de la matriz detectado por cualquier único contacto eléctrico noproduce ...

Medication injector apparatus

Un aparato inyector de medicamentos (620), que comprende: una carcasa (670); un recipiente de fluido (632) montado sobre dicha carcasa, dicho recipiente de fluido definiendo un depósito lleno de medicina e incluyendo un pistón móvil (638)en un extremo proximal de dicho depósito; un conjunto de aguja (628) fijado de forma que pueda desmontarse a un extremo distal de dicho recipiente defluido para tener una aguja de inyección de dicho conjunto de aguja en comunicación de flujo con dichodepósito; un miembro impulsor (780) avanzable dentro de dicha carcasa en una dirección distal para mover dicho pistónhacia dicha aguja de inyección para empujar medicina desde dicho recipiente; un elemento de ajuste de la dosis (680) que incluye una parte de control (690, 695) externa a dicha carcasa,caracterizado por que: dicha parte de control es giratoria de forma manual en una primera dirección para atornillar dicho elementode ajuste de la dosis desde una posición hundida a una posición hundible en la que dicho elemento deajuste de la dosis se proyecta más lejos proximalmente desde dicha carcasa que en dicha posiciónhundida; medios (685, 700, 705, 710, 712, 716), accionables trasladando sin rotación dicho elemento de ajuste de ladosis de dicha posición hundible a dicha posición hundida, para hacer avanzar a dicho miembro impulsoren dicha dirección distal, comprendiendo dichos medios de avance un manguito impulsor (710) y un cuerpocilíndrico (700) dentro de dicha carcasa que experimentan rotación relativa durante al menos una parte deun movimiento de dicho elemento de ajuste de la dosis entre dicha posición hundida y dicha posiciónhundible, en el que dicho cuerpo cilíndrico y dicho manguito impulsor se disponen para trasladarsedistalmente sin rotación dentro de dicha carcasa de una primera posición axial a una segunda posición axialcuando dicho elemento de ajuste de la dosis se traslada sin rotación durante un segmento de sudesplazamiento de dicha posición hundible a dicha posición ...

Device for injecting drugs

Medication injector apparatus

Medication injector apparatus with drive assembly that facilitates reset

The invention relates to a medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. The injection pen also may include an injection clicker assembly. The injection pen also may include a doseable quantity identifier. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus

Un aparato inyector de medicamentos (620), que comprende: una carcasa (670); un recipiente lleno de medicina (632) montado sobre dicha carcasa y que incluye un pistón móvil (638) en unextremo y una salida en el otro extremo; un miembro impulsor (780) avanzable dentro de dicha carcasa en unadirección distal para mover a dicho pistón hacia dicha salida para empujar a la medicina desde dicho recipiente;un manguito impulsor (710) alrededor y conectado de forma operativa a dicho miembro impulsor, dichomanguito impulsor giratorio para hacer avanzar a dicho miembro impulsor distalmente; y un elemento de ajuste de la dosis (680) que incluye una parte giratoria manualmente (690, 695) externa a dichacarcasa, dicho elemento de ajuste de la dosis en acoplamiento roscado con dicho manguito impulsor; siendodicha parte giratoria manualmente giratoria en una primera dirección de modo que dicho elemento de ajuste dela dosis gira y se mueve proximalmente a lo largo de dicho manguito impulsor debido al acoplamiento roscadoentre ambos, con lo cual dicho elemento de ajuste de la dosis se mueve desde una posición hundida a unaposición hundible en la cual dicho elemento de ajuste de la dosis se proyecta más lejos proximalmente desdedicha carcasa que en dicha posición hundida; caracterizado por que: el aparato comprende además un cuerpo cilíndrico (700) alrededor de dicho manguito impulsor y móvil endicha dirección distal dentro de dicha carcasa mediante acoplamiento con dicho manguito impulsor desdeuna primera posición axial a una segunda posición axial, siendo dicho cuerpo cilíndrico libre en rotación conrespecto a dicha carcasa en dicha primera posición axial y estando fijado en rotación con respecto a dichacarcasa en dicha segunda posición axial; dicho elemento de ajuste de la dosis enchavetado con dicho cuerpo cilíndrico dentro de dicha carcasa paraser móvil axialmente y fijo en rotación con respecto a dicho cuerpo cilíndrico; y con lo cual cuando dicho elemento de ajuste de la dosis ...

MEDICATION INJECTOR DEVICE WITH MOTOR ASSEMBLY THAT FACILITATES REARME.

Un conjunto de dispositivo de inyección que al ser accionado emite un clic para un aparato inyector de medicación, incluyendo el aparato un tornillo motriz (270, 354) que puede avanzar en una dirección distal para desplazar un émbolo móvil (365) de un cartucho para empujar a la medicación desde una salida del cartucho, un manguito motriz (242, 325) de un mecanismo de inyección de la dosis que puede girar en una primera dirección dentro de una carcasa (254) del aparato, incluyendo el manguito motriz una superficie orientada hacia el lado distal y definiendo un orificio en el que se extiende el tornillo motriz, y un embrague (266, 350), conectado al tornillo motriz, que se hace girar mediante acoplamiento con la superficie orientada hacia el lado distal del manguito motriz para, de este modo, hacer girar y avanzar al tornillo motriz a través de una tuerca (275, 360) dentro de la carcasa, comprendiendo el conjunto de dispositivo de inyección que al ser accionado emite un clic: un collar (240, 290) dispuesto de forma coaxial en el manguito motriz en una ubicación proximal de la superficie orientada hacia el lado distal del manguito motriz, siendo dicho collar conectable al manguito motriz para ser móvil axialmente con respecto a éste y fijo en rotación con respecto a éste cuando el manguito motriz gira en la primera dirección, incluyendo dicho collar una pluralidad de dientes (248, 296) que se extienden en una dirección axial y adaptados para acoplarse a dientes correspondientes (250, 347) de una superficie de tope (252, 348), pudiendo dicha superficie de tope formarse de una sola pieza con o conectarse de forma que no pueda girar a una carcasa del aparato; un elemento de empuje (258, 320) adaptado para empujar a dicho collar axialmente para que se acople mediante engranado con dicha superficie de tope; y estando dicho collar y dicha superficie de tope configuradas de forma complementaria, de modo que durante la rotación del manguito motriz en la primera dirección, y ...

Drug injection device with drive unit facilitating back position

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen includes a doseable quantity identifier that uses a rotational matrix (500) and a sensor (502) for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and the drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The pen also includes an electronics assembly that has a display (871) to show a dose of medicine to be injected.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

MEDICAMENT INJECTION DEVICE WITH RESERVATION OF SIMILAR DRIVE ARRANGEMENT

Medication Injector Apparatus with Drive Assembly that Facilitates Reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a closeable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen further may include an assembly for selectively rotating a drive sleeve (710) of the pen, which assembly has a dial (680) that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

The invention relates to a medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. The injection pen also may include an injection clicker assembly. The injection pen also may include a doseable quantity identifier. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen further may include an assembly for selectively rotating a drive sleeve (710) of the pen, which assembly has a dial (680) that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen includes a doseable quantity identifier that uses a rotational matrix (500) and a sensor (502) for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and the drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The pen also includes an electronics assembly that has a display (871) to show a dose of medicine to be injected.

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen (20) includes a resettable, cartridge plunger drive assembly, and may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose.

Medication injector apparatus with drive assembly that facilitates reset

The invention relates to a medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. The injection pen also may include an injection clicker assembly. The injection pen also may include a doseable quantity identifier. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Injection clicker assembly, dose indicator, doseable quantity identifier, dose displaying method, and medication injection device

【課題】改良された薬物放出器具を提供する。 【解決手段】注射ペンが、注射クリッカーアセンブリーを備えており、この注射クリッカーアセンブリーが、駆動スリーブ上に同心に配置されたカラーを備えており、このカラーは、駆動スリーブ上を軸方向に往復し、そのスリーブは、薬剤投与中に回転して可聴クリック音を生じ、ペンの注射中であることを表示する。この注射ペンは、また、服用可能量確認器を備えており、この確認器は、ペンの服用量セッテイング機構の配置を電気的に検知するための、回転マトリックスとセンサーとを使用し、その確認器は治療上服用量表示システムの一部であり、このシステムは薬物の濃度を認識するためのカートリッジ認識器を使用し、これよって治療上服用量の自動的決定を可能にしている。注射ペンは、更に、ペンの駆動スリーブを選択的回転させるためのアセンブリーを含有しており、このアセンブリーは服用量セッテイング中に外側に回転し、かつ服用量の注射中には回転せずに移行する、ダイヤルを有している。 【選択図】図２７

Medication injector apparatus with drive assembly that facilitates reset

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pcn, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Therapeutic dose indicating apparatus, doseable quantity identifier, method of idicating therapeutic dose, and medication injector apparatus

【課題】改良された薬物放出器具を提供する。 【解決手段】注射ペンが、注射クリッカーアセンブリーを備えており、この注射クリッカーアセンブリーが、駆動スリーブ上に同心に配置されたカラーを備えており、このカラーは、駆動スリーブ上を軸方向に往復し、そのスリーブは、薬剤投与中に回転して可聴クリック音を生じ、ペンの注射中であることを表示する。この注射ペンは、また、服用可能量確認器を備えており、この確認器は、ペンの服用量セッテイング機構の配置を電気的に検知するための、回転マトリックスとセンサーとを使用し、その確認器は治療上服用量表示システムの一部であり、このシステムは薬物の濃度を認識するためのカートリッジ認識器を使用し、これよって治療上服用量の自動的決定を可能にしている。注射ペンは、更に、ペンの駆動スリーブを選択的回転させるためのアセンブリーを含有しており、このアセンブリーは服用量セッテイング中に外側に回転し、かつ服用量の注射中には回転せずに移行する、ダイヤルを有している。 【選択図】図２７

Bcma/taci antigen-binding molecules

BCMA/TACI antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the BCMA/TACI antigen-binding molecules.

Tomosynthesis using high speed CT scanning system

A tomogram is obtained by tomosynthesis in a high speed CT scanning system in which fan beams of radiation are generated by sweeping an electron beam along a target, and collimated X-rays emitted by the target are received by an array of detectors after passing through a patient area between the target and array of detectors. The patient is moved through the collimated x-rays as the measurments are obtained, and the measurements are time-correlated to correspond to data measurements for a plurality of projection radiographs. The measurements for the plurality of radiographs are combined to tomosynthesize a tomogram at a selected plane in the patient.

Irradiation system including an electron-beam scanner

A property of a treatment beam is controlled during a scanning period. A portion of a region is exposed to an imaging x-ray beam during a scanning period, the imaging x-ray beam being generated by an electron-beam scanner. X-ray radiation from the region is detected, the x-ray radiation representing an attenuation of the imaging x-ray beam caused by the portion of the region. A first image of the portion of the region is generated based on the detected x-ray radiation. A characteristic of the portion of the region is determined from the generated first image. An input derived from the characteristic is generated, the input configured to cause a source of a treatment beam to modify a property of the treatment beam. The source of the treatment beam modifies a property of the treatment beam during the scanning period by providing the input to the source of the treatment beam.

System for conducting the identification of bacteria in urine

A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

METHOD AND APPARATUS FOR X-RAY OR .gamma.-RAY 3-D TOMOGRAPHY USING A FAN BEAM

Application for Patent of Douglas P. Boyd for METHOD AND APPARATUS FOR X-RAY OR .gamma.-RAY ABSTRACT OF THE DISCLOSURE A fan-shaped beam of penetrating radiation, such as X-ray or y-ray radiation, is directed through a slice of the body to be analyzed to a position sensitive detector for deriving a shadow-graph of transmission or absorption of the penetrating radiation by the body. A number of such shadowgraphs are obtained for different angles of rotation of the fan-shaped beam relative to the center of the slice being analyzed. The detected fan beam shadowgraph data is reordered into shadowgraph data corres-ponding to sets of parallel paths of radiation through the body. The reordered parallel paths shadowgraph data is then convoluted in accordance with a 3-D reconstruction method of convolution in a computer to derive a 3-D reconstructed tomograph of the body under analysis. In a preferred embodiment, the position sensitive detector comprises a multiwire detector wherein the wires are arrayed parallel to the direction of the divergent penetrating rays to be detected. A focused grid collimator is interposed be-tween the body and the position sensitive detector for collimating the penetrating rays to be detected. The source of penetrating radiation is preferably a monochromatic source.

Electrochemical analytical cartridge

An electro-analytical cartridge adapted for use in analyzing fluids. The cartridge (10) includes an electrochemical device (22) that measures ionic activity using ion-specific electrodes. The cartridge (10) further includes a plumbing system composed of the electrochemical device (22) and various wells or chambers which are interconnected by passageways (60 and 62). After introduction into the cartridge (10), liquid samples are measured out and transported to the electrochemical device (22) utilizing a sequential application of centrifugal force followed by pressurization of the system. Reference fluid is transported from a reference fluid well (80) or reservoir to the electrochemical device (22) for use in measuring ionic activity. The cartridge (10) may be used to measure the ionic activity of a wide variety of ions in fluids including bodily fluids.

Sweep flow valve with removable valve seat

A fluid control valve for controlling fluid flow includes a valve housing having an inlet port (28), and outlet port (32), and a passage (40) in the valve housing interconnecting and permitting fluid communication between the inlet port and the outlet port. The passage is substantially smoothly contoured along the length of the interior thereof so that when fluid flows through the passage, the flow of fluid will not substantially increase in turbulence in the passage. The fluid control valve further includes a removable valve seat (46) having an inner flow aperture substantially matching the interior contour of the passage thereby minimizing the turbulence of fluid flow in the passage. A valve element (50) is moveable between a first position wherein fluid flow is permitted through the passage and a second position wherein the valve elemnt sealing engages the valve seat substantially blocking fluid flow through the passage. The valve seat is removably mounted in the passage.

Organic Pork Broth Crisps that have no preservatives. They are made using a trade secret process and are not perfect in shape. They are wafer like and crunchy.

- Only made from Certified Organic Pork - Cooked in filtered water to contain no impurities found in water - No salt added - No other additives - Gluten Free - GAPS Diet friendly - Paleo and Keto Diet accepted - A convenient and healthy way to consume Organic Pork Broth - 12 months shelf life - Made from Organic Pork Broth - Freeze Dried - Not symmetric in shape - Light and Crispy in texture - Varying from Smm to 1 Omm in thickness - Wafer like )i aA 21e

Vista antigen-binding molecules

VISTA antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules.

Particle-toughened polymer compositions

Particle-toughened polymer compositions include a base polymer formula-tion and a plurality of toughening particles. In certain embodiments, the base polymer formu-lation includes bismaleimides or other polymer resins capable of high temperature service. A first plurality of toughening particles may in-clude core shell rubbers. A second plurality of toughening particles may be selected from a variety of polymer compositions, including polyimides, polyether ketone (PEK), polyether ether ketone (PEEK), polyether ketone ketone (PEKK), polyether imide, polyether sulfones, and polyphenylene oxide. It is found that in-creasing concentration of the core shell rub-bers may improve the toughness of the compo-sition while preserving thermal properties of the composition, such as glass transition tem-perature.

Method for pneumatically controlling blender for asphalt shingles

The method for applying granules to a coated asphalt sheet includes accumulating granules in a nozzle having an opening at the bottom for discharging the granules onto the coated asphalt sheet. and changing the air pressure in a buffer chamber positioned in communication with the accumulation of granules to control the flow of granules through the opening.

HEAT-CURING BISMALEIMID RESIN SYSTEM, PRE-IMPREGNATED, IMPREGNATED WITH MATRIX RESIN, HEAT-CURING AND CURED COMPOSITE MATERIAL

Coffee Crisps that have no preservatives. They are made using a trade secret process and are not perfect in shape. They are wafer like and crunchy.

- Only made from high quality coffee beans - Strained through hot water and filtered - Proteins added in the form of Organic Bone Broth and other natural proteins - No salt added - No other additives - Gluten Free - Paleo and Keto Diet accepted - A convenient and healthy way to consume coffee in a non liquid form - 12 months shelf life - Made from Coffee grinds and water - Natural proteins added to bind in cooking process - Freeze Dried - Not symmetric in shape - Light and Crispy in texture - Varying from 5mm to 10mm in thickness - Wafer like ) ) ) 21 ) ) ) )

Particle-toughened fiber-reinforced polymer composites

Method for pneumatically controlling blender for asphalt shingles

The method for applying granules to a coated asphalt sheet includes accumulating granules in a nozzle having an opening at the bottom for discharging the granules onto the coated asphalt sheet. and changing the air pressure in a buffer chamber positioned in communication with the accumulation of granules to control the flow of granules through the opening.

Vendor and scanner independent common workstation for security

Integrating a plurality of security imaging units for an airport security checkpoint into networked common workstations, including: scanning items with a first security imaging unit at a primary inspection area, wherein the first security imaging unit is coupled to a first networked common workstation; displaying the scanned items as a displayed image on a display of the first networked common workstation located at the primary inspection area; re-scanning the items with a second security imaging unit coupled to the first networked common workstation when a possible concealment is observed, wherein the first networked common workstation includes a conversion unit which converts outputs of the first and second security imaging units into a common format for the displayed image; routing the displayed image to a second networked common workstation located at a secondary inspection area when the possible concealment is observed, wherein the secondary inspection area is remote from the primary inspection area.

Particle-toughened fiber-reinforced polymer composites

Particle toughened, fiber-reinforced composites include a fiber region and an interlayer region between the fibers. The fiber region includes a plurality of fibers at least partially within a first polymer composition including a first base polymer formulation and a first plurality of toughening particles. The interlayer region includes a second polymer composition including a second base polymer formulation and at least one of the first plurality of toughening particles and a second plurality of toughening particles. Examples of first and second pluralities of toughening particles, respectively, may include core shell rubbers and polyimides. Increasing concentration of the first plurality of toughening particles may improve the composite toughness while preserving thermal properties of the composite, such as weight loss after extended duration exposure to elevated temperature. It is further discovered that the relative placement of the toughening particles influences composite mechanical properties, such as compression after impact (CAI) strength.

FAN BEAM X- OR .gamma.-RAY 3-D TOMOGRAPHY

Application for Patent of Douglas P. Boyd and Michael C. Goitein for ABSTRACT OF THE DISCLOSURE A fan-shaped beam of penetrating radiation, such as X-ray or .gamma.-ray radiation, is directed through a slice of the body to be analyzed to a position sensitive detector for deriving a shadowgraph of transmission or absorption of the penetrating radiation by the body. A number of shadowgraphs are obtained for different angles of rotation of the fan-shaped beam relative to the center of the slice being analyzed. The detected fan beam shadowgraph data is reordered into shadowgraph data corresponding to sets of parallel paths of radiation through the body. The reordered parallel path shadowgraph data is then convoluted in accordance with a 3-D reconstruction method by convolution in a computer to derive a 3-D reconstructed tomograph of the body under analysis. In a preferred embodiment, the position sensitive detector comprises a multiwire detector wherein the wires are arrayed parallel to the direction of the divergent penetrating rays to be detected. A focused grid collimator is interposed between the body and the position sensitive detector for collimating the penetrating rays to be detected. The source of penetrating radiation is preferably a monochromatic source.

Toughened thermosetting structural materials

Toughened bismaleimide resin systems capable of preparing carbon fiber reinforced composites having compres­sion after impact strengths of greater than 40 Ksi are prepared from bismaleimide matrix resin systems containing a member of a limited set of thermoplastic polyimides in parti­culate form.