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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 133. Отображено 133.
11-05-2011 дата публикации

Electric energy supply system for electric vehicle

Номер: CN0102055214A
Принадлежит:

The invention provides electric energy supply system for an electric vehicle, and particularly relates to a highly intelligent electric energy supply system for the electric vehicle. The electric energy supply system comprises a power supply and distribution system, a charging system, a monitoring system and a metering and billing system; the charging system comprises a direct current charger and an alternating current charging pile; the metering and billing system comprises a gateway meter, a direct current ammeter, an alternating current ammeter, a metering manager and a billing system; and the monitoring system comprises power supply and distribution system monitor, charging system monitor and a monitoring center. The electric energy supply system for the electric vehicle improves the intelligence and the automation level of the electric energy supply system for the electric vehicle while meeting the basic function of the electric energy supply system for the electric vehicle, and achieves ...

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22-10-2008 дата публикации

Cooling system of ultra-high strength steel hot stamping forming die

Номер: CN0101288890A
Принадлежит:

The invention discloses a cooling system used for an ultra-high strength steel plate thermal die cutting and forming die. The die comprises a concave die and a concave die seat; a water chamber is arranged between the concave die and the concave die seat; the water chamber is communicated with a water inlet and a water outlet. The water chamber is arranged between the concave die and the concave die seat of the invention; after cooled water is arranged in the water chamber, the steel plate workpiece can be quickly cooled by the thermal conduction between the die and the steel plate so as to meet the quenching condition of the steel plate. Especially, the water chamber is also internally provided with a supporting column; the upper end of the supporting column is contacted with the lower bottom surface of the concave die; the lower end of the supporting column is contacted with the upper bottom surface of the concave die seat; therefore, the structural strength of the concave die is ensured ...

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22-10-2008 дата публикации

Ultra-high strength steel hot stamping forming die

Номер: CN0101288889A
Принадлежит:

The invention discloses an ultra-high strength steel plate thermal die cutting and forming die, comprising an upper die seat and a convex die which is fixed on the upper die seat, a lower die seat and a concave die that is fixed on the lower die seat; the concave die is internally provided with a cooling water passage which is connected with a cooling water circulation system. Especially, the concave die consists of a trough-shaped concave die seat and a cavity body; the concave die seat is provided with a water inlet and a water outlet; the cavity body is arranged in the concave trough of the concave die seat; a gap is arranged between the cavity body and the concave die seat; the gap is communicated with the water inlet and the water outlet. The ultra-high strength steel plate thermal die cutting and forming die improves cooling speed, ensures the uniformity of cooling, has simple and practical structure, and fast cools the die and the punching parts in the die by the water cooling system ...

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04-05-2011 дата публикации

Controller for permanent magnet synchronous brushless motor

Номер: CN0102045012A
Автор: FENG NI, NI FENG
Принадлежит:

The invention discloses a controller for a permanent magnet synchronous brushless motor, which comprises a singlechip and a power module connected with the singlechip, wherein a current detection and calculation module is arranged in the singlechip; and a feedback device is arranged between the singlechip and the power module. The invention overcomes the drawbacks of the prior art and provides the controller which is cheap and does not require an electric brush for the permanent magnet synchronous brushless motor.

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01-07-2015 дата публикации

PCIE SWITCH based multi-interface functional module

Номер: CN104753720A
Принадлежит:

The invention provides a PCIE SWITCH based multi-interface functional module which is applied to the technical field of reinforcing servers. The PCIE SWITCH based multi-interface functional module is that a processor and two PCIE SWITCH form a system core circuit, wherein the PCIE SWITCH can provide rich and various PCIE interfaces such as PCIEX1, PCIEX2, PCIEX4 and PCIEX8; a user can mount a daughter card to expand the function as demand; a peripheral chip SATA controller, a display controller and a network controller expansion SATA/ VGA/ LAN interface can be connected for the user to use; meanwhile, the PCIE interface is converted into the PCI interface through a PCIE-to-PCI bridge chip, and thus a transmission channel is provided for a low-speed chip; the server can perform comprehensive intelligent management for each functional module; the replacement is convenient; the maintenance performance is high.

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10-11-2011 дата публикации

Peptide ligands for clusterin and uses thereof

Номер: AU2010237569A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

Peptides are disclosed that are useful for molecular imaging or diagnosis of a disease state, such as cancer, in which clusterin is upregulated.

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21-01-2009 дата публикации

Uses of ampelopsin and total flavone valid target rich in ampelopsin in preparing medicament for preventing and treating prostate gland cancer

Номер: CN0101347425A
Принадлежит:

The invention provides an ampelopsin and an application of a total flavonoid effective part with rich ampelopsin in preparing a medicine for preventing and treating prostatic cancer. A new, high-efficiency, and low-toxic natural medicine resource is found out by aiming at the difficulty in treating the prostatic cancer, which has obvious curative effect and little toxic or side effect.

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08-07-2009 дата публикации

Door board for warehouse

Номер: CN0101476431A
Принадлежит:

The invention relates to a door panel for a storehouse, which consists of a surface material, reinforcing ribs and supporting frames. Two ends of the surface material are provided with the supporting frames, and a cavity of the surface material on the upper surface and the lower surface of the door panel is provided with a plurality of reinforcing ribs connected in V-shape, so that the door panel has good strength and hardness and definite bending resistance, and can be suitable for various large-sized storehouse doors. The door panel has the characteristics of simple structure, convenient installation, and the like.

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10-06-2009 дата публикации

Preparation of (R)-(-)-apomorphine

Номер: CN0100497315C
Принадлежит:

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24-11-1994 дата публикации

Thrombin inhibitors based on the amino acid sequence of hirudin

Номер: AU0000654820B2
Принадлежит:

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27-04-2011 дата публикации

Synergistic herbicidal composition containing rimsulfuron and bromoxynil

Номер: CN0102027982A
Принадлежит:

The invention discloses a synergistic herbicidal composition containing rimsulfuron and bromoxynil, which comprises the following active ingredients: rimsulfuron and bromoxynil in mass ratio of 1-70:1-50. Compared with single-component herbicides, the synergistic herbicidal composition delays the resistance of weeds, has a broad herbicidal spectrum and acts for a long time on the premise of improving herbicide effect, is safe for corn and afterculture crops, and particularly has an obvious effect of controlling various gramineae weeds and broad leaf weeds in corn fields. The synergistic herbicidal composition can be used for preparing herbicides for controlling postemergence weeds in the corn fields.

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25-02-2004 дата публикации

STAPHYLOCOCCAL NUCLEASE FUSION PROTEINS FOR THE PRODUCTION OF RECOMBINANT PEPTIDES

Номер: AU2003254680A1
Принадлежит:

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07-01-1992 дата публикации

THROMBIN INHIBITORS BASED ON THE AMINO ACID SEQUENCE OF HIRUDIN

Номер: AU0008085591A
Принадлежит:

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09-12-2009 дата публикации

Protecting device of upwards-folding door

Номер: CN0101597992A
Автор: NI FENG, FENG NI
Принадлежит:

The invention relates to a protecting device of an upwards-folding door, which comprises a hook, a pullback spring or a torsional spring or a pressure spring, an on-off wire cable, transverse levers, and the like, wherein both ends of a lower frame of the lowest bottom of the door are respectively provided with a bracket; the brackets are articulated with the hook; one end of the hook is of a hook shape, and the other end is connected with the pullback spring or the torsional spring or the pressure spring; the other end of the pullback spring or the torsional spring or the pressure spring is connected with the upper end of the frame at the same side; the on-off wire cable is fixed on the hook; and a plurality of transverse levers are evenly distributed on an upright post of the door. In the invention, once the on-off wire cable is broken for abrasion or aging, the hook rotates around the brackets for the action of the pullback spring, and therefore, the door is hooked on a close transverse ...

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25-05-2011 дата публикации

Charging and replacing power station, charging and replacing control method and system and operation monitoring system

Номер: CN0102074978A
Принадлежит:

The invention discloses charging and replacing control method and system of a charging and replacing power station, an operation monitoring system of the charging and replacing power station and the charging and replacing power station. The charging and replacing control method comprises the following steps of: acquiring power replacement demand information of an electric automobile; and controlling the battery charging of the charging and replacing power station and the distribution of the battery of a charging and replacing power station network according to the power replacement demand information of the electric automobile. The method, system and the charging and replacing power station disclosed by the invention ensure that the power replacement demand can be met by predicting the power replacement demand, controlling the battery charging and distributing the battery.

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19-05-2010 дата публикации

Megawatt-level permanent magnet direct-drive wind-force generating converter and control method

Номер: CN0101710789A
Принадлежит:

The invention discloses a megawatt-level permanent magnet direct-drive wind-force generating converter and a control method. The converter comprises a rectifying unit, an inverting unit, a control system, an auxiliary unit and a cabinet body, wherein the rectifying unit and the inverting unit are arranged by adopting a symmetrical structure; both a rectifying circuit and a power inverting circuit consist of three groups of six insulated gate bipolar transistors; and the auxiliary unit comprises an auxiliary protective circuit, a precharging circuit, an auxiliary control circuit, a master contactor on the inverting unit side and a filtering circuit. The control method adopts multiple controls of speed control, torsion limit power control, direct power control and direct-current bus voltage control; when the speed control, the torsion limit power control and the direct power control fail, the converter switches to the direct-current bus voltage control automatically; and the converter adopts ...

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06-04-2011 дата публикации

Cooling system of ultra-high strength steel hot stamping forming die

Номер: CN0101288890B
Принадлежит:

The invention discloses a cooling system used for an ultra-high strength steel plate thermal die cutting and forming die. The die comprises a concave die and a concave die seat; a water chamber is arranged between the concave die and the concave die seat; the water chamber is communicated with a water inlet and a water outlet. The water chamber is arranged between the concave die and the concave die seat of the invention; after cooled water is inlet in the water chamber, a steel plate workpiece can be quickly cooled by the thermal conduction between the die and the steel plate so as to meet the quenching condition of the steel plate. Especially, the water chamber is also internally provided with a supporting column; the upper end of the supporting column is contacted with the lower bottomsurface of the concave die; the lower end of the supporting column is contacted with the upper bottom surface of the concave die seat; therefore, the structural strength of the concave die is ensured, the ...

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23-09-2015 дата публикации

Reinforced disk array data centralized storage realization method and system

Номер: CN104932840A
Принадлежит:

The invention discloses a reinforced disk array data centralized storage realization method and system. According to the method, a storage control module performs data centralized management and transmission on a hard disk group; and multi-path of data centralized management and storage by the storage control module over the hard disk group is realized through a network. The system adopts a modular design, is simple in assembling, and is convenient to maintain. Multi-path of data centralized management and storage by the storage control module over the hard disk group is realized through the network, so that scattered information isolated islands among users can be eliminated, furthermore, stability and security of important information in a key information system can be guaranteed, and a strong support is provided for a mass storage manner in the future. Compared with the conventional storage manners, the method realizing data centralized management and mass storage has high security, ...

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13-04-2011 дата публикации

Floating connector

Номер: CN0102013597A
Принадлежит:

The invention provides a floating connector having X, Y, Z axial displacements. The floating connector can ensure that two connector clips can be reliably connected in the inserting process and under the vibration condition. The floating connector comprises at least one connector clip in a connector consisting of the two connector clips which can be inserted and pulled out, and also comprises a front fixed plate and a rear fixed plate which are fixed at both ends of a fixed shaft; the axial direction of the fixed shaft is parallel to the direction of inserting and pulling out the connector; the fixed shaft passes through a floating hole formed on a shell of one connector clip; a gap is reserved between the floating hole and the fixed shaft; and an elastic element which can ensure that theconnector clip is contacted with the front fixed plate in an ordinary state is arranged between the connector clip with the floating hole and the rear fixed plate.

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16-06-2010 дата публикации

Superplastic welding experimental device and method by utilizing electric field action

Номер: CN0101733571A
Принадлежит:

The invention relates to a superplastic welding experimental device which belongs to the technical field of material processing. The superplastic welding experimental device comprises a high-voltage power system, an electric field applying device, a welding heating and temperature control system and a loading and data acquisition system, wherein the high-voltage power system is used for providing stable voltage; the electric field applying device is used for enabling samples or specimens to be welded to be in a uniform and stable electric field with adjustable atmosphere; the welding heating and temperature control system is used for ensuring the samples or the specimens to be at a given welding temperature; and the loading and data acquisition system is used for realizing that the samples or the specimens is loaded in a deformation speed range of 0.02-100mm/min and the full welding process can be automatically detected. By utilizing the invention, real time tracking recording and data ...

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17-12-2014 дата публикации

Method for realizing CPCI (Compact Peripheral Component Interconnect)/CPCI-E (Compact Peripheral Component Interconnect Express) hybrid bus interconnection

Номер: CN104216844A
Принадлежит:

The invention discloses a method for realizing CPCI (Compact Peripheral Component Interconnect)/CPCI-E (Compact Peripheral Component Interconnect Express) hybrid bus interconnection. The method comprises the following steps: firstly, a switch is additionally mounted in a computer system, three to ten virtual CPCI-E bridge ports are extended through the switch, a peripheral module is mounted on each CPCI-E bus, exclusive channel bandwidth is provided for each peripheral module, and then, the point-to-point serial communication between each virtual CPCI-E bridge port and peripheral equipment can be realized; a hybrid bridge module is configured in the virtual CPCI-E bridge ports, then, the conversion of data between the CPCI-E buses and CPCI buses is realized, two to eight CPCI peripheral modules can be mounted on each CPCI bus, and the CPCI peripheral modules share bus resources and complete the parallel transmission of valid data. Compared with the prior art, the method has the characteristics ...

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16-11-2011 дата публикации

Method for synthesizing phosphamide compound

Номер: CN0101555258B
Принадлежит:

A method for synthesizing a phosphamide compound relates to a compound, and a method for synthesizing the phosphamide compound is provided. Sodium trimetaphosphate (P<3m>) and organic amine react in water phase to produce trimeric phosphamide under the presence of a stabilizing agent; the trimeric phosphamide is added into NaOH, vacuum concentration is executed, and the unreacted organic amine and the stabilizing agent are removed; and a precipitating agent is added into the trimeric phosphamide from which the unreacted organic amine and the stabilizing agent are removed, then the stirring, filtering and removing of the precipitate are executed, and the filtrate is condensed and recrystallized by NaOH solution and ethanol, thus obtaining the phosphamide which can be widely applied to first-grade amine, secondary amine and the like. The raw materials are easily obtained, and the reaction is executed in water phase at normal temperature, which is beneficial to environmental protection. Theoperation ...

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30-03-2005 дата публикации

Method for preparing health protection tea

Номер: CN0001600137A
Принадлежит:

A health-care tea rich in flavone for lowering blood sugar is prepared from mulberry leaf, red jujube, chrysanthemum flower and ganoderma through removing impurities, pretreating, breaking, proportionally mixing and disinfecting.

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07-09-2011 дата публикации

Motor control method based on DCS system

Номер: CN0101667807B
Принадлежит:

The invention relates to a motor control method and discloses a motor control method based on a DCS system. A computer sets motor operation and control parameters via network service so as to operate and control the motor. The DCS system comprises a control motor and an upper computer connected with the control motor, wherein the control motor is connected with a plurality of motors of various types, and a standard motor module is arranged in the control motor. The control method is as follows: firstly setting the equipment parameter, the operation parameter, the starting up and stopping parameter and the fault alarm parameter of each motor; calling the motor subprogram; then calling the standard motor module to perform signal processing and control on different types of motors; after finishing subprogram processing, returning to the body program which controls the motor; and meanwhile, outputting a corresponding control order, the current operation state of each motor and the fault information ...

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27-04-2011 дата публикации

Synergetic weeding composite containing rimsulfuron and cyanazine and application thereof

Номер: CN0102027983A
Принадлежит:

The invention discloses a synergetic weeding composite containing rimsulfuron and cyanazine, which is characterized in that the rimsulfuron and the cyanazine are taken as the main effective components; and the weight ratio of the rimsulfuron to the cyanazine is (1-60):(1-60). Compared with a single preparation, on the premise of enhancing the pesticide effect, the weeding composite has the advantages of weed resistance delay, wide weeding spectrum, long effect lasting period and high safety on corn and after-reap crops, particularly has obvious effect on preventing and weeding various gramineae and broadleaf weeds in the corn field. The synergetic weeding composite can be used for preparing an herbicide for the weeding after the seedling emergence of the corn field.

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20-04-2011 дата публикации

Synergistic insecticidal composition containing nitenpyram and imidacloprid and application thereof

Номер: CN0102017980A
Принадлежит:

The invention discloses a synergistic insecticidal composition containing nitenpyram and imidacloprid and the application thereof. The insecticidal composition uses the nitenpyram and the imidacloprid as main active contents, wherein the weight ratio of the nitenpyram to the imidacloprid is 0.1-80 to 0.5-80. The insecticidal composition can generate higher synergy, overcome and delay the drug resistance of pests and expand control spectrum, has high insecticidal rate, long pesticide duration and remarkably higher prevention effect than the single preparation thereof, decreases the drug cost and lessens the toxicity. The invention can be used for preparing insecticide for preventing hemiptera pests on crops and particularly can be used for preparing insecticide for preventing paddy delphacidae and wheat aphids.

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10-11-2010 дата публикации

Process for manufacturing energy-saving glass-fibre reinforced resin plate

Номер: CN0101544066B
Принадлежит:

The invention relates to a process for manufacturing an energy-saving glass-fibre reinforced plate, which is characterized by comprising the following steps: a. manufacturing a bottom plate; b. manufacturing a support; c. adhering the bottom plate and the support; d. manufacturing a top plate; and e. adhering the top plate, the bottom plate and the support. The plate manufactured by the process has smooth surface, light weight, high ultraviolet resistance, transmittance, fire resistance, elasticity and impact resistance strength, good heat insulation and preservation performance and mechanical performance, is manufactured at high temperature with lower energy consumption and without causing pollution and is nonhazardous.

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21-10-2009 дата публикации

Method for controlling flow of transmission control system of paper machine

Номер: CN0101560741A
Принадлежит:

The invention discloses a method for controlling the flow of a transmission control system of a paper machine. In the method, a control system comprising a programmable control device PLC, a speed governing device and a field bus is used; the control operating flow of preparation, operation, creeping, shut-down, cleaning and fault treating functions, which is included in the transmission control system of the paper machine is modularized; according to the functions required to control by the transmission system of the paper machine, 10 to 50 subsection states are set, and the address indexed addressing mode is used for subsection state logic control of all subsections such as logic conversion, data treatment and speed/torque control switch; the PLC repeatedly controls the transmission system according to the steps of input sampling, program operation, output refreshing and under the support of a flow control module; and the speed governing device executes all functions according to the ...

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13-07-2011 дата публикации

Bactericidal composition containing fluazinam and prochloraz and application thereof

Номер: CN0102119699A
Принадлежит:

The invention belongs to the field of pesticides and discloses a bactericidal composition containing fluazinam and prochloraz and application thereof. The composition is characterized by taking fluazinam and prochloraz as active ingredients, wherein the total mass percent of fluazinam and prochloraz is 5-70%; and the mass ratio of fluazinam to prochloraz is 30:1-1:20. The composition can be used for controlling rice blast, rice sheath blight, wheat leaf blight/rust, peanut leafspot/web blotch, tomato/potato late blight, cucumber gray mold/powdery mildew/anthracnose and citrus anthracnose. Thecomposition has wide range of application, low cost and good effect.

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30-09-2009 дата публикации

Process for manufacturing energy-saving glass-fibre reinforced resin plate

Номер: CN0101544066A
Принадлежит:

The invention relates to a process for manufacturing an energy-saving glass-fibre reinforced plate, which is characterized by comprising the following steps: a. manufacturing a bottom plate; b. manufacturing a support; c. adhering the bottom plate and the support; d. manufacturing a top plate; and e. adhering the top plate, the bottom plate and the support. The plate manufactured by the process has smooth surface, light weight, high ultraviolet resistance, transmittance, fire resistance, elasticity and impact resistance strength, good heat insulation and preservation performance and mechanical performance, is manufactured at high temperature with lower energy consumption and without causing pollution and is nonhazardous.

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15-06-2011 дата публикации

Method for breeding high-yield maize hybrid

Номер: CN0102090323A
Принадлежит:

The invention discloses a method for breeding a high-yield maize hybrid. The method comprises the following steps of: preparing an inbred line crown 268 serving as a female parent and an inbred line 1058 serving as a male parent; repeatedly planting according to different densities; and performing evaluation tests at multiple points and different places to breed a new high-quality, high-yield and disease-resistant maize hybrid species, namely crown No.3, wherein the female parent crown 268 is an inbred line crown 268 with high general combining ability which is formed by hybridizing American commercial maize and agricultural maize 3138, performing six continuous generations of selfing to obtain a stable material, and selecting a disease-resistant and lodging-resistant head progeny row; and the male parent inbred line 1058 is an inbred line 1058 with high fecundity, high resistance, drought endurance and flood resistance, which is formed by hybridizing a Shanxi material and LX9801, alternatively ...

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16-03-2011 дата публикации

Method for recognizing non-integrity string running mode under half circuit breaker connection mode

Номер: CN0101355247B
Принадлежит:

The invention discloses a recognition method for a bus protection incomplete string operating mode under a half circuit breaker connection mode. The operating mode of an incomplete string is determined by detecting the closing situation of a bus isolating switch at the current side and a bus isolating switch at the opposite side, a new discriminant result is generated, the new discriminant resultand a discriminant result stored in a memory are compared; the recognition is finished if the new discriminant result is the same as that stored in the memory; whether the current exists in a circuitbreaker is judged if the new discriminant result is not the same as that stored in the memory; the new discriminant result is used to substitute the discriminant result stored in the memory if no current exists in the circuit breaker, a bus protection uses the new discriminant result to calculate differential current; and the discriminant result stored in the memory is maintained and the alarm isperformed ...

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04-04-2023 дата публикации

Stereoscopic cassava planting method

Номер: CN115885795A
Принадлежит:

The invention provides a three-dimensional cassava planting method. According to the three-dimensional cassava planting method, a planting groove frame is arranged, a culture medium layer, an overhead layer and an underground soil layer are sequentially arranged from top to bottom, the overhead layer is located between the underground soil layer and the culture medium layer, and cassava stems are inserted into the underground soil layer; before the cassava stems are placed in the culture medium, peeled wound surfaces are arranged on the cassava stems at the position of the culture medium layer. The three-dimensional cassava planting method is adopted, two-layer tuberization on the ground and underground is achieved for the first time, and the method belongs to a major technical breakthrough in the field. According to the three-dimensional planting method, the yield of the cassava is greatly increased, the starch content of the underground tuberization part of the cassava is higher than ...

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11-05-2011 дата публикации

Control method and operation monitoring system of charging and exchanging station of electric vehicle

Номер: CN0102055215A
Принадлежит:

The invention discloses a control method of a charging and exchanging station of an electric vehicle and an operation monitoring system of the charging and exchanging station. The method comprises the following steps of: receiving power control information for a system from a distribution automation system; confirming the maximum usable charging capability of the charging and exchanging station according to the power control information for the system; and controlling the charging equipment of the charging and exchanging station according to the maximum usable charging capability of the charging and exchanging station. The charging and exchanging station of the electric vehicle is combined with the distribution automation system, the maximum usable charging capability of the charging and exchanging station is confirmed according to the power control information for the system and the power load of the charging and exchanging station is adjusted in real time. By intelligently controlling ...

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15-09-1993 дата публикации

Centrifugal casting process for hollow casts of high-Al-Zn-base alloy

Номер: CN0001076148A
Принадлежит:

The invented centrifugal casting process is suitable for horizontal casting of hollow workpieces of high-Al-Zn-base alloy, as well as Al, Cu, Fe and other alloys. The pouring system is composed of pouring tank and rotor. Molten metal flows into casting mould via pouring tank, rotor and gap at side of rotor. On going into casting mould, molten metal has no or little relative rotational motion to the casting mould as rotor and casting mould axially rotate in the same direction at same or near rotating speed, so avoiding air being carried into casting mould by molten metal flow and in-turn the generation of pores. The segregation of specific weight in cast workpiece can also be controlled effectively ...

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12-10-2005 дата публикации

Preparation of (R)-(-)-apomorphine

Номер: CN0001680330A
Принадлежит:

Production of (R)-(-)-apomorphine is carried out by using isoquinoline as material, salifying, crystallizing and resoluting racemic apomorphine dimethyl ether by d-dibenzoyl tartaric acid, obtaining (R)-(-)-apomorphine dimethyl ether and mother liquid containing (S)-(+)-apomorphine dimethyl ether, racemization reacting by basic catalyst, converting (S)-(+)-apomorphine dimethyl ether in mother liquid into racemic apomorphine dimethyl ether, and resoluting racemic apomorphine dimethyl ether.

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14-10-2009 дата публикации

Method for synthesizing phosphamide compound

Номер: CN0101555258A
Принадлежит:

A method for synthesizing a phosphamide compound relates to a compound, and a method for synthesizing the phosphamide compound is provided. Sodium trimetaphosphate (P3m) and organic amine react in water phase to produce trimeric phosphamide under the presence of a stabilizing agent; the trimeric phosphamide is added into NaOH, vacuum concentration is executed, and the unreacted organic amine and the stabilizing agent are removed; and a precipitating agent is added into the trimeric phosphamide from which the unreacted organic amine and the stabilizing agent are removed, then the stirring, filtering and removing of the precipitate are executed, and the filtrate is condensed and recrystallized by NaOH solution and ethanol, thus obtaining the phosphamide which can be widely applied to first-grade amine, secondary amine and the like. The raw materials are easily obtained, and the reaction is executed in water phase at normal temperature, which is beneficial to environmental protection. The ...

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01-04-2015 дата публикации

System management method based on AST2400 chip

Номер: CN104486126A
Принадлежит:

The invention discloses a system management method based on an AST2400 chip. According to the management method, the AST2400 management chip and peripheral assemblies FLASH and DDR3 constitute a server management module, an I<2>C (inter-integrated circuit) interface, a USB interface, a PCIE interface, a serial port, a network port, a VGA interface and a GPIO interface are provided externally, and a server system is managed. With the adoption of the management method, information monitoring and remote operation of the system can be realized, system interfaces can be provided for top management, intelligent management of system heat dissipation can be realized, monitoring of voltages and state control can be realized, and the normal operation of a server can be guaranteed.

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25-08-2010 дата публикации

Automatic microwave electronic adjustable loading device and detection method thereof

Номер: CN0101814963A
Принадлежит:

The invention relates to an automatic microwave electronic adjustable loading device, which is used for simulating a matching state of an antenna port of a to-be-detected piece so as to detect an antenna mismatching load alarm module of the to-be-detected piece. The device comprises a forward signal generator, a forward radio-frequency power amplifier, a reverse signal generator, a reverse radio-frequency power amplifier, a radio-frequency signal coupler, a power meter, a radio-frequency terminal load and a computer. The device judges the running state of the antenna mismatching load alarm module of the to-be-detected piece and the precision of the alarm module by simulating different standing-wave ratio outputs based on simulating a working condition of a base station of a specific to-be-detected piece. Through the device, the detection is more precise, the running is faster and the detection time is efficiently shortened, so the production efficiency is promoted and the manufacturing ...

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20-04-2011 дата публикации

Synergistic insecticidal composition containing chlorfluazuron and chlorpyrifos-methyl and application thereof

Номер: CN0102017992A
Принадлежит:

The invention discloses a synergistic insecticidal composition containing chlorfluazuron and chlorpyrifos-methyl and the application thereof. The synergistic insecticidal composition uses the chlorfluazuron and the chlorpyrifos-methyl as main active contents, wherein the weight ratio of the chlorfluazuron to the chlorpyrifos-methyl is 0.1-65 to 0.1-80. The insecticidal composition can generate higher synergy, overcome and delay the drug resistance of pests and expand control spectrum, has high insecticidal rate, decreases the drug cost and can be used for preventing resistant lepidoptera withthe effect remarkably higher than the single preparation thereof.

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04-05-2011 дата публикации

Network-based functional test load simulation device

Номер: CN0102043698A
Автор: FENG NI, NI FENG
Принадлежит:

The invention relates to a network-based functional test load simulation device, which comprises a device box body (1), wherein a load module (2) is arranged in the device box body (1). The device is characterized in that: the communication end of the load module (2) is connected with a control component (3); the control component (3) comprises a communication port (4) which is connected with the load module (2); simultaneously, the communication port (4) is connected with a network control interface module (6) through a signal bus (5); moreover, the network control interface module (6) is provided with an upper computer input interface (7); the signal bus (5) is connected in series with a microprocessor module (8) and a memory module; and the control component and the network control interface module (6) can realize load simulation in cooperation with the program of an upper computer by taking a network as a medium. Moreover, quick response can be realized without a complex connecting ...

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16-11-2011 дата публикации

Aluminum-plastic co-extrusion high-resistance liquid package membrane material and preparation method thereof

Номер: CN0102241299A
Принадлежит:

The invention relates to an aluminum-plastic co-extrusion high-resistance liquid package membrane material and a preparation method thereof. The aluminum-plastic co-extrusion high-resistance liquid package membrane material comprises a printing layer, an aluminum-plastic layer and a heat-sealing layer from outside to inside, wherein the printing layer comprises 55-65 percent of high-density polyethylene, 25-35 percent of linear low-density polyethylene and 5-15 percent of white master batch; the aluminum-plastic layer comprises 55-65 percent of high-density polyethylene, 15-25 percent of linear low-density polyethylene, 5-15 percent of metallocene linear low-density polyethylene and 5-10 percent of aluminum-plastic master match; and the heat-sealing layer comprises 45-55 percent of high-density polyethylene, 15-25 percent of linear low-density polyethylene, 25-35 percent of metallocene linear low-density polyethylene and 1-3 percent of slip agent. The preparation method comprises the following ...

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13-07-2011 дата публикации

Bactericidal composition containing fluazinam and dimethachlon and application of same

Номер: CN0102119684A
Принадлежит:

The invention belongs to the field of farm chemicals and discloses a bactericidal composition containing fluazinam and dimethachlon and the application of the same. The fluazinam and the dimethachlon serve as effective components of the composition, wherein the total content of the fluazinam and the dimethachlon in mass percentage is 5% to 80%, and the mass ratio of the fluazinam to the dimethachlon is 30:1 to 1:20. The composition can be used for preventing and treating diseases such as rice blast, pestilence, anthracnose, leaf mold, scab and the like caused by fungi and other pathogens of cereal crops, vegetable and fruit trees, and has the advantages of wide application range, low cost and good effect.

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25-07-2012 дата публикации

Guide rail apparatus of garage door

Номер: CN0101469593B
Принадлежит:

The present invention discloses a guide way device of storehouse gate, which is composed by components of support, door panel, connecting component, mounting deck, the door panel mounted on the rotating shaft can move glidingly along with the orbit up and down freely through the double-layer orbit; meanwhile, because the door panel is connected with the rotating shaft, and that can guaranty good toughness when used on storehouse gate of large size without obvious bending phenomenon. The invention is of simple structure, security and reliability, low cost etc. and can be applied on large size storehouse gates.

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10-03-2010 дата публикации

Motor control method based on DCS system

Номер: CN0101667807A
Принадлежит:

The invention relates to a motor control method and discloses a motor control method based on a DCS system. A computer sets motor operation and control parameters via network service so as to operateand control the motor. The DCS system comprises a control motor and an upper computer connected with the control motor, wherein the control motor is connected with a plurality of motors of various types, and a standard motor module is arranged in the control motor. The control method is as follows: firstly setting the equipment parameter, the operation parameter, the starting up and stopping parameter and the fault alarm parameter of each motor; calling the motor subprogram; then calling the standard motor module to perform signal processing and control on different types of motors; after finishing subprogram processing, returning to the body program which controls the motor; and meanwhile, outputting a corresponding control order, the current operation state of each motor and the fault information ...

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18-02-2015 дата публикации

KVM cascade connection sharing method

Номер: CN104363116A
Принадлежит:

The invention discloses a KVM cascade connection sharing method. The KVM cascade connection sharing method achieves centralized management and remote control through communications between a cascade connection input end of a master server and a cascade connection output end of a slave server, and then can support resource sharing and flexible invoking of multiple platform strengthening server. By adopting the above breakthrough, the KVM cascade connection sharing method improves resource utilization rate, simplifies a process flow, has good expansibility, and can be applied in the strengthening server field.

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28-07-2010 дата публикации

Preparation process of flat tube of heat exchanger

Номер: CN0101786230A
Принадлежит:

The invention relates to a preparation process of a flat tube of a heat exchanger, relates to the preparation of a flat tube of a heat exchanger, and provides a preparation process of a flat tube of a heat exchanger, which adopts a step of adding a refining agent without stirring to fully blend raw materials. In order to solve the technical problem, the preparation process adopts the technical scheme comprising the following steps of the blending of aluminum and aluminum copper alloy, which are used as the raw materials, the addition of a CL-J202 refining agent for fusion assistance, wire drawing, extrusion molding and cooling. The preparation process is applied to the preparation of the flat tube of the heat exchanger, and has the advantage that the aluminum and the aluminum copper alloy in the raw materials can be blended fully, has the effect of removing slag and improving the purity of the materials, and improves the quality of products.

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04-05-2011 дата публикации

Retinex based nonlinear color image enhancement method

Номер: CN0102044070A
Принадлежит:

The invention provides a Retinex based nonlinear color image enhancement method. The method comprises the following steps of: switching an image from an RGB (Red, Green, Blue) space to YCbCR space so as to avoid color distortion easy to cause by processing directly in the RGB space; then carrying out local self-adaptive enhancement by adopting an improved Retinex illuminate reflection model to better reserve the detail information of the image; carrying out global brightness control by utilizing Gamma correction to compress the whole dynamic range of the image; and finally, switching the image from the YCbCR space to the RGB space. The color distortion phenomenon does not appear in an experiment result, thus the method enhances the detail information of the image while improving the visual effect.

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30-06-2010 дата публикации

Five-layer co-extrusion high barrier liquid packaging film and preparation method thereof

Номер: CN0101758959A
Принадлежит:

The invention relates to five-layer co-extrusion high barrier liquid packaging film and a preparation method thereof. The packaging film comprises a printed layer, a bonding layer, a high barrier layer, another bonding layer and a heat sealing layer in sequence from outside to inside. The packaging film is characterized in that the oxygen permeability coefficient of the packaging film in the condition of 24 h and 0.1MPa is not larger than 12000m3/m2, and the water vapor permeability coefficient is not larger than 2g/m2. According to weight percentage, the packaging film comprises the following components: 18-22 percent of low-density polyethylene, 8-10 percent of white masterbatch of polyethylene, 12-16 percent of linear low-density polyethylene and 1-1.5 percent of slip agent in the printed layer; 4-5 percent of acrylonitrile-styrene-butadiene copolymer in the bonding layer; 6-10 percent of ethylene-vinyl alcohol copolymer and 8-12 percent of black masterbatch of polyethylene in the high ...

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11-05-2011 дата публикации

Charging control method for battery of electric vehicle and equipment thereof

Номер: CN0102055216A
Принадлежит:

The invention discloses a charging control method for a battery of an electric vehicle and equipment thereof. The method comprises the following steps of: measuring the current electromotive force and charging current of the battery; determining a current charging parameter according to the current electromotive force and charging current, and an ideal charging current of the battery; and controlling the charging of the battery according to the current charging parameter. A charging station operation monitoring system can acquire available charging capacity information of a charging station from a distribution network automation system; and under the limit of the available charging capacity of the charging station, the output power of the battery is adjusted according to the charging parameter and a charging emergency degree of the battery. When the charging of a battery pack is controlled by the charging station of the electric vehicle, the charging parameter is adjusted automatically ...

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27-04-2011 дата публикации

Synergistic herbicidal composition containing picloram and pendimethalin and application thereof

Номер: CN0102027923A
Принадлежит:

The invention discloses a synergistic herbicidal composition containing picloram and pendimethalin and application thereof. The herbicidal composition comprises the picloram and the pendimethalin serving as main active ingredients, and a mass ratio of the picloram to the pendimethalin is 1-60:1-80. The synergistic herbicidal composition can be applied to preparation of herbicides for controlling postemergence weeds in corn fields. Compared with single-component herbicides, the herbicidal composition delays the weed resistance, has broad herbicidal spectrums and acts for a long time on the premise of improving herbicide effect, is safe for corns and afterculture crops, and has an obvious effect particularly when used for controlling various gramineous weeds and broadleaf weeds in the corn fields.

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11-07-2012 дата публикации

Ultra-high strength steel hot stamping forming die

Номер: CN0101288889B
Принадлежит:

The invention discloses an ultra-high strength steel plate thermal die cutting and forming die, comprising an upper die seat and a convex die which is fixed on the upper die seat, a lower die seat and a concave die that is fixed on the lower die seat; the concave die is internally provided with a cooling water passage which is connected with a cooling water circulation system. More particularly, the concave die is compose of a trough-shaped concave die seat and a cavity body; the concave die seat is provided with a water inlet and a water outlet; the cavity body is arranged in the concave trough of the concave die seat; a gap is arranged between the cavity body and the concave die seat; the gap is communicated with the water inlet and the water outlet. The die improves cooling speed, ensures the uniformity of cooling, has simple and practical structure, and fast cools the die and the punching parts in the die by the water cooling system of the die, so as to achieve the effect of quenching ...

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28-07-2010 дата публикации

Film special for shockproof buffer air bag and application thereof

Номер: CN0101787154A
Принадлежит:

The invention relates to a film special for a shockproof buffer air bag. The film comprises the following components in percentage by weight: 45 to 50 percent of low-density polyethylene, 18 to 24 percent of linear low-density polyethylene, 15 to 20 percent of bimodal polyethylene, 8 to 12 percent of metallocene linear low-density polyethylene and 2 to 3 percent of slip agent. The film has the advantages that: when an air bag prepared by the film is air-charged, the compression strength of the air bag is over 62 kilograms, which is 20 percent higher than the basic requirement of 50 kilograms, the smoothness(anti-blocking property) is good, and the thermal seal temperature region is wider and reaches 160+/-30 DEG C.

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28-01-2009 дата публикации

Method for recognizing non-integrity string running mode under half circuit breaker connection mode

Номер: CN0101355247A
Принадлежит:

The invention discloses a recognition method for a bus protection incomplete string operating mode under a half circuit breaker connection mode. The operating mode of an incomplete string is determined by detecting the closing situation of a bus isolating switch at the current side and a bus isolating switch at the opposite side, a new discriminant result is generated, the new discriminant result and a discriminant result stored in a memory are compared; the recognition is finished if the new discriminant result is the same as that stored in the memory; whether the current exists in a circuit breaker is judged if the new discriminant result is not the same as that stored in the memory; the new discriminant result is used to substitute the discriminant result stored in the memory if no current exists in the circuit breaker, a bus protection uses the new discriminant result to calculate differential current; and the discriminant result stored in the memory is maintained and the alarm is performed ...

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27-04-2011 дата публикации

Herbicide composition containing dithiopyr and fluroxypyr and application thereof

Номер: CN0102027914A
Принадлежит:

The invention belongs to the field of pesticides, and discloses a herbicide composition containing dithiopyr and fluroxypyr and application thereof. In the herbicide composition, the dithiopyr and the fluroxypyr are taken as main active ingredients, wherein the mass ratio of the dithiopyr to the fluroxypyr is 1-80: 1-80, and the dithiopyr and the fluroxypyr account for 1 to 85 percent of the total mass of the herbicide composition. The herbicide composition can be used for preparing a herbicide for controlling post-emergence weeds in a lawn, has an obvious effect when used for preparing herbicide for controlling pre-emergency weeds in a planted lawn, and is particularly suitable for preparing herbicide for controlling tall fescue and bluegrass in a lawn. Compared with a single-composition herbicide, the herbicide composition postpones the resistance of weeds, has a broad herbicide spectrum and acts for a long time on the premise of improving herbicide effect, and is safe for the lawns and ...

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15-06-2011 дата публикации

Seed selection method for new strain of maize inbred line

Номер: CN0102090322A
Принадлежит:

The invention relates to a seed selection method for new strain of a maize inbred line, comprising the following steps: taking huangzaosi (seed of maize) and dan 340 (seed of maize) as base materials and mixing to obtain the first generation seed; backcrossing huangzaosi once; then alternately and circularly carrying out inbred for three years continuously in the north and south; planting the first generation in the north in the first summer; sheathing the bags for selfing; selecting the second generation seed with good disease resistance; implementing high-density planting and disease inoculation test in the south in winter; screening for selfing; oppositely crossing with REID line material; selecting the third generation seed with good disease resistance; planting in the north in the second year; screening the fourth generation seed; and implementing planting and selfing in the north in the year; screening the fifth generation seed after combining an ability test; implementing planting ...

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02-02-2011 дата публикации

Group control system for multi-path start-stop control

Номер: CN0101963807A
Принадлежит:

The invention relates to a group control system, in particular to a group control system for multi-path start-stop control. A control core consists of an upper computer (1) for displaying the group control state, configuration group control parameters and group control picture and a lower computer (2) for executing group control logic, wherein the lower computer (2) collects state information of a controlled device and transmits control commands to the controlled device through a site bus (25) or a remote IO (Input Output) control module (21). By adopting the technical scheme, start and stop are realized between every two groups through a program interior chain start-stop interface and the whole production line can start and stop by one-key operation, thereby being convenient to operate, saving time and solving the problem that separate start-stop operation is needed in each process in the traditional start-stop control.

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18-07-2012 дата публикации

Superplastic welding experimental device and method by utilizing electric field action

Номер: CN0101733571B
Принадлежит:

The invention relates to a superplastic welding experimental device which belongs to the technical field of material processing. The superplastic welding experimental device comprises a high-voltage power system, an electric field applying device, a welding heating and temperature control system and a loading and data acquisition system, wherein the high-voltage power system is used for providingstable voltage; the electric field applying device is used for enabling samples or specimens to be welded to be in a uniform and stable electric field with adjustable atmosphere; the welding heating and temperature control system is used for ensuring the samples or the specimens to be at a given welding temperature; and the loading and data acquisition system is used for realizing that the samples or the specimens is loaded in a deformation speed range of 0.02-100mm/min and the full welding process can be automatically detected. By utilizing the invention, real time tracking recording and data processing ...

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01-07-2009 дата публикации

Guide rail apparatus of garage door

Номер: CN0101469593A
Принадлежит:

The present invention discloses a guide way device of storehouse gate, which is composed by components of support, door panel, connecting component, mounting deck, the door panel mounted on the rotating shaft can move glidingly along with the orbit up and down freely through the double-layer orbit; meanwhile, because the door panel is connected with the rotating shaft, and that can guaranty good toughness when used on storehouse gate of large size without obvious bending phenomenon. The invention is of simple structure, security and reliability, low cost etc. and can be applied on large size storehouse gates.

Подробнее
08-12-2010 дата публикации

Transmission control method for rewinding machine

Номер: CN0101905821A
Принадлежит:

The invention relates to a transmission control flow for a rewinding machine and discloses a transmission control flow for a papermaking rewinding machine, comprising the following steps: controlling an unwinding roll (1), a front bed roll (2), a rear bed roll (3), curved rolls (6,7,8), a dancer roll (5) arranged on a paper roll (12), a feed roll (4) and a paper cutter (9); carrying out transmission control by adopting a control state conversion mode; and dividing the operation process and security protection function of rewinding machine transmission control into an operational control stateand a protective control state. The invention is characterized in that a modular design is adopted aiming at the control flow of the traditional papermaking rewinding machine, thus improving the generality of the control flow; multiple control states are set, thus control information quantity is increased, the operating steps are simplified, maintenance and diagnosis are convenient, the operatingperiod ...

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04-05-2011 дата публикации

Stepping motor controller

Номер: CN0102045017A
Автор: FENG NI, NI FENG
Принадлежит:

The invention discloses a stepping motor controller comprising a body, a control module, an input module, a driving module and a rotary speed control module, wherein the control module, the input module, the driving module and the rotary speed control module are arranged on the body; the input module and the rotary speed control module are respectively connected with the control module; the driving module is connected with the rotary speed control module; the output end of the rotary speed control module is connected with the control module by a feedback loop; and the control module comprises a microprocessor. The invention solves the defects in the prior art and provides the stepping motor controller, which is convenient to carry, can be held by hands and has control accuracy.

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09-02-2011 дата публикации

Uses of ampelopsin and total flavone valid target rich in ampelopsin in preparing medicament for preventing and treating prostate gland cancer

Номер: CN0101347425B
Принадлежит:

The invention provides an ampelopsin and an application of a total flavonoid effective part with rich ampelopsin in preparing a medicine for preventing and treating prostatic cancer. A new, high-efficiency, and low-toxic natural medicine resource is found out by aiming at the difficulty in treating the prostatic cancer, which has obvious curative effect and little toxic or side effect.

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27-04-2011 дата публикации

Synergistic herbicidal composition containing picloram and bentazon and application thereof

Номер: CN0102027944A
Принадлежит:

The invention discloses a synergistic herbicidal composition containing picloram and bentazon and application thereof. The active ingredients of the herbicidal composition are picloram and bentazon in a mass ratio of 1-70:1-80. The synergistic herbicidal composition can be used for controlling post-emergence weeds in wheat fields and particularly has an obvious effect of controlling various broadleaf weeds in the wheat fields. Compared with a single-component herbicide, the herbicidal composition delays the resistance of the weeds, has a broad herbicidal spectrum and acts for a long time on the premise of improving the herbicide effect, and is safe for wheat and afterculture crops.

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12-10-2011 дата публикации

Method for controlling flow of transmission control system of paper machine

Номер: CN0101560741B
Принадлежит:

The invention discloses a method for controlling the flow of a transmission control system of a paper machine. In the method, a control system comprising a programmable control device PLC, a speed governing device and a field bus is used; the control operating flow of preparation, operation, creeping, shut-down, cleaning and fault treating functions, which is included in the transmission control system of the paper machine is modularized; according to the functions required to control by the transmission system of the paper machine, 10 to 50 subsection states are set, and the address indexed addressing mode is used for subsection state logic control of all subsections such as logic conversion, data treatment and speed/torque control switch; the PLC repeatedly controls the transmission system according to the steps of input sampling, program operation, output refreshing and under the support of a flow control module; and the speed governing device executes all functions according to thePLC ...

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15-06-2011 дата публикации

High-yield and high-quality breeding method for new corn hybrid variety

Номер: CN0102090324A
Принадлежит:

The invention relates to a high-yield and high-quality breeding method for new corn hybrid variety, comprising the following steps: taking a self-bred line Guanfeng 128 with high combining ability, pure gene and far genetic relationship as a male parent and taking a self-bred line 103 as a female parent to perform the hybridization so as to prepare the high-yield, high-quality, disease-resistant and close planting resistance new corn hybrid variety Guanfeng 118; breeding the female parent 103 by building a group from three land corn varieties in America, isolating freely, mixing powder for two generations, mixing and continuously self-crossing for multiple generations; after matching the male parent self-bred line 128 with dan 340 with huangzaosi, forming a first-generation base material by crossing huangzaosi once; obtaining a second-generation seed by bagging and self-crossing; obtaining a third-generation seed by taking pollen and REID series material to cross; and then breeding by alternatively ...

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20-10-2010 дата публикации

Series-resonant direct-current/direct-current converter

Номер: CN0101867296A
Принадлежит:

The invention discloses a series-resonant direct-current/direct-current converter based on 3525, which comprises a load, a control circuit based on a 3525 chip, a driving circuit and a series resonant circuit, wherein the driving pulse sent by the 3525 chip is insulated and amplified by the driving circuit and then sent to the series resonant circuit, and the converted direct-current electric energy is supplied for the load by the series resonant circuit under the action of a driving signal. In the invention, the pulse frequency modulation and the pulse width modulation of the convertor are realized by utilizing an ordinary 3525 pulse width modulation chip and a small quantity of peripheral circuits, the voltage-stabilizing or current-limiting work of the converter can be ensured under various loading conditions, and the maximum value and the minimum value of the working frequency of the converter can be respectively set, thereby facilitating the design and the optimization of magnetic ...

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17-05-2012 дата публикации

PEPTIDE LIGANDS FOR CLUSTERIN AND USES THEREOF

Номер: US20120121507A1
Принадлежит:

Peptides are disclosed that are useful for molecular imaging or diagnosis of a disease state, such as cancer, in which clusterin is upregulated. 1. A peptide comprising the amino acid sequence as set forth in SEQ ID NO:1 , SEQ ID NO:2 or SEQ ID NO:3 , or an amino acid sequence substantially identical thereto.2. The peptide according to linked to a cargo molecule.3. The peptide according to claim 2 , wherein the cargo molecule comprises an enzyme claim 2 , an imaging moiety claim 2 , a radioisotope or a cytotoxic agent.4. The peptide according to claim 2 , wherein the cargo molecule comprises an imaging moiety.5. The peptide according to claim 4 , wherein the imaging moiety comprises a radiolabel claim 4 , a fluorophore claim 4 , a near infra-red fluorochrome or a magnetic nanoparticle.6. Use of a peptide as defined in any for molecular imaging claim 1 , diagnosis of a disease state in which clusterin is upregulated or treatment of a disease state in which clusterin is upregulated.7. The use according to for molecular imaging of a tumor.8. The use according to claim 7 , wherein the molecular imaging is optical imaging claim 7 , positron emission tomography claim 7 , single photon emission computed tomography or magnetic resonance imaging.9. The use according to claim 6 , wherein the disease state is cancer.10. A method of imaging a tumor comprising linking a peptide as defined in to a cargo molecule comprising an imaging moiety claim 1 , administering the peptide linked to the cargo molecule to a subject claim 1 , and detecting the imaging moiety in the subject.11. The peptide according to claim 1 , wherein the amino acid sequence has 75% sequence identity to SEQ ID NO:1 claim 1 , SEQ ID NO:2 or SEQ ID NO:3.12. The peptide according to claim 1 , wherein the amino acid sequence has 80% sequence identity to SEQ ID NO:1 claim 1 , SEQ ID NO:2 or SEQ ID NO:3.13. The peptide according to claim 1 , wherein the amino acid sequence has 85% sequence identity to SEQ ID NO:1 ...

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14-03-2013 дата публикации

Small molecule inhibitors of hepatitis c virus

Номер: US20130065875A1

The invention provides derivatives and analogues of triazatetracyclo[7.7.0.0 1,13 ,0 2,7 ]-hexadeca-2,4,6,10,12-pentaenes, 5,7,11-triazatetracyclo[8.7.0.0 1,6 ,0 12,17 ]-heptadeca-6,8,12,14,16-pentaenes, pharmaceutical compositions comprising these compounds and methods for treatment of hepatitis C viral infections using these compounds.

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10-01-2019 дата публикации

ANTENNA AND UNMANNED AERIAL VEHICLE

Номер: US20190013578A1
Автор: Ni Feng
Принадлежит:

The present invention discloses an antenna and an unmanned aerial vehicle, where the antenna is applied to the unmanned aerial vehicle and the unmanned aerial vehicle includes a camera apparatus, the antenna including an antenna body and a bending part connected to the antenna body; and the bending part bends to a direction avoiding a field of view of the camera apparatus. Based on the foregoing technical solutions, in the embodiments of the present invention, it can be ensured that the antenna has a certain effective length to obtain a relatively strong radio signal, and avoids a shooting vision of the camera apparatus at the same time, so that images satisfying user demands are obtained. 1. An antenna , applied to an unmanned aerial vehicle , the unmanned aerial vehicle comprising a camera apparatus , wherein the antenna comprises an antenna body and a bending part connected to the antenna body; and the bending part bends to a direction avoiding a field of view of the camera apparatus.2. The antenna according to claim 1 , wherein the antenna body and the bending part are in a fixed connection.3. The antenna according to claim 1 , wherein the antenna body is hingedly connected to the bending part.4. The antenna according to claim 3 , wherein the antenna is further provided with a limiting structure.5. The antenna according to claim 4 , wherein the antenna body has a first bevel claim 4 , the bending part having a second bevel claim 4 , the second bevel abuts against the first bevel in a state the bending part bending to the antenna body.6. The antenna according to claim 1 , wherein the antenna body extends to a direction perpendicular to the ground.7. The antenna according to claim 6 , wherein the field of view of the camera apparatus is FOV claim 6 , and an angle formed by the antenna body and the bending part is: 90°+FOV/2 or 90°−FOV/2.8. The antenna according to claim 7 , wherein the angle formed by the antenna body and the bending part is: 90°+FOV/2.9. An ...

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24-04-2014 дата публикации

Locally-Active Anticoagulants and Anti-Inflammatory Agents

Номер: US20140113854A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

A locally-activatable bivalent thrombin binding agent is provided having two thrombin binding moieties for non-overlapping sites on a surface of thrombin linked together by a linker. The linker is a polypeptide having 5 to 30 amino acid residues existing in a folded state under an environmental condition where the binding agent is inactive. The linker changes conformation from the folded state to an unfolded state in response to a change in bulk temperature and/or to the presence of hyper-mobile water thereby activating the binding agent. Such locally-activatable thrombin binding agents can be administered systemically while only targeting specific sites of coagulation or inflammation since the thrombin binding agent will only activate at the site where the existence of atherosclerotic plaques has changed the local bulk temperature and/or created hyper-mobile water sufficiently to unfold the linker and activate the binding agent. Such binding agents are useful as site-specific anti-coagulant, anti-thrombotic and/or antiinflammatory agents. 2. The binding agent according to claim 1 , wherein the change in conformation is in response to an increase in bulk temperature.34-. (canceled)5. The binding agent according to claim 1 , wherein the first environmental condition comprises a bulk temperature of about 37° C.6. The binding agent according to claim 1 , wherein the change in conformation is in response to the presence of hyper-mobile water.7. The binding agent according to claim 1 , wherein the linker comprises SEQ ID NO: 19.8. The binding agent according to claim 7 , wherein Xaa at position 5 is tyrosine or tryptophan claim 7 , Xaa at position 12 is phenylalanine or tryptophan claim 7 , Xaa at position 14 is valine or tryptophan claim 7 , or a combination thereof.9. The binding agent according to claim 1 , wherein the linker comprises SEQ ID NO: 2 claim 1 , SEQ ID NO: 3 claim 1 , SEQ ID NO: 4 or SEQ ID NO: 5.10. The binding agent according to claim 1 , wherein the ...

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17-02-2022 дата публикации

NOVEL INHIBITORS OF GUANOSINE MONOPHOSPHATE SYNTHETASE AS THERAPEUTIC AGENTS

Номер: US20220048866A1
Принадлежит:

The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders. 5. The compound of wherein the compound is selected from the group consisting of 2-chloro-N-(4-((3-(prop-2-yn--yloxy)phenyl)amino)quinazolin-6-yl)acetamide; 2-chloro-N-(4-((3-methoxyphenyl)amino)quinazolin-6-yl)acetamide; and N-(4-((3-methoxyphenyl)amino)quinazolin-6-yl)acetamide.6. The compound of wherein the compound is selected from the group consisting of 3-(2-chloroacetamido)-N-(3-(prop-2-yn-l-yloxy)phenyl)benzamide and N-(3-(2-chloroacetamido)phenyl)-3-(prop-2-yn-1-yloxy)benzamide.9. The method of claim 7 , wherein the disease or disorder is cancer or viral infection.10. The method of claim 9 , wherein the cancer is selected from the group consisting of leukemia claim 9 , non-small cell lung cancer claim 9 , colon cancer claim 9 , central nervous system (CNS) cancer claim 9 , melanoma claim 9 , ovarian cancer claim 9 , renal cancer and breast cancer.11. The method of claim 9 , wherein the viral infection is selected from the group consisting of gastroenteritis claim 9 , fatal encephalitis claim 9 , encephalitis claim 9 , fever claim 9 , joint pain claim 9 , meningitis claim 9 , myocarditis claim 9 , paralysis claim 9 , hemorrhagic fever claim 9 , thrombocytopaenia claim 9 , common cold claim 9 , mononucleosis claim 9 , renal or respiratory syndrome claim 9 , hepatitis claim 9 , pneumonia claim 9 , diarrhea claim 9 , neurological disorder claim 9 , skin lesions claim 9 , skin lymphoma claim 9 , AIDS claim 9 , skin warts claim 9 , genital warts claim 9 , cervical cancer claim 9 , leukemia ...

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17-02-2022 дата публикации

NOVEL FGFR INHIBITORS AND USES THEREOF

Номер: US20220048883A1
Принадлежит:

The invention provides novel FGFR inhibitors based on the pyridinylpyrimidine. The invention includes inhibitors with broad inhibitory activity against all FGFR isoforms, and inhibitors with selective inhibition against FGFR4. These novel pyridinylpyrimidine-based FGFR inhibitors, or their derivatives, have strong potential to be used to treat cancer. 3. The compound of claim 1 , wherein the compound is selected from the group consisting of 6-(2-((2 claim 1 ,6-dichloro-3 claim 1 ,5-dimethoxyphenyl)amino)pyridin-3-yl)-N-(4-(4-ethylpiperazin-1-yl)phenyl)pyrimidin-4-amine; N-(2-((6-(2-((2 claim 1 ,6-dichloro-3 claim 1 ,5-dimethoxyphenyl)amino)pyridin-3-yl)pyrimidin-4-yl)amino)-3-methylphenyl)acrylamide; N-(2-((6-(2-((2 claim 1 ,6-dichloro-3 claim 1 ,5-dimethoxyphenyl)amino)pyridin-3-yl)pyrimidin-4-yl)amino)-3-methylphenyl)propionamide; and (E)-N-(2-((6-(2-((2 claim 1 ,6-dichloro-3 claim 1 ,5-dimethoxyphenyl)amino)pyridin-3-yl)pyrimidin-4-yl)amino)-3-methylphenyl)-4-(methyl(prop-2-yn-1-yl)amino)but-2-enamide.4. The compound of claim 1 , wherein the compound inhibits a fibroblast growth factor receptor (FGFR).5. The compound of claim 4 , wherein the compound inhibits FGFR4.8. The method of claim 1 , wherein the cancer is selected from the group consisting of breast claim 1 , lung claim 1 , bladder claim 1 , prostate claim 1 , ovarian claim 1 , endometrial claim 1 , rhabdomyosarcoma claim 1 , liver and gastric.9. The method of claim 6 , wherein the compound inhibits an FGFR.10. The method of claim 9 , wherein the compound inhibits FGFR4.11. The method of claim 6 , wherein the compound targets amino acid residue 484 of SEQ ID NO: 52 claim 6 , amino acid residue 512 of SEQ ID NO: 56 claim 6 , or amino acid residue 552 of SEQ ID NO: 50 or 54.12. The method of claim 6 , further comprising administering a chemotherapeutic agent.13. The method of claim 12 , wherein the compound is administered prior to claim 12 , simultaneously with or following the administration of the ...

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13-02-2020 дата публикации

Chemoproteomic approach for discovering covalent ligands for diverse protein targets

Номер: US20200048204A1
Принадлежит: University of Southern California USC

Despite its power in identifying highly potent ligands for select protein targets, conventional medicinal chemistry is limited by its low throughput and lack of proteomic selectivity information. We seek to develop a chemoproteomic approach for discovering covalent ligands for protein targets in an unbiased, high-throughput manner. Tripartite probe compounds composed of a heterocyclic core, an electrophilic ‘warhead’ and an alkyne tag have been designed and synthesized for covalently labeling and identifying targets in cells. We have developed a novel condensation reaction to prepare 2-chloromethylquinoline (2-CMQ), a novel electrophilic heterocycle. These chloromethylquinolines potently and covalently bind to a number of cellular protein targets including Prostaglandin E Synthase 2 (PTGES2), a critical regulator of cell proliferation, apoptosis, angiogenesis, inflammation, and immune surveillance.

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13-02-2020 дата публикации

Method for Forming III-Nitride Semiconductor Device and the III-Nitride Semiconductor Device

Номер: US20200052076A1
Автор: Fan Qian, HE Wei, Ni Xian-Feng
Принадлежит:

The present disclosure includes but is not limited to the III-Nitride semiconductor devices including a barrier layer, a gallium nitride or indium gallium nitride channel layer having a Ga-face coupled with the barrier layer, and a patterned thermoconductive layer having a thermal conductivity of at least 500 W/(m-K) within 1000 nanometers of a Ga-face of the gallium nitride channel layer. The semiconductor device may be a high-electron-mobility transistor or a semiconductor wafer. Methods for making the same also are described. 1. A method for fabricating a III-Nitride semiconductor device , comprising:providing a substrate;forming a nucleation layer on the substrate;forming a back barrier layer on the nucleation layer;forming a patterned dielectric layer on the back barrier layer;forming a patterned thermoconductive layer on the patterned dielectric layer;wherein the pattern of the thermoconductive layer is the same as the pattern of the patterned dielectric layer;wherein the back barrier layer is formed of Group III-Nitride material.2. The method of claim 1 , further comprising:forming a dielectric layer on the back barrier layer; andusing photoresist and masked lithography to pattern the dielectric layer for forming the patterned dielectric layer with a predetermined pattern.3. The method of claim 1 , further comprising at least one of the following:{'sub': '2', 'the dielectric layer being formed of one or more materials selected from the group consisting of SiN, AlN and SiO; and'}the dielectric layer having a thickness range from 1 nanometer to 100 nanometer.4. The method of claim 1 , further comprising:forming a high thermal conductive seedling layer over the patterned dielectric layer; andchanging the high thermal conductive seedling layer into the patterned thermoconductive layer.5. The method of claim 4 , further comprising one of the following:micronized grinding the patterned dielectric layer to form the patterned high conductive seeding layer;processing ...

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13-02-2020 дата публикации

Group III-Nitride Semiconductor device and Corresponding Fabricating Method

Номер: US20200052102A1
Автор: Fan Qian, HE Wei, Ni Xian-Feng
Принадлежит:

The invention relates to the group III-nitride semiconductor device and corresponding fabricating method. Specifically, a method to reduce RF dispersion in a group III-nitride high electron mobility transistor (HEMT), especially for reduced barrier thickness epi materials and scaled deices for higher frequency applications. Periodic n-type doping within barrier is used to screen surface state traps, which are responsible for the above-mentioned RF dispersion, without introducing additional gate leakage current path. Within the method, the barrier (typically AlGaN, AlInN) layer is periodically n-type doped with its composition (such as Al % within AlGaN) periodically modulated. The periodic structure is effective in both screening surface state traps and reducing the leakage current within the AlGaN/gate Schottky barrier. Therefore, the growth method could be used for fabricate the dispersion-free III-nitride based HEMT devices, which will be highly desirable for making high frequency materials and devices in the applications such as higher frequency wireless communications. 1. A Group III-Nitride semiconductor device , comprising:a buffer layer formed on a substrate; anda barrier layer formed on the buffer layer;wherein the barrier layer consists of a plurality of repetitive cycles that each cycle consists of n sub-layers;wherein the barrier layer is made of n-type doped nitride with modulated n-type doping levels and modulated additional Group III element compositions.2. The device of claim 1 , wherein the energy band gap of the barrier layer is larger than the energy band gap of the buffer layer.3. The device of claim 1 , wherein the material of the barrier layer is chosen from a group consisting of AlGaN claim 1 , AlInN claim 1 , AlGaInN claim 1 , InN claim 1 , ScN claim 1 , BN and combination thereof.4. The device of claim 1 , wherein the N-type doping level is inversely proportional to the additional group III element composition for each sub-layer.5. The ...

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08-03-2018 дата публикации

FLUORESCENT BISPHOSPHONATE ANALOGS

Номер: US20180064829A1
Принадлежит: UNIVERSITY OF SOUTHERN CALIFORNIA

Fluorescent probes based on N-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. Methods for preparing the probes include the use of two complementary linking strategies, one involving an amino group and the other involving a chloride group as a precursor to an amino group. In other versions, bifunctional N-heterocyclic bisphosphonates are provided having an amino group and an azido group as linking moieties. In some versions, the linking chemistry allows attachment of a wide selection of fluorescent dyes in the visible to near-infrared range to any of three clinically important heterocyclic bisphosphonates. 1. A toolkit for use in bone tissue , comprising a plurality of N-heterocyclic bisphosphonates , or phosphonocarboxylate analogues thereof , linked to imaging tags , wherein the imaging tag-linked N-heterocyclic bisphosphonates , or phosphonocarboxylate analogues thereof , exhibit preselected physical , optical and biological characteristics.2. The toolkit of claim 1 , comprising the imaging tag-linked N-heterocyclic bisphosphonates claim 1 , or the phosphonocarboxylate analogues thereof claim 1 , selected from the group consisting of 5 (6)-FAM-RIS (7a1) claim 1 , 5-FAM-RIS (7a2) claim 1 , 6-FAM-RIS (7a3) claim 1 , 5 (6)-RhR-RIS (7a4) claim 1 , 5 (6)-ROX-RIS (7a5) claim 1 , AF647-RIS (7a6) claim 1 , 5 (6)-FAM-RISPC (7b1) claim 1 , 5 (6)-RhR-RISPC (7b2) claim 1 , 5 (6)-ROX-RISPC (7b3) claim 1 , AF647-RISPC (7b4) claim 1 , 5 (6)-FAM-dRIS (7c1) claim 1 , 5 (6)-RhR-dRIS (7c2) claim 1 , 5-FAM-ZOL (7d1) claim 1 , 6-FAM-ZOL (7d2) claim 1 , AF647-ZOL (7d3) claim 1 , 800 CW-ZOL (7d4) claim 1 , Sulfo-Cy5-ZOL (7d5) claim 1 , 5-FAM-MIN (7e1) claim 1 , 6-FAM-MIN (7e2) claim 1 , 5-FAM-MINPC (7f1) claim 1 , and 6-FAM-MINPC (7f2) claim 1 , in Table 1.3. A method for analyzing bone claim 1 , bone metabolism claim 1 , bone interaction ...

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15-09-2022 дата публикации

PROCESS FOR DISTILLING A CRUDE COMPOSITION IN A RECTIFICATION PLANT INCLUDING AN INDIRECT HEAT PUMP

Номер: US20220288504A1
Автор: NI Lin Feng, ZUBER Laurent
Принадлежит:

A process for purifying a crude composition comprising rectifying the crude composition in a rectification plant. The rectification plant comprises a rectification column including: a first overhead condenser for condensing a head fraction, and a reboiler for evaporating a bottom fraction. A difference between a temperature of the head fraction and a temperature of the bottom fraction is less than or equal to 20° C. A heat pump is provided between the first overhead condenser and the reboiler. The heat pump is an indirect heat pump that is operated with water or methanol as a refrigerant, and the indirect heat pump includes an expansion valve and a compressor. The heat pump comprises a second condenser located upstream of the compressor. 1. A process for purifying a crude composition comprising:rectifying the crude composition in a rectification plant comprising a rectification column including: a first overhead condenser for condensing a head fraction, and a reboiler for evaporating a bottom fraction,wherein a difference between a temperature of the head fraction and a temperature of the bottom fraction is less than or equal to 20° C.,wherein a heat pump is provided between the first overhead condenser and the reboiler, the heat pump being an indirect heat pump that is operated with water or methanol as a refrigerant, the indirect heat pump including an expansion valve and a compressor, andwherein the heat pump comprises a second condenser located upstream of the compressor.2. The process in accordance with claim 1 , wherein the difference between the temperature of the head fraction and the temperature of the bottom fraction is less than or equal to 15° C.3. The process in accordance with claim 1 , wherein the temperature of the bottom fraction is 80° C. to 150° C.4. The process in accordance with claim 1 , wherein the temperature of the head fraction is 65° C. to 130° C.5. The process in accordance with claim 1 , wherein the crude composition includes a silane as ...

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07-05-2020 дата публикации

GIMBAL, PHOTOGRAPHING ASSEMBLY AND UNMANNED AERIAL VEHICLE (UAV) THAT HAVE GIMBAL

Номер: US20200142283A1
Принадлежит:

The present invention relates to the technical field of aircrafts, and provides a gimbal, a photographing assembly and an unmanned aerial vehicle (UAV) that have the gimbal. The gimbal includes: a first rotating member and a second rotating member. The first rotating member includes a first drive apparatus, the first drive apparatus including a first rotating portion, and the second rotating member includes a second drive apparatus and a first connecting arm, the second drive apparatus including a second fixing portion and a second rotating portion that may rotate relative to the second fixing portion, the first connecting arm being fixedly connected between the first rotating portion and the second fixing portion, and the first connecting arm is integrally formed with the first rotating portion and the second fixing portion. 1. A gimbal configured to carry a load , wherein the gimbal comprises:a first rotating member comprising a first drive apparatus, the first drive apparatus comprising a first rotating portion; anda second rotating member comprising a second drive apparatus and a first connecting arm, the second drive apparatus comprising a second fixing portion and a second rotating portion that may rotate relative to the second fixing portion, the first connecting arm being fixedly connected between the first rotating portion and the second fixing portion, and the first connecting arm being integrally formed with the first rotating portion and the second fixing portion.2. The gimbal according to claim 1 , wherein the first drive apparatus comprises a first fixing portion and a first rotating shaft claim 1 , the first rotating portion rotating relative to the first fixing portion about the first rotating shaft; andwherein the second drive apparatus comprises a second rotating shaft, the second rotating portion rotating relative to the second fixing portion about the second rotating shaft.3. The gimbal according to claim 1 , wherein the gimbal comprises a third ...

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14-05-2020 дата публикации

Undercarriage and unmanned aerial vehicle (uav) having undercarriage

Номер: US20200148337A1
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

Embodiments of the present invention relate to the technical field of aircrafts, and provide an undercarriage and an unmanned aerial vehicle (UAV) having the undercarriage. The undercarriage includes a power assembly and an undercarriage body. The power assembly includes a connecting member and a drive apparatus for driving the connecting member to reciprocate. The undercarriage body includes a plurality of hinged connecting rods, the plurality of hinged connecting rods constituting at least one parallelogram mechanism, and projections of at least two of the hinged connecting rods on a side face of the fuselage are staggered. The undercarriage body is connected to the connecting member, and when the connecting member reciprocates, the undercarriage body is driven to be folded or unfolded. In the foregoing manner, driven by the reciprocating motion of the connecting member, the undercarriage body may be retracted and folded on two sides or in an interior of the fuselage, so that the undercarriage may be retracted and folded during flight of the UAV, thereby avoiding unnecessary resistance in the air.

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14-05-2020 дата публикации

UNMANNED AERIAL VEHICLE AND UNDERCARRIAGE

Номер: US20200148338A1
Автор: DONG Fei, Ni Feng, WU Xingwen
Принадлежит:

The utility model relates to an unmanned aerial vehicle and an undercarriage thereof. The undercarriage includes: a power assembly disposed within a fuselage, the power assembly including a first connecting member and a drive apparatus configured to drive the first connecting member to perform a reciprocating linear motion; and an undercarriage body connected to the power assembly, the undercarriage body including a first connecting rod hinged on the first connecting member, and a second connecting rod of which one end is hinged on the power assembly and the other end is hinged on the first connecting rod. When the first connecting member performs the reciprocating linear motion, the undercarriage body is driven to be unfolded or folded into the fuselage. The utility model further relates to an unmanned aerial vehicle. For the foregoing unmanned aerial vehicle and the undercarriage thereof, the power assembly may be used to drive the undercarriage body to switch between an unfolded state and a folded state. When aerial photography is required, the undercarriage body may be at least partially folded into the fuselage, to avoid blocking an aerial photography device on the unmanned aerial vehicle. 1. An undercarriage applied to an unmanned aerial vehicle , the unmanned aerial vehicle comprising a fuselage , wherein the undercarriage comprises:a power assembly disposed within the fuselage, the power assembly comprising a first connecting member and a drive apparatus configured to drive the first connecting member to perform a reciprocating linear motion; andan undercarriage body comprising a first connecting rod hinged on the first connecting member, and a second connecting rod of which one end is hinged on the power assembly and the other end is hinged on the first connecting rod; when the first connecting member performs the reciprocating linear motion, the undercarriage body being driven to be unfolded or folded into the fuselage;wherein the drive apparatus comprises ...

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14-05-2020 дата публикации

Unmanned aerial vehicle

Номер: US20200148353A1
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

The present invention relates to the field of air vehicle technologies and provides an unmanned aerial vehicle (UAV), including a vehicle body and arms connected to the vehicle body. The arm is hinged to the vehicle body by using a spherical hinge portion and may be folded or unfolded relative to the vehicle body. Through the forgoing manner, the arm is connected to the vehicle body of the UAV by using the spherical hinge. The arm can be folded and unfolded smoothly without interference, which conforms to known operation habits of users, so that after the entire UAV is folded, the structure becomes more compact and easier to carry. In addition, it can be effectively avoided that the UAV is damaged due to impact in the carrying process.

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16-06-2016 дата публикации

Derivatives of collagen-binding hairpin peptides

Номер: US20160168210A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

Compounds of interest, for example active pharmaceutical ingredients, probes or inactive carriers, may be delivered to a site of interest by conjugating the compound of interest to a collagen-binding linear hairpin (CBLH) peptide to form a molecule of Formula (I) and then providing the molecule to the site of interest where the CBLH peptide binds to collagen at the site of interest thereby delivering the compound of interest to the site of interest. Molecule of Formula (I) are: (I) where: Y is a first compound of interest; Z is a second compound of interest; n and m are independently 0 or 1 with the proviso that at least one of n and m is 1; and, CBLH is a collagen-binding linear hairpin peptide having 19 or fewer amino acids and having a turn amino acid sequence comprising 4 to 6 amino acid residues providing a stable turn structure, the turn sequence flanked on one side by a first flanking sequence having a WT(W/Y) motif and flanked on the other side by a RR second flanking sequence having a WT(W/R) motif, the W residue at position 1 of the first flanking sequence forming a cross-strand indole-indole or cation-π interaction pair with the amino acid residue at position 3 of the second flanking sequence without any disulfide bond.

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04-06-2020 дата публикации

ARM AND UNMANNED AERIAL VEHICLE

Номер: US20200172226A1
Автор: Ni Feng
Принадлежит:

Embodiments of the present invention disclose an arm and an unmanned aerial vehicle (UAV). The arm is mounted on a movable object and is in contact with an outline of the movable object after being folded. The UAV includes a vehicle body, the arm connected to the vehicle body and a power device disposed on the arm. The arm is in contact with an outline of the vehicle body after being folded. According to the technical solutions, the arm provided in the embodiments of the present invention can be in contact with the outline of the movable object after being folded, so that the structure of the movable object to which the arm is applied is more compact. 1. An arm mounted on a movable object , wherein the arm is in contact with an outline of the movable object after being folded.2. The arm according to claim 1 , wherein the arm comprises a main arm and an auxiliary arm connected to the main arm.3. The arm according to claim 2 , wherein the main arm comprises at least two connecting rods claim 2 , one end of at least one of the at least two connecting rods being connected to the auxiliary arm.4. The arm according to claim 3 , wherein the main arm comprises a first connecting rod and a third connecting rod connected to one end of the first connecting rod claim 3 , and the auxiliary arm is connected to a tail end of the third connecting rod.5. The arm according to claim 4 , wherein the main arm further comprises a second connecting rod claim 4 , one end of the second connecting rod being connected to one end of the first connecting rod claim 4 , and the other end being connected to one end of the third connecting rod.6. The arm according to claim 5 , wherein the second connecting rod is hinged to one end of the first connecting rod.7. The arm according to claim 5 , wherein the third connecting rod is hinged to the second connecting rod.8. The arm according to claim 5 , wherein an included angle α between the first connecting rod and the second connecting rod is an obtuse ...

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12-07-2018 дата публикации

UNMANNED AERIAL VEHICLE

Номер: US20180194458A1
Автор: Ni Feng
Принадлежит:

Embodiments of the present invention relate to the field of aircraft technologies, and provide an unmanned aerial vehicle including an unmanned aerial vehicle body and a landing gear. The landing gear is entirely accommodated in the unmanned aerial vehicle body when being in a folded state. When being folded, the landing gear in the present invention is entirely accommodated in the unmanned aerial vehicle body, and therefore neither causes unnecessary resistance in air nor blocks an aerial photographing field of view in an aerial photographing process of the unmanned aerial vehicle. In addition, when the unmanned aerial vehicle is not in use, the landing gear is accommodated in the unmanned aerial vehicle body, so that the unmanned aerial vehicle is very compact in structure and easy to accommodate and carry. 1. An unmanned aerial vehicle , comprising an unmanned aerial vehicle body and a foldable landing gear connected to the unmanned aerial vehicle body , wherein the landing gear is entirely accommodated in the unmanned aerial vehicle body when being in a folded state.2. The unmanned aerial vehicle according to claim 1 , wherein the landing gear comprises a linkage mechanism and a power apparatus used for driving the linkage mechanism to fold or unfold claim 1 , and the power apparatus is connected to the unmanned aerial vehicle body.3. The unmanned aerial vehicle according to claim 2 , wherein the linkage mechanism comprises:a support rod; anda first rotation rod, wherein one end of the first rotation rod is connected to the power apparatus, and the other end of the first rotation rod is hingedly connected to the support rod.4. The unmanned aerial vehicle according to claim 3 , wherein the first rotation rod comprises a mounting portion connected to the power apparatus claim 3 , a first connecting rod extending from the mounting portion claim 3 , and a first bending portion bent and extend from the first connecting rod; and one end of the support rod is hingedly ...

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27-06-2019 дата публикации

UNMANNED AERIAL VEHICLE

Номер: US20190193854A1
Принадлежит:

The present invention discloses an unmanned aerial vehicle, including: a fuselage; a battery accommodation cavity, disposed on the fuselage; a battery pack, including at least two battery blocks and mounted inside the battery accommodation cavity; a battery circuit board, electrically connected to the battery blocks in the battery pack; and a functional module, electrically connected to the battery circuit board, the battery blocks in the battery pack supplying power to the functional module via the battery circuit board at the same time. By using the solution of the present invention, endurance of the unmanned aerial vehicle is increased. 1. An unmanned aerial vehicle , comprising:a fuselage having a battery accommodation cavity, wherein the battery accommodation cavity comprises at least two openings;a plurality of arms, wherein each arm is coupled to the fuselage;a propulsion assembly mounted on the each arm, wherein the propulsion assembly comprises a propeller and a motor, the motor being configured to rotate the propeller in order to generate lift force;at least two battery blocks configured to be installed in the battery accommodation cavity, wherein each of the at least two battery blocks comprises a battery housing and a battery disposed in the battery housing; andan electronic board disposed inside the fuselage;wherein the each of the at least two battery blocks is inserted into the battery accommodation cavity via one of the at least two openings;wherein at least a portion of the each of the at least two battery blocks is visible in a state where the each of the at least two battery blocks is installed into the battery accommodation cavity.2. The unmanned aerial vehicle according to claim 1 , further comprising a battery circuit board electrically connected to the at least two battery blocks claim 1 , the at least two battery blocks powering the electronic board at the same time via the battery circuit board.3. The unmanned aerial vehicle according to ...

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11-10-2018 дата публикации

UNMANNED AERIAL VEHICLE

Номер: US20180290749A1
Принадлежит:

The present invention discloses an unmanned aerial vehicle, including: a fuselage; a battery accommodation cavity, disposed on the fuselage; a battery pack, including at least two battery blocks and mounted inside the battery accommodation cavity; a battery circuit board, electrically connected to the battery blocks in the battery pack; and a functional module, electrically connected to the battery circuit board, the battery blocks in the battery pack supplying power to the functional module via the battery circuit board at the same time. By using the solution of the present invention, endurance of the unmanned aerial vehicle is increased. 1. An unmanned aerial vehicle , comprising:a fuselage having a battery accommodation cavity;a plurality of arms, wherein each arm is coupled to the fuselage;a propulsion assembly mounted on the each arm, wherein the propulsion assembly comprises a propeller and a motor, the motor being configured to rotate the propeller in order to generate lift force;at least two battery blocks, wherein the at least two battery blocks are mounted inside the battery accommodation cavity; andan electronic board disposed inside the fuselage, wherein the electronic board comprise at least one of a flight control board, an electronic speed control board, a steering driving board and a radar electronic board;wherein the at least two battery blocks power the electronic board at the same time.2. The unmanned aerial vehicle according to claim 1 , further comprising a battery circuit board electrically connected to the at least two battery blocks claim 1 , the at least two battery blocks powering the electronic board at the same time via the battery circuit board.3. The unmanned aerial vehicle according to claim 2 , wherein the at least two battery blocks are connected to the battery circuit board respectively to form a parallel structure.4. The unmanned aerial vehicle according to claim 3 , wherein the at least two battery blocks comprise a first battery ...

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18-10-2018 дата публикации

PHOTOGRAPHIC ASSEMBLY AND UNMANNED AERIAL VEHICLE HAVING SAME

Номер: US20180297716A1
Автор: Ni Feng
Принадлежит:

The present invention relates to the field of aircrafts and provides a photographic assembly applied to an aircraft, where the aircraft includes a vehicle body. The photographic assembly includes: a vibration absorption member, a frame provided at the periphery of the vehicle body and connected to the vehicle body through a vibration absorption member, a gimbal connected to the frame and a camera connected to the gimbal. The frame of the photographic assembly in embodiments of the present invention can be mounted on unmanned aerial vehicle bodies of different specifications and the frame is sleeved over the vehicle body, so that the structure of the vehicle body can be designed compactly. The embodiments of the present invention further provide an unmanned aerial vehicle having the photographic assembly. 1. A photographic assembly , applied to an aircraft that comprises a vehicle body , wherein the photographic assembly comprises:a vibration absorption member;a frame, provided at the periphery of the vehicle body and connected to the vehicle body through the vibration absorption member;a gimbal, connected to the frame; anda camera, connected to the gimbal.2. The photographic assembly according to claim 1 , wherein the frame comprises a first frame portion and a second frame portion which is disposed opposite to the first frame portion.3. The photographic assembly according to claim 2 , wherein claim 2 ,the first frame portion comprises a first mounting arm and first extension arms bending and extending from two ends of the first mounting arm respectively;the second frame portion comprises a second mounting arm and second extension arms bending and extending from two ends of the second mounting arm respectively; andthe first extension arm is connected to the second extension arm.4. The photographic assembly according to claim 3 , wherein the first mounting arm is substantially perpendicular to the first extension arm; andthe second mounting arm is substantially ...

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01-11-2018 дата публикации

ARM AND UNMANNED AERIAL VEHICLE

Номер: US20180312254A1
Автор: Ni Feng
Принадлежит:

The present invention relates to the field of air vehicle technologies and provides an arm, a power assembly and an unmanned aerial vehicle. The arm includes a principal arm and an auxiliary arm. The principal arm is mounted on the vehicle body and the principal arm can rotate relative to the vehicle body. One end of the auxiliary arm is connected to the principal arm. The auxiliary arm can rotate relative to the principal arm. In the foregoing manner, an unmanned aerial vehicle having the arm is compact in structure, small in volume and easy to carry after being folded. 1. An arm , applied to an unmanned aerial vehicle , wherein the unmanned aerial vehicle comprises a vehicle body and the arm comprising:a principal vehicle arm, wherein the principal arm is mounted on the vehicle body and the principal arm can rotate relative to the vehicle body; andan auxiliary arm, wherein one end of the auxiliary arm is connected to the principal arm and the auxiliary arm can rotate relative to the principal arm.2. The arm according to claim 1 , wherein the other end of the auxiliary arm is used for mounting a driving apparatus.3. The arm according to claim 1 , wherein a limiting structure and an elastic part are disposed at a joint between the principal arm and the vehicle body.4. The arm according to claim 1 , wherein a limiting structure and an elastic part are disposed at a joint between the principal arm and the auxiliary arm.5. The arm according to claim 1 , wherein a spring lock is disposed at a joint between the principal arm and the auxiliary arm.6. The arm according to claim 1 , wherein a spring lock is disposed at a joint between the principal arm and the vehicle body.7. The arm according to claim 1 , wherein the arm comprises one principal arm and four auxiliary arms claim 1 , a mounting part used for connecting the principal arm to the vehicle body being disposed at the middle of the principal arm.8. The arm according to claim 7 , wherein the mounting part can rotate ...

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05-12-2019 дата публикации

UNMANNED AERIAL VEHICLE

Номер: US20190367167A1
Принадлежит:

The present invention discloses an unmanned aerial vehicle, including: a fuselage; a battery accommodation cavity, disposed on the fuselage; a battery pack, including at least two battery blocks and mounted inside the battery accommodation cavity; a battery circuit board, electrically connected to the battery blocks in the battery pack; and a functional module, electrically connected to the battery circuit board, the battery blocks in the battery pack supplying power to the functional module via the battery circuit board at the same time. By using the solution of the present invention, endurance of the unmanned aerial vehicle is increased. 1. An unmanned aerial vehicle , comprising:a fuselage having a battery accommodation cavity, wherein the battery accommodation cavity comprises at least two openings;a plurality of arms, wherein each arm is coupled to the fuselage;a propulsion assembly mounted on the each arm, wherein the propulsion assembly comprises a propeller and a motor, the motor being configured to rotate the propeller in order to generate lift force;at least two battery blocks configured to be installed in the battery accommodation cavity, wherein each of the at least two battery blocks comprises a battery housing and a battery disposed in the battery housing; andan electronic board disposed inside the fuselage;wherein the each of the at least two battery blocks is configured to be inserted into the battery accommodation cavity via one of the at least two openings;wherein at least a portion of the each of the at least two battery blocks is visible in a state where the each of the at least two battery blocks is installed into the battery accommodation cavity.2. The unmanned aerial vehicle according to claim 1 , further comprising a battery circuit board electrically connected to the at least two battery blocks claim 1 , the at least two battery blocks powering the electronic board at the same time via the battery circuit board.3. The unmanned aerial vehicle ...

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05-12-2019 дата публикации

Fabrication of Group III-Nitride Semiconductor devices

Номер: US20190371598A1
Автор: Fan Qian, HE Wei, Ni Xian-Feng
Принадлежит:

The invention relates to a method to reduce the contact resistance of ohmic contact in group III-nitride high-electron mobility transistor (HEMT). A heavily n-type doped nitride layer with modulation doping is epitaxially grown on selected contact regions for use as ohmic contact layer. The method for producing the n++ ohmic contact layer includes at least the following: deposition of nitride HEMT epitaxial structure on substrates (such as SiC, silicon, sapphire, GaN etc), deposition in-situ or ex-situ mask for selective growth of n-contact, selective etching to create of openings within the mask layer, deposition of modulation doped n++ nitride ohmic contact layer followed by ohmic metal deposition. The modulation doping involves alternating epitaxy of high and low doped nitride layers with common n-type dopant such as Ge, Si etc. The modulation doping significantly increases the range of n-type doping without detrimental effect on the material quality of the contact layer. 1. A method for fabricating a Group III-Nitride semiconductor device , comprising:forming a buffer layer on a substrate;forming a barrier layer on the buffer layer;removing partial of the barrier layer to form two separated trenches; andforming two n++ nitride layers with modulation doping on the two trenches respectively;wherein the modulation doping involves alternating epitaxy of high and low doped layers.2. The method of claim 1 , wherein the n++ nitride layer is formed by the regrowth of materials selected from the group consisting of GaN claim 1 , InGaN claim 1 , AlGaN claim 1 , AlInGaN claim 1 , other nitride material(s) and combination thereof.312. The method of claim 2 , wherein the growth of the n++ nitride layer consist of a plurality of repetitive cycles claim 2 , and wherein each cycle consists of two small periods of t and t.4. The method of claim 3 , further comprising one of the following:{'b': 1', '2, 'the high doped layer being formed during the t periods and the low doped ...

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09-05-2000 дата публикации

Thrombin inhibitors based on the amino acid sequence of hirudin

Номер: US6060451A
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic site of thrombin responsible for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atoms. Connecting the first bulky hydrophobic portion and the linker is a peptidomimetic bond. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders.

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24-07-2001 дата публикации

Thrombin inhibitors based on the amino acid sequence of hirudin

Номер: CA2085465C
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic sits of thrombin responsi-ble for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of na-tive hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atomes. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders.

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24-03-2020 дата публикации

Automatic gun grabbing equipment for automatic charging of automobile

Номер: CN210174648U
Автор: Feng Ni, Yong Jin, 倪峰, 金勇�
Принадлежит: Global Car Sharing and Rental Co Ltd

本实用新型提供了一种用于汽车自动充电的自动抓枪设备,其中设备包括抓枪机构,包括第一连接部和第二连接部,第一连接部连接至一机械臂的末端,第二连接部设置有至少一弹性卡爪;充电枪,一端设置有连接盘,其上设置有与弹性卡爪一一对应的卡爪卡槽,抓枪机构的第二连接部与连接盘连接时,弹性卡爪的末端卡设于所对应的卡爪卡槽中,充电枪的另一端设置有充电插头,侧面开设有线缆穿孔,充电线缆穿过所述线缆穿孔后与所述充电插头电连接。通过采用本实用新型,抓枪机构可以抓取充电枪,也可以与充电枪分离,从而实现一台自动充电装置可以为多个汽车同时充电,并在自动充电装置出现故障的情况下,仍然可以手动充电。

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15-12-1992 дата публикации

THROMBIN INHIBITORS BASED ON THE AMINO ACID SEQUENCE OF HIRUDIN

Номер: NO924834L
Принадлежит: Ca Nat Research Council

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29-03-1993 дата публикации

Thrombine inhibitors based on the amino acid sequence of hirudine

Номер: HU9203968D0
Принадлежит: Ca Nat Research Council

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26-10-2012 дата публикации

Locally-active anticoagulants and anti-inflammatory agents

Номер: CA2833614A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

A locally-activatable bivalent thrombin binding agent is provided having two thrombin binding moieties for non-overlapping sites on a surface of thrombin linked together by a linker. The linker is a polypeptide having 5 to 30 amino acid residues existing in a folded state under an environmental condition where the binding agent is inactive. The linker changes conformation from the folded state to an unfolded state in response to a change in bulk temperature and/or to the presence of hyper-mobile water thereby activating the binding agent. Such locally-activatable thrombin binding agents can be administered systemically while only targeting specific sites of coagulation or inflammation since the thrombin binding agent will only activate at the site where the existence of atherosclerotic plaques has changed the local bulk temperature and/or created hyper-mobile water sufficiently to unfold the linker and activate the binding agent. Such binding agents are useful as site-specific anti-coagulant, anti-thrombotic and/or anti¬ inflammatory agents.

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19-07-2007 дата публикации

Device and method for measuring gray to gray transition response time

Номер: US20070164776A1
Принадлежит: R2D TECHNOLOGY Inc

A device for measuring gray-to-gray response times in a display utilizes light detectors to measure the response time of gray images of the display rapidly. The device is used in a measuring system having a temporal signal integrator and a light scope. The temporal signal integrator provides a plurality of signals of gray images for multiple areas on the display, and the light scope includes the light detectors. Each active light detector is distributed to measure the response time of the gray images on each of the areas.

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03-04-2019 дата публикации

Unmanned aerial vehicle

Номер: EP3366577A4
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

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22-11-2011 дата публикации

Bivalent thrombin binding molecules comprising linkers

Номер: US8063018B2
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

There is provided herein a multivalent binding molecule and uses thereof. The molecule is useful in binding a target under certain conditions and releasing it under other conditions. The molecule has the general formula (1) of BM1-L-(BM2) n (1) wherein, BM1 is a binding moiety 1 having an affinity for site 1 on the target, BM2 is a binding moiety 2 having an affinity for a site other than site 1 on the target, n is 1 or greater, and L is a linker joining BM1 and BM2, said linker being adapted to respond to a change in its environment with a change in conformation and/or flexibility, wherein BM1 and BM2 may be the same or different and are selected such that in use each of the BM1 and BM2 existing separately has a lower binding affinity then the complex of BM1 and BM2 does when they are linked to form the molecule. BM2 may have a single binding region or multiple binding regions with affinity for the target. The binding affinity of BM1 or BM2 to the target alone is no more than ½ the binding affinity of the molecule of formula (1). The molecule of formula (1) can be constructed using an oligomeric or polymeric linker, such as a polypeptide sequence. Such molecules can be useful in the delayed release of drugs, in screening assays, for stabilizing enzymes such as proteases, and for controlling reactions such as blood clotting.

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29-08-2018 дата публикации

Unmanned aerial vehicle

Номер: EP3366577A1
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

Embodiments of the present invention relate to the field of aircraft technologies, and provide an unmanned aerial vehicle including an unmanned aerial vehicle body and an landing gear. The landing gear is entirely accommodated in the unmanned aerial vehicle body when being in a folded state. When being folded, the landing gear in the present invention is entirely accommodated in the unmanned aerial vehicle body, and therefore neither causes unnecessary resistance in air nor blocks an aerial photographing field of view in an aerial photographing process of the unmanned aerial vehicle. In addition, when the unmanned aerial vehicle is not in use, the landing gear is accommodated in the unmanned aerial vehicle body, so that the unmanned aerial vehicle is very compact in structure and easy to accommodate and carry.

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06-10-2016 дата публикации

Fluorescent bisphosphonate analogs

Номер: CA2981678A1
Принадлежит: University of Southern California USC

Fluorescent probes based on N-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. Methods for preparing the probes include the use of two complementary linking strategies, one involving an amino group and the other involving a chloride group as a precursor to an amino group. In other versions, bifunctional N-heterocyclic bisphosphonates are provided having an amino group and an azido group as linking moieties. In some versions, the linking chemistry allows attachment of a wide selection of fluorescent dyes in the visible to near-infrared range to any of three clinically important heterocyclic bisphosphonates.

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19-03-1998 дата публикации

THROMBIN INHIBITORS WITH A HIRUDIN-LIKE SEQUENCE

Номер: DE69128247T2
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic site of thrombin responsible for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atomes. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders.

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15-12-1992 дата публикации

PAO HIRUDINETS AMINOSYRASE SEQUENCE BASERADE THROMBIN INHIBITOR

Номер: FI925696A0
Принадлежит: Ca Nat Research Council

A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic site of thrombin responsible for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atomes. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders.

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21-11-1997 дата публикации

Elimination method of the lax face of the umbrella

Номер: TW320556B
Автор: Feng-Ming Ni
Принадлежит: Feng-Ming Ni

Подробнее
26-08-2015 дата публикации

Derivatives of collagen-binding hairpin peptides

Номер: EP2909226A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

Compounds of interest, for example active pharmaceutical ingredients, probes or inactive carriers, may be delivered to a site of interest by conjugating the compound of interest to a collagen-binding linear hairpin (CBLH) peptide to form a molecule of Formula (I) and then providing the molecule to the site of interest where the CBLH peptide binds to collagen at the site of interest thereby delivering the compound of interest to the site of interest. Molecule of Formula (I) are: (I) where: Y is a first compound of interest; Z is a second compound of interest; n and m are independently 0 or 1 with the proviso that at least one of n and m is 1; and, CBLH is a collagen-binding linear hairpin peptide having 19 or fewer amino acids and having a turn amino acid sequence comprising 4 to 6 amino acid residues providing a stable turn structure, the turn sequence flanked on one side by a first flanking sequence having a WT(W/Y) motif and flanked on the other side by a second flanking sequence having a WT(W/R) motif, the W residue at position 1 of the first flanking sequence forming a cross-strand indole-indole or cation-π interaction pair with the amino acid residue at position 3 of the second flanking sequence without any disulfide bond.

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12-12-2018 дата публикации

Photographing assembly and unmanned aerial vehicle having same

Номер: EP3412579A4
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

Подробнее
03-08-2006 дата публикации

Staphylococcal nuclease fusion proteins for the produciton of recombinant peptides

Номер: US20060173164A1
Автор: Feng Ni, Zhengding Su
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier protein acts to promote the over-expression of the peptide-protein fusion in the form of inclusion bodies, which minimizes in-cell proteolysis of desired peptides. The fusion protein is readily purified by conventional procedures or His-tag affinity chromatography when His-tag is inserted into the fusion protein. The target peptide is released from the purified fusion protein by a simple cleavage step and separated from the librated carrier protein by use of a reverse-phase HPLC process or by repeating the same affinity purification method. A particular advantage of the disclosed method, in addition to the obvious advantage of high yields, is its use for producing isotopically labeled peptides for NMR characterization of bioactive peptides and their interactions with target proteins.

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15-06-2011 дата публикации

Verfahren und verwendungen von linker enthaltenden polypeptidliganden

Номер: ATE510013T1
Принадлежит: Ca Nat Research Council

Подробнее
17-10-2023 дата публикации

Unmanned aerial vehicle

Номер: US11787542B2
Принадлежит: Autel Robotics Co Ltd

An unmanned aerial vehicle includes a fuselage, a battery accommodation cavity, a battery pack, a battery circuit board, and a functional module. The battery accommodation cavity is disposed on the fuselage. The battery pack includes at least two battery blocks which are mounted inside the battery accommodation cavity. The battery circuit board is electrically connected to the battery blocks in the battery pack. The functional module is electrically connected to the battery circuit board, and the battery blocks in the battery pack supply power to the functional module via the battery circuit board at the same time.

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21-03-1993 дата публикации

Making process for seam-free umbrella canopies

Номер: TW202383B
Автор: Feng-Ming Ni
Принадлежит: Ming Teh Flag Co Ltd

Подробнее
29-04-2020 дата публикации

Unmanned aerial vehicle

Номер: EP3643602A1
Автор: Feng Ni
Принадлежит: Autel Robotics Co Ltd

The present invention relates to the field of air vehicle technologies and provides an unmanned aerial vehicle (UAV), including a vehicle body and arms connected to the vehicle body. The arm is hinged to the vehicle body by using a spherical hinge portion and may be folded or unfolded relative to the vehicle body. Through the forgoing manner, the arm is connected to the vehicle body of the UAV by using the spherical hinge. The arm can be folded and unfolded smoothly without interference, which conforms to known operation habits of users, so that after the entire UAV is folded, the structure becomes more compact and easier to carry. In addition, it can be effectively avoided that the UAV is damaged due to impact in the carrying process.

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01-06-2023 дата публикации

Ladesäule zum Laden von Elektro- oder Plug-in-Hybridfahrzeugen

Номер: DE102020212875B4
Автор: Matthias KÜBEL, Ni Feng
Принадлежит: VOLKSWAGEN AG

Ladesäule (1) zum Laden von Elektro- oder Plug-in-Hybridfahrzeugen, umfassend ein Ladekabel (2) mit einem Ladestecker (3) und ein Steuergerät (15), wobei in dem oder an dem Ladestecker (3) mindestens eine Sensorik (10) angeordnet ist, wobei die Sensorik (10) und das Steuergerät (15) derart ausgebildet sind, dass das Steuergerät (15) aus den Daten der Sensorik (10) auf einen Fall und/oder Aufschlag des Ladesteckers (3) auf den Boden (6) schließt, wobei die mindestens eine Sensorik (10) als Beschleunigungssensor ausgebildet ist, dadurch gekennzeichnet, dass die Sensorik (10) mehrere Druck- oder Kraftsensoren am oder im Ladestecker (3) aufweist, wobei das Steuergerät (15) derart ausgebildet ist, dass die Anzahl und Schwere der Aufpralle erfasst werden und das Steuergerät (15) derart ausgebildet ist, in Abhängigkeit der Anzahl und der Schwere der Aufpralle eine Service-Anforderungsnachricht an eine Zentrale (17) zu übermitteln.

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21-03-2005 дата публикации

Levelness-adjustable jig

Номер: TWM259663U
Принадлежит: Advanced Int Multitech Co Ltd

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27-06-2024 дата публикации

Methods and systems for operating object detection-based indicia scanner

Номер: US20240211710A1
Принадлежит: HAND HELD PRODUCTS INC

Various embodiments are directed to an indicia scanner. In an embodiment, a scanning operation is started in response to detecting an object within a field of view of indicia scanner. Starting the scanning operation comprises energizing an illumination source of the indicia scanner. The scanning operation is continued responsive to determining that the object is within a region of interest within the field of view. The scanning operation is stopped upon decoding of an indicia embodied by the object.

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01-12-2009 дата публикации

Method of measuring display motion artifacts

Номер: TW200949787A
Принадлежит: R2D TECHNOLOGY Inc

Подробнее
22-09-2011 дата публикации

High efficiency welding device

Номер: US20110226750A1
Автор: Xue Feng Ni
Принадлежит: Individual

The high efficiency welding device has two pairs of clamps mounted in two pairs of sliders movable in a reciprocating movement relative to one another. One pair of sliders is mounted at 0 and 180 degree positions around the circumferential surface of a support block and the other pair of sliders is mounted at 90 and 270 degree positions. Each pair of clamps is in the close condition while moving forward in the reciprocating movement to clamp onto selected air gaps of the welding electrode to advance the electrode towards the work piece as well as delivering the welding current to the welding operation, and it is in the open condition releasing the grasp of the welding electrode while moving backward.

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03-07-2024 дата публикации

Methods and systems for operating object detection-based indicia scanner

Номер: EP4394653A1
Принадлежит: Honeywell International Inc

Various embodiments are directed to an indicia scanner. In an embodiment, a scanning operation is started in response to detecting an object within a field of view of indicia scanner. Starting the scanning operation comprises energizing an illumination source of the indicia scanner. The scanning operation is continued responsive to determining that the object is within a region of interest within the field of view. The scanning operation is stopped upon decoding of an indicia embodied by the object.

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14-04-2022 дата публикации

Ladesäule zum Laden von Elektro- oder Plug-in-Hybridfahrzeugen

Номер: DE102020212875A1
Автор: Matthias KÜBEL, Ni Feng
Принадлежит: VOLKSWAGEN AG

Die Erfindung betrifft eine Ladesäule (1) zum Laden von Elektro- oder Plug-in-Hybridfahrzeugen, umfassend ein Ladekabel (2) mit einem Ladestecker (3) und ein Steuergerät (15), wobei in dem oder an dem Ladestecker (3) mindestens eine Sensorik (10) angeordnet ist, wobei die Sensorik (10) und das Steuergerät (15) derart ausgebildet sind, dass das Steuergerät (15) aus den Daten der Sensorik (10) auf einen Fall und/oder Aufschlag des Ladesteckers (3) auf den Boden (6) schließt.

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22-02-2007 дата публикации

Peptide inhibitors of thrombin as potent anticoagulants

Номер: US20070042946A1
Принадлежит: NATIONAL RESEARCH COUNCIL OF CANADA

The tetrapeptide Phe-Asn-Pro-Arg is a structurally-optimized sequence for binding to the active site of thrombin. By conjugating this tetrapeptide or variants thereof to a C-terminal fragment of hirudin, we were able to generate a series of new multivalent inhibitors of thrombin containing only genetically encodable natural amino acids. We found that synergistic binding to both the active site and an exosite of thrombin can be enhanced through substitutions of amino acid residues at the P 4 , P 3 and P 3′ sites of the active-site directed sequence, Xaa(P 4 )-Yaa(P 3 )-Pro(P 2 )-Arg(P 1 )-Pro(P 1′ )-Gln(P 2′ )-Zaa(P 3′ ). Complementary to rational design, a phage library was constructed to explore further the residue requirements at the P 4 , P 3 and P 3′ sites for multivalent and optimized bridge-binding. Panning of the phage library has led to thrombin-inhibitory peptides possessing strong anti-clotting activities in the low nanomolar range and yet interfering only partially with the catalytic active site of thrombin. In all, the availability of potent and genetically-encodable polypeptide inhibitors of thrombin opens the door for much wider applications of this clinically-successful class of anticoagulants, e.g. through more cost-effective recombinant peptide production, in areas such as gene therapy as well as to improve clinical efficacy/safety through the incorporation of homing peptides for targeted delivery.

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16-10-2003 дата публикации

Quantitative ranking of transient ligand binding to target biomolecules

Номер: WO2003057258A3

There is provided a method of quantitatively ranking transient ligand binding to target biomolecules by means of NMR relaxation dispersion profiles. The present invention also relates to a method to identify ligand site obeying two-state and more complex binding behavior in a transient complex of a ligand with a target molecule, still with the use of NMR. There is also provided an efficient method to quantitate fast dissociation rates of ligands containing at least one magnetic nuclei by performing NMR relaxation dispersion experiments at different protein concentrations, enabling the evaluation of populations and exchange rates, and extending the practical applicability of the NMR relaxation dispersion experiments.

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12-04-2018 дата публикации

A chemoproteomic approach for discovering covalent ligands for diverse protein targets

Номер: WO2018067659A1
Принадлежит: UNIVERSITY OF SOUTHERN CALIFORNIA

Despite its power in identifying highly potent ligands for select protein targets, conventional medicinal chemistry is limited by its low throughput and lack of proteomic selectivity information. We seek to develop a chemoproteomic approach for discovering covalent ligands for protein targets in an unbiased, high-throughput manner. Tripartite probe compounds composed of a heterocyclic core, an electrophilic 'warhead' and an alkyne tag have been designed and synthesized for covalently labeling and identifying targets in cells. We have developed a novel condensation reaction to prepare 2-chloromethylquinoline (2-CMQ), a novel electrophilic heterocycle. These chloromethylquinolines potently and covalently bind to a number of cellular protein targets including Prostaglandin E Synthase 2 (PTGES2), a critical regulator of cell proliferation, apoptosis, angiogenesis, inflammation, and immune surveillance. The 2-CMQs that we have developed here are novel PTGES2 inhibitors that have the potential to serve as novel therapies for the treatment of human diseases such as inflammation. Beyond this case study, our methodology can be extended to additional electrophiles and scaffolds for discovering covalent ligands for diverse targets in the human proteome.

Подробнее
15-12-1997 дата публикации

Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Номер: ATE160356T1
Принадлежит: Ca Nat Research Council

Подробнее
06-08-2024 дата публикации

Process for distilling a crude composition in a rectification plant including an indirect heat pump

Номер: US12053725B2
Автор: Laurent Zuber, Lin Feng NI
Принадлежит: SULZER MANAGEMENT AG

A process for purifying a crude composition comprising rectifying the crude composition in a rectification plant. The rectification plant comprises a rectification column including: a first overhead condenser for condensing a head fraction, and a reboiler for evaporating a bottom fraction. A difference between a temperature of the head fraction and a temperature of the bottom fraction is less than or equal to 20° C. A heat pump is provided between the first overhead condenser and the reboiler. The heat pump is an indirect heat pump that is operated with water or methanol as a refrigerant, and the indirect heat pump includes an expansion valve and a compressor. The heat pump comprises a second condenser located upstream of the compressor.

Подробнее
07-02-2018 дата публикации

Fluorescent bisphosphonate analogs

Номер: EP3278107A1
Принадлежит: University of Southern California USC

Fluorescent probes based on N-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. Methods for preparing the probes include the use of two complementary linking strategies, one involving an amino group and the other involving a chloride group as a precursor to an amino group. In other versions, bifunctional N-heterocyclic bisphosphonates are provided having an amino group and an azido group as linking moieties. In some versions, the linking chemistry allows attachment of a wide selection of fluorescent dyes in the visible to near-infrared range to any of three clinically important heterocyclic bisphosphonates.

Подробнее
06-10-2016 дата публикации

Fluorescent bisphosphonate analogs

Номер: WO2016161407A1
Принадлежит: UNIVERSITY OF SOUTHERN CALIFORNIA

Fluorescent probes based on N-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. Methods for preparing the probes include the use of two complementary linking strategies, one involving an amino group and the other involving a chloride group as a precursor to an amino group. In other versions, bifunctional N-heterocyclic bisphosphonates are provided having an amino group and an azido group as linking moieties. In some versions, the linking chemistry allows attachment of a wide selection of fluorescent dyes in the visible to near-infrared range to any of three clinically important heterocyclic bisphosphonates.

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