03-11-2022 дата публикации
Номер: US20220347346A1
Автор:
CHANG Dehua,
GAO Shuang,
JIN XIN,
Liu Donghua,
LIU Shuai,
Liu Yang,
MA Jianlin,
TAN Yuqin,
Wang Jing,
Wang Juan,
ZHAO Yufei
Принадлежит:
Provided is a method for treating diseases related to cardiac tissue damage or cardiac insufficiency in a subject. The method includes the step of locally applying a mesenchymal stem cell sheet such as an umbilical cord mesenchymal stem cell sheet to the heart of the subject. Also provided are related use and compositions of the mesenchymal stem cell sheet. 1. A method of treating a disease related to cardiac tissue damage or cardiac insufficiency in a subject , comprising applying an effective amount of a mesenchymal stem cell sheet to the heart of the subject topically.2. (canceled)3. The method of claim 1 , wherein the disease is selected from ischemic heart disease claim 1 , rheumatic heart disease claim 1 , congenital heart disease claim 1 , cardiomyopathy claim 1 , coronary heart disease and valvular heart disease.4. The method of claim 3 , wherein the cardiomyopathy is dilated cardiomyopathy.5. The method of claim 3 , wherein the disease is ischemic heart failure.6. The method of claim 1 , wherein the mesenchymal stem cell sheet is applied topically by attaching it to anterior or lateral wall of left ventricle of heart.7. The method of claim 1 , wherein the mesenchymal stem cell sheet is applied topically by attaching or implanting it to damaged or defective sites of heart claim 1 , or adjacent sites thereof.8. (canceled)9. The method of claim 1 , wherein the cell ratio of mesenchymal stem cells in the mesenchymal stem cell sheet is at least 90%.10. The method of claim 1 , wherein the mesenchymal stem cells are derived from a tissue selected from: amniotic fluid claim 1 , amniotic membrane claim 1 , chorion claim 1 , chorionic villus claim 1 , decidua claim 1 , placenta claim 1 , umbilical cord blood claim 1 , Wharton's jelly claim 1 , umbilical cord claim 1 , adult bone marrow claim 1 , dental pulp claim 1 , adult peripheral blood and adult adipose tissue.11. The method of claim 1 , wherein the mesenchymal stem cells are selected from umbilical cord ...
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