01-03-2018 дата публикации
Номер: US20180055819A1
The invention discloses statins compounds used as local intraosseous application for the treatment of ischemic diseases, in particular, discloses local intraosseous application of statin compounds in the treatment of peripheral ischemic diseases or cardio-cerebrovascular ischemic diseases. 1. A composition comprising a statin or a pharmaceutically acceptable salt thereof , and a pharmaceutically acceptable carrier , wherein said composition is formulated for administration as a single dose administered locally into bone as a treatment for an ischemic disease , disorder or condition in a mammal.2. The composition according to claim 1 , wherein the statin is selected from the group consisting of simvastatin claim 1 , atorvastatin claim 1 , fluvastatin claim 1 , lovastatin claim 1 , pravastatin claim 1 , rosuvastatin claim 1 , pitavastatin claim 1 , bervastatin claim 1 , cerivastatin claim 1 , crilvastatin claim 1 , dalvastatin claim 1 , mevasatin claim 1 , tenivastatin and any combinations thereof.3. The composition of claim 2 , wherein the statin is simvastatin.4. The composition of claim 1 , wherein said composition further comprises a pharmaceutically acceptable adjuvant.5. The composition of claim 1 , wherein said pharmaceutically acceptable salt of statin is selected from the group consisting of hydrochloride claim 1 , hydrobromide claim 1 , hydriodate claim 1 , sulfate claim 1 , nitrate claim 1 , phosphate claim 1 , citrate claim 1 , mesylate claim 1 , trifluoroacetate claim 1 , and acetate.6. The composition of claim 1 , wherein the composition is selected from the group consisting of an injectable solution claim 1 , an injectable suspension liquid claim 1 , an injectable emulsion claim 1 , an injectable gel claim 1 , and an injectable implantable solid form.710-. (canceled)11. The composition of claim 1 , wherein the statin or pharmaceutically acceptable salt thereof is in a range from 0.1 mg to 50 mg.12. The composition of claim 1 , wherein the composition is ...
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