11-07-2013 дата публикации
Номер: US20130178468A1
Принадлежит:
Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: 2. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein ring A is a 6-membered claim 1 , saturated or mono-unsaturated heterocyclic ring containing in addition to the nitrogen shared with the naphthyridine ring from 1 to 3 heteroatoms independently selected from N claim 1 , O claim 1 , and S claim 1 , wherein each S is optionally oxidized to S(O) or S(O); and wherein the saturated or mono-unsaturated heterocyclic ring is optionally substituted with a total of from 1 to 6 substituents claim 1 , wherein: (1) halogen,', {'sub': '1-6', '(2) Calkyl,'}, {'sub': '1-6', '(3) Chaloalkyl,'}, {'sub': 1-6', '1-6', '1-6', '2', '1-6', '1-6', '2', '2', '2', '2', '2, 'sup': A', 'B', 'A', 'B', 'A', 'A', 'A', 'B', 'A', 'B', 'A', 'A', 'A', 'A', 'B', 'A', 'B', 'A', 'B', 'A', 'B', 'A', 'A', 'B', 'A', 'A', 'B', 'A', 'B, '(4) Calkyl substituted with OH, O—Calkyl, O—Chaloalkyl, CN, N(R)R, C(O)N(R)R, C(O)R, COR, C(O)—N(R)—Calkylene-ORwith the proviso that the N(R) moiety and the ORmoiety are not both attached to the same carbon of the Calkylene moiety, SR, S(O)R, SOR, SON(R)R, N(R)C(O)R, N(R)COR, N(R)SOR, N(R)SON(R)R, N(R)C(O)N(R)R, or OC(O)N(R)R,'}, {'sub': '1-6', '(5) O—Calkyl,'}, {'sub': '1-6', '(6) O—Chaloalkyl,'}, '(7) oxo,', {'sup': A', 'B, '(8) ═C(R)R,'}, {'sup': A', 'B, '(9) C(O)N(R)R,'}, {'sup': A', 'B, '(10) C(O)C(O)N(R)R,'}, {'sup': 'A', '(11) C(O)R,'}, {'sub': '2', 'sup': 'A', '(12) COR,'}, {'sup': 'A', '(13) SR,'}, {'sup': 'A', '(14) S(O)R,'}, {'sub': '2', 'sup': 'A', '(15) SOR, or'}, {'sub': '2', 'sup': A', 'B, '(16) SON(R)R, and'}], '(i) from zero to 6 substituents are each independently{'sup': 'L', 'claim-text': [{'sub': 1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '2', '1-6', '2', '1-6', '1-6', '1-6', '2, 'sup': A', 'A', 'A', 'A, 'each Z is independently a single bond, Calkylene, O, O—Calkylene ...
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