22-05-2014 дата публикации
Номер: US20140142032A1
Принадлежит:
A caspofungin composition includes caspofungin acetate and at least one amino acid, where the composition is a solid. The solid composition may be made by forming a liquid mixture including a solvent, caspofungin acetate and the amino acid(s), and lyophilizing the liquid mixture. 1. A composition , comprising:caspofungin acetate, andat least one an amino acid;where the composition is a solid.2. The composition of claim 1 , where the at least one amino acid comprises an amino acid having at least two primary or secondary amine groups.3. The composition of claim 2 , where the at least one amino acid comprises an amino acid selected from the group consisting of arginine claim 2 , asparagine claim 2 , lysine claim 2 , methyl lysine claim 2 , and ornithine.4. The composition of claim 1 , where the at least one amino acid comprises an amino acid selected from the group consisting of alanine claim 1 , 4-aminobutanoic acid claim 1 , 3-aminopentanoic acid claim 1 , 5-aminopentanoic acid claim 1 , 6-aminohexanoic acid claim 1 , 8-aminooctanoic acid claim 1 , arginine claim 1 , aspartic acid claim 1 , asparagine claim 1 , cysteine claim 1 , glutamic acid claim 1 , glutamine claim 1 , glycine claim 1 , histidine claim 1 , isoleucine claim 1 , leucine claim 1 , lysine claim 1 , methionine claim 1 , methyl lysine claim 1 , ornithine claim 1 , phenylalanine claim 1 , proline claim 1 , serine claim 1 , threonine claim 1 , tryptophan claim 1 , tyrosine and valine.5. The composition of claim 1 , where the at least one amino acid comprises an amino acid selected from the group consisting of 6-aminohexanoic acid claim 1 , arginine claim 1 , asparagine claim 1 , glycine claim 1 , lysine claim 1 , methyl lysine claim 1 , and ornithine.6. The composition of claim 1 , where the at least one amino acid comprises at least two amino acids.7. The composition of claim 1 , comprising from 10 to 150 mg caspofungin acetate.8. The composition of claim 1 , comprising from 25 to 100 mg caspofungin ...
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