28-06-2012 дата публикации
Номер: US20120165352A1
Принадлежит:
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification. 2. The compound according to claim 1 , the tautomer claim 1 , racemate claim 1 , enantiomer claim 1 , diastereoisomer or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof claim 1 , wherein A is carbon atom; Ris alkoxyl; and Ris cyano.3. The compound according to claim 1 , the tautomer claim 1 , racemate claim 1 , enantiomer claim 1 , diastereoisomer or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof claim 1 , wherein A is nitrogen atom; Ris hydrogen; and Ris absent.4. The compound according to claim 1 , the tautomer claim 1 , racemate claim 1 , enantiomer claim 1 , diastereoisomer or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof claim 1 , wherein n is 2.6. The compound according to claim 5 , the tautomer claim 5 , racemate claim 5 , enantiomer claim 5 , diastereoisomer or mixture thereof claim 5 , or the pharmaceutically acceptable salt thereof claim 5 , wherein A is carbon atom; Ris alkoxyl; and Ris cyano.7. The compound according to claim 5 , the tautomer claim 5 , racemate claim 5 , enantiomer claim 5 , diastereoisomer or mixture thereof claim 5 , or the pharmaceutically acceptable salt thereof claim 5 , wherein A is nitrogen atom; Ris hydrogen; and Ris absent.8. The compound according to claim 5 , the tautomer claim 5 , racemate claim 5 , enantiomer claim 5 , diastereoisomer or mixture thereof claim 5 , or the ...
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