Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials

The invention provides FIG. 1 novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens. The new classes of compounds show extended action against Gram positive bacteria including MRSA drug resistant pathogens. In the Gram-positive organisms, they specifically target and functionally inhibit microbial attachment to surfaces and biofilm formation. In Gram-negative bacteria, including enteroaggregative E. coli strains, these compounds function as pilicides by inhibiting the assembly of pilin subunits into adhesive filaments. Several of these compounds show potent antimicrobial action against Gram positive bacteria, perhaps involving novel targets. Many of the benzothiophene derivatives exhibit antimicrobial activity in the low micrograms per ml range and in blocking biofilm formation in the nanomolar range; ranges considered are well within the range of utility as therapeutics.

Composite Tooling

A carbon foam article useful for, inter alia, composite tooling or other high temperature applications, which includes a substrate, wherein the substrate includes at least one material selected from carbon foam, extruded graphite, graphite foam, and isomolded graphite. The tool may also include a skin as a working surface and a filler disposed below the skin. The tool has a surface roughness of no more than about 63 micro-inches. Such a tool may be used to make a composite prototype part.

Method for Principal Frequency Magnetic Resonance Elastography Inversion

A method for calculating a mechanical property of a material using a magnetic resonance imaging (“MRI”) system is provided. The method is particularly robust to image data having low signal-to-noise ratio (“SNR”). An MRI system is used to acquire magnetic resonance elastography (“MRE”) data from a subject containing the material. Exemplary materials include lung tissue. Images are reconstructed from the MRE data and used to produce a wave image from which a spatial frequency spectrum is produced. A principal frequency of the spatial frequency spectrum is produced and used to calculate a mechanical property of the material. For example, shear stiffness may be calculated.

Compositions and methods for the delivery of therapeutic peptides

Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.

Distal bearing support

In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Catheter pump

A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self-expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.

System and method for magnetic resonance elastography of the breast

A system and method for performing magnetic resonance elastography (MRE] of a patient's breasts is provided. An MRE driver configured to be placed on the sternum of the patient is used to impart mechanical energy to the sternum, which in turn generates shear waves in at least one of the patient's breasts. Such a driver is amenable to use with standard breast radio frequency (RF] coils without the need for modification of the existing breast RF coil hardware.

Distal bearing support

In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.

Sheath assembly for catheter pump

In one embodiment, a catheter pump assembly is disclosed. The catheter pump assembly can include an impeller assembly. A catheter body can be coupled with the proximal end of the impeller assembly, the catheter body having a reduced stiffness section disposed proximally of the impeller assembly. A sheath assembly can be configured to be translate over the catheter body relative to the impeller assembly from an impeller assembly delivery position to an impeller assembly deployment position. When the sheath assembly is in the impeller assembly deployment position, a reduction in stiffness is provided between the distal end of the sheath assembly and the impeller assembly.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Fluid handling system

A system for coupling a motor assembly to a control console is disclosed. The motor assembly is configured to drive a percutaneous heart pump. The system includes a motor coupling comprising a first end having an electrical connection and a fluid connection coupled to a respective electrical conduit and fluid conduit of the motor assembly, and a second end spaced apart from the first end including an interface coupling coupled to the electrical conduit and fluid conduit. An interface member is configured to be removably coupled to the control console, the interface member comprising a corresponding connector coupleable to the interface coupling of the second end of the motor coupling, wherein the interface member is configured to provide a sterile attachment of the fluid conduit to the control console.

Distal bearing support

In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.

Affinity-assisted protein modification and recycling

Methods for preparing a protein conjugate having a defined number of conjugate groups are provided. The method includes: forming a mixture containing a macrocyclic matrix material and a plurality of proteins; eluting the proteins to obtain a first separated protein fraction and a second separated protein fraction, wherein substantially all of the proteins in the first separated protein fraction have the same number of handle moieties; contacting the handle moieties with a conversion reagent under conditions sufficient to convert the handle moieties in the first separated protein fraction to reactive moieties; and contacting the reactive moieties with a conjugation reagent under conditions sufficient to form a plurality of protein conjugates, wherein substantially all of the protein conjugates in the plurality have the same number of conjugate groups. Methods also include recovering enzymes and other proteins from mixtures for isolation and/or reuse of the enzymes and proteins.

Monoclonal antibody fusions

Antibody fusions comprising any antibody or fragment thereof, operably linked, and expressed as a fusion with a label of interest are provided. Plasmids, vectors, host cells, methods, and kits related to the described antibody fusions are also provided. The antibody fusions are useful at least in the diagnostic and reagent setting.

Negative pressure device having oxygen scavenger and volume reduction

A negative pressure tissue treatment system useful for negative pressure therapy includes a drape, a gasket material, a reactor housing, a reactor, and any fluid connection(s). The drape covers the skin of a patient and maintains negative pressure under the drape. The gasket material cooperates with the drape to define an enclosed volume that is sealed by the gasket material. The reactor housing defines a closed chamber in fluid communication with the enclosed volume, and the re- actor is disposed in the reactor housing. The reactor consumes oxygen from a system volume defined by the enclosed volume, closed chamber, and/or any fluid connection(s). As a result of the oxygen consumption, the system volume is reduced to between about 95% to about 80% of the initial system volume.

Microprotrusion member retainer for impact applicator

A retainer ( 34 ) is provided for holding a microprotrusion member ( 44 ) for application of the microprotrusion member ( 44 ) to the stratum corneum with an impact applicator ( 10 ). The microprotrusion member ( 44 ) includes a plurality of microprotrusions ( 90 ) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.

Dressing

Peristaltic pump module having jaws for gripping a peristaltic pump tube cassett

A peristaltic pumping apparatus includes a peristaltic pump rotor and pump race. A pump tube cassette includes a body for supporting a flexible tubing loop in an erect, outwardly bowed position for placement within the pump race and for removal from the pump race. A surface juxtaposed the peristaltic pump rotor and race carries a gripping jaw assembly. The gripping jaw assembly opens to receive the pump tube cassette body as the body is moved toward the pump rotor to place the tubing loop within the pump race. The gripping jaw assembly closes to secure the pump tube holder body on the surface in an orientation in which the tubing loop lies within the pump race for engagement with the peristaltic pump rotor.

Self loading peristaltic pump tube cassette

A self-loading peristaltic pumping apparatus includes a pump race for receiving a tubing loop, a pump rotor carrying a roller, and a drive mechanism for rotating the rotor within the pump race. The apparatus also includes a roller locating mechanism that moves the pump roller between a retracted position, free of contact with the received tubing loop, and an extended position, at least partially within the pump race for operative contact with the received tubing loop. The apparatus includes at least one tubing guide element carried by the rotor. The guide element extends from the rotor at least partially into the pump race. The guide element serves during rotation of the rotor with the roller in its retracted position, for contacting the received tubing loop to orient the tubing loop within the pump race.

Medical system, method and apparatus employing mems

A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least on microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selectedcharacteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.

Fluid handling system

Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console.

Fluid handling system

Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console.

Sensors for catheter pumps

Sensors for catheter pumps are disclosed herein. The catheter pump can include a catheter assembly comprising a catheter and a cannula coupled to a distal portion of the catheter. The cannula can have a proximal port for permitting the flow of blood therethrough. The catheter assembly can include a sensor to be disposed near the proximal port. A processing unit can be programmed to process a signal detected by the sensor. The processing unit can comprise a computer-readable set of rules to evaluate the signal to determine a position of the cannula relative to an aortic valve of a patient.

Catheter pump

A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self-expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.

Fluid handling system

Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console.

Catheter pump

A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self-expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.

Sensors for catheter pumps

Sensors for catheter pumps are disclosed herein. The catheter pump can include a catheter assembly comprising a catheter and a cannula coupled to a distal portion of the catheter. The cannula can have a proximal port for permitting the flow of blood therethrough. The catheter assembly can include a sensor to be disposed near the proximal port. A processing unit can be programmed to process a signal detected by the sensor. The processing unit can comprise a computer-readable set of rules to evaluate the signal to determine a position of the cannula relative to an aortic valve of a patient.

Peristaltic pump tube holder with pump tube shield and cover

A peristaltic pump tube holder includes a body that supports a flexible tubing loop in an erect, outwardly bowed position extending from the body for engagement with a peristaltic pump rotor. The holder also includes a receptacle carrying the body. The receptacle includes a wall forming a chamber that covers the flexible tubing loop and at least partially shields it from contact. The chamber further serves, during engagement between the tubing loop and a peristaltic pump rotor, as a cover for the peristaltic pump rotor.

Novel 1,2-bis-sulfonamide derivatives as chemokine receptor modulators

Optically transparent elastomers

A novel optically clear combination which is a composition of matter is disclosed. The disclosed composition is an EPDM vulcanizate of remarkable clarity, the formulation of which involves a synergistic combination of EPDM elastomer, fumed silica, coupling agent, antioxidant, at least one and preferably two curing coagents, and preferably an antistatic agent.

Optically transparent elastomers

A novel optically clear combination which is a composition of matter. The disclosed composition is an EPDM vulcanizate of remarkable clarity, the formulation of which involves a synergistic combination of EPDM elastomer, fumed silica, coupling agent, antioxidant, at least one and preferably two curing coagents, and preferably an antistatic agent.

Poly-1-butene master batches

Copolyesters and fibrous materials formed therefrom

Copolyesters and fibrous materials formed therefrom

This invention relates to aliphatic-aromatic copolyesters, as well as blends of cellulose esters and/or aliphatic polyesters and aliphatic-aromatic copolyesters and/or polymeric compounds as well as fibers, nonwovens, molded objects, and films prepared therefrom.

Copolyester und daraus hergestellte fasermaterialien

Blends of alpha-monoolefin block copolymers with ethylene-acrylate or alkenyl carboxylate copolymers

COPOLYMERS SUCH AS ETHYLENE/ALKYL ACRYLATE, ETHYLENE/ ARYL ACRYLATE AND ETHYLENE/ALKENYL CARBOXYLATE ARE HIGHLY COMPATIBLE WITH 2-PERIOD SEQUENTIAL ALPHA - MONOOLEFIN BLOCK POLYMERS SUCH AS PROPYLENE/ETHYLENE POLYMERS HAVING FROM ABOUT 50% TO ABOUT 99% BY WEIGHT OF POLYPROPYLENE SEGMENT IN THE POLYMER CHAIN. MOLDED OBJECTS PREPARED FROM 2-PERIOD SEQUENTIAL BLOCK POLYMER AND ETHYLENE/ALKYL ACRYLATE, ETHYLENE/ARYL ACRYLATE AND ETHYLENE/ALKENYL ACRYLATE BLENDS HAVE EXCELLENT CLARITY, IMPROVED LOW TEMPERATURE PROPERTIES AND GOOD IMPACT STRENGTH AT LOW TEMPERATURE.

Foamed compositions and methods of use in subterranean zones

The current invention provides improved methods and compositions for completing a well bore. In one aspect, the current invention provides a process for preparing a foamed cement composition. The process utilizes air to foam the cement after the air has been treated to lower the oxygen content below that concentration necessary to support combustion. Additionally, the current invention provides a process for completing a well bore using foamed cement wherein the foam is generated with reduced oxygen content air. Finally, the current invention provides a foamed cement composition wherein the gaseous portion of the composition is air having a reduced oxygen content.

Wavelength shift correction technique for a laser

A wavelength shift correction system for a laser system is provided for correcting wavelength chirps. This wavelength shift correction system includes a learning algorithm that learns characteristics of a wavelength chirp from a laser and a computer system that executes the learning algorithm and provides wavelength correction control signals based on the learned characteristics to reduce the magnitude of the wavelength shift of the present wavelength chirp and subsequent wavelength chirps.

Negative pressure device for articulating joint

A negative pressure device includes a drape covering a dressing site on a patient, a sealing element connected with the drape, a flexible gas chamber housing disposed outwardly from the drape with respect to the enclosed chamber, and a reactor. The drape is made from a thin sheet film and is capable of maintaining a negative pressure underneath the drape. The sealing element and the drape are configured so that the sealing element cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element when applied to skin. The flexible gas chamber housing defines a flexible gas chamber. The reactor is positioned with respect to the enclosed volume and the flexible gas chamber to consume a gas found in air within the enclosed volume and the flexible gas chamber.

EUV light source with subsystem(s) for maintaining LPP drive laser output during EUV non-output periods

A device is disclosed herein which may comprise a droplet generator producing droplets of target material; a sensor providing an intercept time signal when a droplet reaches a preselected location; a delay circuit coupled with said sensor, the delay circuit generating a trigger signal delayed from the intercept time signal; a laser source responsive to a trigger signal to produce a laser pulse; and a system controlling said delay circuit to provide a trigger signal delayed from the intercept time by a first delay time to generate a light pulse that is focused on a droplet and a trigger signal delayed from the intercept time by a second delay time to generate a light pulse which is not focused on a droplet.

Master oscillator—power amplifier drive laser with pre-pulse for EUV light source

A device is described herein which may comprise an optical amplifier having a gain band including wavelengths λ 1 and λ 2 , with λ 1 ≠λ 2 ; a pre-pulse seed laser having a tuning module for tuning a pre-pulse output to wavelength λ 1 ; a main pulse seed laser generating a laser output having wavelength, λ 2 ; and a beam combiner for directing the pre-pulse output and the main pulse output on a common path through the optical amplifier.

Method and apparatus for EUV plasma source target delivery

An EUV plasma formation target delivery system and method is disclosed which may comprise: a target droplet formation mechanism comprising a magneto-restrictive or electro-restrictive material, a liquid plasma source material passageway terminating in an output orifice; a charging mechanism applying charge to a droplet forming jet stream or to individual droplets exiting the passageway along a selected path; a droplet deflector intermediate the output orifice and a plasma initiation site periodically deflecting droplets from the selected path, a liquid target material delivery mechanism comprising a liquid target material delivery passage having an input opening and an output orifice; an electromotive disturbing force generating mechanism generating a disturbing force within the liquid target material, a liquid target delivery droplet formation mechanism having an output orifice; and/or a wetting barrier around the periphery of the output orifice.

Extendable electrode for gas discharge laser

Disclosed herein are systems and methods for extending one or both of the discharge electrodes in a transverse discharge gas laser chamber in which one or both the electrodes are subject to a dimensional change due to erosion. Electrode extension can be performed to increase the chamber life, increase laser performance over the life of the chamber, or both. Operationally, the inter-electrode spacing may be adjusted to maintain a specific target gap distance between the electrodes or to optimize a specific parameter of the laser output beam such as bandwidth, pulse-to-pulse energy stability, beam size, etc.

Laser produced plasma EUV light source

A device is disclosed herein which may include a plasma generating system comprising a source of target material droplets and a laser producing a beam irradiating the droplets at an irradiation region, the plasma producing EUV radiation, wherein the droplet source comprises a fluid exiting an orifice and a sub-system producing a disturbance in the fluid which generates droplets having differing initial velocities causing the spacing between at least some adjacent droplets to decrease as the droplets travel to the irradiation region.

Oscillator-amplifier drive laser with seed protection for an EUV light source

As disclosed herein, in a first aspect, a device may comprise: an oscillator producing a light output on a beam path; a target material for interaction with light on the beam path at an irradiation site; a beam delay on the beam path the beam delay having a beam folding optical arrangement; and a switch positioned along the beam path and interposed between the oscillator and the beam delay; the switch closable to divert at least a portion of light on the beam path from the beam path, the switch having close time, t 1 and the beam path having a length, L 1 , along the path from the switch to the irradiation site; with t 1 <cL 1 , where c is the speed of light on the path, to protect the oscillator.

EUV light source with subsystem(s) for maintaining LPP drive laser output during EUV non-output periods

A device is disclosed herein which may comprise a droplet generator producing droplets of target material; a sensor providing an intercept time signal when a droplet reaches a preselected location; a delay circuit coupled with said sensor, the delay circuit generating a trigger signal delayed from the intercept time signal; a laser source responsive to a trigger signal to produce a laser pulse; and a system controlling said delay circuit to provide a trigger signal delayed from the intercept time by a first delay time to generate a light pulse that is focused on a droplet and a trigger signal delayed from the intercept time by a second delay time to generate a light pulse which is not focused on a droplet.

Master oscillator-power amplifier drive laser with pre-pulse for EUV light source

A device is described herein which may comprise an optical amplifier having a gain band including wavelengths λ 1 and λ 2 , with λ 1 ≠λ 2 ; a pre-pulse seed laser having a tuning module for tuning a pre-pulse output to wavelength λ 1 ; a main pulse seed laser generating a laser output having wavelength, λ 2 ; and a beam combiner for directing the pre-pulse output and the main pulse output on a common path through the optical amplifier.

Multi-pass optical apparatus

An apparatus includes a first plurality of concave reflecting surfaces; a second plurality of reflecting surfaces facing the first plurality of concave reflecting surfaces such that a region is defined between the first and second pluralities; and an input for an optical beam to enter the region and an output for the optical beam to exit the region. The first and second pluralities of reflecting surfaces are arranged relative to each other so that the optical beam is re-imaged at a reflecting surface of one of the pluralities after only one reflection from a reflecting surface of the other of the pluralities and so that overlap of two or more optical beams on each of the reflecting surfaces is avoided.

Extreme ultraviolet light source

A target material is provided at a target location, the target material including a material that emits extreme ultraviolet light when converted to plasma, and the target material extending in a first extent along a first direction and in a second extent along a second direction; an amplified light beam is directed along a direction of propagation toward the target location; and the amplified light beam is focused in a focal plane, where the target location is outside of the focal plane and an interaction between the amplified light beam and the target material converts at least part of the target material to plasma that emits EUV light.

Extendable electrode for gas discharge laser

A movable electrode assembly for use in laser system includes a first electrode, a second electrode arranged opposite from the first electrode, the second electrode being spaced apart from the first electrode by a discharge gap and a discharge gap adjuster interfaced with at least one of the second electrode or the first electrode, the discharge gap adjuster configured to adjust the discharge gap. A movable electrode assembly for integration into a housing of a laser system includes a first electrode having a discharge surface, a second electrode having a discharge surface, such that the discharge surface of the first electrode and the discharge surface of the second electrode face each other in a spaced apart setting that defines a desired discharge gap, and a mechanism for moveably adjusting the spaced apart setting toward the desired discharge gap. A method of adjusting a discharge gap is also disclosed.

Extendable electrode for gas discharge laser

A movable electrode assembly for use in a laser system, includes a first electrode having a first discharge surface, a second electrode having a second discharge surface. The second electrode being arranged opposite from the first electrode. The second discharge surface being spaced apart from the first discharge surface by a discharge gap. A discharge gap adjuster interfaced with at least one of the second electrode or the first electrode, the discharge gap adjuster configured to adjust the discharge gap. A method of adjusting a discharge gap is also disclosed.

Extreme ultraviolet light source

A target material is provided at a target location, the target material including a material that emits extreme ultraviolet light when converted to plasma, and the target material extending in a first extent along a first direction and in a second extent along a second direction; an amplified light beam is directed along a direction of propagation toward the target location; and the amplified light beam is focused in a focal plane, where the target location is outside of the focal plane and an interaction between the amplified light beam and the target material converts at least part of the target material to plasma that emits EUV light.

Catheter pump

A heart pump and a catheter assembly therefor are provided that include a flexible catheter body having a proximal end and a distal end, the catheter body having a plurality of lumens therethrough. The catheter body can be sufficiently flexible to extend from a peripheral access to a patient's heart. The catheter assembly can also include an impeller assembly having an impeller and a housing. The impeller assembly can be coupled with the flexible catheter body such that a tensile force applied to opposite ends of the catheter assembly enhances the security of the connection between the catheter body and the impeller assembly.

Sheath system for catheter pump

A catheter pump assembly is provided that includes an elongate polymeric catheter body, a cannula, and a tubular interface. The elongate polymeric catheter body has a proximal end and a distal end. The cannula has an expandable portion disposed distally of the elongate polymeric catheter body. The cannula can also have another tubular portion that is proximal to the distal portion. The tubular interface has an outer surface configured to be joined to the tubular portion of the cannula and an inner surface. The inner surface is disposed over the distal end of the elongate polymeric catheter body. The tubular interface has a plurality of transverse channels extending outward from the inner surface of the tubular interface. An outer surface of the elongate polymeric catheter body projects into the transverse channels to mechanically integrate the elongate polymeric catheter body with the tubular interface.

Distal bearing support

In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Sheath assembly for catheter pump

In one embodiment, a catheter pump assembly is disclosed. The catheter pump assembly can include an impeller assembly. A catheter body can be coupled with the proximal end of the impeller assembly, the catheter body having a reduced stiffness section disposed proximally of the impeller assembly. A sheath assembly can be configured to be translate over the catheter body relative to the impeller assembly from an impeller assembly delivery position to an impeller assembly deployment position. When the sheath assembly is in the impeller assembly deployment position, a reduction in stiffness is provided between the distal end of the sheath assembly and the impeller assembly.

Catheter pump with access ports

A catheter pump is disclosed herein. The catheter pump can include an elongate catheter body and an impeller assembly coupled to a distal portion of the elongate catheter body. The impeller assembly can comprise an impeller configured to rotate during operation of the catheter pump. A tube can extend through at least portions of the elongate catheter body and the impeller assembly. The tube can extend distal the impeller and can be configured to remain in the portions of the elongate catheter body and the impeller assembly during operation of the catheter pump.

Sheath system for catheter pump

Es wird eine Katheterpumpenbaugruppe bereitgestellt, welche einen länglichen polymeren Katheterkörper, eine Kanüle und eine röhrenförmige Schnittstelle beinhaltet. Der längliche polymere Katheterkörper weist ein proximales Ende und ein distales Ende auf. Die Kanüle weist einen ausdehnbaren Abschnitt auf, welcher distal von dem länglichen polymeren Katheterkörper angeordnet ist. Die Kanüle kann auch einen weiteren röhrenförmigen Abschnitt aufweisen, der sich proximal zu dem distalen Abschnitt befindet. Die röhrenförmige Schnittstelle weist eine Außenfläche auf, welche derart konfiguriert ist, dass sie mit dem röhrenförmigen Abschnitt der Kanüle und einer Innenfläche verbunden werden kann. Die Innenfläche ist über dem distalen Ende des länglichen polymeren Katheterkörpers angeordnet. Die röhrenförmige Schnittstelle weist mehrere Querkanäle auf, welche sich von der Innenfläche der röhrenförmigen Schnittstelle nach außen erstrecken. Eine Außenfläche des länglichen polymeren Katheterkörpers steht in die Querkanäle hervor, um den länglichen polymeren Katheterkörper mechanisch in die röhrenförmige Schnittstelle zu integrieren. A catheter pump assembly is provided which includes an elongated polymeric catheter body, a cannula, and a tubular interface. The elongated polymeric catheter body has a proximal end and a distal end. The cannula has an expandable portion disposed distally of the elongated polymeric catheter body. The cannula may also include another tubular section proximal to the distal section. The tubular interface has an outer surface configured to be connected to the tubular portion of the cannula and an inner surface. The inner surface is disposed over the distal end of the elongated polymeric catheter body. The tubular interface has a plurality of transverse channels extending outwardly from the inner surface of the tubular interface. An outer surface of the elongate polymeric catheter body protrudes into the transverse channels to mechanically integrate the ...

Apparatus and method for piercing skin with microprotrusions

A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent acro ss the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.

Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices

A metallic composite coating, and methods for forming same, for an implantable medical device is disclosed. The composite coating comprises at least one metal or metallic tie layer formed on the surface of the device, followed by an electroless electrochemical cladding of one or more additional layers over the tie layer. One or more therapeutic or biologically active agents are co-deposited with at least one of the electroless electrochemical claddings.

Metallic structures incorporating bioactive materials and methods for creating the same

Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.

Manufacture of semiconductor element

(57)【要約】 【課題】 本発明の目的はエキシマレーザーを必要な波 長の出力光に正確にチューニングする技術を提供するこ とにある。 【解決手段】 チューニング可能なレーザーに用いられ る波長測定器をキャリブレートするための絶対的な波長 基準として、既知の原子又は分子の吸収線を用いる。波 長器には吸収ガスを含むガスセルが装備されており、キ ャリブレーションの間に、測定された波長が原子あるい は分子の吸収線と比較され、波長器のキャリブレーショ ン定数は絶対的な水準にキャリブレートされ。酸素分子 のようないくつかのガスは、レーザーのチューニング可 能範囲に複数分子吸収線を持っており、これを利用すれ ば目的の最終波長の精度が増す。

In home oral fluid sample collection device and package for mailing of such device

This reagent strip is comprised of a testing portion which contains an absorbent cotton pad. This absorbent cotton pad may be placed in the mouth on the tongue to collect an oral fluid sample. A plastic frame surrounds the pad to help hold the fluid thereon. This testing strip contains at its opposite end a sealing mechanism for sealing engagement with a preservative pouch, and an oversized handle with a patient identifying mechanism. The preservative pouch of the present invention contains a pair of seals. The first seal, located proximally to the user, enables a preservative which is maintained within the pouch to be sealed during shipment of the pouch to the user. Thereafter, the user punctures the first seal upon placement of the reagent pad into the pouch. The sealing mechanism contained on the reagent pad then seals at the opening in the pouch to maintain the reagent pad in sealing arrangement within the pouch. At its distal end, the pouch contains a second sealing mechanism. This sealing mechanism helps protect the preservative as well as the oral sample, within the pouch during shipment from the user back to the testing laboratory.

Distal bearing carrier

In verschiedenen Ausführungsformen ist hierin eine Katheterpumpe offenbart. Die Katheterpumpe kann einen länglichen Katheterkörper mit einem distalen Abschnitt einschließlich einer ausdehnbaren Kanüle, welche einen Einlass und einen Auslass aufweist, beinhalten. Die ausdehnbare Kanüle kann ein Bereitstellungsprofil und ein Betriebsprofil, das größer als das Bereitstellungsprofil ist, aufweisen. Eine Laufradbaugruppe kann eine Laufradwelle beinhalten und ein Laufradkörper kann ein oder mehrere Blätter beinhalten. Die Laufradblätter können Blut in die Kanüle ziehen, wenn sie gedreht werden. Ferner kann ein ausdehnbarer Träger einen Befestigungsabschnitt, der auf der Laufradwelle distal zu dem Laufradkörper angeordnet ist, und einen mit der Kanüle in Kontakt stehenden Abschnitt zum Verringern einer Veränderung im Spitzenspalt aufgrund eines Biegens der Kanüle aufweisen. Der mit der Kanüle in Kontakt stehende Abschnitt kann distal zu dem Befestigungsabschnitt angeordnet sein. In various embodiments, a catheter pump is disclosed herein. The catheter pump may include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula may have a deployment profile and an operational profile that is larger than the deployment profile. An impeller assembly may include an impeller shaft and an impeller body may include one or more blades. The impeller blades may draw blood into the cannula when rotated. Further, an expandable support may include a mounting portion disposed on the impeller shaft distal to the impeller body and a cannula-contacting portion for reducing a change in the tip gap due to bending of the cannula. The cannula-contacting portion may be located distal to the attachment portion.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Binary level charge pulse device which easily determines position of nerve during peripheral nerve block treatment

(57)【要約】 【課題】 植え込み型電子的デバイスを持つ患者に使用 でき、小さく安価で単一使用及び滅菌可能で、更に唯一 人の技術者が用いることができるようにする。 【解決手段】 針組立体１２を含み、その針組立体は導 電性の針カニューレ２０とそれに固定された非導電性の 管２８と、その管上の導電性メッキ３６とを有する。導 体は、一定電流レベルで交替する高電荷パルスと低電荷 パルスとを発生する刺激器１４に接続されている。高電 荷パルスは、針を患者に挿入直後顕著な筋肉単収縮を発 生する。高電荷パルスに応答した筋肉単収縮はその大き さがピークになり、そして低電荷パルスに応答した筋肉 単収縮は針が目標とされる神経に近づくにつれ観察可能 となり、針が麻酔薬の投与の位置にあるとき高電荷パル スに応答する筋肉単収縮と区別不能となる。

Disposable absorbent article

A disposable absorbent article for personal wear has a generally liquid permeable liner adapted for contiguity with the wearer's skin, and an outer cover. An absorbent body lies between the liner and the outer cover for absorbing liquid body waste. A surge layer lies between the liner and the absorbent body for receiving liquid body waste penetrating the liner and for subsequently releasing liquid body waste to the absorbent body. The surge layer has an inner surface, an outer surface generally facing the absorbent body and an opening extending from its inner surface toward its outer surface. A flow control layer between the liner and the absorbent body at least retards the flow of liquid body waste from the surge layer opening to the absorbent body to facilitate a prolonged feeling of wetness against the wearer's skin upon the release of liquid body waste into the article.

Movable member for use with a tissue thickness compensator.

Una cuchilla de corte para un instrumento de corte y engrapado quirúrgico se describe en la presente descripción; la cuchilla de corte puede incluir uno o más elementos para dirigir o desplazar sustancias liberadas desde dentro de los compensadores de grosor de tejido usado con el instrumento quirúrgico; la cuchilla de corte puede incluir una superficie texturizada que puede provocar que la sustancia se extienda desde el compensador de grosor de tejido a lo largo de la superficie de la cuchilla.

Surgical stapling instrument with shaft release, powered firing, and powered articulation

A surgical instrument includes a shaft assembly, a handle assembly, and a latch system configured to operatively couple the shaft and handle assemblies. The latch system includes shaft and a handle lock members respectively connected to the shaft and handle assemblies for inhibiting operative uncoupling of the shaft and handle assemblies. The latch member has a cam surface and a latch member. The latch member is configured to selectively move from a locked position to a released position such that movement of the latch member causes the shaft and handle lock members to disengage and uncouple the shaft and handle assemblies. The latch member is further configured to selectively move from the released position to a removal position such that further movement of the latch member causes the cam surface of the latch member to engage the cam base and urge the shaft assembly in a removal direction.

Catheter pump

A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self- expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.

Sensors for catheter pumps

Sensors for catheter pumps are disclosed herein. The catheter pump can include a catheter assembly comprising a catheter and a cannula coupled to a distal portion of the catheter. The cannula can have a proximal port for permitting the flow of blood therethrough. The catheter assembly can include a sensor to be disposed near the proximal port. A processing unit can be programmed to process a signal detected by the sensor. The processing unit can comprise a computer-readable set of rules to evaluate the signal to determine a position of the cannula relative to an aortic valve of a patient.

Sheath system for catheter pump

A catheter pump assembly is provided that includes an elongate polymeric catheter body, a cannula, and a tubular interface. The elongate polymeric catheter body has a proximal end and a distal end. The cannula has an expandable portion disposed distally of the elongate polymeric catheter body. The cannula can also have another tubular portion that is proximal to the distal portion. The tubular interface has an outer surface configured to be joined to the tubular portion of the cannula and an inner surface. The inner surface is disposed over the distal end of the elongate polymeric catheter body. The tubular interface has a plurality of transverse channels extending outward from the inner surface of the tubular interface. An outer surface of the elongate polymeric catheter body projects into the transverse channels to mechanically integrate the elongate polymeric catheter body with the tubular interface.

Distal bearing support

In various embodiments, a catheter pump is disclosed herein. The catheter pump can include an elongated catheter body having a distal portion including an expandable cannula having an inlet and an outlet. The expandable cannula can have a delivery profile and an operational profile larger than the delivery profile. An impeller assembly can include an impeller shaft, and an impeller body can include one or more blades. The impeller blades can draw blood into the cannula when rotated. Further, an expandable support can have a mounting portion disposed on the impeller shaft distal of the impeller body and a cannula contact portion for reducing a change in tip gap due to bending of the cannula. The cannula contact portion can be disposed distal of the mounting portion.

Catheter pump

A catheter pump is provided that includes a rotatable impeller and an elongate cannula. The elongate cannula has a mesh that has a plurality of circumferential members disposed about the impeller. The elongate cannula has a plurality of axial connector extending between a proximal side of a distal circumferential member and a distal side of a proximal circumferential member. The circumferential members are radially self-expandable. The cannula is configured to minimize fracture within at least in the distal zone of the mesh as the elongated cannula moves into a sheathing device.

Motor assembly for catheter pump

A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.

Catheter pump with access ports

A securing assembly for connecting a drive assembly to a driven assembly of a catheter pump includes a motor housing, a flow diverter housing, and a flow diverter positioned within the flow diverter housing, wherein one of the flow diverter or the flow diverter housing includes a securement device. The securing assembly also includes a cap coupled between the motor housing and the flow diverter housing. The cap includes a central opening and a locking recess extending circumferentially about the central opening. Insertion of the flow diverter into the central opening causes securement device to engage the locking recess.

Catheter pump with access ports

A catheter pump is disclosed herein. The catheter pump can include an elongate catheter body and an impeller assembly coupled to a distal portion of the elongate catheter body. The impeller assembly can comprise an impeller configured to rotate during operation of the catheter pump. A tube can extend through at least portions of the elongate catheter body and the impeller assembly. The tube can extend distal the impeller and can be configured to remain in the portions of the elongate catheter body and the impeller assembly during operation of the catheter pump.

Microblade array impact applicator

An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44, 90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.

Plasma focus light source with active and buffer gas control

A high energy photon source. A pair of plasma pinch electrodes are located in a vacuum chamber. The chamber contains a working gas which includes a noble buffer gas and an active gas chosen to provide a desired spectral line. A pulse power source provides electrical pulses at repetition rates of 1000 Hz or greater and at voltages high enough to create electrical discharges between the electrodes to produce very high temperature, high density plasma pinches in the working gas providing radiation at the spectral line of the source or active gas. A fourth generation unit is described which produces 20 mJ, 13.5 nm pulses into 2 π steradians at repetition rates of 2000 Hz with xenon as the active gas. This unit includes a pulse power system having a resonant charger charging a charging capacitor bank, and a magnetic compression circuit comprising a pulse transformer for generating the high voltage electrical pulses at repetition rates of 2000 Hz or greater. Gas flows in the vacuum chamber are controlled to assure desired concentration of active gas in the discharge region and to minimize active gas concentration in the beam path downstream of the pinch region. In a preferred embodiment, active gas is injected downstream of the pinch region and exhausted axially through the center of the anode. In another preferred embodiment a laser beam generates metal vapor at a location close to but downstream of the pinch region and the vapor is exhausted axially through the anode.

Lithographic projection apparatus equipped with extreme ultraviolet window serving simultaneously as vacuum window

A lithographic projection apparatus has a discharge plasma radiation source that is contained in a vacuum chamber. The radiation source is to generate a beam of EUV radiation. A chamber wall of the vacuum chamber incorporates a channel structure comprising adjacent narrow channels separated by walls that are substantially parallel to a propagation direction of the radiation generated so as to pass the radiation from the vacuum chamber through the structure to another subsequent vacuum chamber. In the subsequent vacuum chamber, a much higher vacuum level (lower pressure) can be maintained than is present in the vacuum chamber of the radiation source.

An intravascular drug delivery system

An intravascular material delivery dilation catheter (10) having a pair of longitudinally spaced inflatable balloons (20, 22) with a drug delivery region (26) defined therebetween. The catheter is ideally suited for use after a PTCA procedure, wherein the proximate balloon (20) seals the blood vessel while the distal balloon (22) is uniquely contoured when inflated to define fluid communication paths (60) therepast and proximate a blood vessel (54) to be treated. The distal balloon (22), when inflated, has four lobes but could also be textured. Each lobe is separated from the next by a groove, which groove in combination with the blood vessel inner wall forms a fluid communication path therebetween. Upon inflation of both balloons (20, 22) in a blood vessel (54), a medicament such as heparin can be injected, via the drug delivery region (26) between the inflated balloons (20, 22), wherein the medicament flows past the distal balloon (22) at a selected rate. Accordingly, a medicament can be injected directly to a treatment site rather than injected as a bolus dose, thus, a smaller dosage may be employed to minimize side effects. Alternatively, perfusion can be accomplished by only partially inflating the proximate balloon (20) to constrict flow therepast, or eliminating the proximate balloon (20) entirely, where the drug delivery region is disposed upstream of the contoured distal balloon (22).

Laser wavelength control unit with piezoelectric driver

An electric discharge laser (34) with fast wavelength correction. Fast wavelength correction equipment includes at least one piezoelectric drive and a fast wavelength measurement system (104) and fast feedback response times. In a preferred embodiment, equipment is provided to control wavelength on a slow time frame of several milliseconds, on a intermediate time from of about one to five milliseconds and on a very fast time frame of a few microseconds. Preferred techniques include a combination of a relatively slow stepper motor and a very fast piezoelectric driver for tuning the laser wavelength using a tuning mirror. Very fast wavelength control is provided with a piezoelectric load cell in combination with the piezoelectric driver. Preferred embodiments provide fast feedback control based on wavelength measurements, fast vibration control, active damping using the load cell and an active damping module (320), and transient inversion using feed forward algorithms based on historical burst data.

Apparatus and method for writing a signal information track on a disc

This invention relates to an apparatus and process for writing video information in the form of a frequency modulated signal upon a video disc member and for recovering the video information from the video record is described. The video disc member (10) formed by the writing apparatus is also described. The writing apparatus includes a laser (30) as a source of a laser write beam (29) and a write optical system (40) for directing the stationary laser write beam to a moving video disc member. The video disc member comprises a substrate member carrying a light responsive coating (26) at least one surface. The write optical system focuses the beam to a small spot of light approximately one micron in diameter upon the light responsive layer. The intensity of the focused spot is changeable under the control of a light intensity modulating assembly (44). This light intensity modulator changes the intensity of the write laser beam with respect to a predetermined threshold intensity sufficient to form a first type of indicia (37) in the coating. A read system (165) is employed to retrieve the video signal stored on the video disc member. This read system includes a read laser (150) for generating a read beam, and a motion control assembly for rotating and translating the video disc member relative to the read light beam. A read optical system directs the read beam to impinge upon the successively positioned specular light reflective and non-specular light reflective regions (37, 38) carried by the video disc member. The read optical system also collects the light (150) reflected from these regions. The reflected light beam is intensity modulated by the specular light reflective and non-specular light reflective regions. The read optical system also directed the reflected light beam to a light sensing circuit for changing the intensity modulated reflected light beam to a corresponding frequency modulated electrical signal (165) which is representative of the video signal ...

Enzyme activated supports for enantiomeric separations

An enzyme is immobilized on a solid support and can react selectively with one enantiomer in an enantiomeric mixture. A methods of using the enzyme immobilized solid support in conjunct with a separating means to separate enantiomeric mixtures is described. An apparatus for separating an enantiomeric mixture using an enzyme immobilized on a solid support is also described.

PROCESS FOR PURIFYING SILICA POWDER

Purification of natural/synthetic silica powder, useful in production of synthetic quartz glass powder, comprises treating silica powder in oxidizing atmosphere to reduce content of silica powder in carbonated compound

Process of purification of a natural or synthetic silica powder (I) comprises, treating (I) in an oxidizing atmosphere at lower than 1400[deg]C to reduce the content of (I) in carbonated compound by less than 10 ppm.

Method for controlling sulfur concentration in ammonia

It is disclosed that the conductivity of a sulfur in ammonia solution is a measure of the sulfur concentration and that sulfur in ammonia solution of predetermined concentration can be continuously prepared by monitoring the conductivity of such solution and controlling at least one feed stream responsive to such monitoring.

ADHESIVES FORMED FROM VINYL COPOLYMERS

LA COMPOSITION COMPREND, EN POIDS, ENVIRON 10 A 30 D'UN COPOLYMERE D'UN ACRYLAMIDE OU ACRYLAMLIDE SUBSTITUE ET D'UN ACIDE MONO- OU DICARBOXYLIQUE INSATURE DE 2 A 6 ATOMES DE CARBONE OU D'UN SEL DE METAL ALCALIN DE CELUI-CI, LE COPOLYMERE AYANT UNE VISCOSITE INHERENTE D'ENVIRON 0,1 A 3,0; ENVIRON 1 A 10 D'UN AGENT DE GELIFICATION QUI EST LE DIBENZAL-SORBITOL, UN SEL DE METAL ALCALIN D'UN ACIDE ALIPHATIQUE SATURE OU INSATURE DE 12 A 20 ATOMES DE CARBONE OU UN SEL DE CALCIUM OU DE MAGNESIUM D'UN ACIDE ALIPHATIQUE SATURE OU INSATURE DE 12 A 20 ATOMES DE CARBONE COMPLEXE AVEC LE SEL TETRASODIQUE DE L'ACIDE ETHYLENE-DIAMINE-TETRA-ACETIQUE; ET ENVIRON 67 A 89 D'EAU OU D'UN MELANGE D'ALCOOL ET D'EAU. THE COMPOSITION COMPRISES, BY WEIGHT, APPROXIMATELY 10 TO 30 OF A COPOLYMER OF AN ACRYLAMIDE OR SUBSTITUTED ACRYLAMLIDE AND OF AN UNSATURATED MONO- OR DICARBOXYLIC ACID WITH 2 TO 6 CARBON ATOMS OR AN ALKALI METAL SALT OF CELUIN- CI, THE COPOLYMER HAVING AN INHERENT VISCOSITY OF APPROXIMATELY 0.1 TO 3.0; APPROXIMATELY 1 TO 10 OF A GELLING AGENT WHICH IS DIBENZAL-SORBITOL, AN ALKALI METAL SALT OF A SATURATED OR UNSATURATED ALIPHATIC ACID OF 12 TO 20 CARBON ATOMS OR A CALCIUM OR MAGNESIUM SALT OF AN ALIPHATIC ACID SATURE OR UNSATURATED FROM 12 TO 20 CARBON ATOMS COMPLEXED WITH THE TETRASODIC SALT OF ETHYLENE-DIAMINE-TETRA-ACETIC ACID; AND APPROXIMATELY 67 TO 89 OF WATER OR A MIXTURE OF ALCOHOL AND WATER.

Microprojection array immunization patch and method

Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, an d methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

Integrated broadside coupled transmission line element

Chemical pump housing for negative pressure system

A chemical pump assembly useful for negative pressure therapy includes a chemical pump housing having an inner chamber, a reactor located within the inner chamber, an opening provided in the chemical pump housing, a first pull tab which extends from the inner chamber to ambient through the opening, and a removable layer connected to the first pull tab. The reactor is configured to react with a selected gas found in air so as to consume the selected gas when exposed to air in the inner chamber. The removable layer shields the reactor from air in the inner chamber atmosphere until the removable layer is removed.

Insulated panel for mine safe rooms

A structural insulated panel (10) for use in a mine safe room, which includes a carbon foam core (12) having a high ratio of compressive strength to density, desirable fire retardant properties, and resistance to environmental stress. The carbon foam structural insulated panel also includes a first layer (14) and a second layer (16) bound to a first surface and second surface of the carbon foam core.

Laser system

An apparatus/method may comprise a line narrowed pulsed lithography laser light source which may comprise: a seed pulse providing laser system which may comprise: a first pulsed seed laser producing seed pulses at a rate of X kHz; a second pulsed seed laser producing seed pulses at a rate of X kHz; an amplification system which may comprise: a first amplifier gain system which may comprise a first and a second pulsed gas discharge amplifier gain medium, each with a nominal center wavelength in the UV range, and each operating at ½ X kHz on output pulses from the first seed laser; a second amplifier gain system which may comprise a first and a second pulsed amplifier gain medium, each with a nominal center wavelength in the UV range, and each operating at ½ X kHz on output pulses from the second seed laser.

Interchangeable shaft assemblies for use with a surgical instrument.

Un ensamble de flecha intercambiable para usarse con un instrumento quirúrgico; el instrumento quirúrgico puede incluir una estructura que soporta una de manera operativa una pluralidad de sistemas de impulso y define un eje de accionamiento; el ensamble de flecha puede comprender una primera flecha que está configurada para aplicar primeros movimientos de accionamiento a un efector de extremo quirúrgico que está acoplado operativamente al mismo; un extremo proximal de la primera flecha está configurado para ser acoplado de manera operativamente desmontable a un primer de los sistemas de impulso soportados por la estructura en una dirección que es sustancialmente transversal al eje de accionamiento.

Indicator means for fluid pressure and fluid supply

MAGNETIC SWITCH MEANS WITHIN A FLUID ACTUATOR HAVING A CLOSED ELECTRICAL CIRCUIT MEANS OPERATIVE ON FAILURE TO DEVELOP PRESSURE AND/OR LOW FLUID SUPPLY TO WARN AN OPERATOR OF SUCH PROBLEMS.

Apparatus for gripping a pipe on a drilling rig

Fremgangsmåte og apparat for kjøring av rør inn i og ut av et brønnhull. Et gripeapparat aktiveres med en aktuator som har en primær aktuator og et redundant sikkerhetstrekk. Det redundante sikkerhetstrekk kan innbefatte ett eller flere redundante fluidopererte stempler. Gripeapparatet kan innbefatte integrert sikkerhetssystem som er tilpasset for å hindre skade på rørene mens forbindelser mellom rørene og rørstrengen gjøres opp og frakoples. Method and apparatus for driving pipes into and out of a wellbore. A gripper is activated by an actuator having a primary actuator and a redundant safety feature. The redundant safety feature may include one or more redundant fluid operated pistons. The gripper may include an integrated safety system adapted to prevent damage to the pipes while making connections and disconnecting the pipes.

Negative pressure device and method

A negative pressure device includes a drape, a wicking element, a sealing element, a reactor, a chamber and an air permeable liquid impervious element. The drape includes an opening and is made from a flexible material that inhibits passage of liquid and air through the drape other than through the opening. The wicking element is covered by the drape. The sealing element surrounds the wicking element and cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. Air within the enclosed volume is inhibited from exiting the enclosed volume other than through the opening. The reactor is configured to react with a gas found in air to consume the gas. The chamber is in fluid communication with the reactor and the enclosed volume via the opening. The chamber is configured to maintain a predefined chamber volume while the gas is being consumed from the enclosed volume. The air permeable liquid impervious element is interposed between the chamber and the enclosed volume and is configured to preclude liquid from entering the chamber.