16-05-2019 дата публикации
Номер: US20190144464A1
Принадлежит:
The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof. 2. The compound according to claim 1 , wherein the compound is selected from the group consisting of:N1-pyrrolidine-N5-(benzo[1,3]dioxol-5-ylmethyl) biguanide,N1-pyrrolidine-N5-(4-methoxy)phenyl biguanide,N1-pyrrolidine-N5-(3-chloro-4-methoxy)phenyl biguanide,N1-pyrrolidine-N5-(2,6-difluorophenyl)-N-methyl)phenyl biguanide,N1-pyrrolidine-N5-(4-dimethylamino)phenyl biguanide,N1-pyrrolidine-N5-(4-isopropyl)phenyl biguanide,N1-pyrrolidine-N5-(3-phenoxy)phenyl biguanide,N1-pyrrolidine-N5-(N-biphenyl-3-yl) biguanide,N1-pyrrolidine-N5-(N-biphenyl-4-yl) biguanide,N1-pyrrolidine-N5-(4′-fluorobiphenyl-3-yl) biguanide,N1-pyrrolidine-N5-(3′-fluorobiphenyl-4-yl) biguanide,N1-pyrrolidine-N5-(4-fluoro)phenethyl biguanide,N1-pyrrolidine-N5-(2-phenylpropane-2-yl) biguanide,N1-pyrrolidine-N5-(5,6,7,8-tetrahydronaphthalene-2-yl) biguanide,N1-pyrrolidine-N5-((1,2,3,4-tetrahydronaphthalene-1-yl) biguanide,N1-(S)-2-methyl pyrrolidine-N5-(4-(trifluoromethoxy)phenyl biguanide,N1-(S)-3-hydroxy pyrrolidine-N5-(4-trifluoromethoxy)phenyl biguanide,N1-(R)-3-hydroxy pyrrolidine-N5-(4-trifluoromethoxy)phenyl biguanide,N1-3-hydroxy methyl pyrrolidine-N5-(4-trifluoromethoxy)phenyl biguanide,N1-pyrrolidine-N5-4-benzamide biguanide,N1-pyrrolidine-N5-4-methyl-N-ethyl benzamide biguanide,N1-pyrrolidine-N5-4-(2-oxo-2-(piperidine-1-yl)ethyl thio)phenyl, andN1-(S)-2-hydroxy pyrrolidine-N5-4-(2-oxo-2-(piperidine-1-yl)ethyl thio)phenyl biguanide.3. The compound according to claim 1 , wherein the compound of ...
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