13-03-2014 дата публикации
Номер: US20140073627A1
The invention relates to compounds of formula (I) 2. The compound of claim 1 , wherein X is phenyl claim 1 , or thiophene claim 1 , and wherein X is substituted with Rand is optionally substituted with one or more R claim 1 , which are the same or different.3. The compound of claim 1 , wherein two adjacent Rare joined together with the atoms to which they are attached to form benzo and wherein benzo is optionally substituted with one or more R claim 1 , which are the same or different.4. The compound of claim 1 , wherein X is substituted in 2-position relative to the sulfonamide group in formula (I) with Rand is optionally substituted with one or more R claim 1 , which are the same or different.5. The compound of claim 1 , wherein R claim 1 , R claim 1 , Rare independently selected from the group consisting of CH claim 1 , CF claim 1 , CHCH claim 1 , CHOH claim 1 , OCH claim 1 , Cl claim 1 , Br claim 1 , and phenyl.6. The compound of claim 1 , wherein Ris methyl claim 1 , ethyl claim 1 , isopropyl claim 1 , cyclopropyl claim 1 , cyclobutyl claim 1 , phenyl claim 1 , or cyclopropylmethyl.7. The compound of claim 1 , wherein R claim 1 , Rare independently selected from the group consisting of H claim 1 , and methyl.9. The compound of claim 1 , wherein Ris H; or CH.10. The compound of claim 1 , wherein R claim 1 , Rare joined to form a ring selected from the group consisting of piperidine; piperazine; morpholine; 2 claim 1 ,8-diazaspiro[4.5]decane; pyrrolidine; and diazepane claim 1 , wherein the ring is optionally substituted with one or more R claim 1 , which are the same or different.11. The compound of claim 1 , wherein Ris CH-T claim 1 , CH—CH(CH)-T claim 1 , or CH—CH-T.12. The compound of claim 1 , wherein Tis phenyl; or pyridine.13. The compound of claim 1 , wherein R claim 1 , Rare independently selected from the group consisting of CN claim 1 , C(O)N(RR) claim 1 , C(NR)N(RR) claim 1 , C(NR)N(R)OR claim 1 , N(RR) claim 1 , N(R)C(O)N(RR) claim 1 , C(O)R claim 1 ...
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