30-07-2020 дата публикации
Номер: US20200239470A1
Автор:
Ge Hui,
HAN Yanan,
HUO Guoyong,
LIAO Xuemei,
LIU Yanjun,
MAO Yu,
SHI CHEN,
WANG Qian,
XIA Guangxin,
XIANG Zhixiong,
ZHAI Xiong
Принадлежит:
The present invention discloses a substituted pyridine compound represented by formula I, and a pharmaceutically acceptable salt, stereoisomer and tautomer thereof. The compounds of the present invention are useful in the treatment of cancers. 2. The compound according to or a pharmaceutically acceptable salt claim 1 , stereoisomer or tautomer thereof claim 1 , wherein the C-Calkenyl is independently C-Calkenyl;{'sub': 2', '20', '2', '12, 'and/or, the C-Calkynyl is independently C-Calkynyl;'}{'sub': 1', '20', '1', '20', '1', '20', '1', '20', '2', '1', '12, 'and/or, the C-Calkyl in the definition of C-Calkyl, NH(C-Calkyl) and N(C-Calkyl)is independently C-Calkyl;'}{'sub': 1', '20', '1', '12, 'and/or, the C-Calkylthio is C-Calkylthio;'}{'sub': 1', '20', '1', '12, 'and/or, the C-Calkoxy is independently C-Calkoxy;'}{'sub': 1', '20', '1', '12, 'and/or, the C-Csilyl is C-Csilyl;'}{'sub': 3', '12', '3', '8, 'and/or, the C-Ccycloalkyl is independently C-Ccycloalkyl;'}{'sub': 1', '9', '3', '8, 'and/or, the C-Cheterocycloalkyl is independently C-Cheterocycloalkyl having 1, 2, 3 or 4 heteroatom independently selected from the group consisting of O, N, P, S, Se, B and Si;'}{'sub': 1', '9', '1', '6, 'and/or, the C-Cheteroaryl is C-Cheteroaryl;'}{'sub': 6', '12', '6', '10, 'and/or, the C-Caryl is C-Caryl.'}3. The compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , stereoisomer or tautomer thereof claim 1 , wherein the C-Calkenyl is independently C-Calkenyl;{'sub': 2', '20', '2', '6, 'and/or, the C-Calkynyl is independently C-Calkynyl;'}{'sub': 1', '20', '1', '20', '1', '20', '1', '20', '2', '1', '6, 'and/or, the C-Calkyl in the definition of C-Calkyl, NH(C-Calkyl) and N(C-Calkyl)is independently C-Calkyl;'}{'sub': 1', '20', '1', '6, 'and/or, the C-Calkylthio is C-Calkylthio;'}{'sub': 1', '20', '1', '6, 'and/or, the C-Calkoxy is independently C-Calkoxy;'}{'sub': 1', '20', '1', '6, 'and/or, the C-Csilyl is C-Csilyl;'}{'sub': 3', '12', '3', '6, 'and/or, ...
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