Animal model for hepatitis virus infection
Номер патента: AU6949994A
Опубликовано: 20-12-1994
Автор(ы): Yair Reisner
Принадлежит: Yeda Research and Development Co Ltd
Опубликовано: 20-12-1994
Автор(ы): Yair Reisner
Принадлежит: Yeda Research and Development Co Ltd
Реферат: A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.
Animal model for hepatitis virus infection
Номер патента: US5858328A. Автор: Yair Reisner. Владелец: Yeda Research and Development Co Ltd. Дата публикации: 1999-01-12.