Methods and compounds for altering the load of hepatitis virus
Номер патента: EP1709178A1
Опубликовано: 11-10-2006
Автор(ы): Ee Chee Genome Inst. of Singapore REN, Lisa Genome Inst. of Singapore NG FONG POH
Принадлежит: Agency for Science Technology and Research Singapore
Опубликовано: 11-10-2006
Автор(ы): Ee Chee Genome Inst. of Singapore REN, Lisa Genome Inst. of Singapore NG FONG POH
Принадлежит: Agency for Science Technology and Research Singapore
Реферат: The present invention relates to a method for altering the load of a Hepatitis virus present in an infected host organism. The method involves modulation of the complex formation of a heterogeneous nuclear ribonucleoprotein K (hnRNP K) and the regulatory region of a Hepatitis virus, enhancer II region. Additionally there are methods of identifying compounds that modulate complex formation, and the use of such compoundsin diagnosis of a Hepatitis infrection. The present invention also relates to a mutation in enhancer II region at position 1752 of the virus sequence which reduces the binding affinity of hnRNP K with the enhancer II region.
Methods and compositions to treat drug-induced diseases and conditions
Номер патента: US20190078086A1. Автор: Maria Luz Martinez Chantar,Mercedes Rincon,Juan Anguita,Oliver Dienz. Владелец: Centro de Investigacion Cooperativa en Biociencias. Дата публикации: 2019-03-14.