METHOD FOR PRODUCING AN ORGAN-SPECIFIC SUBSTANCE MARKED WITH TECHNETIUM-99M.
Номер патента: DE3783745D1
Опубликовано: 04-03-1993
Автор(ы): Alexander Dr Schwarz, Axel Dr Dr Steinstraesser, Karl-Heinz Dr Bremer, Ludwig Dr Kuhlmann
Принадлежит: Hoechst AG
Опубликовано: 04-03-1993
Автор(ы): Alexander Dr Schwarz, Axel Dr Dr Steinstraesser, Karl-Heinz Dr Bremer, Ludwig Dr Kuhlmann
Принадлежит: Hoechst AG
Реферат: Prodn. of 99mTc-labelled organ-specific substances (I) is effected by treating an organ-specific substance (II) (opt. pretreated or coupled with a complexing agent for 99mTc) with 99mTc-pertechnetate (III) and a complex-stabilised reducing agent (IV). (II) is an antibody, F(ab')2 fragment, protein, enzyme, sugar or polymer, esp. a monoclonal antibody against a tumour-associated antigen or a F(ab')2 fragment of such an antibody, opt. in partially reduced form. (IV) is a stannous phosphonate or pyrophosphate, esp. a stannous salt of methanediphosphonic acid, aminomethane diphosphonic acid, 3,3-diphosphonopropionic acid, 3,3-diphosphono-1,2 -propanedicarboxylic acid or 1,1,2,3-propanetetra phosphonic acid. (IV) is used in an amt. corresp. to 1-100 (esp. 5-10) mcg of Sn per mg of (II).
PROCEDURE FOR MANUFACTURING A TECHNETIUM-99M LABELED ORGAN-SPECIFIC SUBSTANCE AND PROCEDURES FOR MANUFACTURING A TEST KIT AND DIAGNOSTIC
Номер патента: DK167851B1. Автор: Ludwig Kuhlmann,Alexander Schwarz,Axel Steinstraesser,Karl-Heinz Bremer. Владелец: Hoechst AG. Дата публикации: 1993-12-27.