Optimizing selection of srm transitions for analysis of biomolecules by tandem mass spectrometry
Номер патента: EP2310862A2
Опубликовано: 20-04-2011
Автор(ы): Amol Prakash
Принадлежит: Thermo Finnigan LLC
Опубликовано: 20-04-2011
Автор(ы): Amol Prakash
Принадлежит: Thermo Finnigan LLC
Реферат: Methods for selecting a set of SRM transitions for a peptide of interest include selecting a first transition based on sensitivity criteria and selecting at least a second transition based on selectivity criteria. A determination of the uniqueness of the first transition combined with the at least a second transition is made. When the combination of the first transition and the at least a second transition is determined to be unique to the peptide of interest, a sample containing the peptide of interest is subjected to a SRM workflow by monitoring the first transition and the second transition. Also described is an apparatus for carrying out the methods.
Optimizing selection of srm transitions for analysis of biomolecules by tandem mass spectrometry
Номер патента: WO2010011438A3. Автор: Amol Prakash. Владелец: Thermo Finnigan LLC. Дата публикации: 2010-03-18.