Enhancement of transgene expression from viral-based vaccine vecors by expression of suppressors of the type i interferon response
Номер патента: EP2190979A1
Опубликовано: 02-06-2010
Автор(ы): Jerald C. Sadoff, John Fulkerson, Michele R. Stone, Mohamad Fakruddin-Jamiluddin, Ravi Anantha
Принадлежит: Aeras Global TB Vaccine Foundation
Опубликовано: 02-06-2010
Автор(ы): Jerald C. Sadoff, John Fulkerson, Michele R. Stone, Mohamad Fakruddin-Jamiluddin, Ravi Anantha
Принадлежит: Aeras Global TB Vaccine Foundation
Реферат: Viral-based vectors are genetically engineered to express inhibitors of the anti- viral immune system (e.g. inhibitors of the type I interferon response) in order to enhance transgene expression. The transgenes may encode antigens or other therapeutic agents.
Enhancement of transgene expression from viral-based vaccine vecors by expression of suppressors of the type i interferon response
Номер патента: WO2009029770A1. Автор: John Fulkerson,Jerald C. Sadoff,Michele R. Stone,Ravi Anantha,Mohamad Fakruddin-Jamiluddin. Владелец: Aeras Global TB Vaccine Foundation. Дата публикации: 2009-03-05.