Method to predict the presence of inflammation or itaconic acid, irg1 and/or protein irg1 in a subject and pharmaceutical composition for treating or preventing inflammation
Номер патента: EP2758069A2
Опубликовано: 30-07-2014
Автор(ы): Alessandro Michelucci, Andre WEGNER, Jenny GHELFI, Karsten HILLER, Rudi BALLING, Thekla CORDES
Принадлежит: UNIVERSITE DU LUXEMBOURG
Опубликовано: 30-07-2014
Автор(ы): Alessandro Michelucci, Andre WEGNER, Jenny GHELFI, Karsten HILLER, Rudi BALLING, Thekla CORDES
Принадлежит: UNIVERSITE DU LUXEMBOURG
Реферат: The present invention is directed to in vitro methods to predict the presence of inflammation, gene IRG1 or protein encoded by IRG1 in a subject by determining presence of itaconic acid in a biological sample isolated from the subject. The invention is also directed to methods to predict the ability of a subject to produce itaconic acid under inflammation by determining the presence IRG1 in a biological sample. The invention is also related to pharmaceutical composition to initiate production of itaconic acid in a subject for preventing or treating inflammation, or bacterial infection.
Method to predict the presence of inflammation or itaconic acid, irg1 and/or protein irg1 in a subject and pharmaceutical composition for treating or preventing inflammation
Номер патента: WO2013041692A2. Автор: Alessandro Michelucci,Karsten HILLER,Thekla CORDES,Andre WEGNER,Jenny GHELFI,Rudi BALLING. Владелец: UNIVERSITE DU LUXEMBOURG. Дата публикации: 2013-03-28.