Interaction of draxin and y-netrins
Номер патента: EP3097114A1
Опубликовано: 30-11-2016
Автор(ы): Christian Söllner, Christiane NÜSSLEIN-VOLHARD, Xuefan GAO
Принадлежит: Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Опубликовано: 30-11-2016
Автор(ы): Christian Söllner, Christiane NÜSSLEIN-VOLHARD, Xuefan GAO
Принадлежит: Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Реферат: This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to γ-Netrins comprising SEQ ID NO.: 1, 2 or 3, and variants thereof, with γ-Netrins, and the use of this interaction to disrupt γ-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to γ-Netrins. Further, the invention relates to fragments of γ-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against γ-Netrins inhibiting binding of γ-Netrins to Netrin receptors.
Interaction of draxin and y-netrins
Номер патента: US20200040047A1. Автор: Christian Söllner,Xuefan GAO,Christiane NÜSSLEIN-VOLHARD. Владелец: Max Planck Gesellschaft zur Foerderung der Wissenschaften eV. Дата публикации: 2020-02-06.