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Novel compound having pd-l1 expression-suppressing action

Номер патента: EP3954387B1
Опубликовано: 08-11-2023
Автор(ы): Haruhisa Kikuchi, Jing Zhang, Osamu Yamada, Shinya KIDA, Shinya Murase, Toshio Hattori, Yoshiteru Oshima
Принадлежит: Fuso Pharmaceutical Industries Ltd, Junsei Educational Inst, JUNSEI EDUCATIONAL INSTITUTION, Tohoku University NUC
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Mitochondrial permeability transition pore (mptp)-opening inhibitor, novel compound exhibiting mptp-opening inhibitory activity, and use therefor

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MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mPTP)-OPENING INHIBITOR, NOVEL COMPOUND EXHIBITING mPTP-OPENING INHIBITORY ACTIVITY, AND USE THEREFOR

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Novel compounds as cathepsin inhibitors, pharmaceutical composition based on thereof, their using and method for their preparing

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Compound having neurite-outgrowing activity

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Novel compound as inhibitor against binding of pf34 protein to nedd4-1 protein and use thereof

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Novel compounds that are erk inhibitors

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Method of synthesis of novel compounds obtained from 3-hydroxycyclopentylacetic acid

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Compound having gpr119 agonistic activity, method for preparing the same, and pharmaceutical composition including the same as effective component

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Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof

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Use of tricyclic derivatives of 1,4-dihydro-1,4-dioxo-1h-naphthalene and its novel compounds, pharmaceutical composition based on thereof and derivatives of substituted naphthalenes as intermediate compounds

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Novel compounds for treatment of cardiac arrhythmia, synthesis, and methods of use

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Novel compounds having a tetracyclic iridoid skeleton and an anti-trypanosomal, anti-leishmanial and anti-plasmodial agents comprising the same as an active ingredient

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Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient

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Substituted macrocyclic compounds having proteasome inhibitory activity

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Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same

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Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same

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Novel compounds and use thereof for targeted delivery

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Novel compound of stemphones and production thereof

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Novel compounds and therapeutic uses thereof

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Novel compound and composition for preventing or treating neuroinflammatory brain diseases comprising same as active ingredient

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Novel compound and pharmaceutical composition comprising same

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Novel compounds

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Novel compounds and compositions for targeting at malignant stem cells

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compound and pharmaceutical composition comprising same

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Novel compounds derived from schweinfurthins g, e and f

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NOVEL COMPOUND AS mTOR INHIBITOR AND USE THEREOF

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Novel compound and use thereof in treating autoimmune diseases

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Novel compounds derived from schweinfurthins g, e and f

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Novel compounds useful in treating ppar mediated diseases

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Novel compounds useful in treating ppar mediated diseases

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Novel compounds, their preparation and use

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Novel compound, preparation method thereof, and antibiotic composition comprising same

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Novel compounds and their application as positive modulators of ampa-receptors

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Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

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Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof

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Novel compound having inhibitory activity against pendrin, and pharmaceutical uses thereof

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Novel compounds comprising a new class of transthyretin ligands for treatment of common age-related comorbidities

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Novel compounds and method of preparing a metal-radionuclide-labelled protein

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Novel compounds, compositions comprising the same and uses thereof

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Novel compounds and compositions for inhibiting nampt

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Novel compounds and compositions for inhibiting nampt

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Novel compounds for the treatment of cancer and inflammatory diseases

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Novel compounds for the treatment of cancer and inflammatory diseases

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Novel compound exhibiting therapeutic effect on inflammatory disease as p38 map kinase inhibitor

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Novel compounds

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Novel compound modulating gsk-3 activity

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Novel compounds for tau imaging

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Novel compound and use thereof for treating emotional behavioral disorders

Номер патента: EP4400494A1. Автор: Jung Hyun Choi,Kyeong Man Kim,So Hyun JOO,Chan Young Shin,Eun Yeong SONG,Kyoung Ja KWON,Suresh Paudel,Se Jin Jeon,Kyu Suk CHO,Jae Hoon Cheong,Chilly Gay REMONDE,Edson Luck GONZALES. Владелец: Neuroventi Inc. Дата публикации: 2024-07-17.

Novel compound inducing expression of anti-aging gene klotho

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Novel compound and pharmaceutical composition comprising same for enhancing anticancer activity

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Novel gspt1 compounds and methods of use of the novel compounds

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Novel compounds having inhibitory activity on prostaglandin e2 receptor and uses thereof

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Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use therefor

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Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use thereof

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Compound Having Activity Of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using The Same

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Compound having activity of blocking nmda receptor channel, and pharmaceutical agent using the same

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Compound having activity of blocking NMDA receptor channel, and pharmaceutical agent using the same

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Novel compounds

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Novel compounds

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Novel compounds having inhibitory activity on prostaglandin E2 receptor and uses thereof

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Novel compounds

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Novel compounds

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Novel compounds

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Novel compounds

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NOVEL COMPOUNDS OF 2-ARYLTHIAZOLE AS AGONISTS OF PPAR α AND PPAR γ

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Novel compounds possessing antibacterial activity

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Novel compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof

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Novel compound having cancer metastasis inhibitory activity, preparation method therefor, and pharmaceutical composition for inhibiting cancer metastasis and invasion or treating colorectal cancer, comprising compound

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Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same

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Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same

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Novel compound as protein kinase inhibitor

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Novel compounds useful for treating cardiovascular diseases

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Novel compounds and compositions for inhibition of fasn

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Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity

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Pyrimidine compounds having phosphonate groups, method for their preparation and their use in the manufacture of medicaments for treating viral infection

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Compound having gpr119 agonistic activity, method for preparing the same, and pharmaceutical composition including the same as effective component

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Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect

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Gspt1 compounds and methods of use of the novel compounds

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Nitrogen-containing condensed ring compounds having dopamine d3 antagonistic effect

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Nitrogen-containing condensed ring compounds having dopamine d3 antagonistic effect

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Novel Compound, And Method For Producing Regulatory T Cells

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Novel compound for degrading target protein or polypeptide by using polyubiquitination

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Novel compound for degrading target protein or polypeptide by using polyubiquitination

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Novel compounds

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Novel compounds for regeneration of terminally-differentiated cells and tissues

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Structural and mechanistic basis for novel compound biosynthesis using the 4-electron hexose oxidase

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Structural and mechanistic basis for novel compound biosynthesis using 4-electron hexose oxidase

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Structural and mechanistic basis for novel compound biosynthesis using the 4-electron hexose oxidase

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Compound having inhibitory activity against o-glusacase and use thereof

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Use of novel compound, for preventing, improving or treating amyotrophic lateral sclerosis

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Novel compound comprising ester group and uses thereof

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Novel compounds with analgesic effect

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Novel compound produced by means of marine microorganism and composition for improving skin wrinkles, enhancing elasticity and skin whitening comprising same compound as active ingredient

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Novel compounds with analgesic effect

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Novel compounds as gcn2 inhibitors, pharmaceutical compositions and uses thereof

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Compound having inhibitory activity against o-glcnacase and use thereof

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Novel compounds and their use as prar-modulators

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Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds

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Novel compounds, their preparation and use

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Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

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Novel compound and use thereof in treating autoimmune diseases

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Novel compound and pharmaceutical composition comprising same as active ingredient

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Novel compound and pharmaceutical composition for prevention or treatment of cancer comprising same

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Novel compounds, their preparation and use

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Novel compound, and pharmaceutical composition for preventing or treating resistant cancer, comprising same

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Novel Compounds

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Novel compounds for the treatment of mammalian infections

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Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same

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Novel compound and composition for prevention or treatment of respiratory diseases comprising same as active ingredient

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Novel compound, preparation method thereof, and antibiotic composition comprising same

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Novel compound, preparation method thereof, and antibiotic composition comprising same

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Novel compound, preparation method thereof, and antibiotic composition comprising same

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Novel compounds

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Novel compounds and compositions for inhibiting nampt

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Composition for glomerulopathy treatment and prophylaxis, novel compounds comprising to thereof, pharmaceutical composition for inhibition of matrix metalloproteinases activity and composition for inhibition of collagenases of type iv

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Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety

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Novel compounds

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Novel compounds and methods for synthesis and therapy

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Novel compounds

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Novel compounds

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Novel compounds

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Novel compound ceramidastin, method for producing the same, and use of the same

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Novel compounds

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Novel compounds and their use in the treatment of schistosomiasis

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Novel compounds and their use in the treatment of schistosomiasis

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Pharmaceutical compositions containing fused-ring 1,4-diazepin derivatives certain such novel compounds and their preparation

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Novel compounds with analgesic effect

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Novel compounds

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Novel compounds which bind to cereblon, and methods of use thereof

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Novel compound and mri contrast agent containing same

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Novel compound and mri contrast agent containing same

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Novel compound and mri contrast agent containing same

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Novel compound exhibiting therapeutic effect on inflammatory disease as p38 map kinase inhibitor

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Novel compounds

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Novel compounds

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Novel compound and mri contrast agent containing same

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Novel compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same

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Novel compounds that are useful for improving pharmacokinetics

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Novel compounds as rearranged during transfection (ret) inhibitors

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Method of quenching singlet and triplet excited states of pigments, such as porphyrin compounds, particularly protoporphyrin IX, with conjugated fused tricyclic compounds have electron withdrawing groups, to reduce generation of reactive oxygen species, particularly singlet oxygen

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Fused tricyclic compound having aldose reductase inhibitory activity

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Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain

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Novel compounds, compositions, and therapeutic uses thereof

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Compositions and methods relating to novel compounds and targets thereof

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Compositions and methods relating to novel compounds and targets thereof

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Compositions containing compounds having retinoid-like activity and reduced skin toxicity effects and some such novel compounds

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Novel compounds having inhibitory activity on prostaglandin e2 receptor and uses thereof

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Novel compound having malate dehydrogenase inhibitory activity and pharmaceutical composition for preventing or treating cancer comprising same as active ingredient

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Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

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Novel compounds as cannabinoid receptor ligands

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Novel compounds as cannabinoid receptor ligands

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Novel compounds as cannabinoid receptor ligands and uses thereof

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Novel compounds as cannabinoid receptor ligands and uses thereof

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Novel compounds as cannabinoid receptor ligands

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Novel compounds and their use

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Novel compounds as cannabinoid receptor ligands and uses thereof

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Novel compounds as cannabinoid receptor ligands and uses thereof

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Novel compound having affinity for amyloid

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Novel compounds and use thereof

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Novel compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

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Novel compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

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Novel compounds and their use as selective inhibitors of caspase-2

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Novel compounds comprising a new class of transthyretin ligands for treatment of common age-related comorbidities

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Novel compounds comprising a new class of transthyretin ligands for treatment of common age-related comorbidities

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Novel compounds and use thereof

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Novel compounds and use thereof

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A novel compound for the treatment of hepatitis c

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Novel compounds

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Novel compounds for the diagnosis of tdp-43 proteinopathies

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Novel compounds having hypolipedemic, hypocholesteremic activites, process for their preparation and pharmaceutical compositions containing them

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Novel compounds

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Novel compounds as receptor modulators with therapeutic utility

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Novel compounds as receptor modulators with therapeutic utility

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Novel compounds

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Novel compound for treatment of allergy and asthma

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Compositions and methods relating to novel compounds and targets thereof

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Novel compounds and antimalarials

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Novel compounds

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Novel compounds

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Novel compounds

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Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.

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Compounds having mif antagonist activity

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Compounds having antibacterial activity and methods of use

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Compounds having antibacterial activity and methods of use

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PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACITIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND

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Use of a compound having two gold(i) atoms each covalently bonded to a carbon atom in a covalent link connecting the two gold(i) atoms for the treatment of cancer

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Novel compounds

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Hydrophilic resin compound having sugar chain affixed thereto, polymer substrate for virus-removal, and biocompatible material

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Novel compounds and their use in therapy

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Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same

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Novel compounds

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Novel compounds having a dopaminergic and/or serotoninergic activity

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Novel compounds for the treatment and prevention of neurological complications of viral infections

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Novel compounds as anti-mycobacterials

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Novel compounds as anti-mycobacterials

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Novel compounds as indoleamine 2,3-dioxygenase inhibitors

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Novel compounds as cannabinoid receptor ligands

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Novel compound or salt thereof, and antitumor activator containing same as active ingredient

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Surface treatment method, surface treatment agent, and novel compound

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Novel compounds having selective inhibiting effect at GSK3

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Novel compounds for use as hiv protease inhibitors

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Novel compound, phosphorylation inhibitor, insulin resistance improving agent, agent to prevent or to treat diabetes, and screening method

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Novel compound, use thereof, method for producing same, compound-containing composition, method for producing 4-trehalosamine, and microorganism

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Novel compound, and flavor and/or fragrance composition containing said compound

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Novel compounds for use as hiv protease inhibitors

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Novel compounds for use as HIV protease inhibitors

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Novel compounds

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Novel compounds having antiviral activity

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Methods of using novel compounds as neuro-protective agents

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Novel compounds useful as neuro-protective agents

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Process for analyzing low molecular weight organic compound having at most 20 carbon atoms in cloth made of chemical fibers treated with water and oil repellent agent

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Magnetic recording medium having a binder comprising a copolymer which includes a vinyl compound having a dialkylaminoalkyl group

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Process for regenerating of an adsorbing material in the form of particles charged with at least two volatile compounds having different thermal stabilities

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Method for forming high sensitivity positive patterns employing a material containing a photosensitive compound having a diazo group, an alkaline-soluble polymer, a compound capable of adjusting the pH to 4 or less and a solvent

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Search system for chemical compound having biological activity

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Search system for chemical compound having biological activity

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Methods for predicting an active set of compounds having alternative cores, and drug discovery methods involving the same

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Predicting an active set of compounds having alternative cores

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Method of obtaining novel 2-2[4-(aminomethyl)phenylpropan-2-ol and this novel compounds as such as well as novel intermediate compounds

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Novel compounds and derivatization of dnas and rnas on the nucleobases of pyrimidines for function, structure, and therapeutics

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Novel compounds and synthesis of tellurium-derivatized oligonucleotides for structural and functional studies

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Novel Compounds and Synthesis of Tellurium-Derivatized Oligonucleotides for Structural and Functional Studies

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Composition for etching, method for etching insulator and method for manufacturing semiconductor device, and novel compounds

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Cobalt base film-forming method, cobalt base film-forming material, and novel compound

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Novel compound, and photoelectric device, image sensor, and electronic device including same

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Novel compound and organic electroluminescence device

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Non-aqueous electrolyte solution for battery, novel compound, polyelectrolyte, and lithium secondary battery

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Novel compound and organic device employing same

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Novel compounds having herbicidal and fungicidal properties and herbicidal and fungicidal compositions containing the said compounds

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Compound, and method for measuring iron concentration by using novel compound as chelate color former

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Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds

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COMPOUNDS HAVING ACTIVITY IN CORRECTING MUTANT CFTR CELLULAR PROCESSING

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NOVEL COMPOUNDS

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Novel compounds, isomers thereof or pharmacutically acceptable salts thereof as vanilloid receptor antagonists and pharmaceutical composition containing said compounds

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Complex substituted imidazole compounds having antidote and antihypoxanthic activities

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Novel compounds useful in modulating gene expression of retinoid responsive genes and/or having anti-ap-1 activity

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A novel compound form

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Novel compounds of thebaine

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Novel compounds and compositions for treating diseases associated with tryptase activity

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NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE

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Improvements in Processes of Obtaining Carbon Compounds having the General Formula C10 H16 O.

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Compounds having super-aspirin effects

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Flame retardant polyolefin compound having low smoking and toxicity.

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Process for reaction of epoxides with organic compounds having an active hydrogen

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Flame retardant polyolefin compound having low smoking and toxicity

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Novel compound having tert-butyloxycarbonyl group and its preparation

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