Medicaments and methods for promoting wound contraction
Номер патента: EP2101786A2
Опубликовано: 23-09-2009
Автор(ы): Kerry Nield, Mark William James Ferguson, Nicholas Occleston, Nick Goldspink, Sharon O'kane
Принадлежит: Renovo Ltd
Опубликовано: 23-09-2009
Автор(ы): Kerry Nield, Mark William James Ferguson, Nicholas Occleston, Nick Goldspink, Sharon O'kane
Принадлежит: Renovo Ltd
Реферат: Provided are antagonists of FXR activity for use as medicament for the prevention, reduction or inhibition of scarring. This use may preferably be to prevent, reduce or inhibit scarring formed on healing of wounds. The invention also provides corresponding methods of treatment. Preferred antagonists of FXR activity include guggulsterone (Z); guggulsterone (E); a scalarane; 80-574; and a 5α-bile alcohol. In advantageous embodiments, up to 32 μM of the antagonist of FXR activity may be provided per linear cm of wound, or cm2 of a wound or fibrotic disorder, over a 24 hour period in order to inhibit scarring.
Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium
Номер патента: US20030158257A1. Автор: Hiroyuki Watanabe,Takatoshi Murase,Tadashi Hase,Hidehiko Kondo. Владелец: Kao Corp. Дата публикации: 2003-08-21.