Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
Номер патента: EP1105098A1
Опубликовано: 13-06-2001
Автор(ы): Boris Piskoun, Elijah M. Bolotin, Gilbert J. Grant, Herman Turndorf, Yechezkel Barenholz
Принадлежит: New York University NYU, Yissum Research Development Co of Hebrew University of Jerusalem
Опубликовано: 13-06-2001
Автор(ы): Boris Piskoun, Elijah M. Bolotin, Gilbert J. Grant, Herman Turndorf, Yechezkel Barenholz
Принадлежит: New York University NYU, Yissum Research Development Co of Hebrew University of Jerusalem
Реферат: Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising 'GMV' (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
Номер патента: IL140892A. Автор: . Владелец: Univ New York. Дата публикации: 2010-04-15.