Traditional Chinese medicine formula for treating autologous allergic dermatitis and preparation method thereof

Technical Field

The present invention relates to the technical field of treating allergic dermatitis, in particular to a Glepp allergic dermatitis formulation and its preparation method.

Background Art

Allergic dermatitis is skin diseases caused by allergens, mainly refers to the human body caused by contact to the skin of the certain allergens, itched, nettle rash, peeling skin disorders. Specific allergen can be divided into contact with allergens, allergen, glycosyl allergens and injection into the allergen four categories. Each type of allergen can cause corresponding allergic reaction, mainly of the performance of a variety of dermatitis, eczema, urticaria. Allergic dermatitis major clinical realized the skin by red, swollen, heat, pain, itching, redness, blisters, dandruff; to the patient's normal serious impact on the lives. Self-allergic dermatitis often if these thoughts are applied four limbs, when the onset of, all of the pruritus plants, if the graze skin, large-area infection; at present, for treating allergic dermatitis adopts the western medicine to alleviate the wipe, recurrence, it is difficult to cure.

Content of the invention

The purpose of this invention is to provide a treating self-allergic dermatitis formulation, the traditional Chinese medicine formulation to be administrated with instant effect, for treating short period of treatment, the symptoms, the treatment effect is good; at the same time provides the Chinese medicine preparation method.

In order to achieve the purpose of the invention, the invention adopts the technical scheme is as follows:

For treating self-allergic dermatitis formulation, the traditional Chinese medicine formulation according to weight comprises the following components: Cimicifuga root 10 - 16 parts, turtle shell 20 - 30 parts, Ramulus Cinnamomi (cassia twig) 10 - 18 parts, radix Paeoniae Rubra 12 - 15 parts, white peony root 12 - 15 parts, soil Poria (Indian bread) 22 - 35 parts, cortex Phellodendri 8 - 15 parts, matrine 8 - 18 parts.

In the present invention, further, the traditional Chinese medicine formulation according to weight comprises the following components: Cimicifuga root 15 parts, turtle shell 30 parts, Ramulus Cinnamomi (cassia twig) 15 parts, radix Paeoniae Rubra 15 parts, white peony root 15 parts, soil Poria (Indian bread) 30 parts, cortex Phellodendri 15 parts, matrine 15 parts.

In the present invention, further, the Chinese medicine preparation method comprises the following steps: the turtle shell-shattering water after suffering, intense first 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance first 30 minutes; to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, taking the liquid medicine to get the.

In the present invention, further, the Chinese medicine preparation method comprises the following steps: the turtle shell-shattering water after suffering, turtle shell of the total water amount to 15 - 20 times, with high heat 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance of the first 30 minutes, adding water to the higher than the said component 10 - 15 cm; then the two mixed, to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 300 - 500 ml of the liquid medicine to get the.

The formulation of this invention oral method: the traditional Chinese medicine formulation twice a day in the morning and half hours taking meal; taking the 7 days for a period of treatment, seven days after two days stops the clothing, in the next period of treatment, 4 the course of a cycle for a total of 36 days. Mild patients 1 - 2 treatment, moderate the patient 3 - 5 period of treatment, severe patients 6 - 9 a course of treatment.

The formulation of this invention not only can be taken orally, but also can be made into external medicine.

The turtle shell crushing mill, over 100 mesh sieve, the pressure 10 - 25 mpa, temperature 4 - 8 °C for supercritical carbon dioxide extraction, 1 - 3 h, get the turtle shell fat-soluble extract; the turtle shell for fat-soluble extract volume concentration is 95% anhydrous ethanol reflux extraction 2 - 3 h, filter, collecting the filtrate; extracting the residue again 2 - 3 times, the filtrate, vacuum steaming and in addition to the solvent, to get the turtle shell of the water-soluble extract.

The rest of the Cimicifuga root, Ramulus Cinnamomi (cassia twig), radix Paeoniae Rubra, Paeoniae alba, soil Poria (Indian bread), phellodendron bark, matrine mixed in proportion, adding 10 times of the 75% ethanol soaking 8 - 12 h, heating reflux extraction 2 - 3 h, filter, collecting the filtrate; decompression in addition to ethanol, the dregs of plus 10 times water decoction, intense first 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 50 - 100 ml of the liquid medicine so as to obtain the composition of the extract of Chinese traditional medicine.

The above-mentioned two extracts are mixed, supplemented with excipient, additive, additive and the like, to make the medicinal liquid or paste, can be wiped on the skin surface.

In the present invention, further, the traditional Chinese medicine formulation used for the treatment of self-allergic dermatitis.

According to Chinese medicine: allergic dermatitis is because , diet not festival, labour excessive, mental excitement and hurt the spleen, cause the compressor out-of-sync, outside canada feeling wind, heat, wet and the cutting part, so that the intrusion of evil-skin, mucosa, or even muscle, with the blood, bodily fluids, such as phlegm strongly, but the long time melts hotly, on to the outside of the fiery , then must find a way out for a long time, so the disease.

In formulation of this invention:

Cimicifuga root: Oct, Ganong, ; turns over to the lung, spleen, colon, introgastric; published eruptions, clearing away heat, Qi and Yang;

Turtle shell: the taste is salty, slightly cold; turns over to the liver, the kidney by; yin, for dispensing, the hard lumps;

Ramulus Cinnamomi (cassia twig): Oct, Ganong, temperature; into the lung, heart, bladder channel; sweating the muscles, blood and, with the help of the positive carburetion;

Radix Paeoniae Rubra: bitter, slightly cold; turns over to the liver by; clearing blood, blood stasis relieves pain;

Radix Paeoniae alba: liver, spleen, lung three through; enriching the soothing, liver pain, for the treatment of dizziness, pains, dysentery, irregular menstruation;

Soil Poria (Indian bread): Ganong, light, flat; turns over to the liver, stomach channel; and toxic materials, dehumidification, the tonneau joint;

Cortex Phellodendri: bitter, cold natured; kidney, bladder channel; and drying damp clearing, and expelling, the efficacy of the detoxifying and;

Matrine: bitter, cold natured; centering, liver, stomach, colon, bladder channel; clearing, insecticidal, diuresis;

The formulation of this invention in order to turtle shell, mainly Ramulus Cinnamomi (cassia twig), with yin, for dispensing, the role of the blood and, nourishing the spleen, liver; Cimicifuga root, radix Paeoniae Rubra, phellodendron bark, matrine complement, with clearing, the role of the detoxifying , clearing away heat, expelling wind, wind and relieving itching and; in addition Paeoniae alba, soil Poria (Indian bread), flavoring supplement, enriching the soothing, detoxification, dehumidification, the tonneau joint; eight common role of Chinese herbal medicine, not only effectively consolidate internal, nourishing the spleen, liver; and clearing away heat, expelling wind, wind and relieving itching and, accompanied stasis, eruptions and sores; so this Chinese medicinal formula symptoms, administration with instant effect, for treating short period of treatment, the treatment effect is good.

Description of drawings

Figure 1 is the region of disease symptoms Figure of clinical trials wherein a mild patients before the formulation of this invention.

Figure 2 is the region of disease symptoms Figure of the mild clinical trial in patients after the formulation of this invention.

Figure 3 is the region of disease symptoms diagram of one of the clinical trial in patients with moderate before the formulation of this invention.

Figure 4 is the region of disease symptoms Figure of clinical trials the moderate patients after the formulation of this invention.

Mode of execution

In order to re-launch the technical means realized in this invention, creative characteristic, reached the easy understanding of the goal and the efficacy of understanding, combined embodiment below, further elaboration of the invention. It should be understood, described herein a specific embodiment of the invention used to interpret only, not for limiting the invention.

The raw materials used in the present invention can be purchased from the market.

Embodiment 1

For treating self-allergic dermatitis formulation comprising the following components: Cimicifuga root 10 g, turtle shell 20 g, Ramulus Cinnamomi (cassia twig) 10 g, radix Paeoniae Rubra 12 g, white peony root 12 g, soil Poria (Indian bread) 22 g, cortex Phellodendri 8 g, matrine 8 g.

Decocting method: the turtle shell-shattering adding 300 ml with water, with high heat 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance of the first 30 minutes, adding water to the higher than the said component 10 cm; then the two mixed, to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 300 ml of the liquid medicine to get the.

Embodiment 2

For treating self-allergic dermatitis formulation comprising the following components: Cimicifuga root 12 g, turtle shell 22 g, Ramulus Cinnamomi (cassia twig) 10 g, radix Paeoniae Rubra 14 g, white peony root 12 g, soil Poria (Indian bread) 25 g, cortex Phellodendri 10 g, matrine 10 g.

Decocting method: the turtle shell-shattering added 400 ml with water, with high heat 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance of the first 30 minutes, adding water to the higher than the said component 10 cm; then the two mixed, to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 400 ml of the liquid medicine to get the.

Embodiment 3

For treating self-allergic dermatitis formulation comprising the following components: Cimicifuga root 15 g, turtle shell 30 g, Ramulus Cinnamomi (cassia twig) 15 g, radix Paeoniae Rubra 15 g, white peony root 15 g, soil Poria (Indian bread) 30 g, cortex Phellodendri 15 g, matrine 15 g.

Decocting method: the turtle shell-shattering adding 500 ml with water, with high heat 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance of the first 30 minutes, adding water to the higher than the said component 12 cm; then the two mixed, to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 400 ml of the liquid medicine to get the.

Embodiment 4

For treating self-allergic dermatitis formulation comprising the following components: Cimicifuga root 16 g, turtle shell 30 g, Ramulus Cinnamomi (cassia twig) 18 g, radix Paeoniae Rubra 15 g, white peony root 15 g, soil Poria (Indian bread) 35 g, cortex Phellodendri 15 g, matrine 18 g.

Decocting method: the turtle shell-shattering added 600 ml with water, with high heat 10 minutes, after the boiling slow fire slow frying 20 minutes; the remaining components of the water soaked in advance of the first 30 minutes, adding water to the higher than the said component 15 cm; then the two mixed, to be turtle shell of the torment, mixture of the two, and then boiling 10 minutes, after the boiling slow fire slow frying 20 minutes, frying to 500 ml of the liquid medicine to get the.

A large number of clinical study proves to study the effect of traditional Chinese medicine formulation of:

The observation of the 2005 years - 2017 a total of 136 example acute and chronic recurrent allergic dermatitis patients, of which female 84 example, male 52 example, all the patients are entitled to use other methods of treatment history, but have the characteristic of repeatedly. Disable the other treatment means during the treatment period.

Treatment method: will the patient taking the embodiment of batches 1 - 4 obtained by the method of the liquid medicine suffering from: the above-mentioned liquid medicine is taken by two times, one for each of the meal in the morning and the half hours taking; taking the 7 days for a period of treatment, seven days after two days stops the clothing, in the next period of treatment, 4 the course of a cycle for a total of 36 days. Mild patients 1 - 2 treatment, moderate the patient 3 - 5 period of treatment, severe patients 6 - 9 a course of treatment.

Recording-related data, the specific circumstances of treatment effect in table 1 shown:

Table 1

By table 1 and Figure 1 - 4 can be seen, the embodiment of the invention 1 - 4 preparation of the liquid medicine to the allergic dermatitis does have very good mitigation, repairing, mild patients 1 - 2 after the period of treatment, the symptoms with the sign also were lifted, and temporary shaping of 1 year not recurrences occur; moderate patients and heavy patient can also take the after the liquid medicine is most obviously improved, also reduce the recurrence; only 1 example although not fully recover, swelling and pruritus of uncomfortable symptoms and sign obviously diminished; at the same time, the experiment not found in patients of other discomfort.

The invention is not limited to those specific embodiments. The invention extends to any disclosure in this specification of the new feature or any novel combination, and the disclosure of any new method or process step or any new combination.