PHARMACEUTICAL COMPOSITION CONTAINING MELIOSMA OLDHAMII EXTRACT AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING MULTI-DRUG RESISTANT CANCER
The invention relates to the total leg tree ( The tumor (tumor) excess of abnormal cells which occur because of disordered cellular proliferation but not [e[e] and whether the product obtained, destructive proliferative, infiltration and metastatic malignancies are classified into the materials (malignant tumor). 3 essentially is a method of treating malignancies i.e. therapy, radiation therapy, surgical surgery and chemotherapy uses, etc. through one or a combination thereof one of treating cancer. Cancer chemotherapy in cancer therapy used to treating cancer by perturbing the metabolism or copy of which, which is useful for development as therapeutics true cladding not, further side effects of anticancer agent due to tolerance induced by anticancer agent pipe piece is very low, only a short life in an auxiliary therapeutic agent helps with the lugs extending degree are disclosed. Generation of large disorders like cancer treatment using anti-nucleophosmin cells is under or over. Most of the function associated with cancer is already lost state variant inhibiting gene, one arm mass within each of the cells is equal to off so that gene expression pattern. Ultimately due to the majority of the genetic diversity in the treatment chemical anticancer drug resistant cells are anticancer agent which is selectively companies, the companies most cancer cells proliferation tolerance kind having tolerance to be coated and the eventual mass of cells. In addition to mutations tolerance due to genetic diversity, the side effects of administering sufficient amount of anticancer agents or transmits patient too far, when oral administration is abnormally times of drug intake, or physiologically between tissue cells to vascular arm barriers can be shaped part through an electrical connection cable drug tolerance. Furthermore, many cases outside cell by discharging a broad substrate specificity anticancer drug transporter (transporter) due to, be similar to control both different types of anticancer agents can then be mixed. A general agent or an anti-suction, limit accumulation of cells via change in membrane lipid can be anticancer agent, other pharmaceutical agents relative to the tolerance cells may be completely visible formula (MDR, multi drug resistance) to be coated simultaneously with resistance. Thereby different types simply administering anticancer agent for treating cancer advance order receipt tolerance cannot be 2.0. On the other hand, belonging to the genus meliosma myrianthathe total leg treemeliosma myriantha and which, is the size of one or several small big height treeleafwide leaf to stem and stem is becoming twisting diver who grew into 8 provided 10m is in many cases disclosed. Extending obliquely above and I is a power supply [twung[twung] Under smoking via the network. Where under Roh [lu[lu] roentgen per hour at one meter case which features a mainly south reside western-style paper [lu[lu] polyaddition format. 5-a 10 cm length 9 - 15 degree of leaf divided depending the leaf it decreases, magazines shift odd feather relative to one other. As long pointed egg shape of ellipsoidal and tail end toothed edge it is rare and it is rare and in 2000. Leather feels as tough disclosed. The rear leaf pulse hair using silicon rubber a large family. The pin is to leaf sack hair using silicon rubber. In autumn gilded machines and other. 6 - 7 with the pin end and a month is roh column year S. white. As each shift is to pull the end cone and is combined with a flower and end and I think phalaenopsis cracks, such as crack length as to shift with each end and I think phalaenopsis is flower combined with a substrate. cancerous flowerpossibility flower wooden pins and to one other. The yolk-free [hes[hes] Possibilityalcoholic beverage among 2 and 5 possibility flower surgery among pollen, leaves 3 times than the petals 3 field calyx of flower and greater. The promoter having the two cancerous flower 1, 4 field calyx of flower leaf are disclosed. 9 - 10 a month with 7 mm diameter rigid degree rounded fruit is red to nuclear impressed seeds chopped hay substrate. Even winter having suspended disclosed. Young tree to represent a light brown and gray light 72 [mis[mis] Under disclosed. Brown powder that a shallow horizontal corrugated this region can comprise a light grey a spot slightly longitudinally while [mis[mis] Under crack substrate. Brown shell longitudinal eye be divided. Methods and systems are also brown stone yellow light edge 72 other. Brown tint inside a broad shape white brown sequentially shim of 2000. Have a small white brown inside auriclethe very middle is 2000. Light brown to represent a green band multivalent are a light grey is gradually having hat. If thick gray powder strip substrate. With a regular [ccwu[ccwu] writing [ccwu[ccwu] writing wrinkles appearing to be short. An example of related techniques known the total leg tree extract include quelpaertensis universitymaster my degree thesis (2012. 02) to the total leg tree ( The present invention relates to elicited to request such as provided, the present invention relates the total leg tree ( In order to attain the object, the present invention relates the total leg tree ( Also, the invention relates to the total leg tree ( Also, the invention relates to the total leg tree ( The invention relates to the total leg tree ( Figure 1 the total leg tree extract ( The invention relates to the total leg tree ( Said extract water, C1 To C4 Extraction into a solvent of lower alcohols or mixtures thereof preferably, the lower alcohols preferably but not limited to methanol or ethanol. The the total leg tree ( The the total leg tree to extract produced by a process comprising the steps of preferably but not limited to: 1) extracting in the total leg tree extraction solvent applied; 2) step 1) extract of filtering step; and 3) step 2) filtering cream extract after drying. In the method, step 1) or the like free the total leg tree of medical products commercially available can be used. In the manufacturing method, extraction is propylene the total leg tree extract, an extract, immersion extraction, using conventional methods known in the reflux cooling extraction and ultrasonic extraction such as all can be. The extraction solvent volume of 2 to 20 times a dried the total leg tree added preferably extraction. Extraction temperature is preferably 20 to 50 °C does not limited. Also, extraction time is preferably 10 to 100 times, specifically preferably function of 24 to 96, more specifically 72 time most preferably does not limited. In the method, step 3) the decompression of enrichment is limited using vacuum decompression thickener or vacuum rotary Eq preferably does not. Also, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited. The arm is lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, colon cancer, skin cancer, bladder cancer, prostate cancer, ovarian cancer, cervical cancer, thyroid cancer, kidney, fiber sarcoma, melanoma and blood cancer cancer but without transferring any preferably selected from, but not limited to and, cancer diagnosis if not limiting. The multi medicine antitumor antibiotic (antitumor antibiotics), phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) or can be a taxane (taxane) based anticancer agent, does not limited to, clinical, pharmaceutical or therapeutic anticancer drug can be lifestyle comprising all available. The antitumor antibiotic (antitumor antibiotics) misfortune mote Roh E D (actinomycin D) is clarithromycin, erythromycin [pul[pul] five sulfate (bleomycin sulfate), capsaicin (daunomycin) multi rightroh E, multi rightdeer rain shoes (daunorubicin), doxorubicin (doxorubicin), epitaxial (epirubicin) doxorubicin, doxorubicin (idarubicin) it is a child, american toe (mitomycin) erythromycin, erythromycin - C american toe (mitomycin-a C), and least one mitt feed (mitramycin) may be selected from, the phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) is irinotecan (irinotecan), camp camptothecin (camptothecin), norbornene biot new (novobiocin), epitaxial doxorubicin (epirubicin), leucine (dactinomycin) [tak[tak] Mote Roh E, cancerous company clean (amsacrine), etoposide (etoposide) daunomycin reel [ni[ni] gun hour [tu[tu] (teniposide) and least one may be selected from, the taxane (taxane) paclitaxel (paclitaxel) or docetaxel (docetaxel) based is useful for but not limited to one having an. In the present invention 'formula' or 'tolerance' when cancer patients using an anticancer agent, velocity that is not effective treatment or therapeutic effects of which initially but, when compared to the treatment, reduce lost or cancer which means that the other. The compositions of the invention can be various oral or parenteral formulation. The composition there is usually formulated using filler, extender, binder, wetting agent, disintegrating agent, surfactant such as diluent or excipient agent formulated as a substrate. Purification is a solid preparation for oral administration, annularity system, inhaled, granules, etc. included in a capsule, at least one such solid formulation contains at least one compound of one or more excipients for example, starch, calcium carbonate, sucrose (sucrose) or lactose (lactose), gelatin pressure is lowered formulated as a substrate. Also, in addition to simple excipients magnesium salt of stearic acid, talc such as lubricant are also are used. Liquid formulations include suspending agent for oral administration, liquid content, corresponding to emulsion or syrup and the like, commonly used for producing a simple diluent, in addition to the paraffin droplet various excipients, for example wetting agent, sweetener, aromatic or preservative can be like. For parental administration preparations contain a sterile aqueous solution, non-aqueous solvent, solvent suspension, emulsion, freeze-dried preparation or the like left system multiple myelomas are included. Non-aqueous solvent and suspension solvent (propylene glycol) include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, an injectable the [ley[ley] which comes the [thu[thu] and ethyl ester is used as the alkali such as can be. Base include above [theyp[theyp] brushleft proposal (witepsol), mark with goal, twin (tween) 61, carcass five fingers, the it soaked, glycerol, gelatin or the like can be used. The oral or parenteral compositions of the invention can be administered, either intraperitoneally or external skin upon parenteral administration, rectal, intravenous, muscle, subcutaneous, intrauterine epidural or preferably in scan mode selecting the above described shortcomings. A pharmaceutically effective amount of compositions of the invention is administered. In the present invention, 'pharmaceutical effective amount' rational possibility [hyey[hyey]/risk ratio applicable to medical treatment in an amount sufficient to treat conditions and means, effective capacity level type of patient disease, severity, drug, drug sensitivity, administration time, routes and discharge rate, a treatment period, simultaneous use the sealed elements and other medical fields can be determined according to well-known element. The compositions of the invention can be administered in conjunction with other therapeutic agents or therapeutic administration of individual conventional therapeutic agents are administered simultaneously can be sequential or from, can be single or multiple administration. The components in an amount of at least maximum effect can be obtained without adverse considers both the amount administered important, this is facilitated by one skilled can be determined. Body weight of patients dosage is composition of the present invention, age, sex, health condition, dietary, administration time, method of administration, excretion rate range along with a variety of severe diseases and which generates, based on the amount of extract daily dosage is the total leg tree 0. 01 and to 1000 mg/kg, preferably between 30 and 500 mg/kg, more preferably 50 to 300 mg/kg and, by administering a single day 1 - 6 can be. However routes, the severity of obesity, sex, weight, age or the like be scaled according to which the dose not the define the scope of this invention in certain even. The compositions of the invention alone, or surgical, radiation therapy, hormone therapy, chemical treatment and biological reactions using modulators can be used in combination with methods. Also, the invention relates to the total leg tree ( Said extract water, C1 To C4 Extraction into a solvent of lower alcohols or mixtures thereof preferably, the lower alcohols preferably but not limited to methanol or ethanol. The the total leg tree ( The the total leg tree to extract produced by a process comprising the steps of preferably but not limited to: 1) extracting in the total leg tree extraction solvent applied; 2) step 1) extract of filtering step; and 3) step 2) filtering cream extract after drying. In the manufacturing method, step 1) or the like free the total leg tree of medical products commercially available can be used. In the manufacturing method, extraction is propylene the total leg tree extract, an extract, immersion extraction, using conventional methods known in the reflux cooling extraction and ultrasonic extraction such as all can be. Adding 2 to 20 times the volume of the extraction solvent is dried sum leg preferably extraction. Extraction temperature is preferably 20 to 50 °C does not limited. Also, extraction time is preferably 10 to 100 times, specifically preferably function of 24 to 96, more specifically 72 time most preferably does not limited. In the method, step 3) the decompression of enrichment is limited using vacuum decompression thickener or vacuum rotary Eq preferably does not. Also, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited. The arm is lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, colon cancer, skin cancer, bladder cancer, prostate cancer, ovarian cancer, cervical cancer, thyroid cancer, kidney, fiber sarcoma, melanoma and blood cancer cancer but without transferring any preferably selected from, but not limited to and, cancer diagnosis if not limiting. The multi medicine antitumor antibiotic (antitumor antibiotics), phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) or can be a taxane (taxane) based anticancer agent, does not limited to, clinical, pharmaceutical or therapeutic anticancer drug can be lifestyle comprising all available. The antitumor antibiotic (antitumor antibiotics) misfortune mote Roh E D (actinomycin D) is clarithromycin, erythromycin [pul[pul] five sulfate (bleomycin sulfate), capsaicin (daunomycin) multi rightroh E, multi rightdeer rain shoes (daunorubicin), doxorubicin (doxorubicin), epitaxial (epirubicin) doxorubicin, doxorubicin (idarubicin) it is a child, american toe (mitomycin) erythromycin, erythromycin - C american toe (mitomycin-a C), and least one mitt feed (mitramycin) may be selected from, the phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) is irinotecan (irinotecan), camp camptothecin (camptothecin), norbornene biot new (novobiocin), epitaxial doxorubicin (epirubicin), leucine (dactinomycin) [tak[tak] Mote Roh E, cancerous company clean (amsacrine), etoposide (etoposide) daunomycin reel [ni[ni] gun hour [tu[tu] (teniposide) and least one may be selected from, the taxane (taxane) paclitaxel (paclitaxel) or docetaxel (docetaxel) based is useful for but not limited to one having an. In the present invention 'health food' cottonseed meal nutrients that are prone to deficient in dampening or made using raw materials or components that function (functional materials), human health through the central or normal physiology activation maintaining or improving food safety bureau chief meaning that the medicine is defined food, not limited to the meanings of health food including both a conventional sense less than 2000. The health nutraceutical tablet, capsule, powder, granules, liquid, in the form of ring, processing but, not limited to law with some aspects according to manufacturing, can be processed. Either adding the total leg tree extract of the present invention can be use with other food it is food or food ingredients, can be suitable for use according to conventional methods. Mixing of active ingredient amount according to its intended use (for treatment or prevention of) can be determined. Generally, the amount of the compound of 0 total food weight of health food. 1 to 90 parts by weight can be applied. However health and hygiene or health control purposes is a long ingestion of said range may be less than in the case of said quantity, as the active ingredient in an amount of at least insofar as safety problem because said range can be also be used. As a health drink composition of said compounds as essential ingredients indicated proportions containing other ingredients such as beverage is simplified and spraying is conventional except that the various flavors or natural carbohydrate or the like can be further active ingredient. An example of the above-described natural carbohydrate mono pathogenic agent, e.g., glucose, such as oligosaccharides; d company Kara id, e.g. liver, such as sucrose; and polysaccharide, for example dextrin, cyclodextrin such as conventional sugar, and xylitol, sorbitol, such as processes for the preparation of party alcohol[thol[thol] among others. As flavoring agent other than the above-described natural flavoring agent (TAU denaturing, Stevia extract (e.g., [ley[ley] right D coming [tu[tu] A, such as writing hour [lu[lu] position) and synthetic flavors (saccharin, aspartame or the like) can be advantageously used. In addition to the extract of the present invention have various the total leg tree nutritional supplements, vitamin, mineral (electrolyte), synthetic flavorants and natural flavor such as a flavorant, colorant and first prominent figure (cheese, such as chocolate), [pheyk[pheyk] The [thu[thu] it buys and salts thereof, alginic acid and salts thereof, organic acid, protective colloidal thickener, pH modulators, stabilizer, preservative, glycerin, alcohol, carbonic acid agent can be used in carbonated beverages and the like. In addition to natural fruit juice and fruit juice beverage and vegetable beverages the total leg tree extract of the present invention for the production of pulp can be containing. These components can be used in combination or independently. The ratio of these additives increase per 100 parts by weight of triazines of the present invention but not so important the total leg tree extract 0. 1 to about 20 parts by weight of generally is selected from the range are disclosed. Also, the invention relates to the total leg tree ( Below, embodiments using broadcast receiver which utilizes the present invention more specifically described. These embodiments only to explain the present invention more specifically is not limited by the scope of this invention that these are advantageously easier to consultation with is reduced to are disclosed. Embodiments 1. the total leg tree extract the total leg tree ( 2 embodiments. Normal cell lines the total leg tree extract on the payout rate identifying a cell survival The embodiments 1 to identify survival of normal cells made in the total leg tree extract on the payout rate for, MTS (3 - (4, 5 a-dimethylthiazol-a 2 a-yl) - 5 - (3 a-carboxy methoxy phenyl) - 2 - (4 a-sulfophenyl) - 2H-a tetrazolium salt) experiment method has been confirmed that the survival rate of cells. Specifically, 1 × 10 96 well plate3 Normal cells of normal cell lines (IMR90) waste of colon normal cell lines a suitable culture medium (CCD provided 112Co and CCD provided 18Co) after dividing with 100 micro l, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. Then the embodiments 1 obtained in 100 micro g/Ml the total leg tree extract after treated, 48 him as additional time. Removing culture medium, following addition of 100 micro l MTS solution, by reacting about 1 - 3 time, measured in absorbance 490 nm, measuring absorbance value (relative proliferation index) determined the voice controls of relative lifestyle field index. As a result, as also disclosed 1, active ingredient of the present invention hardly do not affect normal cell lines polyphenol extract the total leg tree 3 species has been confirmed. 3 embodiments. Attention on the payout rate the total leg tree extract identifying cancer cell survival The embodiments 1 made in attention on the payout rate for identifying cancer survival the total leg tree extract, MTS (3 - (4, 5 a-dimethylthiazol-a 2 a-yl) - 5 - (3 a-carboxy methoxy phenyl) - 2 - (4 a-sulfophenyl) - 2H-a tetrazolium salt) experiment method has been confirmed that the survival rate of cells. Stomach cancer derived cell lines SNU638 bank is prepared cell lines, cancer cell lines (ATCC: American Type Culture Collection) seller it gives remaining 17 species from U.S. bank using the air. Specifically, 5 × 10 96 well plate3 18 15 kDa species of suitable culture medium after dividing cancer cells with 100 micro l, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. Then the embodiments 1 obtained in 100 micro g/Ml the total leg tree extract after treated, 48 him as additional time. Removing culture medium, following addition of 100 micro l MTS solution, by reacting about 1 - 3 time, measured in absorbance 490 nm, measuring absorbance value (relative proliferation index) determined the voice controls of relative lifestyle field index. As a result, table 1 as disclosed, the total leg tree extract lung cancer are (Lung cancer), breast cancer (Breast cancer), hepatocellular carcinoma (Liver cancer), cervical cancer (Cervix cancer), cancer (Fibrosarcoma) sarcoma, colon cancer (Colorectal cancer), stomach cancer (Stomach cancer), minimum 50% 95% or more of inhibiting skin cancer (Skin cancer) in relativity field strong cytotoxicity to cells has been confirmed. Embodiments 4. the total leg tree Extract MDR(MultidrugResistance) Influence the cell identifying 1) the total leg tree By extract HL-60/MX2 Lines Survival rate Change Acute promyelocytic leukemia (Acute promyelocytic leukemia) cell line (ATCC CCL-a 240) HL-a 60 of a patient's blood isolated from blood cancer cell lines, such as cell active search widely used anticancer agent are disclosed. HL-a 60/MX2 (ATCC CRL-a 2257) cell lines HL-a 60 cell lines being american toe of anticancer agent derived cell lines (mitoxantrone) long-term exposure to the tolerance take-acid oxide inclusion content. The formula in cell lines HL-a 60/MX2 is 4 this implementation of verifying his tolerance. Specifically, cell line (ATCC) seller in U.S. bank lines HL-a 60 and HL-a 60/MX2, processing cells to doxorubicin (doxorubicin, 500 nm) relative survival rates (viability) 2 has been confirmed in the same manner on the embodiments. As a result, capillary gun week (HL-a 60) when compared to doxorubicin (doxorubicin) cell line HL-a 60/MX2 is provided which shows tolerance has been confirmed (2 also). Also, toxin in ruby shoes anticancer agent for active ingredient of the present invention resistant cell line HL-a 60/MX2 the total leg tree extract processing result, cell lines HL-a 60/MX2 the total leg tree extract reduces the tolerance inducing cytotoxicity against the arms to anticancer (also 2) were confirmed. 2) the total leg tree By extract H69/AR Lines Survival rate Change H69 (small cell lung cancer) (ATCC HTB provided 119) cell lines small cell lung cancer cell lines that have been split from which patient gun lung cancercancerous lump, H69/AR H69 cell line (ATCC CRL-a 11351) cell lines of anticancer agent (adriamycin) 14 months while increasing concentration over a erythromycin being oh [tu[tu] Oh derived cell lines resistant to culturing are disclosed. This implementation in the formula was H69/AR verifying a tolerance of 4 cell lines. Specifically, H69 cell line (ATCC) seller in U.S. bank lines and H69/AR, processing cells to doxorubicin (doxorubicin, 1 μm) relative survival rates (viability) 2 has been confirmed in the same manner on the embodiments. As a result, capillary gun week H69/AR doxorubicin (doxorubicin) when compared to cell lines (H69) is provided which shows tolerance has been confirmed (3 also). Also, toxin active ingredient of the present invention cell lines resistant to anticancer in ruby shoesthe total leg tree extract processing result, H69/AR the total leg tree cell extract reduces the tolerance inducing cytotoxicity against the arms to anticancer were confirmed (3 also). 3) cell survival rate change by MES provided SA/MX2 and MES-a SA/Dx5 the total leg tree extract Cell line (ATCC CRL-a 1976) uterine cancer tissue of cancer patients is MES provided SA sarcoma cell lines isolated from this cell derived from a cell line (ATCC CRL-a 2274) 2 species tolerance on MES provided SA/MX2 (ATCC CRL-a 1977) is widely known formula MES provided SA/Dx5 protein overexpression of MDR (multidrug resistant gene) gene are the product P - (P-a glycoprotein) is the main cancer writing nose protein representative tolerance work environment. The embodiments 4 2 species of formula in the cell lines (MES provided SA/MX2, MES provided SA/Dx5) tolerance of verifying his. Specifically, MES provided SA, cell lines (ATCC) seller in MES provided SA/MX2 and MES-a SA/Dx5 U.S. bank, processing cells to doxorubicin (doxorubicin, 1 μm) relative survival rates (viability) 2 has been confirmed in the same manner on the embodiments. As a result, when compared to the capillary gun week (MES provided SA) doxorubicin (doxorubicin) tolerance for MES provided SA/MX2 and MES-a SA/Dx5 cell lines provided which shows has been confirmed that the (also 4 and 5). Also, toxin in ruby shoes anticancer agent for active ingredient of the present invention resistant MES provided SA/MX2 and MES provided SA/Dx5 the total leg tree cell extract processing result, thus inducing cytotoxicity against cell lines the total leg tree extract MES provided SA/MX2 and MES-a SA/Dx5 tolerance has been confirmed that the arms to anticancer were (also 4 and 5). Embodiments 5 the total leg tree By drug resistance protein extract discharge (Efflux) Control Treating cells exhibit tolerance gene (multidrug resistance gene) mediated discharge of internal out from drug which are the product has been confirmed that the MDR1 and MRP1 protein has been colon cancer. Specifically, cervical sarcoma cell lines resistant to anticancer agent on lung cancer cell line (MES provided SA/MX2 and MES-a SA/Dx5) (H69/AR) are separated from each other to confirm the MDR1 and MRP1 [pul[pul]the [wey[wey] the [su[su] it shook off protein from his (6 also) is colon cancer. Then, MDR protein matrix into the said cell lines representing Calcein AM fluorescent methods using formula assay (multidrug-a resistance assay) sum using MDR protein drugs by leg extract for transporting inhibiting (anticancer) (discharge) has been confirmed. Specifically, 5 × 10 96 well plate4 Tolerance of suitable culture medium after dividing with 100 micro l cancer 15 kDa, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. In embodiments 1 then sends an add the total leg tree extract obtained after processing, him as additional 30 minutes. After adding each well 2 times concentrated Calcein provided AM solution, 30 minutes again him as. Plate 400 × g at room temperature in centrifuging, carefully remove the supernatant, 200 micro l excited in a fluorescent plate reader (excitation) of media in adding and 485 nm, 535 nm to measure fluorescence in, voice controls fluorescence measuring value shown in relative values (normalized calcein AM fluorescence). As a result, different steps resistance gene expressing the total leg tree extract two species tolerance cell lines, (also 7) and (8 also) MDR protein produced in MES provided SA/Dx5 H69 provided AR transport of substrates by suppressing, controls than statistically significant intracellular calcein-a AM held high concentration has been confirmed. A transparent conductive layer disposed in dispersion analysis (one a-way ANOVA) statistics processing covalently, controls (group Vehicle) decided on the Bonferroni post assay was analyzed with significant show differences in manufacturing method (p<0. 05). The present invention relates to a pharmaceutical composition for preventing or treating multi-drug resistant cancer, and to a health functional food, wherein the pharmaceutical composition contains a Meliosma oldhamii extract as an active ingredient. In particular, when the Meliosma oldhamii extract which is an active ingredient is treated to normal cells, cytotoxicity is rarely shown. However, cytotoxicity is shown in various cancer cell strains, and the viability of cancer cells in cell strains having resistance due to the administration of an anticancer agent is reduced. Accordingly, the Meliosma oldhamii extract of the present invention is expected to be effective for a patient having multi-drug resistance to an anticancer agent, and is prescribed along with an anticancer agent as an assisting agent, so the possibility of increasing the effect of an anticancer agent is ensured. COPYRIGHT KIPO 2017 the total leg tree ( According to Claim 1, the composition containing the, C1 To C4 Because of lower alcohols or mixtures thereof of a pharmaceutical composition for treatment or prophylaxis of cancer characterized by formula. According to Claim 2, the lower alcohols methanol or ethanol is a pharmaceutical composition for treatment or prophylaxis of cancer characterized by formula. According to Claim 1, the the total leg tree ( According to Claim 1, the arm is lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, colon cancer, skin cancer, bladder cancer, prostate cancer, ovarian cancer, cervical cancer, thyroid cancer, kidney, fiber breeding, melanoma and blood cancer characterized by formula cost selected pharmaceutical composition for treatment or prophylaxis of cancer. According to Claim 1, the multi medicine antitumor antibiotic (antitumor antibiotics), phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) or taxane (taxane) based anti-a pharmaceutical composition for treatment or prophylaxis of cancer characterized by formula. According to Claim 6, the antitumor antibiotic (antitumor antibiotics) misfortune mote Roh E D (actinomycin D) is clarithromycin, erythromycin [pul[pul] five sulfate (bleomycin sulfate), capsaicin (daunomycin) multi rightroh E, multi rightdeer rain shoes (daunorubicin), doxorubicin (doxorubicin), epitaxial (epirubicin) doxorubicin, doxorubicin (idarubicin) it is a child, american toe (mitomycin) erythromycin, erythromycin - C american toe (mitomycin-a C), and mitt feed (mitramycin) characterized by formula selected from least one pharmaceutical composition for treatment or prophylaxis of cancer. According to Claim 6, the phase rational nitrification enzyme inhibitors (topoisomerase inhibitor) is irinotecan (irinotecan), camp camptothecin (camptothecin), norbornene biot new (novobiocin), epitaxial doxorubicin (epirubicin), leucine (dactinomycin) [tak[tak] Mote Roh E, cancerous company clean (amsacrine), daunomycin (etoposide) selected from etoposide reel [ni[ni] gun hour [tu[tu] (teniposide) and least one pharmaceutical compositions for the treatment or prophylaxis of cancer characterized by formula. According to Claim 6, paclitaxel (paclitaxel) or docetaxel (docetaxel) is useful for the taxane (taxane) based characterized in a formula pharmaceutical composition for treatment or prophylaxis of cancer. the total leg tree ( According to Claim 10, the the total leg tree ( the total leg tree (Origin tissue Cell lines Cell survival rate (mean ± S. D. , %) Waste (Lung) A549 23. 8 ± 3. 9 H460 4. 9 ± 0. 2 H1299 102. 1 ± 1. 2 Breast (Breast) MCF-a 7 90. 7 ± 3. 2 MDA-a MB231 37. 2 ± 7. 5 (Liver) between HepG2 4. 7 ± 1. 5 Hep3B 7. 1 ± 3. 3 Cervical (Cervix) HeLa 3. 4 ± 0. 6 Fiber breeding (Fibrosarcoma) HT1080 12. 4 ± 1. 8 Prostate (Prostate) DU145 60. 1 ± 3. 2 PC-a 3 61. 9 ± 15. 9 Colon (Colorectal) CoLo205 7. 8 ± 0. 0 HCT116 12. 0 ± 0. 2 Skin (Skin) SK-a MEL-a 5 49. 3 ± 0. 9 SK-a MEL-a 28 52. 1 ± 0. 5 (Stomach) on SNU638 3. 3 ± 0. 1 (Kidney) elongated ACHN 76. 4 ± 1. 4 Caki-a 1 61. 9 ± 3. 1
