23-05-2013 дата публикации
Номер: US20130131074A1
Novel compounds of structure Formula I: 5. The compound claim 1 , enantiomer claim 1 , diastereomer claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , of claim 1 , wherein:Z is CH;{'sup': 1', '6, "Ris aryl, arylalkyl or heteroaryl, any of which may be optionally substituted with one or more R's;"}{'sup': 2', '5', '5', '6, "Ris cycloalkyl, aryl, heteroaryl, heterocyclyl, —C(═O)Ror —C(═O)OR, wherein the cycloalkyl, aryl, heteroaryl and heterocyclyl may each be optionally substituted with one or more R's;"}{'sup': 5', '6, "Ris alkyl, aryl, cycloalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted with one or more R's;"}{'sup': 6', '10', '10', '10', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '9', '10', '9', '9', '10', '10', '14', '9', '9', '14', '14', '14', '10', '10', '9a, 'sub': 2', '2', '3', '2', '3', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2, 'R, at each occurrence, is independently selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halo, —NH, —CN, —NO, —C(═O)OH, —C(═O)OR, —OCF, —OCHF, —OR, —OH, —SH, —SR, —S(O)H, —P(O)H, —C(═O)NRR, —NRR, —S(O)NRR, —NRS(O)CF, —C(═O)NRS(O)R, —S(O)NRC(═O)OR, —S(O)NRC(═O)NRR, —C(═O)NRS(O)CF, —C(═O)R, —NRC(═O)H, —NRC(═O)R, —OC(═O)R, —C(═NR)NRR, —NHC(═NR)NRR, —S(═O)R, —S(O)Rand ═O, wherein the alkyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl may each be optionally substituted with 0-5 R;'}{'sup': 8a', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14', '14, 'sub': 2', '2', '3', '2', '3', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2, 'R, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, ...
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