11-04-2013 дата публикации
Номер: US20130090309A1
Принадлежит:
The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, R, R, R, R, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase. 3. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 3', '3a', '3a', '3a', '3b', '4', '4b', '5, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '1', '6', '1', '3', '2, 'when Ris —COR, —CHCOR, —CHCHCOR, tetrazole, —C(O)N(R), or —CHOH; then Ris H, halo, C-Calkyl, —O—(C-Calkyl), or —N(R), and Ris H or halo; and'}{'sup': 4', '4a', '4a', '4a', '4b', '3', '3b', '5, 'sub': 2', '2', '2', '2', '2', '2', '2', '2', '1', '6', '1', '3', '2, 'when Ris —COR, —CHCOR, —CHCHCOR, tetrazole, —C(O)N(R), or —CHOH; then Ris H, halo, C-Calkyl, —O—(C-Calkyl), or —N(R), and Ris H or halo.'}4. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris OH.5. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein n is 1.7. The compound of or a pharmaceutically acceptable salt thereof claim 6 , wherein Ris —COR claim 6 , wherein Ris selected from the group consisting of H and CH.9. The compound of or a pharmaceutically acceptable salt thereof claim 6 , wherein Ris H or chloro.11. The compound of claim 1 , selected from the group consisting of:5-(5-{6-[(4-tert-butoxypyridin-2-yl)amino]-4-methylpyridin-2-yl}-1,3-thiazol-2-yl)-5-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;5-[5-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methylpyridin-2-yl)-1,3-thiazol-2-yl]-5-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;5-[5-(6-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]amino}-4-methylpyridin-2-yl)-1,3-thiazol-2-yl]-5-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;5-{5-[6-({4-[4-(2-aminoethyl)piperazin-1-yl] ...
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