08-08-2023 дата публикации
Номер: CN116554120A
Принадлежит:
The invention discloses a preparation method of 2-amino-2-thiazoline, and belongs to the technical field of organic synthesis, the preparation method comprises the following steps: addition reaction: chlorination addition reaction; the chlorination addition reaction comprises the following steps: adding a reaction mother solution, thionyl chloride and N, N-dimethylformamide into a reaction kettle, heating to reflux, keeping the temperature for 3-5 hours, then adding purified water, adjusting the pH to 7 by using a sodium hydroxide aqueous solution, stirring, extracting, evaporating to dryness, recovering a solvent, and drying to obtain 2-amino-2-thiazoline; the method has the advantages of no need of additional addition of acid for catalysis, single reaction solvent, low boiling point of the solvent, facilitation of solvent recovery, cost reduction, strong reaction selectivity, low-price and environment-friendly raw materials, reduction of the generation of waste ammonium salt, strong economical ...
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