15-08-2019 дата публикации
Номер: WO2019156498A1
Автор:
KIM, No Soo,
KIM, Young-Ah,
KIM, Jin Hee,
SHIN, Sarah,
YI, Jin-Mu,
BANG, Ok-Sun
Принадлежит:
The present invention relates to a composition comprising a Sicyos angulatus extract as an effective ingredient for prevention, alleviation, or treatment of diseases attributed to side effects of an anticancer agent. The Sicyosangulatus extract of the present invention can noticeably recover the survival of hematopoietic stem cells decreased by the administration of anticancer agents, increase expression levels of hematopoiesis-related cytokines (IL-3, IL-6, and IFN-γ), alleviate the hematopoietic toxicity caused by anticancer agents having various acting mechanisms as well as promoting the growth of primary splenic immune cells and NO production in exvivo models, and alleviate hematopoietic toxicity even in invivo models. Therefore, the Sicyos angulatus extract of the present invention can be used as a drug product, a health food, or a supplementary anticancer agent for prevention, alleviation, or treatment of diseases attributed to side effects of anticancer agents.
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