합다리나무 추출물을 유효성분으로 함유하는 다약제 내성 암의 예방 또는 치료용 약학 조성물 및 건강기능식품
The present invention refers to the total leg tree ( Tumor (tumor) in excess of abnormal cells is caused by the non-number [e[e] disordered and abnormal cellular proliferation by decomposition, destructive proliferative, infiltration and metastatic malignancies (malignant tumor) is reduced surface to classification with each other. 3 essentially treating malignancies method is therapy i.e., radiation therapy, surgical surgery and chemotherapy uses, etc. through one or a combination thereof one of treating cancer. Prevention of cancer therapy in cancer chemotherapy or metabolism by perturbing the number used to treating cancer which, true number is not developed as anticancer treatment number cladding and, further side effects induced by anticancer number number number is a virtual representation of very low resistance due to cancer or cancer, the adjunct treatment directly sends a short life number helps with the lugs extending degree are disclosed. Anticancer number using number of disorders like cancer treatment is under or over large resistant cancer cells. Most of the cancer gene variant billion number associated with function is already lost state, one arm mass within each of various gene expression patterns having cells also to be coated. The majority of the genetic diversity number ultimately anticancer treatment using chemical resistant cells are cancer number due to selectively all the companies, the number and the eventual mass of most cancer cells proliferation resistance companies kind anticancer resistant cancer cells number to be coated. In addition to genetic diversity due to anticancer number resistance mutations, the side effects of administering sufficient amount of anticancer number patient too far or transmits, when oral administration is abnormally times of drug intake, or physiologically between tissue cells to vascular arm shaped part number as cable number barriers can be through an anticancer drug resistance. Furthermore, many cases a broad substrate specificity anticancer cell number to an attaching member transporter (transporter) due to, be similar in other types of anticancer number can then be mixed to control both. Or anticancer number but number of absorbent, number of membrane lipid accumulation of number can be relayed in cancer cells via change, resistant cells may be simultaneously visible resistance about number relative to the completely different anticancer number number resistance (MDR, multi drug resistance) is, about having to be coated. Thereby treating the cancer is resistant advance order receipt number simply administering anticancer number different types cannot be anticancer door pin is point number. On the other hand, the total leg tree belonging to the genus meliosma myriantha meliosma myriantha and which, is the size of one or several small big height tree leaf to stem 8 provided 10m wide leaf and stem is becoming twisting grew into diver who is in many cases disclosed. Extending obliquely above and I [twung under smoking is a power supply via the network. Where a polyaddition western-style paper [lu reside south and case under roh [lu roentgen per hour at one meter features mainly format. 5-a 10 cm length 9 - 15 degree of leaf divided depending the leaf it decreases, magazines shift odd feather relative to one other. As long pointed egg shape of ellipsoidal and tail end edge whose teeth it is rare and it is rare and in 2000. Leather feels as tough disclosed. The rear leaf pulse hair using silicon rubber a large family. The pin is to leaf sack hair using silicon rubber. In autumn gilded machines and other. 6 - 7 with the pin end and a month is roh column year S. white. As each shift is to pull the end cone and is combined with a flower and end and I think phalaenopsis cracks, such as crack length as to shift with each end and I think phalaenopsis is flower combined with a substrate. Cancerous flower to one possibility flower and wooden pins substrate. The surgery without possibility flower 5 [hes possibility among alcoholic beverage among among pollen and 2, 3 times than the petals 3 field calyx of flower leaves and greater. The promoter having two cancerous flower is 1, calyx of flower leaf 4 field are disclosed. 9 - 10 a month with 7 mm diameter rigid degree rounded fruit is red to nuclear impressed seeds chopped hay substrate. Even winter having suspended disclosed. Young tree to represent a gray light and light brown 72 [mis under disclosed. Brown powder [mis under this region can comprise a light grey a spot that a shallow horizontal corrugated longitudinally while some cracks substrate. Brown shell longitudinal eye be divided. Edge 72 yellow light brown stone methods and systems are also disclosed. Brown tint inside a broad shape white brown sequentially shim of 2000. The very middle small monitoring device 2000 is white brown inside auricle. Light brown to represent a green band multivalent are a light grey is gradually having hat. If thick gray powder strip substrate. [Ccwu writing [ccwu writing wrinkles be reinforcing and short forms. An example of the total leg tree extract relating to my degree thesis number known as expansion school master (2012. 02) to the total leg tree ( The present invention refers to said elicited to request such as provided, the present invention refers to the total leg tree ( In order to achieve said purposes, the present invention refers to the total leg tree ( In addition, the present invention refers to the total leg tree ( In addition, the present invention refers to the total leg tree ( The present invention refers to the total leg tree ( Figure 1 the total leg tree extract ( The present invention refers to the total leg tree ( Said composition containing the, C1 To C4 Extraction into a solvent of lower alcohols or mixtures thereof preferably, said lower alcohols preferably but not limited to methanol or ethanol. said total leg tree ( The total leg tree to extract said steps of bath including manufacturing method preferably but not limited to number by: 1) applied in the total leg tree extraction solvent extracting; 2) step 1) extract of filtering step; and 3) step 2) filtering cream extract after drying. In said method, step 1) or a like number of the total leg tree cultivation can be grudge without using commercially available. In said manufacturing method, the total leg tree extract extraction is propylene, human health, immersion extraction, extraction and ultrasonic extraction using publicly known conventional method such as reflux cooling all contrast can be. Said volume of 2 to 20 times the total leg tree includes a dry extraction solvent extraction preferably added. Extraction temperature is preferably 20 to 50 °C does not limited. In addition, extraction time is preferably 10 to 100 times, specifically preferably function of 24 to 96, more specifically 72 time most preferably does not limited. In said method, step 3) the decompression of enrichment is limited using vacuum decompression thickener or vacuum rotary Eq preferably does not. In addition, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited. Said arm is lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, colon cancer, skin cancer, bladder cancer, prostate cancer, ovarian cancer, cervical cancer, thyroid cancer, renal cancer, fiber sarcoma, melanoma and blood cancer cancer but without transferring any preferably selected from, but not limited to and, cancer diagnosis if the number does not relayed. Antitumor antibiotics is, about said number is number (antitumor antibiotics), phase rational nitrification enzyme billion (topoisomerase inhibitor) or taxane (taxane) based anticancer handler number number number, does not limited to, clinical, pharmaceutical or therapeutic lifestyle including all anticancer number can be available. Antitumor antibiotic is clarithromycin (actinomycin D) D misfortune mote roh e said number (antitumor antibiotics), [pul[pul] five feed sulfate (bleomycin sulfate), capsaicin (daunomycin) multi right roh e, multi right deer rain shoes (daunorubicin), doxorubicin (doxorubicin), epitaxial (epirubicin) doxorubicin, doxorubicin (idarubicin) it is a child, american toe (mitomycin) erythromycin, erythromycin (mitomycin-a C) - C american toe, and least one mitt feed (mitramycin) may be selected from, said phase rational nitrification enzyme billion (topoisomerase inhibitor) is irinotecan (irinotecan) number number, camp camptothecin (camptothecin), norbornene biot new (novobiocin), epitaxial doxorubicin (epirubicin), leucine (dactinomycin) [tak mote roh e, cancerous company clean (amsacrine), daunomycin (etoposide) least one reel [ni gun hour [tu etoposide (teniposide) and can be selected from, said paclitaxel (paclitaxel) or docetaxel (docetaxel) taxane (taxane) based anticancer number is one having a number but not relayed. In the present invention 'resistance' or 'number is, about anticancer number resistance' number when using the anticancer cancer patients, the therapeutic effects of which initially or treatment that is not effective velocity but, when compared to the treatment, reduce lost or cancer which means that the other. Various oral or parenteral composition of the present invention be a type number. Number number number if said composition under anger filling normally used, a specific number, number coupled, wet number, number disintegrating, dilution number or excipients such as surfactants using tank number number number with each other. Positive number number number is solid for oral administration, ring number, acid number, number granules, such as included in a capsule number, one or more compounds of at least one excipient such solid number number number for example, starch, calcium carbonate, sucrose (sucrose) or lactose (lactose), gelatin tank pressure is lowered number with each other. In addition, simple number excipients in addition to the magnesium salt of stearic acid, talc such as lubricating number are also are used. For oral administration include liquid suspension number number number, content number, number or syrup number corresponding to oil and the like, commonly used in a simple water dilution number, in addition to the paraffin droplet number various excipients, for example wet number, sweetener number, direction number or preserving number can be like. For parental administration number number is a sterile aqueous solution, non-aqueous for number, number for suspension, oil number, number and the like left freeze-dried number number or multiple myelomas are included. Number include propylene glycol (propylene glycol) and suspension for non-aqueous for number, polyethylene glycol, vegetable oil such as olive oil, such as the [ley which comes the [thu and ethyl ester is used as the injectable can be. As above [theyp brush left number for number (witepsol), mark with goal, twin (tween) 61, carcass five fingers, that it soaked, glycerol, gelatin or the like can be used. Oral or parenteral composition of the present invention can be administered, either intraperitoneally or external skin upon parenteral administration, rectal, intravenous, muscle, subcutaneous, intrauterine epidural or preferably in scan mode selecting the above described shortcomings. Pharmaceutically effective amount of a composition of the present invention is administered. In the present invention, 'pharmaceutical effective amount' rational possibility [hyey/ risk ratio applicable to medical treatment in an amount sufficient to treat conditions and means, effective capacity level type of patient disease, severity, drug, drug sensitivity, administration time, routes and discharge rate, a treatment period, simultaneous use the sealed elements and other medical fields can be determined according to well-known element. Composition of the present invention individual treatment or administration of other therapeutic number number on with administration of treatment on number of the existing method can be sequential or concurrent administration also can be, can be single or multiple administration. Said components in an amount of at least maximum effect can be obtained without adverse considers both the amount administered important, this can be determined by one skilled for hereinafter. Body weight of patients doses of the present invention composition, age, sex, health condition, dietary, administration time, administration method, excretion rate range along with a variety of severe diseases and which generates, based on the amount of the total leg tree extract daily dosage is 0. 01 and to 1000 mg/kg, preferably between 30 and 500 mg/kg, more preferably 50 to 300 mg/kg and, by administering a single day 1 - 6 can be. However routes, the severity of obesity, sex, weight, age or the like the method of the present invention rotates said even decrease or limit the scope are not correct any dose. Composition of the present invention alone, or surgical, radiation therapy, hormone therapy, using chemotherapeutic and biological reaction control number method and can be used in combination with. In addition, the present invention refers to the total leg tree ( Said composition containing the, C1 To C4 Extraction into a solvent of lower alcohols or mixtures thereof preferably, said lower alcohols preferably but not limited to methanol or ethanol. said total leg tree ( The total leg tree to extract said steps of bath including manufacturing method preferably but not limited to number by: 1) applied in the total leg tree extraction solvent extracting; 2) step 1) extract of filtering step; and 3) step 2) filtering cream extract after drying. In said manufacturing method, step 1) or a like number of the total leg tree cultivation can be grudge without using commercially available. In said manufacturing method, the total leg tree extract extraction is propylene, human health, immersion extraction, extraction and ultrasonic extraction using publicly known conventional method such as reflux cooling all contrast can be. Said leg volume of 2 to 20 times the sum includes a dry extraction solvent extraction preferably added. Extraction temperature is preferably 20 to 50 °C does not limited. In addition, extraction time is preferably 10 to 100 times, specifically preferably function of 24 to 96, more specifically 72 time most preferably does not limited. In said method, step 3) the decompression of enrichment is limited using vacuum decompression thickener or vacuum rotary Eq preferably does not. In addition, drying reduced pressure drying, vacuum drying, boiling drying, preferably spray-dried or lyophilized does not limited. Said arm is lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, colon cancer, skin cancer, bladder cancer, prostate cancer, ovarian cancer, cervical cancer, thyroid cancer, renal cancer, fiber sarcoma, melanoma and blood cancer cancer but without transferring any preferably selected from, but not limited to and, cancer diagnosis if the number does not relayed. Antitumor antibiotics is, about said number is number (antitumor antibiotics), phase rational nitrification enzyme billion (topoisomerase inhibitor) or taxane (taxane) based anticancer handler number number number, does not limited to, clinical, pharmaceutical or therapeutic lifestyle including all anticancer number can be available. Antitumor antibiotic is clarithromycin (actinomycin D) D misfortune mote roh e said number (antitumor antibiotics), [pul[pul] five feed sulfate (bleomycin sulfate), capsaicin (daunomycin) multi right roh e, multi right deer rain shoes (daunorubicin), doxorubicin (doxorubicin), epitaxial (epirubicin) doxorubicin, doxorubicin (idarubicin) it is a child, american toe (mitomycin) erythromycin, erythromycin (mitomycin-a C) - C american toe, and least one mitt feed (mitramycin) may be selected from, said phase rational nitrification enzyme billion (topoisomerase inhibitor) is irinotecan (irinotecan) number number, camp camptothecin (camptothecin), norbornene biot new (novobiocin), epitaxial doxorubicin (epirubicin), leucine (dactinomycin) [tak mote roh e, cancerous company clean (amsacrine), daunomycin (etoposide) least one reel [ni gun hour [tu etoposide (teniposide) and can be selected from, said paclitaxel (paclitaxel) or docetaxel (docetaxel) taxane (taxane) based anticancer number is one having a number but not relayed. In the present invention 'health food' application cottonseed meal food or nutrients that are prone to deficient in raw materials or components using high pressure liquid coolant to number (functional materials), human health through the central or normal physiology activation maintaining or improving food safety bureau chief meaning that the pharmaceuticals are timed food, not limited to conventional meaning of health food including both sense less than 2000. Number said sealer is coated in the health food, capsule, powder, granules, liquid, like in the form of ring number tank, processing but, not limited to law with number bath according to some aspects, can be processed. The total leg tree extract of the present invention can be use with other food it is either adding food or food ingredients, can be suitable for use in accordance with the conventional method. Mixing of active ingredient amount according to its intended use (for treatment or prevention of) can be determined. Generally, any additive effect health food weight of 0 said total amount of the compound. 1 to 90 parts by weight can be applied. However health and hygiene purposes or in the case of ingestion of the amount said range said health control can have long term is hereinafter, door number because as the active ingredient in the aspect of safety insofar as an amount of at least said range can be also be used. As a health drink composition of the invention containing other ingredients except that said ratio indicated as essential ingredients is simplified and number one free lower number or natural carbohydrate give excellent flavor is conventional beverage can be the active ingredient. An example of the above-described natural carbohydrate mono pathogenic agent, e.g., glucose, such as oligosaccharides; d company kara id, e.g. liver, such as sucrose; and polysaccharide, for example dextrin, cyclodextrin such as conventional sugar, and xylitol, sorbitol, such as processes for the preparation of party alcohol [thol[thol] among others. Other than the above-described number flavor as natural flavor number (TAU denaturing, Stevia extract (e.g., [ley[ley] right D coming [tu[tu] A, such as writing hour [lu position) and synthetic flavor (saccharin, aspartame or the like) can be advantageously used a number. In addition to the integration of the present invention said nutritional number the total leg tree extract, vitamin, mineral (electrolyte), synthetic flavor number number number of flavor and natural flavor, colored number and prominent figure number (cheese, such as chocolate), [pheyk the [thu it buys and salts thereof, alginic acid and salts thereof, organic acid, protective colloidal thickening number, pH control number, stabilizing number, antiseptic number, glycerin, alcohol, number of calcium hydroxide can be used in carbonated beverages and the like. In addition to the total leg tree extract of the present invention natural fruit juice and number of fruit juice beverage and vegetable beverages containing pulp can be for numerical control machine. These components can be used in combination or independently. The triazines of the present invention the ratio of the total leg tree extract 100 but not so important parts added number 0. 1 to about 20 parts by weight of generally is selected from the range are disclosed. In addition, the present invention refers to the total leg tree ( Hereinafter, the present invention broadcast receiver using more detailed in the embodiment. In the embodiment of the present invention is more specifically describe the present invention only these for the number one is a person with skill in the art that these range by not notified to the reduced in the art are disclosed. In the embodiment 1. The total leg tree extract number bath The total leg tree ( In the embodiment 2. The total leg tree extract on the payout rate identifying normal cell survival In survival of normal cells to identify said in the embodiment 1 on the payout rate for the total leg tree extract prepared by the number, MTS (3 - (4, 5 a-dimethylthiazol-a 2 a-yl) - 5 - (3 a-carboxy methoxy phenyl) - 2 - (4 a-sulfophenyl) - 2H-a tetrazolium salt) experiment method has been confirmed that the survival rate of cells. Specifically, 1 × 10 96 well plate3 Normal cells of normal cell lines (IMR90) waste of colon normal cell lines a suitable culture medium (CCD provided 112Co and CCD provided 18Co) after dividing with 100 micro l, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. After the total leg tree extract obtained in 100 micro g/Ml treated after said in the embodiment 1, 48 him as additional time. Culture medium number and a stand-alone, following addition of 100 micro l MTS solution, by reacting about 1 - 3 time, measured in absorbance 490 nm, measuring absorbance value (relative proliferation index) determined the voice controls of relative lifestyle field index. As a result, the disclosure also 1 as, active ingredient of the invention herein the total leg tree 3 species without affecting normal cell lines that almost polyphenol extract has been confirmed. In the embodiment 3. The total leg tree extract attention on the payout rate identifying cancer cell survival The total leg tree prepared by the number attention on the payout rate for identifying cancer survival in said in the embodiment 1 to extract, MTS (3 - (4, 5 a-dimethylthiazol-a 2 a-yl) - 5 - (3 a-carboxy methoxy phenyl) - 2 - (4 a-sulfophenyl) - 2H-a tetrazolium salt) experiment method has been confirmed that the survival rate of cells. Stomach cancer derived cell lines SNU638 is Korean cell line bank, it gives a cancer cell line (ATCC: American Type Culture Collection) seller from U.S. bank remaining 17 species using the air. Specifically, 5 × 10 96 well plate3 18 15 kDa species of suitable culture medium after dividing cancer cells with 100 micro l, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. After the total leg tree extract obtained in 100 micro g/Ml treated after said in the embodiment 1, 48 him as additional time. Culture medium number and a stand-alone, following addition of 100 micro l MTS solution, by reacting about 1 - 3 time, measured in absorbance 490 nm, measuring absorbance value (relative proliferation index) determined the voice controls of relative lifestyle field index. As a result, as disclosure to table 1, the total leg tree extract lung cancer are (Lung cancer), breast cancer (Breast cancer), hepatocellular carcinoma (Liver cancer), cervical cancer (Cervix cancer), cancer (Fibrosarcoma) sarcoma, colon cancer (Colorectal cancer), stomach cancer (Stomach cancer), minimum 50% 95% or more of inhibiting skin cancer (Skin cancer) in relativity field strong cytotoxicity to cells has been confirmed. In the embodiment 4. The total leg tree Extract MDR(MultidrugResistance) Influence the cell identifying 1) The total leg tree By extract HL-60/MX2 Lines Survival rate Change Acute promyelocytic leukemia (Acute promyelocytic leukemia) cell line (ATCC CCL-a 240) HL-a 60 of a patient's blood isolated from blood cancer cell lines, such as anticancer activity of cell number search widely used are disclosed. HL-a 60/MX2 (ATCC CRL-a 2257) cell lines HL-a 60 cancer cell number (mitoxantrone) electromagnetic wave is derived cell lines resistant to long-term exposure to anticancer number american toe oestrone acid oxide inclusion content. The number is a number in the embodiment 4 is, about said resistance in cancer cell lines HL-a 60/MX2 was verifying resistance. Specifically, cell line (ATCC) seller in U.S. bank lines HL-a 60 and HL-a 60/MX2, doxorubicin (doxorubicin, 500 nm) of a relative survival rates (viability) processing said in the embodiment 2 is identical to the method has been confirmed. As a result, capillary gun week (HL-a 60) when compared to doxorubicin (doxorubicin) cell line HL-a 60/MX2 is provided which shows resistance has been confirmed that the anticancer number (2 also). In addition, in ruby shoes toxin active ingredient of the present invention shows anti-resistant cell line HL-a 60/MX2 number the total leg tree extract processing result, the total leg tree extract HL-a 60/MX2 inducing cytotoxicity against cancer cell lines reduces the number has been confirmed that the cancer is resistant to anticancer were (2 also). 2) The total leg tree By extract H69/AR Lines Survival rate Change H69 (small cell lung cancer) (ATCC HTB provided 119) cell lines small cell lung cancer cell lines that have been split from which gun lung cancer patient cancerous lump, H69/AR H69 cell line (ATCC CRL-a 11351) cell lines over a number oh [tu oh feed (adriamycin) anticancer electromagnetic wave is 14 months while increasing concentration derived cell lines resistant to culturing are disclosed. The number is a number in the embodiment 4 is, about said resistance in cancer cell lines was H69/AR verifying resistance. Specifically, H69 cell line (ATCC) seller in U.S. bank lines and H69/AR, doxorubicin (doxorubicin, 1 μm) of a relative survival rates (viability) processing said in the embodiment 2 is identical to the method has been confirmed. As a result, capillary gun week (H69) doxorubicin (doxorubicin) cell lines when compared to the H69/AR is provided which shows resistance to anticancer number has been confirmed (3 also). In addition, resistant cell lines of the present invention shows anti-number in ruby shoes toxin active ingredient and the total leg tree extract processing result, inducing cytotoxicity against cancer cell lines and reduces the total leg tree extract H69/AR number has been confirmed that the cancer is resistant to anticancer were (3 also). 3) cell survival rate by the total leg tree extract MES provided SA/MX2 and MES-a SA/Dx5 change Cell line (ATCC CRL-a 1976) uterine cancer tissue of cancer patients is MES provided SA sarcoma cell lines isolated from said cell lines derived from cancer cell lines (ATCC CRL-a 2274) 2 species on a number resistance MES provided SA/MX2 (ATCC CRL-a 1977) is a widely known MES provided SA/Dx5 MDR (multidrug resistant gene) resistance gene are the product number P - (P-a glycoprotein) writing nose protein is, about protein is resistant cancer is colon cancer representative anticancer number main oxide inclusion content. The number 2 in the embodiment 4 is, about a species in said cancer cell resistance (MES provided SA/MX2, MES provided SA/Dx5) number was verifying resistance. Specifically, MES provided SA, cell lines (ATCC) seller in U.S. bank MES provided SA/MX2 and MES-a SA/Dx5, doxorubicin (doxorubicin, 1 μm) of a relative survival rates (viability) processing said in the embodiment 2 is identical to the method has been confirmed. As a result, when compared to the capillary gun week (MES provided SA) doxorubicin (doxorubicin) number for MES provided SA/MX2 and MES-a SA/Dx5 cell lines (4 and 5 also) has been confirmed that the anticancer effect on resistance. In addition, resistant cell lines of the present invention shows anti-number in ruby shoes toxin active ingredient and the total leg tree extract processing result MES provided SA/Dx5 MES provided SA/MX2 and, inducing cytotoxicity against cancer cell lines and reduces the total leg tree extract MES provided SA/MX2 and MES-a SA/Dx5 number has been confirmed that the cancer is resistant to anticancer were (also 4 and 5). In the embodiment 5 The total leg tree By drug resistance protein extract discharge (Efflux) Control Number anticancer drug resistance gene mediated discharge of visible cells may be cells which are the product out from the inner (multidrug resistance gene) has been colon cancer MDR1 and MRP1 protein has been confirmed. Specifically, cervical sarcoma cell lines resistant to anticancer number on lung cancer cell line (MES provided SA/MX2 and MES-a SA/Dx5) (H69/AR) are separated from each other to confirm the MDR1 and MRP1 [pul[pul] protein from the [wey the [su it shook off his (6 also) is colon cancer. Then, the fluoresce in the Calcein AM MDR protein matrix into the cell number resistance assay (multidrug-a resistance assay) methods using is, about using a MDR protein drugs by (anticancer number) (discharge) sum leg extract for transporting a billion number has been confirmed. Specifically, 5 × 10 96 well plate4 Number of suitable culture medium after dividing with 100 micro l anticancer cancer resistance 15 kDa, 24 hours 5% CO2 (Humidified) was culture containing a humidifying. Then add the total leg tree extract obtained after processing in said in the embodiment 1, him as additional 30 minutes. After adding each well 2 times concentrated Calcein provided AM solution, 30 minutes again him as. Plate 400 × g at room temperature in centrifuging, number and carefully dissolves a stand-alone, and in excited in a fluorescent plate reader (excitation) following addition of media 200 micro l 485 nm, 535 nm to measure fluorescence in, voice controls fluorescence measuring value shown in relative values (normalized calcein AM fluorescence). As a result, the total leg tree extract different cancer cell lines expressing the invention number resistance and both number resistance gene, MDR protein produced in (7 also) and MES-a SA/Dx5 H69 provided AR (also 8) transport of number billion to substrate, controls than statistically significant intracellular calcein-a AM held high concentration has been confirmed. A transparent conductive layer disposed dispersion analysis (one a-way ANOVA) embodiment a statistical processing covalently, controls (group Vehicle) decided on the Bonferroni post assay was analyzed with significant show differences in manufacturing method (p<0. 05). The present invention refers to the total leg tree ( The total leg tree ( According to Claim 1, said composition containing the, C1 To C4 Extraction into a solvent of lower alcohols or mixtures thereof characterized in pharmaceutical compositions. According to Claim 2, characterized in that said lower alcohol is methanol or ethanol pharmaceutical compositions. According to Claim 1, said total leg tree ( Back number Back number Back number Back number Back number The total leg tree ( According to Claim 10, said total leg tree ( The total leg tree (Origin tissue Cell lines Cell survival rate (mean ± S. D. , %) Waste (Lung) A549 23. 8 ± 3. 9 H460 4. 9 ± 0. 2 H1299 102. 1 ± 1. 2 Breast (Breast) MCF-a 7 90. 7 ± 3. 2 MDA-a MB231 37. 2 ± 7. 5 (Liver) between HepG2 4. 7 ± 1. 5 Hep3B 7. 1 ± 3. 3 Cervical (Cervix) HeLa 3. 4 ± 0. 6 Fiber breeding (Fibrosarcoma) HT1080 12. 4 ± 1. 8 Prostate (Prostate) DU145 60. 1 ± 3. 2 PC-a 3 61. 9 ± 15. 9 Colon (Colorectal) CoLo205 7. 8 ± 0. 0 HCT116 12. 0 ± 0. 2 Skin (Skin) SK-a MEL-a 5 49. 3 ± 0. 9 SK-a MEL-a 28 52. 1 ± 0. 5 (Stomach) on SNU638 3. 3 ± 0. 1 (Kidney) elongated ACHN 76. 4 ± 1. 4 Caki-a 1 61. 9 ± 3. 1
