14-11-2013 дата публикации
Номер: US20130303546A1
Described herein are injectable compositions containing non-sedating or second and third generation antihistamines such as cetirizine/levocetirizine and methods of use thereof. Specifically, methods of treating acute urticaria or angioedema associated with an acute allergic reaction are disclosed. In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms with the same number of mg of cetirizine. 1. A method of treating a patient in need of injection with cetirizine , comprising , comprisingadministering to the patient an intramuscular injection of an injectable cetirizine composition containing 2 mg to 20 mg of cetirizine,wherein at least about 5 ng/mL of cetirizine appears in the patient's bloodstream within about 4 minutes of administration.2. The method of claim 1 , wherein the patient is in need of treatment for acute urticaria or angioedema associated with an acute allergic reaction claim 1 , wherein the acute allergic reaction optionally includes anaphylaxis.3. The method of claim 1 , wherein it is not feasible to administer oral cetirizine to the patient. This application is divisional of U.S. application Ser. No. 13/238,453 filed on Sep. 21, 2011, which is a continuation in part of U.S. application Ser. No. 12/829,857 filed on Jul. 2, 2010, now U.S. Pat. No. 8,314,083 issued Nov. 20, 2012, which is a continuation in part of U.S. application Ser. No. 12/704,089 filed on Feb. 11, 2010, now U.S. Pat. No. 8,263,581 issued Sep. 11, 2012, which is a nonprovisional of U.S. Provisional Application Ser. Nos. 61/248,441 filed Oct. 3, 2009 and 61/222,951 filed Jul. 3, 2009, all which are hereby incorporated by reference in their entirety.Acute allergic reaction, ranging from the milder cases of acute urticaria to the most severe cases of anaphylaxis, is a systemic, immediate hypersensitivity reaction caused by exposure to a specific antigen. The immune system activates immunoglobulin E (IgE), which reacts with ...
Подробнее