07-07-2016 дата публикации
Номер: US20160193195A1
Принадлежит:
Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia diseases. 2. The use of claim 1 , wherein claim 1 , each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Ris independently hydrogen claim 1 , hydroxy claim 1 , halogen claim 1 , a substituted or unsubstituted C1-C4 alkoxy claim 1 , a substituted or unsubstituted C1-C4 alkyl claim 1 , a substituted or unsubstituted C2-C4 alkenyl claim 1 , a substituted or unsubstituted C2-C4 alkynyl claim 1 , a substituted or unsubstituted C3-C6 cycloalkyl claim 1 , a substituted or unsubstituted benzyloxy claim 1 , wherein a substituent for substitution is halogen claim 1 , hydroxy claim 1 , amino or sulfonyl;{'sub': '3', 'Ris hydrogen, halogen, an unsubstituted or halogen-substituted C1-C4 alkyl, or an unsubstituted or halogen-substituted C1-C4 alkoxy;'}{'sub': 1', '2, 'Rand Rcan together form a substituted or unsubstituted 5-7 membered heterocycle, wherein a substituent for substitution is halogen or unsubstituted or halogen-substituted C1-C4 alkyl, and said heterocycle contains 1-3 heteroatoms selected from N, O, or S;'}{'sub': 4', '5', '6', '7, 'any two adjacent substituents of R, R, Rand Rcan together form a substituted or unsubstituted 5-7 membered heterocycle, wherein a substituent for substitutions is halogen, a unsubstituted or halogen-substituted C1-C4 alkyl or a unsubstituted or halogen-substituted C1-C4 alkoxy, and said heterocycle contains 1-3 heteroatoms selected from N, O, or S;'}the configuration of the chiral carbon atom in compound of general formula (I) is either R or S.3. The use of claim 1 , wherein claim 1 ,{'sub': 1', '2', '4', '5', '6', '7, 'each of R, R, R, R, Rand Ris independently hydrogen, hydroxy, halogen, a substituted or unsubstituted C1-C4 alkoxy, a substituted or unsubstituted C1-C4 alkyl, or a substituted or unsubstituted benzyloxy, wherein a substituent for substitution is halogen, ...
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