02-10-2014 дата публикации
Номер: US20140294866A1
Принадлежит:
The present invention provides methods for treating disorders arising from hypogonadism by administering myostatin antagonists to subjects suffering from such disorders. 2. The method of claim 1 , wherein the peptide is between 20 and 50 amino acids in length.3. The method of claim 1 , wherein the peptide is selected from the group consisting of SEQ ID NO: 305-308 claim 1 , 310-313 claim 1 , 315-331 claim 1 , 333 claim 1 , and 335-346.4. The method of claim 1 , wherein the peptide is SEQ ID NO:325.5. The method of claim 1 , wherein the myostatin binding agent has the structure:{'sup': 1', '1', '2, 'sub': a', 'b, '(X)—F—(X), or multimers thereof;'}{'sup': 1', '1', '2, 'wherein Fis a vehicle; and Xand Xare each independently selected from'}{'sup': 1', '1, 'sub': 'c', '-(L)-P;'}{'sup': 1', '1', '2', '2, 'sub': c', 'd, '-(L)-P-(L)-P;'}{'sup': 1', '1', '2', '2', '3', '3, 'sub': c', 'd', 'e, '-(L)-P-(L)-P-(L)-P;'}{'sup': 1', '1', '2', '2', '3', '3', '4', '4, 'sub': c', 'd', 'e', 'f, 'and -(L)-P-(L)-P-(L)-P-(L)-P;'}{'sup': 1', '2', '3', '4, 'sub': 1', '2', '3', '1', '2', '3, 'wherein P, P, P, and Pare peptides capable of binding myostatin, and each comprise CbbWbWMCPP (SEQ ID NO: 353), wherein bis selected from any one of the amino acids T, I, or R; bis selected from any one of R, S, Q; bis selected from any one of P, R and Q,'}{'sup': 1', '2', '3', '4, 'wherein L, L, L, and Lare each linkers;'}and subscripts a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and physiologically acceptable salts thereof.6. The method of claim 5 , wherein the peptide is between 20 and 50 amino acids in length.7. The method of claim 5 , wherein the peptide is selected from the group consisting of SEQ ID NO: 305-308 claim 5 , 310-313 claim 5 , 315-331 claim 5 , 333 claim 5 , and 335-346.8. The method of claim 5 , wherein the peptide is SEQ ID NO:325.9. The method of claim 5 , wherein the vehicle Fis an Fc domain.10. The method of claim 5 , wherein ...
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