01-08-2019 дата публикации
Номер: US20190233426A1
Автор:
Ho Man CHAN,
Xingnian Fu,
Xiang-Ju Justin Gu,
Ying HUANG,
Ling LI,
Yuan MI,
Wei QI,
Martin SENDZIK,
Yongfeng SUN,
Long WANG,
Zhengtian YU,
Hailong ZHANG,
Ji Yue ZHANG,
Man ZHANG,
Qiong ZHANG,
Kehao ZHAO,
CHAN HO MAN,
FU XINGNIAN,
GU XIANG-JU JUSTIN,
HUANG YING,
LI LING,
MI YUAN,
QI WEI,
SENDZIK MARTIN,
SUN YONGFENG,
WANG LONG,
YU ZHENGTIAN,
ZHANG HAILONG,
ZHANG JI YUE,
ZHANG MAN,
ZHANG QIONG,
ZHAO KEHAO,
CHAN, Ho Man,
Fu, Xingnian,
Gu, Xiang-Ju Justin,
HUANG, Ying,
LI, Ling,
MI, Yuan,
QI, Wei,
SENDZIK, Martin,
SUN, Yongfeng,
WANG, Long,
YU, Zhengtian,
ZHANG, Hailong,
ZHANG, Ji Yue,
ZHANG, Man,
ZHANG, Qiong,
ZHAO, Kehao
Принадлежит:
A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: 2. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein:{'sup': 3A', '3B', '3C', '3D', '3E', '3F', '3E', '3F', '3D', '3E', '3F, 'sub': m', '1', '4', '1', '4', '1', '4', '2', '2', '2', '1', '4', '3', '6, 'each Ris independently selected from: halogen, CN, —(O)—(C-Calkyl substituted with 0-1 R), C-Chaloalkyl, C-Chaloalkoxy, R, —C(═O)R, NRR, —C(═O)NRR, —S(═O)R, —S(═O)NRR, —NHS(═O)(C-Calkyl), and —O—C-Ccycloalkyl;'}{'sup': 6', 'b', '3E', '3D', '3D', '3D', '3E', '3F', 'b', 'b, 'sub': 2', '4', '1', '4', '2', '2', '1', '4', '1', '4', '2', '2', '2, 'Ris independently selected from: H, halogen, CN, C-Calkynyl, —CO(C-Calkyl), —COH, —CO(C-Calkyl), C-Calkyl substituted with 0-1 R, —C(═O)NRR, —S(═O)R, —S(═O)R, —S(═O)NRR, —CONHNH, phenyl substitituted with 0-1 R, oxazolyl, tetrazolyl, pyridyl substituted with 0-2 R;'}{'sup': a', 'b, 'sub': 1', '4', '1', '4', '2', '1', '4', '3', '6, 'each Ris independently selected from: H, →O, C-Calkyl substituted with 0-1 R, —C(═O)H, —C(═O)(C-Calkyl), —CO(C-Calkyl), and C-Ccycloalkyl;'}{'sup': '4', 'Ris H.'}3. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein:{'sup': '1', 'Ris independently H or F;'}{'sup': '2', 'Ris H; and'}{'sup': 3', 'a', '3A, 'Ris independently selected from: phenyl, and a 5- to 6-membered heteroaryl comprising carbon atoms and 1-2 heteroatoms selected from O, N and NR; wherein said phenyl and heteroaryl are substituted with 0-3 R;'}m is independently selected from 0 and 1; andn is O.8. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein:{'sup': '1', 'Ris F.'}9. A compound or a pharmaceutically acceptable salt thereof claim 1 , according to claim 1 , wherein said compound is selected from 8 (2 claim 1 ,4-dimethylpyrimidin ...
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