Beta:adrenergic-blocking, amino-hydroxy-propoxy isoquinoline derivs. - prepd. by reacting epoxy-propoxy-(2)-acyl-isoquinolines with amines
Номер патента: DE2620179A1
Опубликовано: 12-05-1977
Автор(ы): Albert Dipl Chem Dr Westermann, Dirk Dr Med Wuppermann, Frank Dr Med Zimmermann, Ludwig Dr Rer Nat Friedrich, Manfred Dr Rer Nat Raschack
Принадлежит: Knoll Gmbh
Опубликовано: 12-05-1977
Автор(ы): Albert Dipl Chem Dr Westermann, Dirk Dr Med Wuppermann, Frank Dr Med Zimmermann, Ludwig Dr Rer Nat Friedrich, Manfred Dr Rer Nat Raschack
Принадлежит: Knoll Gmbh
Реферат: New 2-acyl-isoquinoline derivs. are cpds. of formula (I) and salts: (where R1 is H or CH3; R2 is H or lower alkyl; R3 is H or OCHof and R4 is isopropyl or tert-butyl). (I) have high adrenergic beta-receptor blocking activity coupled with low toxicity. The beta-blocking activity can be detected on cardiac, vascular and bronchial receptors. Some cpds. (I) have a particular effect on the beta-receptors of the heart and are suitable for treating functional heart disorders. In general, (I) can be used for treating functional heart disorders, such as tachycardia, tachycardic disorders of heart rhythm, extrsystoles, angina pectoris, hyperkinetic heart syndrome etc., as well as hypertension. Specific cpds. (I) include 2-acetyl-1,2,3,4-tetrahydro-6-(2-hydroxy-3-tert-butylaminopropoxy- )-isoquinoline. In an example, this is prepd. by refluxing 2-acetyl-6-(2,3-epoxypropoxy)-1,2,3,4-tetrahydroisoquinoline withtert-butylamine.
Substituted isoquinoline derivatives and their use as anticonvulsants
Номер патента: US20030144320A1. Автор: Peter Edwards,Robert Ward,Mervyn Thompson. Владелец: SmithKline Beecham Ltd. Дата публикации: 2003-07-31.