Systems and methods for estimating cell source fractions using methylation information
Опубликовано: 27-10-2021
Автор(ы): Oliver Claude VENN
Принадлежит: Grail Inc
Реферат: Systems and methods are disclosed for determining a cell source fraction in a biological sample of a test subject. Nucleic acid fragments are obtained from a biological sample, comprising cell-free nucleic acid, of the test subject. A methylation state is obtained for each nucleic acid fragment in a first plurality of nucleic acid fragments. Each respective nucleic acid fragment is individually assigned a first score, thereby obtaining a first plurality of scores. Each respective score represents a likelihood that the corresponding nucleic acid fragment was obtained from a cell-free nucleic acid molecule associated with the first cell source. The first plurality of scores is transformed into a first plurality of counts, each count in the first plurality of counts being for a methylation site in a first predetermined set of methylation sites. A first cell source fraction for the test subject is estimated using the first plurality of counts.
Method for providing information of prediction and diagnosis of small vessel occlusion using methylation level of CYP26C1 gene and composition therefor
Номер патента: KR102085669B1. Автор: 박재호,김명선,차민호. Владелец: 한국 한의학 연구원. Дата публикации: 2020-03-06.