5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists
The present invention relates to novel phenylpyrrole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular as antipsychotic agents. European Patent Application No. 241053, describes compounds of the formula : wherein A is an unsaturated 5-membered heterocyclic ring, such as 2,5-pyrrolyl, or 3,5- or 1,4-pyrazolyl; X is a nitrogen or carbon atom; R1,R2, R3 are each hydrogen or alkyl; R4 is aryl, heteroaryl, arylcarbonyl or heteroaryl-carbonyl; R is selected from a variety of substituents and n is 0-4. The compounds are said to have antipsychotic properties. European Patent Application No. 259930 describes compounds of the formula : wherein A is an unsaturated 5-membered heterocyclic ring, such as 2,5-pyrrolyl, 1,4-pyrazolyl or 2,5-furyl; R is hydrogen, alkyl or optionally substituted phenyl; R1 is alkyl, alkenyl or forms a ring with the phenyl group; R2 is hydrogen, hydroxy or alkoxy; R3 is selected from a variety of substituents and n is 0-3. These compounds are also said to have antipsychotic properties. We have now found a novel class of 2-phenylpyrroles which have high affinity for dopamine D3 receptors and thus have potential as antipsychotic agents. In a first aspect the present invention provides compounds of formula (I) : wherein In the compounds of formula (I) an alkyl group or moiety may be straight or branched. Alkyl groups which may be employed include methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, n-pentyl; sec-pentyl, n-hexyl and the like. Aryl groups or moieties present in any of the substituents R2, R3, R4, R5, R6, R7, R9 and R10 in compounds of formula (I) are selected from phenyl, naphthyl, and tetrahydronaphthyl. Heteroaryl groups are selected from 5 and 6-membered heterocycles containing one or more oxygen, sulphur or nitrogen atoms, such as furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, pyridyl, pyridazyl, pyrimidyl and pyrazyl. Substituents for said aryl and heteroaryl groups are selected from halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyalkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyalkyl, C1-4alkanoyl, C1-4alkoxycarbonyl, amino and mono- or -dialkylamino. When - NR8R9 forms a heterocyclic ring, this preferably has from 4 to 10, e.g. 5 to 8 ring members, and it may be fully or partially saturated. The ring may optionally contain a sulphur atom, provided there are at least two methylene groups between the S and N atoms. A heterocyclic ring -NR8R9 may also be bridged, for example by a C1-3alkylene chain e.g. a methylene or ethylene group. Furthermore, the heterocyclic ring may be substituted, for example by one or more C1-4alkyl groups, or fused to an aromatic ring, such as phenyl. Representative heterocyclic groups include pyrrolidinyl, piperidinyl, 1,2,3,6-tetrahydropyridinyl, 1,2,3,4-tetrahydroisoquinolyl, hexahydroazepinyl, octahydroazocinyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, azabicylo[3.3.1]nonanyl and azabicyclo[3.2.2]nonanyl. When R1 and R2 together form a group -(CH2)mOp wherein p is 1 it will be appreciated that the oxygen atom is attached to the phenyl ring at the R2 position : When the (CH2)m moiety is substituted by two C1-4alkyl groups these are preferably substituted on the same carbon atom e.g. a gem-dimethyl substituent. R1 preferably represents methyl, ethyl or isopropyl. Preferably at least one of R2 to R5 is hydrogen, and the other substituents are selected from halogen, C1-2alkyl, C1-2alkoxy, C1-2alkylsulphonyl, phenylsulphonyl, CF3, CF3O and C1-2dialkylaminosulphonyl. When any of R2 to R5 represent halogen, this may be fluorine, chlorine, bromine or iodine. When Y is a group (a): It will be appreciated that for use in medicine the salts of formula (I) should be physiologically acceptable. Suitable physiologically acceptable salts will be apparent to those skilled in the art and include for example acid addition salts formed with inorganic acids eg. hydrochloric, hydrobromic, sulphuric, nitric or phosphoric acid; and organic acids eg. succinic, maleic, acetic, fumaric, citric, tartaric, benzoic, p-toluenesulphonic, methanesulphonic or naphthalenesulphonic acid. Other non-physiologically acceptable salts eg. oxalates, may be used, for example in the isolation of compounds of formula (I) and are included within the scope of this invention. Also included within the scope of the invention are solvates and hydrates of compounds of formula (I). When an asymmetric centre is present in a compound of formula (I) the compound will exist in the form of optical isomers (enantiomers). The present invention includes within its scope all such enantiomers and mixtures, including racemic mixtures, thereof. In addition, all possible diastereomeric forms (individual diastereomers and mixtures thereof) of compounds of formula (I) are included within the scope of the invention. Particular compounds according to the invention include : The present invention also provides a process for preparing compounds of formula (I) which process comprises : The Mannich reaction according to process (a) may be effected according to conventional methods. Thus for example the amine HNR8R9 may first be reacted with formaldehyde and the product subsequently reacted with a compound of formula (II). The reaction is preferably effected in a protic solvent, for example an alcohol such as ethanol. An organic or inorganic acid, e.g. acetic acid may be employed as a catalyst. The Vilsmeier reaction according to process (b)may also be effected according to conventional methods. Thus, for example, the amide R7C(O)NR8R9 may first be reacted with phosphorus oxychloride and the resulting product subsequently reacted with a compound of formula (II). The product of this reaction is then reduced with, for example, sodium borohydride or cyanoborohydride. These reactions are preferably carried out in a non-protic solvent, for example dichloroethane or dichloromethane. Reductive amination according to process (c) will generally be carried out using a reducing agent such as sodium borohydride or cyanoborohydride and in the presence of a Lewis acid such as titanium (IV) chloride. Reaction of a compound (III) with the amine may conveniently be effected in a solvent such as dichloromethane or dichloroethane. A compound of formula (II) may be prepared by cyclisation of a dicarbonyl compound of formula (IV) : The reaction may be effected using an ammonium salt, e.g. ammonium acetate, in a solvent such as ethanol. (See, for example, C.G. Kruse et al., Heterocycles, vol 26, P3141, 1987). A compound of formula (IV) may itself be prepared by reacting the appropriate substituted benzoyl halide with a metallo derivative of a 2-(2-haloethyl)-1,3-dioxolane and subsequent acid hydrolysis. A compound of formula (III) may be prepared by carrying out a Vilsmeier reaction in which dimethylformamide is reacted with phosphorus oxychloride and the product reacted with a compound of formula (II), in a solvent such as dichloroethane, folowed by acid hydrolysis. When a compound of formula (I) is obtained as a mixture of enantiomers these may be separated by conventional methods such as crystallisation in the presence of a resolving agent, or chromatography, for example using a chiral HPLC column. Compounds of formula (I) have been found to exhibit affinity for dopamine receptors, in particular the D3 receptor and are expected to be useful in the treatment of disease states which require modulation of such receptors. Said compounds exhibit higher affinity for dopamine D3 receptors than for dopamine D2 receptors and may advantageously be used as selective modulators of the D3 receptor. In particular compounds of formula (I) are dopamine D3 receptor antagonists and as such are of potential use as antipsychotic agents for example in the treatment of schizophrenia, schizo-affective disorders, psychotic depression and mania. Other conditions which may be treated by modulation of the D3 receptor include dyskinetic disorders such as Parkinson's disease, neuroleptic-induced parkinsonism and tardive dyskinesias; depression; and drug (eg. cocaine) dependency. The invention also provides the use of a compound of formula (I) or a physiologically acceptable salt thereof in the manufacture of a medicament for the treatment of conditions which require modulation of the dopamine D3 receptor, for example psychoses such as schizophrenia. For use in medicine, the compounds of the present invention are usually administered as a standard pharmaceutical composition. The present invention therefore provides in a further aspect pharmaceutical compositions comprising a novel compound of formula (I) or a physiologically acceptable salt thereof and a physiologically acceptable carrier. The compounds of formula (I) may be administered by any convenient method, for example by oral, parenteral, buccal, sublingual, nasal, rectal or transdermal administration and the pharmaceutical compositions adapted accordingly. The compounds of formula (I) and their physiologically acceptable salts which are active when given orally can be formulated as liquids or solids, for example syrups, suspensions or emulsions, tablets, capsules and lozenges. A liquid formulation will generally consist of a suspension or solution of the compound or physiologically acceptable salt in a suitable liquid carrier(s) for example an aqueous solvent such as water, ethanol or glycerine, or a non-aqueous solvent, such as polyethylene glycol or an oil. The formulation may also contain a suspending agent, preservative, flavouring or colouring agent. A composition in the form of a tablet can be prepared using any suitable pharmaceutical carrier(s) routinely used for preparing solid formulations. Examples of such carriers include magnesium stearate, starch, lactose, sucrose and cellulose. A composition in the form of a capsule can be prepared using routine encapsulation procedures. For example, pellets containing the active ingredient can be prepared using standard carriers and then filled into a hard gelatin capsule; alternatively, a dispersion or suspension can be prepared using any suitable pharmaceutical carrier(s), for example aqueous gums, celluloses, silicates or oils and the dispersion or suspension then filled into a soft gelatin capsule. Typical parenteral compositions consist of a solution or suspension of the compound or physiologically acceptable salt in a sterile aqueous carrier or parenterally acceptable oil, for example polyethylene glycol, polyvinyl pyrrolidone, lecithin, arachis oil or sesame oil. Alternatively, the solution can be lyophilised and then reconstituted with a suitable solvent just prior to administration. Compositions for nasal administration may conveniently be formulated as aerosols, drops, gels and powders. Aerosol formulations typically comprise a solution or fine suspension of the active substance in a physiologically acceptable aqueous or non-aqueous solvent and are usually presented in single or multidose quantities in sterile form in a sealed container, which can take the form of a cartridge or refill for use with an atomising device. Alternatively the sealed container may be a unitary dispensing device such as a single dose nasal inhaler or an aerosol dispenser fitted with a metering valve which is intended for disposal once the contents of the container have been exhausted. Where the dosage form comprises an aerosol dispenser, it will contain a propellant which can be a compressed gas such as compressed air or an organic propellant such as a fluorochlorohydrocarbon. The aerosol dosage forms can also take the form of a pump-atomiser. Compositions suitable for buccal or sublingual administration include tablets, lozenges and pastilles, wherein the active ingredient is formulated with a carrier such as sugar and acacia, tragacanth, or gelatin and glycerin. Compositions for rectal administration are conveniently in the form of suppositories containing a conventional suppository base such as cocoa butter. Compositions suitable for transdermal administration include ointments, gels and patches. Preferably the composition is in unit dose form such as a tablet, capsule or ampoule. Each dosage unit for oral administration contains preferably from 1 to 250 mg (and for parenteral administration contains preferably from 0.1 to 25 mg) of a compound of the formula (I) or a physiologically acceptable salt thereof calculated as the free base. The physiologically acceptable compounds of the invention will normally be administered in a daily dosage regimen (for an adult patient) of, for example, an oral dose of between 1 mg and 500 mg, preferably between 10 mg and 400 mg,e.g. between 10 and 250 mg or an intravenous, subcutaneous, or intramuscular dose of between 0.1 mg and 100 mg, preferably between 0.1 mg and 50 mg, e.g. between 1 and 25 mg of the compound of the formula (I) or a physiologically acceptable salt thereof calculated as the free base, the compound being administered 1 to 4 times per day. Suitably the compounds will be administered for a period of continuous therapy, for example for a week or more. The invention is further illustrated by the following non-limiting examples : A mixture of (5-ethylsulphonyl-2-methoxy)benzoic acid (10 g, 41 mmol), bromine (21 ml, 408 mmol) and 49% hydrogen bromide in acetic acid (1 ml) in glacial acetic acid (200 ml) was heated at 75°C for 5 days. The mixture was cooled and the glacial acetic acid removed Dimethyl sulphate (10.8 g, 85.6 mmol) was added dropwise to a stirred mixture of (3-bromo-5-ethylsulphonyl-2-hydroxy)benzoic acid (D1) (11.5 g, 37.2 mmol) and potassium carbonate (11.3 g, 82 mmol) in AR acetone (200 ml). On complete addition the mixture was heated at reflux for 18 h before being cooled to ambient temperature. The mixture was filtered and the filter cake washed with fresh acetone. Combined filtrates were evaporated (3-Bromo-5-ethylsulphonyl-2-methoxy)benzoic acid (D2) (6.84 g, 21 mmol) was added portionwise to thionyl chloride (40 ml) with stirring and the resultant solution stirred at reflux for 2.5 h. On cooling the solution was evaporated Formed from (3-bromo-5-ethylsulphonyl-2-methoxy)benzoyl chloride (D3) (5.3 g) by the method of Kruse et al (Heterocycles, 26, 3141, 1987). NMR δ (CDCl3) 1.3 (3 H, t, J = 7 Hz), 3.2 (2 H, t, J = 7 Hz), 3.8 (3 H, s), 6.35 (1 H, m), 6.75 (1 H, m), 6.95 (1 H, m), 7.9 (1 H, d, J = 7 Hz), 8.05 (1 H, d, J = 7 Hz), 9.6 (1 H, br s). To a solution of (3,5-Dibromo-2-hydroxy)benzoic acid (11.1 g) in dry DMF (80 ml), was added anhydrous potassium carbonate (24 g) with stirring. Isopropyl iodide (17.5 ml) was added in one portion and the mixture was stirred at room temperature for two days. The mixture was then heated to 70°C for 24 hrs. After cooling, the mixture was partitioned between water (150 ml) and ethyl acetate (500 ml). The organic layer was washed with brine and dried over sodium sulphate. Removal of the solvent gave a solid gum that was dissolved in dichloromethane. The mixture was filtered and the solvent was evaporated in To a slurry of (3,5-Dibromo-2-isopropoxy)benzoic acid (D5) (5.75 g) in dry toluene (18 ml) was added oxalyl chloride (3.0 ml) at room temperature. A drop of DMF was added and the mixture was stirred at room temperature for 2 hrs. The mixture was evaporated Formed from (3,5-Dibromo-2-isopropoxy)benzoyl chloride (D6) by the method of Kruse This material was formed by methods analogous to those of description 2, using diethyl sulphate and (3,5-dibromo-2-hydroxy)benzoic acid to give (3,5-dibromo-2-ethoxy)benzoic acid which was further treated using the methods of descriptions 6 and 7. NMR δ (CDCl3) 1.4 (3 H, t, J = 6 Hz), 3.9 (2 H, q, J = 6 Hz), 6.3 (1 H, m), 6.6 (1 H, m), 6.9 (1 H, m), 7.5 (1 H, d, J = 2 Hz), 7.7(1 H, d, J = 2 Hz). Analysis: Found C, 41.96, H, 3.36, N, 3.72%; C12H11 NOBr2 requires C, 41.77, H, 3.21, N, 4.06%. To a stirred solution of heptamethyleneimine (5.56 ml; 44 mmol) and triethylamine (6.13 ml; 44 mmol) in tetrahydrofuran (20 ml) under nitrogen at 0°C was added dropwise a solution of acetyl chloride (3.13 ml; 44 mmol) in tetrahydrofuran (20 ml). The reaction mixture was then warmed to room temperature and stirred for 1 hr. The resulting solid was filtered off and washed thoroughly with ether. The filtrate was evaporated Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (3,5-dibromo-2-hydroxy)benzoic acid. NMR δ (CDCl3) 3.75 (3 H, s), 6.32 (1 H, m), 6.60 (1 H, m), 6.93 (1 H, m), 7.49 (1 H, d, J = 2 Hz), 7.65 (1 H, d, J = 2 Hz), 9.63 (1 H, br s). Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (3,5-dichloro-2-hydroxy)benzoic acid. NMR δ (CDCl3) 3.78 (3 H, s), 6.30 (1 H, q, J = 3 Hz), 6.61 (1 H, m), 6.93 (1 H, m), 7.17 (1 H, d, J = 2 Hz),7.47 (1 H, d,J = 2 Hz), 9.17 (1 H, br s). To a stirred suspension of 3-methylsalicylic acid (10 g, 66 mmol) in glacial acetic acid (100 ml) at room temperature was added bromine (3.5 ml; 69 mmol). The reaction mixture was stirred at room temperature for 3 hrs, and the resulting solid filtered off to give the title compound (D12). NMR δ (CDCl3) 2.15 (3 H, s), 7.49 (1 H, d, J = 2 Hz), 7.69 (1 H, d, J = 2 Hz), 11.55 (1 H, br s). Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (5-bromo-3-methyl-2-hydroxy)benzoic acid (D12). NMR δ (CDCl3) 2.30 (3 H,s), 3.53 (3 H, s), 6.28 1 H, q, J = 2 Hz), 6.56 (1 H, m), 6.88 (1 H, m), 7.22 (1 H, d, J = 1.5 Hz), 7.54 (1 H, d, J = 1.5 Hz), 9.65 (1 H, br s). Dimethyl sulphate (8.96 g, 70 mmol) was added dropwise to a stirred mixture of (4-trifluoromethyl)phenol (10 g, 62 mmol) and potassium carbonate (9.4 g, 68 mmol) in AR acetone (200 ml) and the resultant mixture stirred at reflux for 4 h. The mixture was cooled and filtered and the filter cake washed with fresh acetone. Combined filtrates were evaporated The reaction was carried out under a nitrogen atmosphere. To a solution of n-butyllithium (1.6 M in hexanes; 71 ml) in hexane (200 ml) at ambient temperature was added tetramethylethylenediamine (17.15 ml, 114 mmol) dropwise with stirring. To this mixture was added (4-trifluoromethyl)anisole (D14) (10 g, 56.8 mmol) in hexane (50 ml) dropwise. After 1.5 h the mixture was poured onto solid carbon dioxide. Water was added and the aqueous layer separated and washed with diethyl ether (200 ml). The aqueous layer was acidified with 5 N HCl and extracted with dichloromethane (3 x 200 ml). Combined halogenated organic extracts were dried (Na2SO4) and evaporated in Prepared from (2-methoxy-5-trifluoromethyl)benzoic acid (D15) (5 g) by the method of description 3. NMR δ (CDCl3) 4.0 (3 H, s), 7.1 (1 H, d, J = 8 Hz), 7.8 (1 H, dd, J = 8 Hz, 2 Hz), 8.3 (1 H, d, J = 2 Hz). Prepared from (2-methoxy-5-trifluoromethyl)benzoyl chloride (D16) (5.2 g) by the method of Kruse et al (Heterocycles, 26, 3141, 1987). NMR δ (CDCl3) 4.0 (3 H, s), 6.3 (1 H, m), 6.7 (1 H, m), 6.9 (1 H, m), 7.0 (1 H, d, J = 8 Hz),7.4(1 H, dd, J = 8 Hz, 2 Hz), 7.8 (1 H, d, J = 2 Hz), 9.8 (1 H, br s). Aqueous AgNO3 (25%; 1.65 ml) and aqueous NaOH (25%; 0.39 ml) were mixed with stirring and the precipitated AgO filtered and washed with water. The AgO was covered with water and stirred as NaOH (0.5 g) was added in one portion. Once the NaOH had dissolved (2-hydroxy-5-trifluoromethoxy)benzaldehyde (0.5 g) was added and the mixture stirred for 1 h. The mixture was filtered and the filtrate acidified with 5 N HCI and extracted with dichloromethane (3 x 50 ml). Combined organic extracts were dried (Na2SO4) and evaporated Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (2-hydroxy-5-trifluoromethoxy)benzoic acid (D18). NMR δ (CDCl3) 4.0 (3 H, s), 6.3 (1 H, m), 6.55 (1 H, m), 6.9 - 7.1 (3 H, m), 7.5 (1 H, d, J = 2 Hz), 9.8 (1 H, br s). Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (3,5-diiodo-2-hydroxy)benzoic acid. NMR δ (CDCl3) 3.7 (3 H, s), 6.3 (1 H, m), 6.6 (1 H, m), 6.9 (1 H, m), 7.85 (1 H, d, J = 2 Hz), 7.9 (1 H, d, J = 2 Hz). Bromine (40 ml, 779 mmol) was added dropwise to a stirred solution of 2,3-dihydroxybenzoic acid (120 g, 779 mmol) in glacial acetic acid (900 ml) at ambient temperature. After 24 h the mixture was evaporated Prepared by methods analogous to those of descriptions 2, 3 and 4, starting from (5-bromo-2,3-dihydroxy)benzoic acid (D21) and using 3 equivalents of dimethyl sulphate. NMR δ (CDCl3) 3.9 (6 H, s), 6.3 (1 H, m), 6.6 (1 H, m), 6.8 (1 H, d, J = 2 Hz), 6.9 (1 H, m), 7.35 (1 H, m), 9.8 (1 H, br m). Phenylsulphonyl chloride (17.7 g, 100 mmol) was added dropwise at ambient temperature to a stirred solution of methyl salicylate (15.2 g, 100 mmol) and triethylamine (14 ml, 100 mmol) in dichloromethane (300 ml). After 2 h the mixture was evaporated (2-Phenylsulphonyloxy)benzoic acid methyl ester (D23) (20.3 g, 69.5 mmol) and aluminium chloride (18.6 g, 139 mmol) were stirred together at 140°C for 1.25 h. The mixture was allowed to cool and stirred with conentrated HCI (150 ml) and ice (50 g). The product was extracted into dichloromethane (3 x 200 ml) and the combined extracts dried (Na2SO4) and evaporated Prepared by methods analogous to those of descriptions 3 and 4, starting from (2-methoxy-5-phenylsulphonyl)benzoic acid (D24). NMR δ (CDCl3) 4.0 (3 H, s), 6.3 (1 H, m), 6.75 (1 H, m), 6.9 (1 H, m), 7.0 (1 H, d, J = 8 Hz), 7.4 - 7.6 (3 H, m), 7.7 (1 H, dd, J = 8 Hz, 2 Hz), 7.95 (2 H, dd, J = 8 Hz, 2 Hz), 8.2 (1 H, d, J = 2 Hz), 9.7 (1 H, br s). To a suspension of sodium hydride (80%, 3.3 g, 0.11 mol) in dry toluene (250 ml) under argon, was added dropwise a solution of δ-valerolactam (9.9 g, 0.10 mol) in toluene (50 ml). When the addition was complete, the mixture was heated under reflux for 1 h, then cooled to ambient termperature. A solution of benzyl bromide (13 ml, 18.8 g, 0.11 mol) in toluene (50 ml) containing dimethyl formamide (1 ml) was then added dropwise over 15 minutes. The resulting mixture was heated under reflux for 4 h. On cooling, the mixture was filtered and the filtrate was dried (Na2SO4) and evaporated This compound was prepared by a method analogous to that of description 9 using hexamethyleneimine in place of heptamethyleneimine. NMR δ (CDCl3) 1.58 (4 H, m), 1.78 (4 H, m), 2.10 (3 H, s), 3.45 (2 H, t, J = 6 Hz), 3.55 (2 H, t, J = 6 Hz). This compound was prepared by a method analogous to that of description 9 using piperidine in place of heptamethyleneimine and propionyl chloride in place of acetyl chloride. NMR δ (CDCl3) 1.15 (3 H, t, J = 7 Hz), 1.58 (6 H, m), 2.35 (2 H, q, J = 7 Hz), 3.40 (2 H, t, J = 6 Hz), 3.55 (2 H, t, J = 6 Hz). Phosphorus oxychloride (0.18 ml, 1.9 mmol) was added to N,N-dimethylformamide (0.15 ml, 1.9 mmol) at 0°C under argon with constant stirring. The resulting mixture was allowed to warm to room temperature and was then stirred for 1.5 h. 1,2-Dichloroethane (1.5 ml) was added and a solution of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (0.30 g, 0.91 mmol) in 1,2-dichloroethane (3 ml) was then added at 0°C. The reaction mixture was stirred at room temperature for 16 h. On cooling, the mixture was poured onto crushed ice and basified with aqueous sodium acetate (50%, 20 ml). The organic phase was separated and the aqueous layer was extracted with ether. The combined organic extracts were washed with aqueous sodium hydrogen carbonate, dried (Na2SO4) and evaporated This compound was prepared by a method analogous to that of description 9 using cyclohexanemethylamine in place of heptamethyleneimine. NMR δ 0.95 (2 H, m), 1.23 (4 H, m), 1.46 (1 H, m), 1.70 (4 H, m), 2.00 (3 H, s), 3.10 (2 H,t,J=6Hz), 5.62 (1 H, br s). To a stirred suspension of lithium aluminium hydride (0.49 g, 12 mmol) in dry tetrahydrofuran (50 ml) under argon was added a solution of (N-Cyclohexylmethyl)acetamide (D30) (2.05 g, 11 mmol) in tetrahydrofuran (50 ml) dropwise at 0°C. The resulting mixture was then heated under reflux for 2.5 h. On cooling, the excess lithium aluminium hydride was decomposed with methanol (2.5 ml) and water (24 ml) and the mixture was then extracted with dichloromethane. The combined organic extracts were acidified with 5N HCl and the aqueous layer then treated with sodium hydrogen carbonate. The basic solution was extracted with dichloromethane and the organic extracts were dried (Na2SO4) and evaporated This compound was prepared by a method analogous to that of description 9 using piperidine in place of heptamethyleneimine and phenylacetyl chloride in place of acetyl chloride. NMR δ (CDCl3) 1.35 (2 H, m), 1.55 (4 H, m), 3.35 (2 H, t, J = 6 Hz), 3.60 (2 H, t, J = 6 Hz), 3.73 (2 H, s), 7.28 (5 H, m). This compound was prepared by a method analogous to that of description 9 using 1,2,3,6-tetrahydropyridine in place of heptamethyleneimine. b.p. 95 - 105 °C at 0.5 mm Hg This compound was prepared by a method analogous to that of description 9 using pyrrolidine in place of heptamethyleneimine. NMR δ (CDCl3) 1.90 (4 H, m), 2.05 (3 H, s) and 3.45 (4 H, m). This compound was prepared by a method analogous to that of description 29, but using 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. NMR δ (CDCl3) 1.34 (3 H, t, J = 7 Hz), 3.19 (2 H, q, J = 7 Hz), 3.88 (3 H, s), 6.84 (1 H, dd, J = 4 Hz and 3 Hz), 7.05 (1 H, dd, J = 4 Hz and 3 Hz), 8.04 (1 H, d, J = 2 Hz), 8.14(1 H, d, J = 2 Hz), 9.61 (1 H, s) and 10.48 (1 H, br. s). A solution of piperidine (0.10 ml; 1 mmol) in ethanol (20 ml) at room temperature was treated with aqueous formaldehyde (40%; 0.075 ml; 1 mmol) and glacial acetic acid (0.08 g, 1 mmol). The mixture was stirred at room temperature for 30 mins then was added dropwise to a solution of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (0.25 g, 0.75 mmol) in ethanol (20 ml). The reaction mixture was stirred at room temperature for 18 hours then evaporated A solution of piperidine (0.027 g, 0.32 mmol) in dry ethanol (2 ml) at room temperature was treated with aqueous formaldehyde (40%; 0.030g, 0.34 mmol) and glacial acetic acid (0.027 g, 0.45 mmol). The mixture was stirred at room temperature for 30 mins then was added dropwise to a solution of 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (0.086 g, 0.32 mmol) in dry ethanol (1 ml). The reaction mixture was stirred at room temperature for 18 hours then evaporated in Phosphorus oxychloride (0.135 ml; 1.5 mmol) was added to 1-ethylhexahydroazepin-2-one (0.212 g, 1.5 mmol) at room temperature under nitrogen with constant stirring. The resulting mixture was stirred at room temperature for 30 mins then dichloroethane (30 ml) was added. The reaction mixture was cooled to 5°C, then 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (0.265 g, 1 mmol) was added portionwise. The reaction mixture was stirred at 5°C for 2 hours, then at room temperature for 48 hours. Sodium borohydride (0.34 g, 8.9 mmol) was added portionwise with ice cooling, and stirring at room temperature was carried out for 3 hours. The mixture was cooled to 5°C and treated dropwise with water (1.6 ml), followed by methanol (1.6 ml). When effervescence had subsided, the mixture was poured onto water (30 ml) and extracted with dichloromethane (3 x 30 ml). The combined organic extracts were dried over anhydrous sodium sulphate, then evaporated This compound was prepared by a method analogous to that used to prepare example 2, but using 2-(5-chloro-2-methoxyphenyl)-1H-pyrrole (prepared according to the method of Kruse et al., [Heterocycles, 26, 3141, 1987] from the corresponding acid chloride) in place of 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole. Analysis: Found C, 66.99, H, 6.94, N, 9.19%; C17H21ClN2O requires C, 66.60, H, 6.89, N, 8.98%. This compound was prepared by a method analogous to that used to prepare example 2, but using 2-(2,3-dimethoxyphenyl)-1H-pyrrole (prepared according to the method of Kruse et al., [Heterocycles, 26, 3141, 1987] from the corresponding acid chloride) in place of 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole. NMR δ(CDCl3) 1.35 - 1.65 (6 H, m), 2.40 (4 H, m), 3.50 (2 H, s), 3.80 (3 H, s), 3.90 (3 H, s), 6.05 (1 H, t, J = 2 Hz), 6.50 (1 H, t, J = 2 Hz), 6.70 (1 H, dd, J = 9, 1 Hz), 7.00 (1 H, t,J=9Hz),7.20(1 H, dd, J = 9, 1 Hz), 9.95 (1 H, br s) This compound was prepared by a method analogous to that used to prepare example 1, but using 1,2,3,4-tetrahydroisoquinoline in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 410.1678; C23H26N2O3S requires M+ 410.1664 This compound was prepared by a method analogous to that used to prepare example 1, but using pyrrolidine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 348.1506; C18H24N2O3S requires M+ 348.1507 This compound was prepared by a method analogous to that used to prepare example 1, but using hexamethyleneimine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 376.1799; C20H28N2O3S requires M+ 376.1820 This compound was prepared by a method analogous to that used to prepare example 1, but using 2-methylpiperidine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 376.1821; C20H28N2O3S requires M+ 376.1820 This compound was prepared by a method analogous to that used to prepare example 1, but using This compound was prepared by a method analogous to that used to prepare example 1, but using heptamethyleneimine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 390.1968; C21H30N2O3S requires M+ 390.1977 This compound was prepared by a method analogous to that used to prepare example 1, but using dimethylamine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 322.1345; C16H22N2O3S requires M+ 322.1351 This compound was prepared by a method analogous to that used to prepare example 2, but using dipropylamine in place of piperidine. NMR δ(CDCl3) 0.90 (6 H, t, J = 7 Hz), 1.25 (3 H, t, J = 7 Hz), 1.70 (4 H, m), 2.80 (2 H, m), 3.15 (2H, t, J = 7 Hz), 4.05 (3 H, s), 4.15 (2 H, s), 6.20 (1 H, t ,J = 2 Hz), 6.60 (1 H, t, J = 2 Hz), 7.05 (1 H, d, J = 9 Hz), 7.70 (1 H, dd, J = 9, 1 Hz), 8.10 (1 H, d, J = 1 Hz), 11.70 (1 H, br s). This compound was prepared by a method analogous to that used to prepare example 2, but using diethylamine in place of piperidine. NMR δ(CDCl3) 1.10 (6 H, t, J = 7 Hz), 1.30 (3 H, t, J = 7 Hz), 2.55 (4 H, q, J = 7 Hz), 3.10 (2 H, q, J = 7 Hz), 3.65 (2 H, s), 4.05 (3 H, s), 6,10 (1 H, t, J = 2 Hz), 6.60 (1 H, t, J = 2 Hz), 7.05 (1 H, d, J = 9 Hz), 7.65 (1 H, dd, J = 1, 9 Hz), 8.05 (1 H, d, J = 1 Hz), 9.75 (1 H, br s). Mass spectrum:m/z 350 (M+, 20%), 278 (100) This compound was prepared by a method analogous to that used to prepare example 3 but using 1-ethylpiperidin-2-one in place of 1-ethylazepin-2-one. Mass spectrum : Found M+ 376.1812; C20H28N2O3S requires M+ 376.1790 This compound was prepared by a method analogous to that used to prepare example 3 but using 1-acetylpiperidine in place of 1-ethylazepin-2-one. NMR δ(CDCl3) 1.27 (3H, t, J = 7 Hz), 1.40 (1H,m), 1.79 (3H, d, J = 7 Hz), 1.55-1.96 (6H,m), 2.08 (1H,m), 2.36 (1H,m), 2.46-2.80 (2H,m), 3.17 (2H, q, J = 7 Hz), 3.40 (2H,m), 4.16 (3H,s), 4.53 (1H,m), 6.25 (1H,m), 6.62 (1H,m), 7.08 (1H, d, J = 9 Hz), 7.70 (1H, dd, J = 9,1 Hz), 8.12 (1H, d, J = 1 Hz), 11.65 (2H,br m). This compound was prepared by a method analogous to that used to prepare example 1, but using 2-(6-chloro-benzo[b]pyran-8-yl)-1H-pyrrole (prepared according to the method of Kruse et al., [Heterocycles, 26, 3141, 1987] from the corresponding acid chloride) in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 330.1499; C19H23ClN2O requires M+ 330.1499 This compound was prepared by a method analogous to that used to prepare example 2, but using 2-(3-bromo-5-ethylsulphonyl-2-methoxy-phenyl)-1H-pyrrole (prepared according to the method of Kruse et al., [Heterocycles, 26, 3141, 1987] from the corresponding acid chloride) in place of 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole. NMR δ(CDCl3) 1.30 - 1.70 (9 H, m), 2.40 (4 H, m), 3.15 (2 H, q, J = 7 Hz), 3.50 (2 H, s), 3.80 (3 H, s), 6.10(1 H, t, J J = 2 Hz), 6.60(1 H, t, J = 2 Hz), 7.80(1 H, d, J = 1 Hz), 8.00 (1 H, d, J = 1 Hz), 9.9 (1 H, s). This compound was prepared by a method analogous to that used to prepare example 1, but using 2-(3,5-dibromo-2-isopropoxyphenyl)-1H-pyrrole (D7) in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. NMR δ (CDCl3) 1.3 (6 H, d, J = 7 Hz), 1.6 (1 H, m), 2.0 (3 H, m), 2.2 (2 H, m), 2.7 (2 H, m), 3.6 (2 H, m), 4.3 (2 H, m), 4.5 (1 H, septet, J = 7 Hz), 6.4 (1 H, m), 6.7 (1 H, m), 7.7 (1 H, d), 7.8 (1 H, d), 11.4(1 H, br s), 12.1 (1 H, br s). Analysis: Found C, 46.25, H, 5.03, N, 5.80%; C19H24N2OBr2.HCl requires C, 46.32, H, 5.11, N, 5.69%. To 1-acetylpiperidine (0.36 ml) under argon was added phosphorous oxychloride (0.26 ml) at room temperature. The mixture was stirred at room temperature for 50 minutes and 1,2-dichloroethane (5 ml) was added. The solution was cooled to 5°C and 2-(3,5-dibromo-2-isopropoxyphenylh-1H-pyrrole (D7) (0.52 g) in 1,2-dichloroethane (5 ml) was added in one portion. The mixture was stirred at 5 - 10°C for 20 minutes and was then stirred at room temperature for 22 hrs. The mixture was cooled in an ice bath and sodium borohydride (0.50 g) was added in one portion. After stirring for a further 2 hrs, water (7.2 ml) was added dropwise over 6 minutes. After a further 4 minutes, MeOH (6 ml) was added over 6 minutes. After stirring for a further 10 minutes, the mixture was partitioned between water (100 ml) and dichloromethane (50 ml). The aqueous layer was re-extracted with dichloromethane (2 x 40 ml) and the combined organic layers were dried over sodium sulphate. The residue was dissolved in MeOH (7 ml), dichloromethane (8 ml) and hydrochloric acid (35%; 2 ml) and was stirred at room temperature for 3 hrs. The mixture was partitioned between dichloromethane (100 ml) and water (60 ml). The aqueous layer was brought to pH 12 with 10% NaOH and was extracted with dichloromethane (2 x 40ml). The combined organic layers were dried over sodium sulphate and the solvent was removed To a solution of N-ethyl-benzylamine (0.38 ml) in EtOH (5 ml) was added formaldehyde (37-40% aqueous solution) (0.22 ml). After 10 minutes, acetic acid (0.21 ml) was added and after a further 10 minutes, 2-(3,5-dibromo-2-isopropoxyphenyl)-1H-pyrrole (D7) (0.81 g) was added in EtOH (10 ml) over 1 hr. The mixture was stirred at room temperature for two days and was then heated to 55°C for 30 hrs. After cooling, the solvent was removed Prepared analogously to Example 1, but using 2-(3,5-dibromo-2-ethoxyphenyl)-1H-pyrrole (D8) in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. NMR δ (d6-DMSO) 1.3 (4 H, m + t, J = 6 Hz), 1.6 - 1.9 (5 H, m), 2.8 (2 H, m), 3.8 (2 H, q, J = 6 Hz), 4.3 (2 H, m), 6.4 (1 H, m), 6.8 (1 H, m), 7.7 (1 H, d, J = 2 Hz), 7.9 (1 H, d, J = 2 Hz). Analysis: Found C, 44.80, H, 4.48, N, 5.73%; C18H22N2OBr2.HCl requires C, 45.17, H, 4.84, N, 5.85%. Prepared analogoulsy to Example 20, but using 2-(3,5-dibromo-2-ethoxyphenyl)-1H-pyrrole (D8) in place of 2-(3,5-dibromo-2-isopropoxyphenyl)-1H-pyrrole. NMR δ (CDC13) 1.4 (4 H, m + t,J = 7 Hz), 1.8 (3 H, d, J = 7 Hz), 1.7 - 2,0 (3 H, m), 2,15 (1 H, m), 2.35 (1 H, m), 2.55 (1 H, m), 2.7, (1 H, m), 3.4 (2 H, m), 3.9 (2 H, q, J = 7 Hz), 4.6 (1 H, m), 6.25 (1 H, m), 6.7 (1 H, m), 7.5 (1 H, m), 7.9, (1 H, m), 11.5 - 11.7 (2 H, br s). Analysis : Found C, 46.22, H, 4.87, N, 5.62%; C19H24N2OBr2.HCl requires C, 46.32, H, 5.11, N, 5.69%. Prepared by analogously to Example 2, using 1-acetyloctahydroazocine (D9) and 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (D10). Mass spectrum: Found M+ 468.0412; C20H26Br2N2O requires M+ 468.0410. Prepared analogously to Example 1, using 2-(3,5-dichloro-2-ethoxyphenyl)-1H-pyrrole (D11). Mass spectrum: Found M+ 338.0956; C17H20Cl2N2O requires M+ 338.0952. Prepared analogously to Example 2, using 1-acetylpiperidine and 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (D10). Mass spectrum: Found M+ 440.0099; C18H22Br2N2O requires M+ 440.0097. Prepared analogously to Example 1, using N-ethylbenzylamine and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 412.1821; C23H28N2O3S requires M+ 412.1821 Prepared analogously to Example 1, using 2-(5-bromo-3-methyl-2-methoxyphenyl)-1H-pyrrole (D13). Mass spectrum: Found M+ 362.0994; C18H23BrN2O requires 362.0993. Prepared analogously to Example 3 using 1-acetylpiperidine and 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (D4). NMR δ (CDCl3) 1.3 - 2.8 (14 H, m), 3.3 - 3.6 (4 H, m), 3.9 (3 H, s), 4.55 (1 H, m), 6.3 (1 H, m), 6.7 (1 H, m), 7.9 (1 H, d, J = 2 Hz), 8.2 (1 H, d, J = 2 Hz), 11.5(1 H, br s), 11.9(1 H, br s). Prepared analogously to Example 21 using 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (D4). Mass spectrum:m/z 492 (M+, 5%), 356 (30), 91 (100). Prepared analogously to Example 1 using 2-(2-methoxy-5-trifluoromethylphenyl)-1H-pyrrole (D17). NMR δ (CDCl3) 1.45 (1 H, m), 1.8 - 2.3 (6 H, m), 2.6 (2 H, m), 3.5 (2 H, m), 4.2 (5 H, m), 6.3 (1 H, m), 6.5 (1 H, m), 7.0 (1 H, d, J = 8 Hz), 7.4 (1 H, dd, J = 8 Hz, 2 Hz), 7.8 (1 H, d, J = 8 Hz), 11.5 (1 H, br s), 11.9 (1 H, br s). Mass spectrum:m/z 338 (M+, 30%), 254 (100). Prepared analogously to Example 1 using 2-(2-methoxy-5-trifluoromethoxyphenyl)-1H-pyrrole (D19). Analysis: Found C, 54.09, H, 5.48, N, 7.07%; C18H21F3N2O2.HCl.0.5H2O requires C, 54.07, H, 5.78, N, 7.01%. Prepared analogously to Example 1 using 2-(3,5-diiodo-2-methoxyphenyl)-1H-pyrrole (D20). NMR δ (CDCl3) 1.3 (1 H, m), 1.8 - 2.3 (5 H, m), 2.55 (2 H, m), 3.5 (2 H, m), 3.7 (3 H, s), 4.2 (2 H, d, J = 7 Hz), 6.3 (1 H, m), 6.6 (1 H, m), 7.95 (2 H, m), 11.4 (1 H, br s), 11.95 (1 H, br s). Prepared analogously to Example 3 but using 1-acetylpiperidine and 2-(3,5-diiodo-2-methoxyphenyl)-1H-pyrrole (D20). Analysis: Found C, 37.98, H, 4.20, N, 4.86%; C18H22I2N2O.HCl requires C, 37.75, H, 4.05, N, 4.89%. Prepared analogously to Example 1 but using 2-(2,3-dimethoxy-5-bromophenyl)-1H-pyrrole (D22). NMR δ (CDCl3) 1.4 (1 H, m), 1.8 - 2.3 (6 H, m), 2.6 (2 H, m), 3.45 (2 H, d, J = 10 Hz), 3.85 (3 H, s), 3.95 (3 H, s), 4.2 (2 H, m), 6.3 (1 H, m), 6.6 (1 H, m), 6.9 (1 H, m), 7.4 (1 H, m), 11.3 (1 H, br s), 12.0 (1 H, m). Mass spectrum:m/z 378 (M+, 20%), 294 (100). Prepared analogously to Example 3 using 1-acetylpiperidine and 2-(2,3-dimethoxy-5-bromophenyl)-1H-pyrrole (D22). NMR δ (CDCl3) 1.3 (1 H, m), 1.7 - 2.7 (10 H, m), 3.4 (2 H, m), 3.85 (3 H, s), 4.55 (1 H, m), 6.3 (1 H, m), 6.6 (1 H, m), 6.9 (1 H, m), 7.5 (1 H, m), 11.3 (1 H, br s), 11.7 (1 H, m). The free base of the title compound was prepared analogously to Example 2 using 2-(2-methoxy-5-phenylsulphonylphenyl)-1H-pyrrole (D25). This material (0.5 g) was dissolved in ethyl acetate (10 ml) and added to a hot solution of oxalic acid (0.11 g) in ethyl acetate (10 ml). Sufficient MeOH was added to dissolve the precipitated solid and the resultant solution cooled. The resulting crystals were To 1-acetylpiperidine (0.61 ml) under argon, was added phosphorus oxychloride (0.45 ml) at ambient temperature. After stirring for 0.5 h 1,2-dichloroethane (10 ml) was added and the mixture cooled to 0°C. A solution of 2-(2-methoxy-3-phenylsulphonylphenyl)-1H-pyrrole (D25) (1.0 g) in 1,2-dichloroethane (10 ml) was added dropwise over 0.3 h. Stirring was continued at 0°C for 3 h and at ambient temperature for 18 h. The mixture was cooled to 0°C and sodium borohydride (1 g) added portionwise over 0.16 h. Stirring was continued at ambient temperature for 2.5 h before the mixture was cooled to 0°C. Water (5 ml) followed by MeOH (5 ml) was added dropwise followed by dilution with more water (50 ml). The mixture was extracted with dichloromethane (3 x 200 ml) and the combined extracts dried (Na2SO4) and evaporated This compound was prepared by a method analogous to that used to prepare example 3, but using N-benzyl-2-piperidinone (D26) in place of 1-ethylazepin-2-one. Mass spectrum:m/z 438 (M+, 100%), 381 (45), 347 (45), 173 (60) and 91 (55). Prepared analogously to Example 2, using 8-azabicyclo[3.2,1]octane hydrochloride (Chem. Abstr., 1968, 69, 35974) and carrying out the Mannich reaction at 80°C for 3 h . The title compound (E40) was obtained as the free base. Mass spectrum: Found M+ 388.1825; C21H28N2O3S requires 388.1820 Prepared analogously to Example 1, using 3-azabicyclo[3.2.2]nonane. NMR δ (CDCl3) 1.25 (3 H, t, J = 8 Hz), 1.78 (6 H, m), 2.15 (2 H, m), 2.40 (2 H, m), 2.75 (2 H, m), 3.10 (2 H, q, J = 8 Hz), 3.65 (2 H, m), 4.20 (3 H, s), 4.25 (2 H, s), 6.25 (1 H, m), 6.60(1 H, m), 7.05 (1 H, d, J = 8 Hz), 7.70 (1 H, dd, J = 8 Hz, 3 Hz), 8.10 (1 H, d, J = 3 Hz), 10.90 (1 H, br s), 11.95 (1 H, br s). Prepared analogously to Example 3, using 1-acetylhexahydroazepine (D27) and 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (D10). Analysis: Found C, 46.68, H, 5.11, N, 5.68% ; C19H24Br2N2O.HCl requires C, 46.32, H, 5.11, N, 5.69%. Prepared analogously to Example 1, using 2-azabicyclo[2.2.2]octane hydrochloride [prepared by the method of Cava Prepared analogously to Example 1, using 9-azabicyclo[3.3.1]nonane hydrochloride (Chem. Abstr., 1968, 69, 35974). In order to effect total conversion to the desired product, the Mannich reaction was performed at room temperature for 16 h and then at 80°C for 16 h. Analysis: Found C, 47.60, H, 4.92, H, 5.47%. C20H24Br2N2O.HCl requires C, 47.60, H, 4.99, N, 5.55%. Prepared analogously to Example 3, using 1-propionylpiperidine (D28) and 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole (D10). Analysis: Found C, 46.70, H, 5.22, N, 5.63%. C19H24N2oBr2.HCl requires C, 46.32, H, 5.11, N, 5.69%. To a mixture of 5-(3,5-Dibromo-2-methoxyphenyl)-1 H-pyrrole-2-carboxaldehyde (D29) (0.31 g, 0.9 mmol), N-ethylcyclohexanemethylamine (D31) (0.12 g, 0.9 mmol) and triethylamine (0.35 ml, 2.6 mmol) in dry dichloromethane (15 ml) under argon was added dropwise a solution of titanium tetrachloride in dichloromethane (1 M; 0.45 ml) at room temperature with constant stirring. The reaction mixture was stirred for 18 h, and was then quenched with a solution of sodium cyanoborohydride (0.16 g, 2.5 mmol) in dry methanol (6 ml). The resulting solution was stirred at room temperature for 18 h and was then basified to pH 13 with aqueous 5 N sodium hydroxide. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic extracts were dried (Na2SO4) and evaporated in vacuo to give a brown oil. Chromatography on alumina (Brockmann grade 1) with pentane - ethyl acetate (10 -100%) gradient elution gave the free base of the title compound (0.19 g). The free base was dissolved in hot ethyl acetate (20 ml) and treated with a solution of oxalic acid (0.035 g) in ethyl acetate. On cooling the mixture, the title compound (E46) was obtained as a pink solid (0.025 g). NMR δ (CDCl3) 0.90 (2 H, m), 1.18 (4 H, m), 1.35 (3 H, t, J = 7 Hz), 1.70 (5 H, m), 2.85 (2 H, m), 3.18 (2 H, m), 3.75 (3 H,s), 4.20 (3 H, m), 6.30 (1 H, m), 6.63 (1 H, m), 7.55 (1 H, s), 7.70 (1 H, s), 11.40 (1 H, br s), 11.30 (1 H, br s). Prepared analogously to Example 3, using 1-phenylacetylpiperidine (D32) and 2-(2,3-dimethoxy-5-bromophenyl)-1H-pyrrole (D22). The title compound (E47) was obtained as the free base. Analysis: Found C, 63.84, H, 6.20, N, 6.09. C25H29BrN2O2 requires C, 63.97, H, 6.23, N, 5.97. The free base was obtained from 2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole hydrochloride (E16) by partition between aqueous sodium bicarbonate and dichloromethane. The resulting material (55.92 mg) was injected, in 2.16 mg aliquots onto a CHIRALCEL OJ column (250 x 20 mm), and isocratic elution was carried out with hexane followed by hexane - ethanol (80 : 20) at a rate of 10.0 ml min-1. The faster eluting material was obtained from each run, and evaporation of the combined relevant fractions gave the title compound (E48) (23.4 mg). HPLC analysis: enantiomeric purity > 97.5% From the chromatography described in example 48, the slower eluting material was obtained from each run, and evaporation of the combined relevant fractions gave the title compound (E48) (13.4 mg). HPLC analysis: enantiomeric purity > 96% This compound was prepared by a method analogous to that used to prepare example 1, but using 1,2,3,6-tetrahydropyridine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 360.1496; C19H24N2O3S requires M+ 360.1508. This compound was prepared by a method analogous to that used to prepare example 3, but using 1-acetyl-1,2,3,6-tetrahydropyridine (D33) in place of 1-ethylazepin-2-one. NMR δ(CDCl3) 1.27 (3 H, t, J = 7 Hz), 1.81, 1.90 (3 H, 2 x d, J = 6 Hz), 2.33 (1 H, br m), 2.75 - 3.75 (6 H, br m), 3,16 (2 H, q, J = 7 Hz), 4.17 (3 H, s), 4.56, 4.73 (1 H, 2 x br m), 5.56 (1 H, m), 5.98 (1 H, m), 6.28 (1 H, m), 6.62 (1 H, m), 7.09 (1 H, d, J = 10 Hz), 7.72 (1 H, dd, J = 10, 2 Hz), 8.13 (1 H, d, J = 2 Hz), 11.49, 11.63 (1 H, 2 x br s), 12.21, 12.34 (1H, 2 x br s). This compound was prepared by a method analogous to that used to prepare example 1, but using 2-azabicyclo[3.2.1]octane [prepared by the method of Barraclough This compound was prepared by a method analogous to that used to prepare example 3, but using N-acetyl-2-pyrrolidinone (D34) in place of 1-ethylazepin-2-one. Mass spectrum:m/z 363 (MH+, 7.5%), 143 (55) and 72 (100). This compound was prepared by a method analogous to that used to prepare example 1, but using N-ethyl-N-(2-thienyl)methylamine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. NMR δ (CDCl3) 1.28 (3 H, t, J = 7 Hz), 1.46 (3 H, t, J = 7 Hz), 2.95 (1 H, m), 3.05 (1 H, m), 3.14 (2 H, q, J = 7 Hz), 4.21 (3 H, s), 4.25 (3 H, m), 4.50 (1 H, m), 6.34 (1 H, t, J = 6 Hz), 6.64 (1 H,t,J=6Hz),7.10(1 H, d, J = 9 Hz), 7,13 (1 H, dd, J = 5 Hz and 4 Hz), 7.36 (1 H, d), 7.47 (1 H, dd, J = 5 Hz and 1 Hz), 7.71 (1 H, dd, J = 9 Hz and 2 Hz), 8,12 (1 H, d, J = 2 Hz), 11.70 (1 H, br. s) and 12.60 (1 H, br. s). This compound was prepared by a method analogous to that used to prepare example 1, but using N-ethyl-N-(2-furyl)methylamine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: m/z 403 (M+, 35%), 278 (15) and 126 (100). This compound was prepared by a method analogous to that used to prepare example 1, but using N-propylbenzylamine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. NMR δ (CDCl3) 0.84 (3 H, t, J = 7 Hz), 1.28 (3 H, t, J = 7 Hz), 1.79 (2 H, m), 2.78 (2 H, m), 3.14 (2 H, q, J = 7 Hz), 3.92 (1 H, m), 4.18 (1 H, m), 4.21 (3 H, s), 4.40 (2 H, m), 6.29(1 H, t, J = 3 Hz), 6.62 (1 H, t, J = 3 Hz), 7.10(1 H, d, J = 9 Hz), 7.45 (3 H, m), 7.61 (2 H, m), 7.71 (1 H, dd, J = 9 Hz and 2 Hz), 8.12 (1 H, d, J = 2 Hz), 11.82 (1 H, br. s) and 12.23 (1 H, br. s). This compound was prepared by a method analogous to that used to prepare example 48, but using 5-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole-2-carboxaldehyde (D36) in place of 5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole-2-carboxaldehyde, and N-ethyl-N-(4-methoxy)benzylamine in place of 1-ethylcyclohexanemethylamine. Mass spectrum: m/z 522 (M+, 7 %), 356 (10), 164 (25) and 121 (100). This compound was prepared by a method analogous to that used to prepare example 1, but using N-ethyl-N-(4-methoxy)benzylamine in place of piperidine, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole in place of 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole. Mass spectrum: Found M+ 442.1920; C24H30N2O4S requires 442.1926. The following compounds were prepared by methods analogous to those used to prepare the examples described hereinbefore. The ability of the compounds to bind selectively to human D3 dopamine receptors can be demonstrated by measuring their binding to cloned receptors. The inhibition constants (Ki) of test compounds for displacement of [125I] iodosulpride binding to human D2 and D3 dopamine receptors expressed in CHO cells have been determined. The cell lines were shown to be free from bacterial, fungal and mycoplasmal contaminants, and stocks of each were stored frozen in liquid nitrogen. Cultures were grown as monolayers or in suspension in standard cell culture media Cells were recovered by scraping (from monolayers) or by centrifugation (from suspension cultures), and were washed two or three times by suspension in phosphate buffered saline followed by collection by centrifugation. Cell pellets were stored frozen at -40°C. Crude cell membranes were prepared by homogenisation followed by high-speed centrifugation, and characterisation of cloned receptors achieved by radioligand binding. Cell pellets were gently thawed at room temperature, and resuspended in about 20 volumes of ice-cold 50 mM Tris salts (pH 7.4 @ 37°C), 20mM EDTA, 0.2 M sucrose. The suspension was homogenised using an Ultra-Turrax at full speed for 15 sec. The homogenate was centrifuged at 18,000 r.p.m for 20 min at 4°C in a Sorvall RC5C centrifuge. The membrane pellet was resuspended in ice-cold 50 mM Tris salts (pH 7.4 @ 37°C), using an Ultra-Turrax, and recentrifuged at 18,000 r.p.m for 15 min at 4°C in a Sorvall RCSC. The membranes were washed two more times with ice-cold 50 mM Tris salts (pH 7.4 @ 37°C). The final pellet was resuspended in 50 mM Tris salts (pH 7.4 @ 37°C), and the protein content determined using bovine serum albumin as a standard (Bradford, M. M. (1976) Anal. Biochem. 72, 248-254). Crude cell membranes were incubated with 0.1 nM [125I] iodosulpride (-2000 Ci/mmol; Amersham, U. K.), and the test compound in a buffer containing 50 mM Tris salts (pH 7.4 @ 37°C), 120 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2, 0.1% (w/v) bovine serum albumin, in a total volume of 1 ml for 30 min at 37°C. Following incubation, samples were filtered using a Brandel Cell Harvester, and washed three times with ice-cold 50 mM Tris salts (pH 7.4 @ 37°C), 120 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2. The radioactivity on the filters was measured using a Cobra gamma counter (Canberra Packard). Non-specific binding was defined as the radioligand binding remaining after incubation in the presence of 100 µM iodosulpride. For competition curves, 14 concentrations (half-log dilutions) of competing cold drug were used. Competition curves were analysed simultaneously whenever possible using non-linear least-squares fitting procedures, capable of fitting one, two or three site models. The compounds of Examples 1, 2, 16, 27, 30, 36 and 49 had IC50 values in the range 0.2-26 nM at the human D3 receptor. Buffer : Suitable buffers include citrate, phosphate, sodium hydroxide/hydrochloric acid. Solvent : Typically water but may also include cyclodextrins (1-100 mg) and co-solvents such as propylene glycol, polyethylene glycol and alcohol. Suspending agent : e.g. Xanthan gum, microcyrstralline cellulose Diluent : e.g. sorbitol solution, typically water Preservative : e.g. sodium benzoate Buffer : e.g. citrate Co-solvent : e.g. alcohol, propylene glycol, polyethylene glycol, cyclodextrin PCT No. PCT/EP93/02030 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Jul. 29, 1993 PCT Pub. No. WO94/03426 PCT Pub. Date Feb. 17, 1994.Compounds of formula (I), <IMAGE> formula (I) <IMAGE> (a) or <IMAGE> (b) wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R1 and R2 together form a linking chain-(CH2)mOp (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group selected from (a) or (b) wherein R6 and R7 independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R8 represents C1-6alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R9 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR8R9 forms a heterocyclic ring (with the proviso that NR8R9 is not piperazine); R10 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl, or optionally substituted heteroarylC1-4alkyl; and n is 1 to 3; and salts thereof, have affinity for dopamine D3 receptors and may be useful in the treatment of e.g., psychotic disorders. A compound of formula (I) : wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl ; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-alkylamino, trifluoromethyl, trifluoromethoxy, hydroxyl, hydroxyalkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, alkylaminosulphonyl or dialkylaminosulphonyl; or R1 and R2 together form a linking chain -(CH2)mOp; R6 and R7 independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R8 represents C1-6alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R9 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR8R9 forms a heterocyclic ringwhich ring has from 4-10 ring members; may be fully or partially saturated; may optionally contain a sulphur atom provided there are at least two methylene groups between the S and N atoms; may be bridged by a C1-3 alkylene chain; and may be optionally substituted by one or more C1-4alkyl groups or fused to an aromatic ring, with the proviso that NR8R9 is not piperazine; R10 represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl , optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; n is 1 to 3; said aryl groups or moieties being selected from phenyl, naphthyl and tetrahydronaphthyl; said heteroaryl groups or moieties being selected from 5- or 6- membered heterocycles containing one or more oxygen , sulphur and nitrogen atoms;and the said optional substituent(s) for such aryl and heteroaryl groups being selected from halogen, C1-4alkyl, C1-4 alkoxy, C1-4alkoxyalkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyalkyl, C1-4alkanoyl, C1-4alkoxycarbonyl, amino and mono- and di-alkylamino; A compound according to claim 1 wherein R1 represents methyl, ethyl, or isopropyl. A compound according to claim 1 or claim 2 wherein at least one of R2 to R5 is hydrogen, and the other substituents are selected from halogen, C1-2alkyl, C1-2alkoxy, C1-2alkylsulphonyl, phenylsulphonyl, CF3, CF3O and dialkylaminosulphonyl. A compound according to any of claims 1 to 3 wherein Y represents a group (a) in which R6 represents hydrogen, and R7 represents hydrogen or methyl. A compound according to any of claims 1 to 4 wherein Y represents a group (a) in which R8 represents C1-4alkyl and R9 represents C1-4alkyl, cyclopropylmethyl, allyl or optionally substituted phenylmethyl; or -NR8R9 forms a fully or partially saturated 5 to 8 membered heterocyclic ring, optionally including a C1-3alkylene bridge. A compound according to any of claims 1 to 3 wherein Y represents a group (b) in which R10 represents C1-4alkyl, cyclopropylmethyl, allyl or benzyl. A compound according to claim 1 selected from : 2-(3,5-dibromo-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(1-ethyl-2-hexahydroazepinyl)-5-(5-ethylsulphonyl-2 methoxyphenyl)-1H-pyrrole, 2-(5-chloro-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(2,3-dimethoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[(2-(1,2,3,4-tetrahydro-isoquinolinyl))-methyl]-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-pyrrolidinylmethyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-hexahydroazepinylmethyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-(2-methylpiperidinyl)-methyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-( 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(1-heptamethylene-iminylmethyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-dimethylaminomethyl-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-dipropylaminomethyl-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-diethylaminomethyl-1H-pyrrole, 2-(1-ethyl-2-piperidinyl)-5-(5-ethylsulphonyl-2 methoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole, 5-(6-chloro-benzo[b]pyran-8-yl)-2-(1-piperidinylmethyl)-1H-pyrrole, 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl-5-(1-piperidinyl-methyl)-1H-pyrrole, 2-(3,5-dibromo-2-isopropoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(3,5-dibromo-2-isopropoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole, 2-(3,5-dibromo-2-isopropoxyphenyl)-5-(N-benzyl-N-ethyl)aminomethyl-1H-pyrrole, 2-(3,5-dibromo-2-ethoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(3,5-dibromo-2-ethoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole, 2-(1-(1-octahydroazocinyl)ethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole, 2-(3,5-dichloro-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(1-(1-piperidinyl)ethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-ethyl)-aminomethyl-1H-pyrrole, 2-(5-bromo-2-methoxy-3-methylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole, 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-ethyl)aminomethyl-1H-pyrrole, 2-(2-methoxy-5-trifluoromethylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(2-methoxy-5-trifluoromethoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(3,5-diiodo-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(3,5-diiodo-2-methoxyphenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole, 2-(2,3-dimethoxy-5-bromophenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(2,3-dimethoxy-5-bromophenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole, 2-(2-methoxy-5-phenylsulphonylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(2-methoxy-5-phenylsulphonylphenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole, 2-(1-benzyl-2-piperidinyl)-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-[(8-azabicyclo[3.2.1]octan-8-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-[(3-azabicyclo[3.2.2]nonan-3-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl )-1H-pyrrole, 2-(3,5-dibromo-2-methoxyphenyl)-5-[1-(1-hexahydroazepinyl)-ethyl]-1H-pyrrole, 2-[(2-azabicyclo[2.2.2]octan-2-yl)methyl]-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole, 2-[(9-azabicyclo[3.3.1]nonan-9-yl)methyl]-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole, 2-(3,5-dibromo-2-methoxyphenyl)-5-[1-(1-piperidinyl)propyl]-1H-pyrrole, 2-(N-cyclohexylmethyl-N-ethylaminomethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole, 2-[2-phenyl-1-(1-piperidinyl)ethyl]-5-(5-bromo-2,3-dimethoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole, faster eluting enantiomer with reference to the conditions of Example 48 herein, and 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole, slower eluting enantiomer with reference to the conditions of Example 49 herein, 2-(5-ethylsulfonyl-2-methoxyphenyl)-5-(1-(1,2,3,6-tetrahydro-pyridinyl)methyl)-1H-pyrrole, 2-(5-ethylsulfonyl-2-methoxyphenyl)-5-(1-(1-(1,2,3,6-tetrahydropyridinyl))ethyl)-1H-pyrrole, 2-[(2-azabicyclo[3.2.1]octan-2-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[ 1-(1-pyrrolidinyl)-ethyl]-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(2-thienyl)methyl-aminomethyl]-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(2-furyl)methyl-aminomethyl]-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-propyl-aminomethyl)-1H-pyrrole, 2-(3-bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(4-methoxyphenyl)methyl-aminomethyl]-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(4-methoxyphenyl)methyl-aminomethyl]-1H-pyrrole, 2-(5-dimethylsulphamoyl-2-methoxyphenyl)-5-[1-(piperidinyl)]methyl-1H-pyrrole, 2-[(2-azabicyclo[2.2.1]heptan-2-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-[(2-azabicyclo[2.2.1]hept-5-en-2-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-[(2-azabicyclo[3.2.1]oct-6-en-2-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-(2-methoxy-5-methylsulphonylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-(2,3-dimethoxy-5-ethylsulphonylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole, 2-[(3-azabicyclo[3.2.1]octan-3-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-[1(1,2,3,4-tetrahydro)naphthyl]-aminomethyl]-1H-pyrrole, 2-(2-ethyl-2-azabicyclo[2.2.1]heptan-3-yl)-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-[1-(2-azabicyclo[2.2.1]heptan-2-yl)ethyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole, 2-(5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(1-naphthyl)methyl-aminomethyl]-1H-pyrrole, 2-(5-isopropylsulphonyl-2-methoxyphenyl)H-pyrrole, (±)trans-2-(5-ethylsulphonyl-2-methoxyphenyl)-5-(perhydroisoquinolinylmethyl)-1H-pyrrole, A process for preparing a compound of formula (I) as defined in claim 1 which process comprises : (a) to prepare a compound of formula (I) wherein Y is -CH2NR8R9, carrying out a Mannich reaction with a compound of formula (II) : and an amine HNR8R9 in the presence of formaldehyde; (b) to prepare a compound wherein Y is -CHR7NR8R9 or a group of formula (b) carrying out a Vilsmeier reaction with a compound of formula (II) and an amide of formula R7C(O)NR8R9 or a 2-oxo derivative of group (b) respectively, followed by reduction; (c) to prepare a compound wherein Y is -CH2NR8R9, reductive amination of a compound of formula (III) : with an amine HNR8R9; The use of a compound of formula (I) as defined in claim 1 or a physiologically acceptable salt thereof in the manufacture of a medicament for the treatment of a condition which requires modulation of the dopamine D3 receptor. The use according to claim 9 wherein a dopamine antagonist is required. The use according to claim 9 or claim 10 wherein the condition is a psychotic condition. A pharmaceutical composition comprising a compound of formula (I) as defined in claim 1 or a physiologically acceptable salt thereof and a physiologically acceptable carrier.
(wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group selected from : wherein
and salts thereof.
When Y is a group (b):
and salts thereof.
and optionally thereafter forming a salt thereof. Description 1
(3-Bromo-5-ethylsulphonyl-2-hydroxy)benzoic acid (D1)
Description 2
(3-Bromo-5-ethylsulphonyl-2-methoxy)benzoic acid (D2)
Description 3
(3-Bromo-5-ethylsulphonyl-2-methoxy)benzoyl chloride (D3)
Description 4
2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (D4)
Description 5
(3,5-Dibromo-2-isopropoxy)benzoic acid (D5)
Description 6
(3,5-Dibromo-2-isopropoxy)benzoyl chloride (D6)
Description 7
2-(3,5-Dibromo-2-isopropoxyphenyl)-1H-pyrrole (D7)
Description 8
2-(3,5-Dibromo-2-ethoxyphenyl)-1H-pyrrole (D8)
Description 9
1.Acetyloctahydroazocine (D9)
Description 10
2-(3,5-Dibromo-2-methoxyphenyl)-1H-pyrrole (D10)
Description 11
2-(3,5-Dichloro-2-methoxyphenyl)-1H-pyrrole (D11)
Description 12
(5-Bromo-2-methoxy-3-methyl)benzoic acid (D12)
Description 13
2-(5-Bromo-3-methyl-2-methoxyphenyl)-1H-pyrrole (D13)
Description 14
(4-Trifluoromethyl)anisole (D14)
Description 15
(2-Methoxy-5-trifluoromethyl)benzoic acid (D15)
Description 16
(2-Methoxy-5-trifiuoromethyl)benzoyl chloride (D16)
Description 17
2-(2-Methoxy-5-trifluoromethylphenyl-1H-pyrrole (D17)
Description 18
(2-Hydroxy-5-trifluoromethoxy)benzoic acid (D18)
Description 19
2-(2-Methoxy-5-trifluoromethoxyphenyl)-1H-pyrrole (D19)
Description 20
2-(3,5-Diiodo-2-methoxyphenyl)-1H-pyrrole (D20)
Description 21
(5-Bromo-2,3-dihydroxy)benzoic acid (D21)
Description 22
2. (2,3-Dimethoxy-5-bromophenyl)-1H-pyrrole (D22)
Description 23
(2-Phenylsulphonyloxy)benzoic acid methyl ester (D23)
Description 24
(2-Methoxy-5-phenylsulphonyl )benzoic acid (D24)
Description 25
2-(2-Methoxy-5-phenylsulphonylphenyl)-1H-pyrrole (D25)
Description 26
N-Benzyl-2-piperidinone (D26)
Description 27
1-Acetylhexahydroazepine (D27)
Description 28
1-Propionylpiperidine (D28)
Description 29
5-(3,5-Dibromo-2-metohxyphenyl)-1H-pyrrole-2-carboxaldehyde (D29)
Description 30
(N-Cyclohexylmethyl)acetamide (D30)
Description 31
N-Ethylcyclohexanemethylamine (D31)
Description 32
1-(1-Phenylacetyl)piperidine (D32)
Description 33
1-Acetyl-1,2,3,6-tetrahydropyridine (D33)
Description 34
N-Acetyl-2-pyrrolidinone (D34)
Description 35
5-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole-2-carboxaldehyde (D35)
Example 1
2-(3,5-Dibromo-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E1)
Example 2
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-piperidinylmethyl-1H-pyrrole (E2)
Example 3
2-(1-Ethyl-2-hexahydroazepinyl)-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole hydrochloride (E3)
Example 4
2-(5-Chloro-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole (E4)
Example 5
2-(2,3-Dimethoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole (ES)
Example 6
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[(2-(1,2,3,4-tetrahydro-isoquinolinyl))-methyl]-1H-pyrrole hydrochloride (E6)
Example 7
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-pyrrolidinylmethyl)-1H-pyrrole hydrochloride (E7)
Example 8
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-hexahydroazepinylmethyl)-1H-pyrrole hydrochloride (E8)
Example 9
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-(2-methylpiperidinyl)-methyl)-1H-pyrrole hydrochloride (E9)
Example 10
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-(
Example 11
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(1-heptamethylene-iminylmethyl)-1H-pyrrole hydrochloride (E11)
Example 12
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-dimethylaminomethyl-1H-pyrrole hydrochloride (E12)
Example 13
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-dipropylaminomethyl-1H-pyrrole (E13)
Example 14
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-diethylaminomethyl-1H-pyrrole (E14)
Example 15
2-(1-Ethyl-2-piperidinyl)-5-(5-ethylsulphonyl-2 methoxyphenyl-1H-pyrrole, hydrochloride (E15)
Example 16
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole hydrochloride (E16)
Example 17
5-(6-Chloro-benzo[b]pyran-8-yl)-2-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E17)
Example 18
2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-(1-piperidinyl-methyl)-1H-pyrrole (E18)
Example 19
2-(3,5-Dibromo-2-isopropoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E19)
Example 20
2-(3,5-Dibromo-2-isopropoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride hemihydrate (E20)
Example 21
2-(3,5-Dibromo-2-isopropoxyphenyl)-5(N-benzyl-N-ethyl)aminomethyl-1H-pyrrole hydrochloride hemihydrate (E21)
Example 22
2-(3,5-Dibromo-2-ethoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E22)
Example 23
2-(3,5-Dibromo-2-ethoxyphenyl)-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride (E23)
Example 24
2-(1-(1-Octahydroazocinyl)ethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole hydrochloride (E24)
Example 25
2-(3,5-Dichloro-2-methoxyphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E25)
Example 26
2-(1-(1-Piperidinyl)ethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole hydrochloride (E26)
Example 27
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-ethyl)-aminomethyl-1H-pyrrole hydrochloride (E27)
Example 28
2-(5-Bromo-2-methoxy-3-methylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E28)
Example 29
2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl-5-[1-(1-piperidinyl)-ethyl]-1H-pyrrole hydrochloride (E29)
Example 30
2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-ethyl)aminomethyl-1H-pyrrole hydrochloride (E30)
Example 31
2-(2-Methoxy-5-trifluoromethylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E31)
Example 32
2-(2-Methoxy-5-trifluoromethoxyphenyl)-5-(1 piperidinylmethyl)-1H-pyrrole hydrochloride hemihydrate (E32)
Example 33
2-(3,5-Diiodo-2-methoxyphenyl-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E33)
Example 34
2-(3,5-Diiodo-2-methoxyphenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole hydrochloride (E34)
Example 35
2-(2,3-Dimethoxy-5-bromophenyl)-5-(1-piperidinylmethyl)-1H-pyrrole hydrochloride (E35)
Example 36
2-(2,3-Dimethoxy-5-bromophenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole hydrochloride (E36)
Example 37
2-(2-Methoxy-5-phenylsulphonylphenyl)-5-(1-piperidinylmethyl)-1H-pyrrole oxalate hemihydrate (E37)
Example 38
2-(2-Methoxy-5-phenylsulphonylphenyl)-5-[1-(1-piperidinyl)ethyl]-1H-pyrrole oxalate (E38)
Example 39
2-(1-Benzyl-2-piperidinyl)-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole hydrochloride (E39)
Example 40
2-[(8-Azabicyclo[3.2.1]octan-8-yl)methyl].5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole (E40)
Example 41
2-[(3-Azabicyclo[3.2.2]nonan-3-yl)methyl]-5-(5-ethylsulphonyl-2-methoxyphenyl)-1H-pyrrole hydrochloride (E41)
Example 42
2-(3,5-Dibromo-2-methoxyphenyl)-5-[1-(1-hexahydroazepinyl)-ethyl]-1H-pyrrole hydrochloride (E42)
Example 43
2-[(2-Azabicyclo[2.2.2]octan-2-yl)methyl]-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole hydrochloride (E43)
Example 44
2-[(9-Azabicyclo[3.3.1]nonan-9-yl)methyl]-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole hydrochloride (E44)
Example 45
2-(3,5-Dibromo-2-methoxyphenyl)-5-[1-(1-piperidinyl)propyl]-1H-pyrrole hydrochloride (E45)
Example 46
2-(N-Cyclohexylmethyl-N-ethylaminomethyl)-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole oxalate (E46)
Example 47
2-[2-Phenyl-1-(1-piperidinyl)ethyl]-5-(5-bromo-2,3-dimethoxyphenyl)-1H-pyrrole (E47)
Example 48
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole, faster eluting enantiomer (E48)
Example 49
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-piperidinyl)-ethyl)-1H-pyrrole, slower eluting enantiomer (E49)
Example 50
2-(5-Ethylsulfonyl-2-methoxyphenyl)-5-(1-(1,2,3,6-tetrahydro-pyridinyl)methyl)-1H-pyrrole hydrochloride (E50)
Example 51
2-(5-Ethylsulfonyl-2-methoxyphenyl)-5-(1-(1-(1,2,3,6-tetrahydropyridinyl))ethyl)-1H-pyrrole hydrochloride (E51)
Example 52
2-[(2-Azabicyclo[3.2.1]octan-2-yl)methyl]-5-(5-ethylsulphonyl-pyrrole hydrochloride (E52)
Example 53
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[1-(1-pyrrolidinyl)ethyl]-1H-pyrrole (E53)
Example 54
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(2-thienyl)methyl-aminomethyl]-1H-pyrrole hydrochloride (E54)
Example 55
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(2-furyl)methyl-aminomethyl]-1H-pyrrole hydrochloride (E55)
Example 56
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-(N-benzyl-N-propyl-aminomethyl)-1H-pyrrole hydrochloride (E56)
Example 57
2-(3-Bromo-5-ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(4-methoxyphenyl )methyl-aminomethyl]-1H-pyrrole hydrochloride (E57)
Example 58
2-(5-Ethylsulphonyl-2-methoxyphenyl)-5-[N-ethyl-N-(4-methoxyphenyl)methyl-aminomethyl]-1H-pyrrole hydrochloride (E58)
Example 59
2-(5-Dimethylsulphamoyl-2-methoxyphenyl)-5-[1-(piperidinyl)]methyl-1H-pyrrole (E59)
Example 60
DATA
Preparation of CHO cell membranes
Binding experiments on cloned dopamine receptors
Results
Pharmaceutical Formulations
P