MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571

27-12-2002 дата публикации

Номер:

CA0003009793A1

Автор: SAWYERS, CHARLES L., GORRE, MERCEDES E., SHAH, NEIL PRAVIN, NICHOLL, JOHN, SAWYERS CHARLES L, GORRE MERCEDES E, SHAH NEIL PRAVIN, NICHOLL JOHN

Принадлежит: University of California San Diego UCSD

Контакты:

Номер заявки: 3009793

Дата заявки: 14-06-2002

[1]

²The invention described herein relates to novel genes and their encoded ²proteins, ²termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), ²and to ²diagnostic and therapeutic methods and compositions useful in the management ²of various ²cancers that express MARS. The invention further provides methods for ²identifying ²molecules that bind to and/or modulate the functional activity of MARS.²²

CPC - классификация

A A6 A61 A61P A61P3 A61P35 A61P35/A61P35/0 A61P35/00 C C0 C07 C07K C07K1 C07K14 C07K14/C07K14/8 C07K14/82 C1 C12 C12Q C12Q1 C12Q1/C12Q1/4 C12Q1/48 C12Q1/485 C12Q1/6 C12Q1/68 C12Q1/688 C12Q1/6886 C12Q2 C12Q26 C12Q260 C12Q2600 C12Q2600/C12Q2600/1 C12Q2600/10 C12Q2600/106 C12Q2600/13 C12Q2600/136 C12Q2600/15 C12Q2600/156 G G0 G01 G01N G01N2 G01N23 G01N233 G01N2333 G01N2333/G01N2333/9 G01N2333/91 G01N2333/912 G01N25 G01N250 G01N2500 G01N2500/G01N2500/1 G01N2500/10 G01N28 G01N280 G01N2800 G01N2800/G01N2800/5 G01N2800/52 G01N3 G01N33 G01N33/G01N33/5 G01N33/57 G01N33/574 G01N33/5748

IPC - классификация

A A6 A61 A61K A61K3 A61K31 A61K31/A61K31/5 A61K31/50 A61K31/505 A61K31/51 A61K31/519 A61K38 A61K38/A61K38/1 A61K38/17 A61P A61P3 A61P35 A61P35/A61P35/0 A61P35/00 C C0 C07 C07D C07D2 C07D23 C07D239 C07D239/C07D239/4 C07D239/42 C07D4 C07D47 C07D471 C07D471/C07D471/0 C07D471/04 C07K C07K1 C07K14 C07K14/C07K14/8 C07K14/82 C1 C12 C12N C12N1 C12N15 C12N15/C12N15/0 C12N15/09 C12N9 C12N9/C12N9/1 C12N9/12 C12Q C12Q1 C12Q1/C12Q1/4 C12Q1/48 C12Q1/6 C12Q1/68 C12Q1/680 C12Q1/6809 C12Q1/688 C12Q1/6886 G G0 G01 G01N G01N3 G01N33 G01N33/G01N33/4 G01N33/48 G01N33/5 G01N33/57 G01N33/574

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