12-05-2022 дата публикации
Номер: US20220144794A1
Принадлежит:
Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activities that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds. 3. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein Y is halogen and Z is H.4. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein Y is H and Z is halogen.5. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein R , R , R , R , R , and Rare independently H or Calkyl.6. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein R , R , R , R , R , and Rare independently H , methyl , or isopropyl.7. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein R , R , and Rare H; and R , R , and Rare independently H , methyl , or isopropyl.8. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein R , R , Rand Rare H; and Rand Rare independently H , methyl , or isopropyl.9. The compound of any one of - , or a pharmaceutically acceptable salt thereof , wherein{'sup': 1', '2', '3', '4', '5', '6, 'R, R, RR, R, and Rare H, Y is halogen, Z is H;'}{'sup': 1', '2', '3', '4', '5', '6, 'R, R, RR, R, and Rare H, Y is H, Z is halogen;'}{'sup': 1', '2', '3', '4', '5', '6, 'R, R, Rand Rare H; Rand Rare methyl, Y is halogen, Z is H; or'}{'sup': 1', '2', '3', '4', '5', '6, 'R, R, Rand Rare H; Rand Rare methyl, Y is H, Z is halogen.'}10. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein{'sup': 1', '2', '3', '4', '5', '6, 'R, R, RR, R, and Rare H, Y is Cl, and Z is H.'}11. The compound of claim 9 , or a pharmaceutically acceptable salt thereof claim 9 , wherein{'sup': 1', ...
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