27-06-2019 дата публикации
Номер: US20190194149A1
Автор:
Fei LIU,
Gang WU,
Weiming JIANG,
Cheng-Gang LIN,
Xuan CAI,
Ping LIN,
Yuling LU,
Lixiang LIU,
LIU FEI,
WU GANG,
JIANG WEIMING,
LIN CHENG-GANG,
CAI XUAN,
LIN PING,
LU YULING,
LIU LIXIANG,
LIU, Fei,
WU, Gang,
JIANG, Weiming,
LIN, Cheng-Gang,
CAI, Xuan,
LIN, Ping,
LU, Yuling,
LIU, Lixiang
Provided are crystal forms A, B, D, E, F, G and H of valsartan disodium salt and a preparation method therefor. 1. A crystalline form A of valsartan disodium salt , wherein , the crystalline form has the following properties:by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.7±0.2, 8.5±0.2, 9.5±0.2, 13.6±0.2, 15.4±0.2, 16.5±0.2, 18.1±0.2, 19.9±0.2, 22.0±0.2, 22.4±0.2, 23.3±0.2, 23.8±0.2, 25.3±0.2, and 27.8±0.2, expressed in degrees 2θ.2. The crystalline form A of valsartan disodium salt according to claim 1 , wherein claim 1 , at a heating rate of 10° C./min claim 1 , a differential scanning calorimetry thermogram of said crystalline form A of valsartan disodium salt shows an endothermic peak at 182-184° C.3. The crystalline form A of valsartan disodium salt according to claim 2 , wherein claim 2 , at a heating rate of 10° C./min claim 2 , the differential scanning calorimetry thermogram shows an endothermic peak at around 183° C.4. A crystalline form B of valsartan disodium salt claim 2 , wherein claim 2 , the crystalline form has the following properties:by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.4±0.2 and 8.8±0.2, expressed in degree 2θ.5. The crystalline form B of valsartan disodium salt according to claim 4 , which has a melting point of about 198±5° C.6. A crystalline form D of valsartan disodium salt claim 4 , wherein claim 4 , the crystalline form has the following properties:by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 4.4±0.2, 9.0±0.2, 14.9±0.2, 21.4±0.2, and 22.4±0.2, expressed in degrees 2θ.7. The crystalline form D of valsartan disodium salt according to claim 6 , which has a melting point of about 207±5° C.8. A crystalline form E of valsartan disodium salt claim 6 , wherein claim 6 , the crystalline form has the following properties:by using a Cu-Ka radiation, its X-ray powder diffraction spectrum shows peaks at about 6.3±0.2, ...
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