Gaze swipe selection

Methods for enabling hands-free selection of virtual objects are described. In some embodiments, a gaze swipe gesture may be used to select a virtual object. The gaze swipe gesture may involve an end user of a head-mounted display device (HMD) performing head movements that are tracked by the HMD to detect whether a virtual pointer controlled by the end user has swiped across two or more edges of the virtual object. In some cases, the gaze swipe gesture may comprise the end user using their head movements to move the virtual pointer through two edges of the virtual object while the end user gazes at the virtual object. In response to detecting the gaze swipe gesture, the HMD may determine a second virtual object to be displayed on the HMD based on a speed of the gaze swipe gesture and a size of the virtual object.

PUBLISH/SUBSCRIBE BROKER MESSAGING SYSTEM AND METHOD

A publish/subscribe broker messaging system and method for processing a data message based on a message broker scheduling algorithm. The scheduling algorithm can be configured in association with a message broker to receive and transmit the data message associated with one or more publishers to a subscriber. The subscriber can register a subscription with respect to the message broker to receive the data message based on a selected topic. An attribute can be added to the selected topic description based on the scheduling algorithm in order to schedule the data message from the publisher with respect to the selected topic via the message broker. The data message with respect to the selected topic from the publisher can be processed sequentially and the scheduling algorithm can process other topics simultaneously. The data messages from other publishers with similar topic can also be processed simultaneously in order to transmit a high volume of message while ensuring high levels of service. 1. A method for processing a data message , said method comprising:configuring a scheduling algorithm in association with a message broker in order to thereafter register a subscription with respect to said message broker by a subscriber for receiving a data message based on a selected topic;adding an attribute with respect to said selected topic description based on said scheduling algorithm in order to schedule said data message from at least one publisher with respect to said selected topic via said message broker; andsequentially processing said data message with respect to said selected topic associated with said at least one publisher in order to thereafter simultaneously process other topic from said at least one publisher thereby transmitting a high volume of data message while ensuring a high level of service.2. The method of further comprising simultaneously processing said data message with similar topic from other publishers.3. The method of further comprising ...

CERAMIC WELDS, AND A METHOD FOR PRODUCING THE SAME

A method of producing a ceramic weld, including identifying a ceramic first surface and a ceramic second surface to be bonded together, maintaining a non-oxidizing atmosphere over the first and second surfaces, and engaging the first and second surfaces to define a joint. An arc is generated between an electrode and the joint to create a liquid phase, and the liquid phase is cooled to yield a solid fusion layer, wherein the first and second surfaces are joined in the fusion layer. 1. A method of producing a ceramic weld , comprising the steps of:a) identifying a ceramic first surface and a second surface to be bonded together;b) maintaining a non-oxidizing atmosphere over the first and second surfaces;c) engaging the first and second surfaces to define a joint;d) generating an arc between an electrode and the joint to create a liquid phase; ande) cooling the liquid phase to yield a solid fusion layer;wherein the first and second surfaces are melted together into the fusion layer.2. The method of wherein the ceramic the second surface is a ceramic material of different composition than the first surface.3. The method of wherein the second surface is metallic.4. The method of wherein the non-oxidizing atmosphere is reducing.5. The method of wherein step (b) further comprises introducing an atmosphere selected from the group including gaseous hydrogen claim 1 , ammonia claim 1 , argon claim 1 , radon claim 1 , xenon claim 1 , helium claim 1 , neon claim 1 , krypton claim 1 , and mixtures thereof.6. The method of and further including the step of (f) before (c) claim 1 , heating the respective ceramic surfaces to a temperature wherein Tis at least about 0.3; and wherein step (e) includes following a post-weld cooling profile that cools the solid fusion layer sufficiently slowly to relieve thermal stress without degrading the fusion layer.7. The method of wherein Tis between 0.4 and 0.5.8. A fusion bond between a first electrically conductive ceramic material and a ...

SYSTEM AND METHOD FOR FILTERING NON-ACTIONABLE ALERTS IN A MANAGED PRINT SERVICE

Methods and systems of filtering non-actionable alerts are disclosed. A processing device receives an alert from a printing device and determines a page count for the printing device. The processing device compares the page count with at least one threshold value associated with the alert and the printing device. In response to the page count satisfying the at least one threshold value, the processing device identifies the alert as a valid alert. 1. A system for filtering non-actionable alerts in a managed print service , the system comprising:a processing device; anda processor-readable storage medium in operable communication with the processing device, receive an alert from a printing device,', 'determine a page count for the printing device,', 'compare the page count with at least one threshold value associated with the alert and the printing device, and', 'in response to the page count satisfying the at least one threshold value, identify the alert as a valid alert., 'wherein the processor-readable storage medium contains one or more programming instructions that, when executed, cause the processing device to2. The system of wherein the alert pertains to a remaining level of a consumable.3. The system of wherein the one or more programming instructions that cause the processing device to determine a page count comprise one or more programming instructions that claim 1 , when executed claim 1 , cause the processing device to receive a page count from the printing device.4. The system of wherein the one or more programming instructions that cause the processing device to determine a page count comprise one or more programming instructions that claim 1 , when executed claim 1 , cause the processing device to:receive an current page count from the printing device; anddetermine the page count to be the difference between the current page count and a stored page count for the printing device.5. The system of wherein the processor-readable storage medium further ...

System and method to detect printing devices with high incident rates

Method and systems of identifying a printing device having an exceptional incident rate among a plurality of printing devices are disclosed. For each of a plurality of printing devices, a processor receiving a printing device model, a print volume, and an incident count that includes a number of incidents occurring within a particular time frame. The processor determines a generalized linear regression model of the incident counts for each printing device model and also determines a predicted incident count for each printing device model using the generalized regression model. The processor determines a residual value for each printing device between the incident count for the printing device and the predicted incident count for the printing device model associated with the printing device. The processor identifies one or more printing devices having a residual value exceeding a threshold value.

GATE ARRAY ARCHITECTURE WITH MULTIPLE PROGRAMMABLE REGIONS

Systems and methods are disclosed for forming a custom integrated circuit (IC) with a first fixed (non-programmable) region on a wafer with non-customizable mask layers, wherein the first fixed region includes multiplicities of transistors and a first interconnect layer and a second interconnect layer above the first interconnect layer which form base cells; and a programmable region above the first fixed region with customizable mask layers, wherein at least one mask layer in the programmable region is coupled to the second interconnect layer which provides electrical access to all transistor nodes of the base cells and wherein the programmable region comprises a third interconnect layer coupled to the customizable mask layers to customize the IC. A second fixed region may be formed above the programmable region to provide multiple fixed regions and reduce the number of required masks in customizing the custom IC. 1. A custom integrated circuit (IC) , comprising:a first fixed (non-programmable) region on a wafer with non-customizable mask layers, wherein the first fixed region includes multiplicities of transistors and a first interconnect layer and a second interconnect layer above the first interconnect layer which form base cells; anda programmable region above the first fixed region with customizable mask layers, wherein at least one mask layer in the programmable region is coupled to the second interconnect layer which provides electrical access to all transistor nodes of the base cells and wherein the programmable region comprises a third interconnect layer coupled to the customizable mask layers to customize the IC.2. The custom IC of claim 1 , comprising a second fixed region above the programmable region to provide multiple fixed regions and reduce the number of required masks in customizing the custom IC.3. The custom IC of claim 1 , wherein the programmable region comprises a second via layer (Via2 layer) and a third interconnect layer (Metal3 layer).4. ...

Endothermic Base-Mounted Heat Pump Water Heater

An endothermic heat pump water heater has a water tank supported atop a hollow base, a heat pump circuit operable to provide primary heat to water in the tank, and an electric resistance heating element operable to provide secondary heat to the water. The heat pump circuit includes refrigerant tubing in which a compressor disposed within the base, a condenser in heat exchange external contact with the tank, a refrigerant expansion device, and an evaporator disposed within the base are connected in series. A vertical duct, external to the tank, has an inlet adjacent the upper tank end, and a fan is operative to sequentially flow air inwardly through the inlet, downwardly through the duct into the base, across the compressor, across the evaporator, and then outwardly from the base.

Gate array architecture with multiple programmable regions

An integrated circuit includes a gate array layer having a two-dimensional array of logic gates, each logic gate including multiple transistors. At least one upper template-based metal layer is coupled to the gate array layer and is configured to define at least one of a power distribution network, a clock network and a global signal network. A configuration of traces attic upper template-based metal layer is at least mainly predetermined prior to design of the integrated circuit. 1. An integrated circuit comprising:a gate array layer comprising a two-dimensional array of logic gates, each logic gate comprising a plurality of transistors; andat least one upper template-based metal layer coupled to the gate array layer and configured to define at least one of a power distribution network, a clock network and a global signal network, wherein a configuration of traces of the upper template-based metal layer is at least mainly predetermined prior to design of the integrated circuit.2. The apparatus of claim 1 , comprising at least one lower template-based metal layer configured to make transistor-level interconnections between individual ones of said transistors claim 1 , wherein a configuration of traces of the tower template-based metal layer is at least mainly predetermined prior to design of the integrated circuit.3. The apparatus of claim 2 , wherein for at least a majority of traces of each of the template-based metal layers claim 2 , a length of each trace and spacing of each trace from adjacent traces is predetermined prior to design of the integrated circuit.4. The apparatus of claim 2 , wherein each of the template-based metal layer comprises a plurality of cells arranged in tiled fashion claim 2 , wherein at least some of the cells have identical geometry.5. The apparatus of claim 2 , comprising a plurality of lower template-based metal layers configured to enable transistor-level interconnection between individual ones of said transistors claim 2 , wherein a ...

APPARATUS AND METHODS FOR CONTROLLING AN ELECTRONIC EXPANSION VALVE IN A REFRIGERANT CIRCUIT

A specially designed electronic expansion valve control system is provided for use with a refrigerant-based air conditioning circuit having a compressor, a condenser coil, an electronic expansion valve and an evaporator coil fluid coupled in series. The control system includes a unit control and an expansion valve control. The unit control is operative to receive compressor operation-related signal information and responsively generate at least one output signal representative of the received compressor operation-related signal information. The expansion valve control is operative to receive from the unit control only the at least one output signal, and to receive from one of the coils coil operation-related signal information, and to responsively output a control useable to control the expansion valve, the control signal being related in a predetermined manner to the signals received by the expansion valve control. 1. For use with a refrigerant-based air conditioning circuit having a compressor , a condenser coil , an electronic expansion valve and an evaporator coil fluid coupled in series , an expansion valve control system comprising:a unit control operative to receive compressor operation-related signal information and responsively generate at least one output signal representative of the received compressor operation-related signal information; andan expansion valve control operative to receive from said unit control only said at least one output signal, and to receive from one of said coils coil operation-related signal information, and to responsively output a control signal useable to control said expansion valve, said control signal being related in a predetermined manner to the signals received by said expansion valve control.2. The expansion valve control system of wherein:said coil operation-related signal information is evaporator coil operation-related signal information.3. The expansion valve control system of wherein:said compressor operation- ...

Chitin nanocrystal containing wellbore fluids

The current invention relates to the use of chitin nanocrystals and chitin nanocrystal derivatives. More specifically, the present invention relates to the use of chitin nanocrystals and chitin nanocrystals used in oil and gas operations. The chitin nanocrystals and chitin nanocrystals derivatives can be used as additives to cement and wellbore fluids and can be used to inhibit corrosion in pipelines, on downhole tools and on other oil and gas related equipment.

SYSTEM AND METHOD FOR MANAGING TOOLS AT A WORKSITE

A method receiving image information with one or more processor(s) and from a sensor disposed at a worksite and determining an identity of a work tool disposed at the worksite based at least partly on the image information. The method further includes receiving location information with the one or more processor(s), the location information indicating a first location of the sensor at the worksite. Additionally, the method includes determining a second location of the work tool at the worksite based at least partly on the location information. In some instances, the method includes generating a worksite map with the one or more processor(s), the worksite map identifying the work tool and indicating the second location of the work tool at the worksite, and at least one of providing the worksite map to an additional processor and causing the worksite map to be rendered via a display. 1. A method , comprising:receiving image information with one or more processor(s) and from a sensor disposed at a worksite;determining an identity of a work tool disposed at the worksite based at least partly on the image information;receiving location information with the one or more processor(s), the location information indicating a first location of the sensor at the worksite;determining a second location of the work tool at the worksite based at least partly on the location information;generating a worksite map with the one or more processor(s), the worksite map identifying the work tool and indicating the second location of the work tool at the worksite; andat least one of providing the worksite map to an additional processor and causing the worksite map to be rendered via a display.2. The method of claim 1 , wherein the sensor is carried by a machine at the worksite.3. The method of claim 2 , wherein the machine comprises a first machine claim 2 , and causing the worksite map to be rendered comprises displaying the worksite map at a monitor carried by a second machine.4. The ...

CONTROLLING MACHINE OPERATION BASED ON SEAT ORIENTATION

A work machine includes a power generator configured to generate power to propel the machine, a brake system, an operator seat, one or more sensors, and a controller. The operator seat is rotatably mounted to the machine. The one or more sensors are configured to generate one or more signals indicative of an orientation of the operator seat relative to a direction of travel of the machine. The controller is coupled to the machine and communicatively coupled to the one or more sensors. The controller is configured to determine that the operator seat is out of alignment with the direction of travel based on the one or more signals and automatically actuate the brake system if the operator seat is out of alignment with the direction of travel for more than a first threshold time. 1. A work machine comprising:a power generator configured to generate power to propel the machine;a brake system;an operator seat rotatably mounted to the machine; andone or more sensors configured to generate one or more signals indicative of an orientation of the operator seat relative to a direction of travel of the machine; and determine that the operator seat is out of alignment with the direction of travel based on the one or more signals; and', 'automatically actuate the brake system if the operator seat is out of alignment with the direction of travel for more than a first threshold time., 'a controller coupled to the machine and communicatively coupled to the one or more sensors, the controller configured to2. The work machine of claim 1 , further comprising an operator control station comprising:the operator seat;the one or more sensors; anda drive control configured to control at least one of a rate and a direction of travel of the machine.3. The work machine of claim 2 , wherein the drive control comprises at least one input control device configured to be disposed in a plurality of positions to control the direction of travel of the machine.4. The work machine of claim 3 , wherein ...

CERAMIC-CERAMIC WELDS

A method of producing a ceramic weld, including identifying a ceramic first surface and a ceramic second surface to be bonded together, maintaining a non-oxidizing atmosphere over the first and second surfaces, and engaging the first and second surfaces to define a joint. An arc is generated between an electrode and the joint to create a liquid phase, and the liquid phase is cooled to yield a solid fusion layer, wherein the first and second surfaces are joined in the fusion layer. 1. A method of welding two ceramic bodies together , comprising the steps of:a) identifying a ceramic first surface and a ceramic second surface to be joined together;b) preheating the ceramic first surface and the ceramic second surface at a predetermined first ramp rate to a predetermined soak temperature;c) inserting a thin volume of a first weld assistive material between the ceramic first surface and the ceramic second surface;d) urging the ceramic first surface and the ceramic second surface together to define an interface volume;e) applying additional heat to the interface volume at a predetermined second ramp rate to heat the interface volume to a predetermined fusion temperature;f) at least partially liquefying the interface volume to define a fusion volume; andg) cooling the fusion volume at a predetermined cooling rate to yield a solid fusion joint;wherein the first and second surfaces are melted together into the fusion joint.2. The method of wherein the ceramic second surface has the same composition as the ceramic first surface.3. The method of wherein the ceramic first surface and the ceramic second surface are both SiC.4. The method of wherein the first weld assistive material is a pressed carbon sheet.5. The method of and further comprising the step of h) after b) and before e) claim 1 , introducing a second weld assistive material to the interface volume.62. The method of wherein the first weld assistive material is a thin carbon sheet; second weld assistive material is ...

BRAZE FOR CERAMIC AND CERAMIC MATRIX COMPOSITE COMPONENTS

In some examples, a technique may include positioning a first part comprising a ceramic or ceramic matrix composite and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region at the interface of the first part and the second part. In some examples, the joint region may be heated using at least one of a laser or a plasma arc source to heat the joint region to an elevated temperature. The first and second parts may be pressed together and cooled to join the first and second parts at the joint region. In other examples, a solid braze material including a filler material and a metal or alloy may be delivered to the joint region and locally heated to cause a constituent of the filler material and a constituent of the metal or alloy to react. When reacted, the constituents may form a solid material, which may join the first and second parts. 1. A method comprising:positioning a first part comprising a ceramic or ceramic matrix composite (CMC) and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region between adjacent portions of the first part and the second part;delivering a solid braze material in the joint region, wherein the solid braze material comprises at least a filler material and a metal or alloy, and wherein the solid braze material comprises at least one of a wire, ribbon, thread, rod, or strand; andlocally heating the solid braze material, wherein a constituent of the filler material reacts with a constituent of the molten metal or alloy to join the first part and the second part.2. The method of claim 1 , wherein locally heating the solid braze material comprises locally heating the solid braze material substantially simultaneously with delivering the solid braze material in the joint region.3. The method of claim 1 , wherein at least one of the first part or the second part comprises a silicon carbide-silicon carbide composite.4. The method of claim 1 , wherein the filler material ...

Gate array architecture with multiple programmable regions

An integrated circuit includes a gate array layer having a two-dimensional array of logic gates, each logic gate including multiple transistors. At least one upper template-based metal layer is coupled to the gate array layer and is configured to define at least one of a power distribution network, a clock network and a global signal network. A configuration of traces of the upper template-based metal layer is at least mainly predetermined prior to design of the integrated circuit. 119-. (canceled)20. An integrated circuit comprising:a gate array layer comprising a two-dimensional array of transistors, each transistor comprising a plurality of transistor nodes corresponding to different terminals of the transistor; andat least one lower template-based metal layer coupled to the gate array layer and configured to define an array of tiled cells, wherein a configuration of traces of the at least one lower template-based metal layer is at least mainly predetermined prior to design of the integrated circuit, at least some of said cells comprising a feed-through comprising one or more feed-through traces located on routing tracks such that, when a tiled cell is placed adjacent to another tiled cell, feed-through traces of the adjacent tiled cell connect with traces of the tiled cell to form longer traces.21. The apparatus of claim 20 , wherein the feed-through comprises two parallel feed-through traces located on adjacent routing tracks such that claim 20 , when the feed-through traces are joined claim 20 , a signal applied to one edge of the cell is fed through to an opposite edge of the cell so as to be available to an adjoining cell.22. The apparatus of claim 21 , wherein one of the feed-through traces comprises an L-shaped portion.23. The apparatus of claim 22 , wherein another of the feed-through traces is entirely straight. This invention relates to a custom semiconductor integrated circuit device.Today's complex and highly integrated Application Specific Integrated ...

GAZE SWIPE SELECTION

Methods for enabling hands-free selection of virtual objects are described. In some embodiments, a gaze swipe gesture may be used to select a virtual object. The gaze swipe gesture may involve an end user of a head-mounted display device (HMD) performing head movements that are tracked by the HMD to detect whether a virtual pointer controlled by the end user has swiped across two or more edges of the virtual object. In some cases, the gaze swipe gesture may comprise the end user using their head movements to move the virtual pointer through two edges of the virtual object while the end user gazes at the virtual object. In response to detecting the gaze swipe gesture, the HMD may determine a second virtual object to be displayed on the HMD based on a speed of the gaze swipe gesture and a size of the virtual object. 1. An electronic device , comprising:a display configured to display a virtual object, the virtual object includes a plurality of edges; andone or more processors configured to detect a gaze swipe activation event performed by an end user of the electronic device and cause the display to display an order of edge traversals in response to detection of the gaze swipe activation event, the one or more processors configured to detect a gaze swipe gesture performed by the end user that traverses through two or more edges of the plurality of edges based on the order of edge traversals, the one or more processors configured to determine a second virtual object different from the virtual object based on the two or more edges traversed by the gaze swipe gesture and cause the display to display the second virtual object.2. The electronic device of claim 1 , wherein:the electronic device comprises a head-mounted display device;the display comprises a see-through display of the head-mounted display device; andthe one or more processors configured to detect that the end user performed the gaze swipe gesture by tracking one or more head movements of the end user using ...

BIFUNCTIONAL ALPHA-SYNUCLEIN BINDING AGENTS AND USES THEREOF

Bifunctional molecules having first and second alpha-synuclein binding agents coupled by a linker are disclosed. The bifunctional molecules have potential utility in the diagnosis, treatment and/or prophylaxis of disorders in which alpha-synuclein is implicated, including Parkinson's disease. Methods of making and using the bifunctional molecules are disclosed. 1. A bifunctional molecule comprising a first alpha-synuclein binding agent covalently linked to a second alpha-synuclein binding agent by a linker.2. A bifunctional molecule as defined in claim 1 , wherein the first alpha-synuclein binding agent and the second alpha-synuclein binding agent comprise the same alpha-synuclein binding agent.3. A bifunctional molecule as defined in claim 1 , wherein the first alpha-synuclein binding agent and the second alpha synuclein binding agent comprise different alpha-synuclein binding agents.5. A bifunctional molecule as defined in claim 1 , wherein the first alpha-synuclein binding agent and the second alpha-synuclein binding agent independently comprise: caffeine claim 1 , theophylline claim 1 , theobromine claim 1 , nicotine claim 1 , metformin claim 1 , 1-aminoindan claim 1 , 2-aminoindan claim 1 , curcumin claim 1 , fluorinated-indans claim 1 , optionally 4-fluoro-1-aminoindan claim 1 , amphetamine claim 1 , methamphetamine claim 1 , methylphenidate claim 1 , cocaine claim 1 , paraquat claim 1 , dopamine claim 1 , 3-methoxydopamine claim 1 , (Z)-1-(4-(2-fluoroethoxy)benzyl)-3-(E)-3-(4-nitrophenyl)-allylidene)indolin-2-one claim 1 , nornicotine claim 1 , buformin claim 1 , 7-ethyltheophylline claim 1 , 8-propenylcaffeine claim 1 , N-aryl-benzimidazole claim 1 , or rotenone claim 1 , or an analogue or derivative thereof claim 1 , optionally a methylated claim 1 , ethylated claim 1 , or halogenated analogue thereof claim 1 , or an analogue incorporating a heteroatom.7. A bifunctional molecule as defined in claim 1 , wherein the first alpha-synuclein binding agent ...

OZONE APPLICATOR AND METHOD FOR POLYMER OXIDATION

Apparatuses and methods are described for distributing gas which may be applicable in the field of polymer oxidation and melt curtain ozonation in particular. Ozone applicators and other features of ozonation apparatuses, which may be used separately or in combination, are also described. 1. An ozone applicator comprising an elongated inner shell disposed within an elongated outer shell , wherein said inner shell surrounds an interior space , for receiving an inlet stream of ozone-containing gas , and said inner shell has at least one opening for flowing the gas from said interior space into an intermediate space formed between said inner shell and said outer shell , and said outer shell has an outlet in the form of a plurality of openings for discharging the gas from said applicator.2. The applicator of claim 1 , wherein said outer shell has a plurality of openings that are holes distributed along at least a portion of the length of said outer shell.3. The applicator of claim 1 , wherein said at least one opening of said inner shell is in the form of one or more elongated apertures extending along a portion of the length of said inner shell.4. The applicator of claim 3 , wherein said at least one opening of said inner shell is in the form of a single elongated aperture extending over the midpoint of said inner shell.5. The applicator of claim 1 , wherein said at least one opening of said inner shell does not align with said plurality of openings of said outer shell.6. The applicator of claim 5 , wherein said at least one opening of said inner shell is aligned substantially opposite said plurality of openings of said outer shell.7. The applicator of claim 1 , having a length of at least about 24 inches.8. An ozone applicator comprising an elongated inner shell disposed within an elongated outer shell claim 1 , wherein said inner shell surrounds an interior space claim 1 , for receiving an inlet stream of ozone-containing gas claim 1 , and said inner shell has at ...

SYSTEM AND METHOD OF MONITORING AND MEASURING PERFORMANCE RELATIVE TO EXPECTED PERFORMANCE CHARACTERISTICS FOR APPLICATIONS AND SOFTWARE ARCHITECTURE HOSTED BY AN IAAS PROVIDER

The present disclosure is directed to a system for monitoring and analyzing operation of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider. The set of virtual resources provided to the IaaS tenant by the IaaS provider is hosted on a set of physical resources selected by the IaaS provider, and both the set of virtual resources and the set of physical resources can change rapidly in both size and composition (i.e., the resources are “ephemeral”). Although the monitoring system may not have visibility into the composition, configuration, location, or any other information regarding the set of physical resources, the monitoring system can evaluate the performance of the virtual resources and infer that a virtual resource within the set of virtual resources may be hosted on at least one physical resource that is underperforming. 1. A system for determining that a virtual resource within a set of virtual resources may be hosted on at least one physical resource that is underperforming , the set of virtual resources being provided by an independent Infrastructure-as-a-Service (IaaS) provider to an IaaS tenant for operating a widely distributed service , wherein the virtual resources are hosted on a set of physical resources that may be at least one of geographically dispersed , part of different communication networks , and disjoint , wherein the IaaS provider is responsible for selection of the set of physical resources and an operational capacity of the set of virtual resources may change substantially and rapidly , and wherein the IaaS tenant has no direct control over and limited visibility into the selection of the set of physical resources , the system comprising:a data gateway configured to receive CPU utilization information related to the operation of the set of virtual resources;an analysis module configured to determine that a candidate ...

SYSTEM AND METHOD OF ALERTING ON EPHEMERAL RESOURCES FROM AN IAAS PROVIDER

The present disclosure is directed to a system for monitoring and analyzing operation of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider. The set of virtual resources provided to the IaaS tenant by the IaaS provider is selected by the IaaS provider and can change rapidly in both size and composition (i.e., the virtual resources are “ephemeral”). The monitoring system can integrate system-level metrics collected directly from virtual resources with infrastructure metadata characterizing the virtual resources collected from the IaaS provider to report on operation of the virtual resources. The infrastructure metadata can contain a resource type, a resource role, an operational status, an outage history, or an expected termination schedule. By integrating different sources of data, the monitoring system can avoid inaccurate analysis. 1. A system for monitoring and analyzing operation of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider and allocated to the IaaS tenant , in which the distributed service may be at least one of geographically dispersed , part of different communication networks , and disjoint , wherein the IaaS provider is responsible for selection of the set of resources , wherein an operational capacity of the set of resources may change substantially and rapidly , and wherein the IaaS tenant has no direct control over , and limited visibility into , the selection of the set of resources , the system comprising:an infrastructure platform collector configured to query Application Program Interfaces (APIs) defined by the IaaS provider to collect infrastructure metadata characterizing at least one of a resource type, a resource role, an operational status, an outage history, and an expected termination schedule of ...

SYSTEM AND METHOD OF ADAPTIVELY AND DYNAMICALLY MODELLING AND MONITORING APPLICATIONS AND SOFTWARE ARCHITECTURE HOSTED BY AN IAAS PROVIDER

The present disclosure is directed to a monitoring system for rapidly updating a service architecture of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider. The set of virtual resources provided to the IaaS tenant by the IaaS provider is selected by the IaaS provider and can change rapidly in both size and composition (i.e., the virtual resources are “ephemeral”). The monitoring system can infer from infrastructure metadata and/or system-level metric data how the virtual resources should be organized into groups, clusters and hierarchies. The monitoring system can also update the service architecture frequently to capture an expected rate of change of the resources, e.g., every five minutes. The monitoring system can then run analytics based on this inferred service architecture to report on service operation. 1. A system for creating and updating a dynamic service architecture to facilitate analysis and monitoring of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider and allocated to the IaaS tenant , in which the distributed service may be at least one of geographically dispersed , part of different communication networks , and disjoint , wherein the IaaS provider is responsible for selection of the set of resources , wherein an operational capacity of the set of resources may change substantially and rapidly , and wherein the IaaS tenant has no direct control over , and limited visibility into , the selection of the set of resources , the system comprising:an infrastructure platform collector configured to frequently query Application Program Interfaces (APIs) defined by the IaaS provider to collect metadata characterizing the set of resources, wherein the infrastructure platform collector queries the provider APIs ...

SYSTEM AND METHOD OF SEMANTICALLY MODELLING AND MONITORING APPLICATIONS AND SOFTWARE ARCHITECTURE HOSTED BY AN IAAS PROVIDER

The present disclosure is directed to a monitoring system for automatically inferring, without human modelling input or information regarding actual physical network connectivity, a service architecture of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider. The monitoring system can collect infrastructure metadata and/or system-level metric data characterizing the set of virtual resources from the IaaS provider, and automatically infer from the metadata and/or metric data how the virtual resources should be organized into groups, clusters and hierarchies. The monitoring system can automatically infer this service architecture using naming conventions, security rules, software types, deployment patterns, and other information gleaned from the metadata and/or metric data. The monitoring system can then run analytics based on this inferred service architecture to report on service operation. 1. A system for inferring a service architecture to facilitate analysis and monitoring of a widely distributed service operated by an Infrastructure-as-a-Service (IaaS) tenant but deployed on a set of virtual resources controlled by an independent IaaS provider and allocated to the IaaS tenant , in which the distributed service may be at least one of geographically dispersed , part of different communication networks , and disjoint , wherein the IaaS provider is responsible for selection of the set of resources , wherein an operational capacity of the set of resources may change substantially and rapidly , and wherein the IaaS tenant has no direct control over , and limited visibility into , the selection of the set of resources , the system comprising:an infrastructure platform collector configured to collect metadata, the metadata comprising (i) IaaS-provider metadata expressed in a fixed format, the fixed format being prescribed by the IaaS provider, the IaaS- ...

Browser Extension for Contemporaneous in-Browser Tagging and Harvesting of Internet Content

Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment. 1. A method for contemporaneous in-browser tagging and harvesting of digital content in a networked environment , the method comprising:executing a browser extension to extend the functionality of the web browser, the browser extension including a user interface and a background process;generating a graphical user interface in a portion of the browser window via the user interface of the browser extension;in response to the web browser retrieving a webpage to be rendered in the browser window, extracting, via the background process of the browser extension, at least one uniform resource locator associated with the webpage;sending a message including the at least one uniform resource locator from the browser extension to a portal, the portal determines whether a record in a database corresponds to the at least one of the uniform resource locators and sends a result to the browser extension; andin response to the result, generating, via the background process, at least one indicator in the graphical user interface or the browser window.2. The method of claim 1 , wherein the at least one of the URLs does not have a corresponding record in the database and the method further comprises:creating a record for the at least one of the URLs in response to input received from a user via the graphical user interface of the browser extension.3. The method of claim 2 , further comprising:adding one or more tags to the record based on input received from the user via the graphical user interface.4. The method of claim 3 , wherein at least one of the tags indicates whether the webpage associated with the at least one of the URLs includes benign or malignant content.5. The method of ...

FRAMELESS TELECOMMUNICATIONS ENCLOSURE

Telecommunications enclosures are described in this document. In one aspect, a telecommunications enclosure includes side panels having seals and an enclosure top connected, independent of a frame, to top ends of the side panels. The enclosure top has an enclosure top outer end that extends between the side panels and includes a seal. An interior panel is connected, independent of a frame, to side panels and has an interior panel outer end that extends between the side panels. The interior panel is separated from the enclosure top by a first distance and separated by a second distance from bottom ends of the side panels. A removable door is formed to engage the seals when the removable door is secured to the frameless telecommunications enclosure. 121.-. (canceled)22. A frameless telecommunications enclosure , comprising:an enclosure top;at least two panels that are each fastened to the enclosure top independent of a frame;a removable door that is formed to engage the at least two panels and create a weather seal; andan interior panel that engages the at least two panels, and separates an interior of the frameless telecommunications enclosure to create a lower chamber and a separate upper chamber.23. The frameless telecommunications enclosure of claim 22 , wherein at least one of the lower chamber or the upper chamber is ventilated.24. The frameless telecommunications enclosure of claim 22 , wherein the removable door also engages the interior panel to create a weather seal between the lower chamber and the upper chamber.25. The frameless telecommunications enclosure of claim 22 , wherein the removable door has a main door portion formed in a first plane and protruding ends that extend out from the main door portion in a second plane that intersects the first plane.26. The frameless telecommunications enclosure of claim 25 , wherein one of the protruding ends has one or more slots defined therein to receive tabs protruding from an enclosure bottom.27. The frameless ...

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues. 221-. (canceled)22. A lipid composition comprising a compound according to or a pharmaceutically acceptable salt thereof.23. The lipid composition according further comprising a biologically active agent.24. The lipid composition according wherein the biologically active agent is a siRNA.2530-. (canceled)31. A pharmaceutical composition comprising the lipid composition according to and a pharmaceutically acceptable carrier or excipient.32. A method for the treatment of a disease or condition comprising administering a therapeutically effective amount of the lipid composition according to to a patient in need of treatment thereof.33. A method for the treatment of a disease or condition comprising administering a therapeutically effective amount of the pharmaceutical composition according to .34. The lipid composition according to wherein the biologically active agent is an mRNA.3540-. (canceled)41. A pharmaceutical composition comprising the lipid composition according to and a pharmaceutically acceptable carrier or excipient.42. A method for the treatment of a disease or condition comprising administering a therapeutically effective amount of the lipid composition according to to a patient in need of treatment thereof.43. A method for the treatment of a disease or condition comprising administering a therapeutically effective amount of the pharmaceutical composition according to .44. A compound according to which is:1-(3,5-bis((Z)-octadec-9-en-1-yloxy)phenyl)-N,N-dimethylmethanamine;1-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)phenyl)-N,N-dimethylmethanamine;2,2′-((3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl)azanediyl)diethanol;1-(3,5-bis((9Z,12Z)- ...

Apparatus and Methods for Controlling an Electronic Expansion Valve in a Refrigerant Circuit

A specially designed electronic expansion valve control system is provided for use with a refrigerant-based air conditioning circuit having a compressor, a condenser coil, an electronic expansion valve and an evaporator coil fluid coupled in series. The control system includes a unit control and an expansion valve control. The unit control is operative to receive compressor operation-related signal information and responsively generate at least one output signal representative of the received compressor operation-related signal information. The expansion valve control is operative to receive from the unit control only the at least one output signal, and to receive from one of the coils coil operation-related signal information, and to responsively output a control useable to control the expansion valve, the control signal being related in a predetermined manner to the signals received by the expansion valve control. 134-. (canceled)35. A method of controlling a refrigerant-based air conditioning circuit having a compressor , a condenser coil , an electronic expansion valve and an evaporator coil fluid coupled in series , said method comprising the steps of:providing an expansion valve control;transmitting to said expansion valve control only signal information relating to operation of said compressor and operation of one of said condenser coil and said evaporator coil; andcontrolling said electronic expansion valve by transmitting from said expansion valve control to said electronic expansion valve a control signal related in a predetermined manner to said signal information.36. The method of claim 35 , wherein said method further comprises the step of providing a unit control and wherein said transmitting step comprises transmitting the signal information relating to operation of said compressor from said unit control to said expansion valve control.37. The method of claim 36 , wherein said transmitting step includes the step of causing said unit control to ...

ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES

The present disclosure relates to compositions and methods for treating APOC3-related diseases such as: hypertriglyceridemia (e.g., Type V Hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including Type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a RNAi agent to APOC3. 1. A double stranded RNAi agent for inhibiting expression of APOC3 , comprising a first strand and a second strand , wherein said first strand is less than about 49 nucleotides in length and comprises at least 14 contiguous nucleotides differing by 0 , 1 , 2 , or 3 nucleotides from any of SEQ ID NOs: 1-546.2. The RNAi agent of claim 1 , wherein the first strand comprises at least one modified nucleotide or modified internucleoside linkage.3. The RNAi agent of claim 2 , wherein the 3′ end of the first strand and/or the second strand comprises a 3′ end cap.4. The RNAi agent of claim 2 , wherein the first strand and the second strand form a duplex region of about 15 to about 30 nucleotide base pairs.5. The RNAi agent of claim 2 , wherein one or more nucleotides of the first strand or the second strand has been replaced by a spacer.6. The RNAi agent of claim 2 , wherein the first strand comprises at least one 2′-modified nucleotide or modified phosphorothioate linkage.7. The RNAi agent of claim 3 , wherein the 3′ end of the first and/or second strand terminates in a phosphate or modified internucleoside linker and further comprises claim 3 , in 5′ to 3′ order: a spacer claim 3 , a second phosphate or modified internucleoside linker claim 3 , and a 3′ end cap.8. The RNAi agent of claim 4 , wherein the spacer is selected from a sugar claim 4 , alkyl claim 4 , cycloalkyl claim 4 , ribitol claim 4 , 2′-deoxy-ribitol claim 4 , diribitol claim 4 , 2′-methoxyethoxy-ribitol claim 4 , C3 claim 4 , ...

INVENTORY MANAGEMENT SYSTEM

The present disclosure provides a system and method of live inventory management. The system includes a plurality of bins that include a plurality of specifically located level sensors and a controller that aggregates the data from the sensors to push to the host server, which ascertains the inventory state of the bins and generates alerts when the bins require replenishment. The method includes the step of automatically generating alerts for replenishment based upon the data from the plurality of level sensors. 1. An inventory management system comprising:a plurality of bins arranged in an array, wherein at least some of the bins have a bottom panel, opposed side walls, a back wall, and an open top, wherein each of the side wall includes an upper portion and a lower portion;at least two lower sensors mounted to the lower portion of at least one of the side walls, each sensor configured to be in at least a first state which corresponds to the absence of material located in the bin adjacent the sensor and a second state which corresponds to the presence of material located in the bin adjacent the sensor;at least two upper sensors mounted to the upper portion of at least one of the side walls, each sensor configured to be in at least a first state which corresponds to the absence of material located in the bin adjacent the sensor and a second state which corresponds to the presence of material located in the bin adjacent the sensor; anda controller configured to aggregate the sensor states.2. The system of claim 1 , wherein the controller is configured to communicate the sensor states to a server and wherein the server determines whether the bins are in an out of stock state claim 1 , below minimum state or a sufficiently full state based on the states of the sensors.3. The system of claim 1 , wherein the server is configured to estimate the amount of a particular material in a bin based on comparing the sum of the weights assigned to each sensor that are a first ...

Tubular Installation Monitoring System and Method

Embodiments of the disclosure include a casing installation monitoring system that monitors surface equipment (that is, equipment of a rig), provides information on casing installation operations (for example, hook load, torque, RPM, and cumulative fatigue) at various times and depths, provides initial casing installation guidelines, and provides alarms before and during the casing installation operation. 1. A method for installing a casing in a well , comprising:receiving data associated with a rig, the data comprising electronic drilling recorder (EDR) data, wherein the EDR data comprises hook load, string depth, revolutions-per-minute (RPM), torque, and block height;determining, using the EDR data, a rig state associated with the rig; anddetermining, using the rig state and the EDR data, a cumulative fatigue associated with the casing.2. The method of claim 1 , comprising installing the casing the well.3. The method of claim 1 , comprising stopping or modifying installation of the casing in the well based on the determination that the cumulative fatigue exceeds a fatigue threshold.4. The method of claim 1 , wherein the data associated with the rig comprises block weight.5. The method of claim 1 , wherein the rig state is selected from the group consisting of running in hole (RIH) claim 1 , reaming in claim 1 , tripping out of hole (TOOH) claim 1 , backreaming claim 1 , rotating on and off Bottom (ROB) claim 1 , in slips claim 1 , making a connection claim 1 , a static state claim 1 , and an unknown state.6. The method of claim 1 , comprising activating an alarm based on the EDR data claim 1 , the cumulative fatigue claim 1 , or a combination thereof.7. The method of claim 1 , comprising determining claim 1 , using the EDR data claim 1 , the rig state claim 1 , or a combination thereof claim 1 , casing installation data.8. The method of claim 7 , wherein the casing installation data comprises a plot of hook load vs depth or a plot of surface torque vs depth.9. The ...

CHITIN NANOCRYSTAL CONTAINING WELLBORE FLUIDS

The current invention relates to the use of chitin nanocrystals and chitin nanocrystal derivatives. More specifically, the present invention relates to the use of chitin nanocrystals and chitin nanocrystals used in oil and gas operations. The chitin nanocrystals and chitin nanocrystals derivatives can be used as additives to cement and wellbore fluids and can be used to inhibit corrosion in pipelines, on downhole tools and on other oil and gas related equipment. 1. A method for treating a wellbore comprising:circulating a wellbore fluid in said wellbore, wherein said wellbore fluid comprises a fluid and at least one additive selected from the group consisting of chitin nanocrystals, chitin nanocrystal derivatives and combinations thereof.2. The method of wherein said chitin nanocrystals have an average diameter of from 10 nm to 20 nm and an average length of from 100 nm to 1000 nm and wherein said chitin nanocrystal derivatives are derived from such chitin nanocrystals.3. The method of wherein said chitin nanocrystals have an average length of from 200 nm to 300 nm.4. The method of claim I wherein said additive is substantially free of amorphous components.5. The method of wherein said wellbore fluid is a drilling fluid and said additive is a chitin nanocrystal derivative.6. The method of wherein said additive is selected from the group consisting of oxidized chitin nanocrystal derivatives and hydrocarbon chitin nanocrystal derivatives and combinations thereof.7. The method of wherein said fluid is a hydraulic cement.8. The method of wherein said circulating said wellbore fluid comprises introducing said cement composition into a space between a pipe string and a subterranean formation.9. The method of further comprising running said pipe string into a wellbore penetrating said subterranean formation.10. The method of wherein said hydraulic cement comprises at least one cement selected from the group consisting of API Class A Portland cement claim 7 , API Class C ...

COMBUSTION EXHAUST VALVE

This document discusses, among other things, a valve assembly for controlling an exhaust pressure of a gas combustion system. The valve assembly can include a valve housing, a flapper, and a biasing device. The valve housing can be coupleable to an exhaust pipe. The flapper can be pivotably couplable to the valve housing to pivot between a full open position and a restricted position in response to exhaust pressure. The biasing device can be couplable to the housing and extendable into the exhaust pipe to engage the flapper, where the biasing device can be configured to bias the flapper toward the restricted position and can be configured to resist movement of the flapper between the restricted position and the full open position. 1. A valve assembly for controlling an exhaust pressure of a gas combustion system , the valve assembly comprising:a valve housing coupleable to an exhaust pipe;a flapper pivotably couplable to the valve housing to pivot between a full open position and a restricted position in response to exhaust pressure; anda biasing device couplable to the housing and extendable into the exhaust pipe to engage the flapper, the biasing device configured to bias the flapper toward the restricted position and to resist movement of the flapper between the restricted position and the full open position.2. The valve assembly of claim 1 , further comprising: a proximal end engageable with the biasing device; and', 'a distal end extendable into the exhaust pipe to engage the flapper., 'a plunger located within the housing, the plunger comprising3. The valve assembly of claim 2 , wherein the plunger is separated from the biasing device to reduce heat transfer to the biasing device.4. The valve assembly of claim 1 , wherein the flapper comprises a shape complimentary to the exhaust pipe to reduce exhaust pressure drop over the flapper when the flapper is in the full open position.5. The valve assembly of claim 1 , wherein a resistance of the biasing device is ...

Tire with tread elements including dual angled chamfer

A tire includes a tread formed with tread elements that include a dual angled chamfer. The tire includes a pair of sidewalls extending radially outward to a ground-engaging tread. A plurality of circumferentially-extending grooves extend about the tread and define a plurality of ribs. A plurality of laterally-extending grooves cooperate with the circumferential grooves to divide the ribs into tread elements. A plurality of selected tread elements are formed with a dual angled chamfer. Each of the selected tread elements includes a body, a radially outer, ground-engaging surface, a chamfer side, and a dual angled chamfer that is formed in the body between the ground-engaging surface and the chamfer side.

BONDING PLASTIC FLOOR PIECES TOGETHER

A method of bonding plastic floor pieces together includes several steps. One step involves laying plastic floor pieces near each other in order to produce a seam between neighboring plastic floor pieces. Another step involves cutting a groove into and along a part or more of the seam. Yet another step involves filling the groove with a bonding compound that can be composed of, among other constituents, methyl methacrylate. 1. A method of bonding plastic floor pieces together , comprising:laying plastic floor pieces adjacent each other to produce a seam between the plastic floor pieces;cutting a groove into and along at least a part of the seam; andfilling the groove with a bonding compound comprising methyl methacrylate.2. The method of claim 1 , further comprising applying tape on top surfaces of the plastic floor pieces and at both sides of the groove before filling the groove with the bonding compound.3. The method of claim 1 , further comprising smoothing out an exposed surface of the bonding compound once the bonding compound is filled in the groove and before the bonding compound is cured.4. The method of claim 1 , further comprising removing a portion of the bonding compound protruding above top surfaces of the plastic floor pieces once the bonding compound is at least partly cured claim 1 , wherein an exposed surface of the bonding compound after removal is substantially flush with the top surfaces of the plastic floor pieces.5. The method of claim 1 , further comprising allowing the bonding compound to cure in the groove.6. The method of claim 1 , wherein cutting the groove comprises cutting the groove via a power groover.7. The method of claim 1 , wherein the groove is cut part way into the seam in a direction generally orthogonal with top surface planes of the plastic floor pieces claim 1 , leaving an extent of the seam uncut claim 1 , and the bonding compound is filled in the uncut extent of the seam before the bonding compound is cured.8. The method of ...

RESOURCE DISCOVERY AGENT COMPUTING DEVICE, SOFTWARE APPLICATION, AND METHOD

A computer-implemented method for retrieving information from information services and providing it to a public application programming interface (API) includes receiving a first request data message using a core discovery agent, the request data message including at least one requested datum, for which a value is sought, and at least one known datum, for which a value is known; calling a resource locator to request a location of an information service that provides a value for the requested datum; calling a resource façade to contact the information service; transmitting a first information service message including the requested datum and known datum from the resource façade to the information service; receiving a second information service message from the information service including a value for the requested datum; and transmitting a resolved data message including the requested datum and its value from the core discovery agent to the public API. 120.-. (canceled)21. A method implemented by a computing device having one or more processors and one or more memories , comprising:communicating with a first software service via a first software interface;applying a rule to the first software service to identify a plurality of datums being required by the first software service;determining that a first set of requested datums in the plurality of datums are unknown, the first set of requested datum comprising a first requested datum and a second requested datum;broadcasting a first request data message comprising the first set of requested datums;receiving a first response from a second software service via a second software interface, the second software service being different from the first software service, the second software interface being different from the first software interface;determining the first requested datum based upon the first response received from the second software service;updating the first set of requested datums to generate a second set of ...

Browser Extension for Contemporaneous In-Browser Tagging and Harvesting of Internet Content

Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, and harvesting digital content in a networked environment, and for removing malignant content from the networked environment. 1. A method for contemporaneous in-browser tagging and harvesting of digital content in a networked environment , the method comprising:generating a graphical user interface in a portion of a browser window of a web browser executing on a computing device;in response to the web browser retrieving a webpage to be rendered in the browser window, extracting at least one uniform resource locator associated with the webpage;sending a first message including the at least one uniform resource locator from the computing device to a portal in response to extracting the at least one uniform resource locator from a data source hosting the webpage, the portal determines a record in a database that corresponds to the at least one uniform resource locator does not exist and sends a result to the graphical user interface indicating that the record does not exist;in response to the result, generating, in the graphical user interface or the browser window, at least one indicator to indicate that the record does not exist; andsending a second message from the computing device to the portal including at least one user-generated tag associated with the at least one uniform resource locator that is input by a user via the graphical user interface,wherein the record for the at least one uniform resource locator is created by the portal in response to receipt of the second message.2. The method of claim 1 , further comprising:adding one or more tags including the user-generated tag to the record based on input received from the user via the graphical user interface.3. The method of claim 2 , wherein at least one of the tags indicates whether the webpage associated with the at least one ...

FRAMELESS TELECOMMUNICATIONS ENCLOSURE

Telecommunications enclosures are described in this document. In one aspect, a telecommunications enclosure includes side panels having seals and an enclosure top connected, independent of a frame, to top ends of the side panels. The enclosure top has an enclosure top outer end that extends between the side panels and includes a seal. An interior panel is connected, independent of a frame, to side panels and has an interior panel outer end that extends between the side panels. The interior panel is separated from the enclosure top by a first distance and separated by a second distance from bottom ends of the side panels. A removable door is formed to engage the seals when the removable door is secured to the frameless telecommunications enclosure. 121.-. (canceled)22. A frameless telecommunications enclosure , comprising:an enclosure top;at least two panels that are each fastened to the enclosure top independent of a frame;a removable door that is formed to engage the at least two panels and create a weather seal; andan interior panel that engages the at least two panels, and separates an interior of the frameless telecommunications enclosure to create a lower chamber and a separate upper chamber.23. The frameless telecommunications enclosure of claim 22 , wherein at least one of the lower chamber or the upper chamber is ventilated.24. The frameless telecommunications enclosure of claim 22 , wherein the removable door also engages the interior panel to create a weather seal between the lower chamber and the upper chamber.25. The frameless telecommunications enclosure of claim 22 , wherein the removable door has a main door portion formed in a first plane and protruding ends that extend out from the main door portion in a second plane that intersects the first plane.26. The frameless telecommunications enclosure of claim 25 , wherein one of the protruding ends has one or more slots defined therein to receive tabs protruding from an enclosure bottom.27. The frameless ...

GAZE SWIPE SELECTION

Methods for enabling hands-free selection of virtual objects are described. In some embodiments, a gaze swipe gesture may be used to select a virtual object. The gaze swipe gesture may involve an end user of a head-mounted display device (HMD) performing head movements that are tracked by the HMD to detect whether a virtual pointer controlled by the end user has swiped across two or more edges of the virtual object. In some cases, the gaze swipe gesture may comprise the end user using their head movements to move the virtual pointer through two edges of the virtual object while the end user gazes at the virtual object. In response to detecting the gaze swipe gesture, the HMD may determine a second virtual object to be displayed on the HMD based on a speed of the gaze swipe gesture and a size of the virtual object. 1. An electronic device for displaying an augmented reality environment , comprising:a see-through display, the see-through display displays a virtual object to an end user of the electronic device, the virtual object includes a plurality of edges; andone or more processors in communication with the see-through display, the one or more processors detect a gaze swipe activation event performed by the end user and display a virtual pointer to the end user in response to detecting the gaze swipe activation event, the one or more processors detect a gaze swipe gesture performed by the end user, the gaze swipe gesture corresponds with the end user moving the virtual pointer using one or more head movements through two or more edges of the plurality of edges, the one or more processors determine a speed of the gaze swipe gesture, the one or more processors determine a second virtual object different from the virtual object based on the speed of the gaze swipe gesture and the two or more edges of the plurality of edges traversed by the gaze swipe gesture, the one or more processors cause the second virtual object to be displayed using the see-through display.2. ...

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): 2. The compound according to wherein X is CR; or a pharmaceutically acceptable salt thereof.3. The compound according to wherein R; is H claim 2 , chloro claim 2 , bromo claim 2 , or Calkyl or a pharmaceutically acceptable salt thereof.4. The compound according to wherein Ris H; or a pharmaceutically acceptable salt thereof.6. The compound according to wherein Rand Rare each independently optionally substituted Calkyl or Rand Rare joined together forming an optionally substituted 4-7 membered heterocyclic ring; or a pharmaceutically acceptable salt thereof.7. The compound according to wherein:L is methylene, ethylene, or propylene, or{'sub': '1-3', 'L is *—Calkylene-OC(O)— or'}{'sub': 1-4', '1-2, 'L is *—Calkylene-L2-Calkylene-, wherein L2, attached in either direction, is C(O)O or OC(O)O; or a pharmaceutically acceptable salt thereof.'}8. The compound according wherein Rand Rare each independently optionally substituted methyl or optionally substituted ethyl; or a pharmaceutically acceptable salt thereof.10. The compound according to wherein Rand Rare each independently:{'sup': 1', 'a, '(a) —Z—R,'}{'sup': 1', 'b', '2', 'a, '(b) —Z—R—Z—R,'}{'sup': 1', 'b', '2', 'b', '3', 'a, '(c) —Z—R—Z—R—Z—R,'}{'sup': b', '1', 'a, '(e) —R—Z—R,'}{'sup': b', '1', 'b', '2', 'a, '(f) —R—Z—R—Z—R,'}{'sup': b', '1', 'b', '2', 'b', '3', 'a, '(g) —R—Z—R—Z—R—Z—R,'}{'sup': 'c', '(i) —R, or'}{'sup': 1', 'b', 'c, '(j) —Z—R—R; or a pharmaceutically acceptable salt thereof.'}11. The compound according to wherein Rand Rare each independently:{'sup': 1', 'a, '(a) —Z—R,'}{'sup': 1', 'b', '2', 'a, '(b) —Z—R—Z—R, or'}{'sup': b', '1', 'b', '2', 'a, '(f) —R—Z—R—Z—R; or a pharmaceutically acceptable salt thereof.'}12. The compound according to wherein Rand Rare each independently (b) —Z—R—Z—R; or a pharmaceutically acceptable salt thereof.13. The compound according to wherein Zis —O—; Ris Calkylene; Zis —OC(O)—; and Ris Calkyl or Calkenyl having one ...

AUTOMATED CONTENT SCROLLING

Methods for controlling the display of content as the content is being viewed by an end user of a head-mounted display device (HMD) are described. In some embodiments, an HMD may display the content using a virtual content reader for reading the content. The content may comprise text and/or images, such as text or images associated with an electronic book, an electronic magazine, a word processing document, a webpage, or an email. The virtual content reader may provide automated content scrolling based on a rate at which the end user reads a portion of the displayed content on the virtual content reader. In one embodiment, an HMD may combine automatic scrolling of content displayed on the virtual content reader with user controlled scrolling (e.g., via head tracking of the end user of the HMD). 1. An electronic device for displaying an augmented reality environment , comprising:a see-through display, the see-through display displays a virtual content reader to an end user of the electronic device; andone or more processors in communication with the see-through display, the one or more processors determine a scrolling rate for the virtual content reader such that the end user views a first portion of the content being read within a first region of the virtual content reader, the one or more processors cause the first portion of the content displayed using the virtual content reader to be scrolled at the scrolling rate, the virtual content reader includes a scrollbar corresponding with a second region of the virtual content reader different from the first region, the one or more processors detect a first triggering event, the first triggering event includes detecting that the end user has gazed at the second region, the one or more processors disable scrolling of the first portion of the content in response to detecting the first triggering event, the one or more processors detect a second triggering event, the second triggering event includes detecting that the end ...

Use of Nanoparticles in Cleaning Well Bores

Embodiments relate to removing residue from a well bore and well bore equipment with a treatment fluid composition, and in some embodiments, to treatment fluid compositions that comprise nanoparticles. An embodiment provides a method of removing drilling fluid residue from the surfaces of well equipment. The method comprising: applying a solid nanoparticle film to at least a portion of the surfaces of the well equipment with a treatment fluid comprising solid nanoparticles; and allowing the solid nanoparticles to interact with the surfaces of the well equipment and the drilling fluid residue adhered to the surfaces of the well equipment to remove at least a portion of the drilling fluid residue from the surfaces of the well equipment.

Organic compounds to treat hepatitis b virus

The disclosure relates to compositions comprising a HBV RNAi agent. In some embodiments, the HBV RNAi agent comprises a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3′ end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5′ to 3′ order: a spacer; a second phosphate or modified internucleoside linker; and a 3′ end cap. In some embodiments, the 3′ end of both the sense and anti-sense strand further comprise, in 5′ to 3′ order: a spacer; a second phosphate or modified internucleoside linker; and a 3′ end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3′ end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the RNAi agent can be modified on one or both 5′ end. Optionally, the sense strand can comprise a 5′ end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference. The disclosure also pertains to methods of treating, ameliorating and preventing HBV in a patient involving the step of administering to the patient a therapeutic amount of a HBV RNAi agent.

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): 2. The compound according to wherein X is CR; or a pharmaceutically acceptable salt thereof.3. The compound according to wherein R; is H claim 2 , chloro claim 2 , bromo claim 2 , or Calkyl or a pharmaceutically acceptable salt thereof.4. The compound according to wherein Ris H; or a pharmaceutically acceptable salt thereof.6. The compound according to wherein Rand Rare each independently optionally substituted Calkyl or Rand Rare joined together forming an optionally substituted 4-7 membered heterocyclic ring; or a pharmaceutically acceptable salt thereof.7. The compound according to wherein:L is methylene, ethylene, or propylene, or{'sub': '1-3', 'L is *—Calkylene-OC(O)— or'}{'sub': 1-4', '1-2, 'L is *—Calkylene-L2-Calkylene-, wherein L2, attached in either direction, is C(O)O or OC(O)O; or a pharmaceutically acceptable salt thereof.'}8. The compound according wherein Rand Rare each independently optionally substituted methyl or optionally substituted ethyl; or a pharmaceutically acceptable salt thereof.10. The compound according to wherein Rand Rare each independently:{'sup': 1', 'a, '(a) —Z—R,'}{'sup': 1', 'b', '2', 'a, '(b) —Z—R—Z—R,'}{'sup': 1', 'b', '2', 'b', '3', 'a, '(c) —Z—R—Z—R—Z—R,'}{'sup': b', '1', 'a, '(e) —R—Z—R,'}{'sup': b', '1', 'b', '2', 'a, '(f) —R—Z—R—Z—R,'}{'sup': b', '1', 'b', '2', 'b', '3', 'a, '(g) —R—Z—R—Z—R—Z—R,'}{'sup': 'c', '(i) —R, or'}{'sup': 1', 'b', 'c, '(j) —Z—R—R; or a pharmaceutically acceptable salt thereof.'}11. The compound according to wherein Rand Rare each independently:{'sup': 1', 'a, '(a) —Z—R,'}{'sup': 1', 'b', '2', 'a, '(b) —Z—R—Z—R, or'}{'sup': b', '1', 'b', '2', 'a, '(f) —R—Z—R—Z—R; or a pharmaceutically acceptable salt thereof.'}12. The compound according to wherein Rand Rare each independently (b) —Z—R—Z—R; or a pharmaceutically acceptable salt thereof.13. The compound according to wherein Zis —O—; Ris Calkylene; Zis —OC(O)—; and Ris Calkyl or Calkenyl having one ...

Scavenging System Including at Least One Mixed Acetal Compound to Remove Hydrogen Sulfide and/or Mercaptans from a Fluid Stream

A solution including at least one mixed acetal compound is used to remove hydrogen sulfide and/or mercaptans from a fluid stream, preferably a fluid gas stream. A mixed acetal compound, as provided in the general structure below, includes an N-glycosidic type bond. The mixed acetal includes nitrogen and oxygen as provided below. 2. The method of claim 1 , wherein said at least one mixed acetal has a pH of 8-9.5.3. The method of claim 1 , wherein said fluid stream is a fluid gas stream.4. The method of claim 1 , wherein said solution is an aqueous solution.5. The method of claim 4 , wherein said solution includes 20-90 wt. % water.6. The method of claim 5 , wherein said solution includes 40-60 wt. % water.7. The method of claim 1 , wherein said mercaptans are selected from the group consisting of methanethiol —CHSH [methyl mercaptan] claim 1 , ethanethiol —CHSH [ethyl mercaptan] claim 1 , 1-propanethiol —CHSH [n-propyl mercaptan] claim 1 , 2-propanethiol —CHCH(SH)CH[2Cmercaptan] claim 1 , allyl mercaptan —CH═CHCHSH [2-propenethiol] claim 1 , butanethiol —CHSH [n-butyl mercaptan] claim 1 , tert-butyl mercaptan —(CH)CSH [t-butyl mercaptan] claim 1 , pentanethiols —CHSH [pentyl mercaptan] claim 1 , and mixtures thereof.8. The method of claim 1 , wherein said fluid gas streams has <10 wt. % hydrogen sulfide claim 1 , mercaptans claim 1 , and mixtures thereof.9. The method of claim 1 , wherein said fluid gas stream has <5 wt. % hydrogen sulfide claim 1 , mercaptans claim 1 , and mixtures thereof.10. The method of claim 1 , wherein said fluid gas stream has <2 wt. % hydrogen sulfide claim 1 , mercaptans claim 1 , and mixtures thereof.11. The method of claim 1 , wherein said at least one mixed acetal compound reduces the concentration of said hydrogen sulfide claim 1 , mercaptans claim 1 , and mixtures thereof provided in said fluid stream by at least 20 wt. %.12. The method of claim 1 , wherein said at least one mixed acetal compound reduces the concentration of said ...

SYSTEM AND METHOD TO MARK AUTONOMOUS WORK AREA

System and methods for marking a work area boundary of an autonomous vehicle are disclosed. A system may receive an indication that boundary marking for a work area is to be activated, and may transmit an activation signal to a marking actuator based on receiving the indication that boundary marking for the work area is to be activated. The activation signal may cause the marking actuator to begin marking the boundary as a vehicle, that includes the system, traverses the boundary. The system may store information that identifies a plurality of marked locations along the boundary. The system may determine that boundary marking for the work area is to be deactivated, and may transmit a deactivation signal to the marking actuator based on determining that boundary marking for the work area is to be deactivated. The deactivation signal may cause the marking actuator to stop marking the boundary. 1. A system for marking a boundary of a work area of an autonomous vehicle , comprising:a memory;a marking actuator configured to mark the boundary of the work area; and receive an indication that boundary marking for the work area is to be activated;', 'transmit an activation signal to the marking actuator based on receiving the indication that boundary marking for the work area is to be activated, the activation signal causing the marking actuator to begin marking the boundary as a vehicle, that includes the system, traverses the boundary;', 'store, in the memory, information that identifies a plurality of marked locations along the boundary;', 'determine that boundary marking for the work area is to be deactivated; and', 'transmit a deactivation signal to the marking actuator based on determining that boundary marking for the work area is to be deactivated, the deactivation signal causing the marking actuator to stop marking the boundary., 'a controller configured to2. The system of claim 1 , wherein the marking actuator is configured to mark the boundary by:dropping an ...

Location Based Advertisement System

An advertising system configured to enable advertisements to be configured by a user via the internet, and then scheduled for display as desired on the back of a bus or other remote fixed or mobile advertising site. The system includes a website configured to enable an ad buyer to log onto the website; upload and approve advertising graphics, and select variables for display of the advertising graphics; and a remote advertising display linked to the website via the internet. The advertisement is displayed on the remote advertising display based on the variables selected by the ad buyer. 1. An advertising system configured to enable advertisements to be configured by a user via the internet , and then scheduled for display as desired on a remote advertising site , comprising:a website configured to enable an ad buyer to log onto the website; upload and approve advertising graphics, and purchase times and geographic locations for display of the advertising graphics; anda remote advertising display linked to the website via the internet,wherein the advertisement is displayed on the remote advertising display at the times and geographic locations purchased by the ad buyer.2. The advertising system of claim 1 , wherein the remote advertising display is located on a vehicle that is transient and equipped with a GPS claim 1 , and the advertisement is displayed on the remote advertising display when the vehicle is located at preselected geographic locations selected by the ad buyer.3. The advertising system of claim 1 , wherein the advertisement is displayed on the remote advertising display only when current weather conditions correspond to preselected weather conditions selected by the ad buyer.4. The advertising system of claim 1 , wherein the advertisement is displayed on the remote advertising display corresponding to variables selected by the ad buyer from the group consisting of date claim 1 , time claim 1 , temperature claim 1 , and weather.5. An advertising system ...

NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE

The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent having a novel format: an 18-mer format with at least one internal spacer. These RNAi agents comprise a first and a second 18-mer strand, wherein the first strand is 18 ribonucleotides or 18 total ribonucleotides and spacer subunit(s), and the second strand is 18 total ribonucleotides and spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand; the two strands form a duplex with at least one blunt end; and the 3 end of one or both strands terminates in a phosphate or modified internucleoside linker and further comprises, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker, and a 3 end cap. In various embodiments, the RNAi agents comprise a first and a second strand, wherein each strand is a 30-mer or shorter, the first strand comprises ribonucleotides, and the second strand comprises ribonucleotides and one or more spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand. In some embodiments, the 3 end of both strands further comprise, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker; and a 3 end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3 end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the first two base-pairing nucleotides on the 3 end of the one or both strand are 2-MOE. Optionally, the RNAi agent can be modified on one or both 5 end. ...

Systems and Methods for Direct In-Browser Markup of Elements in Internet Content

Exemplary embodiments of the present disclosure relate to systems, methods, and non-transitory computer-readable media for contemporaneous in-browser searching, viewing, tagging, comparison, and harvesting of specific elements in digital content in a networked environment via enhanced browser environment, and for refining an operation of a portal based on the contemporaneous in-browser searching, viewing, tagging, comparison and harvesting of elements in digital content.

ORGANIC COMPOSITIONS TO TREAT APOC3-RELATED DISEASES

The present disclosure relates to compositions and methods for treating APOC3-related diseases such as: hypertriglyceridemia (e.g., Type V Hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including Type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a RNAi agent to APOC3. 1. A double stranded RNAi agent for inhibiting expression of APOC3 , comprising a first strand and a second strand , wherein said first strand is less than about 49 nucleotides in length and comprises at least 14 contiguous nucleotides differing by 0 , 1 , 2 , or 3 nucleotides from any of SEQ ID NOs: 1-546.2. The RNAi agent of claim 1 , wherein the first strand comprises at least one modified nucleotide or modified intemucleoside linkage.3. The RNAi agent of claim 2 , wherein the 3′ end of the first strand and/or the second strand comprises a 3′ end cap.4. The RNAi agent of claim 2 , wherein the first strand and the second strand form a duplex region of about 15 to about 30 nucleotide base pairs.5. The RNAi agent of claim 2 , wherein one or more nucleotides of the first strand or the second strand has been replaced by a spacer.6. The RNAi agent of claim 2 , wherein the first strand comprises at least one 2′-modified nucleotide or modified phosphorothioate linkage.7. The RNAi agent of claim 3 , wherein the 3′ end of the first and/or second strand terminates in a phosphate or modified intemucleoside linker and further comprises claim 3 , in 5′ to 3′ order: a spacer claim 3 , a second phosphate or modified internucleoside linker claim 3 , and a 3′ end cap.8. The RNAi agent of claim 4 , wherein the spacer is selected from a sugar claim 4 , alkyl claim 4 , cycloalkyl claim 4 , ribitol claim 4 , 2′-deoxy-ribitol claim 4 , diribitol claim 4 , 2′-methoxyethoxy-ribitol claim 4 , C3 claim 4 , C4 ...

GESTURE PARAMETER TUNING

Embodiments are disclosed herein that relate to tuning gesture recognition characteristics for a device configured to receive gesture-based user inputs. For example, one disclosed embodiment provides a head-mounted display device including a plurality of sensors, a display configured to present a user interface, a logic machine, and a storage machine that holds instructions executable by the logic machine to detect a gesture based upon information received from a first sensor of the plurality of sensors, perform an action in response to detecting the gesture, and determine whether the gesture matches an intended gesture input. The instructions are further executable to update a gesture parameter that defines the intended gesture input if it is determined that the gesture detected does not match the intended gesture input. 1. A head-mounted display device , comprising:a plurality of sensors;a display configured to present a user interface;a logic machine; and detect a gesture based upon information received from a first sensor of the plurality of sensors;', 'perform an action in response to detecting the gesture;', 'determine whether the gesture matches an intended gesture input; and', 'update a gesture parameter if it is determined that the gesture detected does not match the intended gesture input., 'a storage machine holding instructions executable by the logic machine to'}2. The head-mounted display device of claim 1 , wherein the plurality of sensors comprises two or more of an accelerometer claim 1 , a gyroscope claim 1 , a microphone claim 1 , and a camera.3. The head-mounted display device of claim 1 , wherein detecting the gesture further comprises detecting a head movement and matching a motion characteristic of the head movement to one or more gesture parameters of the gesture detected claim 1 , and wherein updating the gesture parameter further comprises adjusting a parameter related to a range of head movements based on the motion characteristic of the ...

TRUCK AND CONVEYOR SYSTEM

In one representative embodiment, a vehicle has a frame, a material hopper mounted on the frame, a swing arm assembly coupled to the frame, and a conveyor mounted on the swing arm assembly. The swing arm assembly can have a support bracket configured to pivot relative to the hopper about a vertical pivot axis, the support bracket also configured to pivot relative to the hopper about a horizontal pivot axis, wherein the support bracket is configured to support the conveyor for pivoting movement of the conveyor relative to the hopper about the vertical pivot axis and about the horizontal pivot axis to move the conveyor from a first, stowed position extending alongside one of the sides of the hopper to a second, use position extending rearwardly away from the rear end of the hopper. 1. A vehicle comprising:a frame;a material hopper mounted on the frame, the hopper having first and second longitudinally extending sides and front and rear ends, the hopper having a length extending from the rear end to the front end and parallel to the sides;a swing arm assembly coupled to the frame or the hopper;a conveyor mounted on the swing arm assembly;wherein the swing arm assembly comprises a support bracket configured to pivot relative to the hopper about a vertical pivot axis, the support bracket also configured to pivot relative to the hopper about a horizontal pivot axis, wherein the support bracket is configured to support the conveyor for pivoting movement of the conveyor relative to the hopper about the vertical pivot axis and about the horizontal pivot axis to move the conveyor from a first, stowed position extending alongside one of the sides of the hopper to a second, use position extending rearwardly away from the rear end of the hopper.2. The vehicle of claim 1 , further comprising a first actuator configured to cause pivoting movement of the support bracket and the conveyor about the vertical pivot axis.3. The vehicle of claim 2 , further comprising a second actuator ...

ENDOTHERMIC BASE-MOUNTED HEAT PUMP WATER HEATER

An endothermic heat pump water heater has a water tank supported atop a hollow base, a heat pump circuit operable to provide primary heat to water in the tank, and an electric resistance heating element operable to provide secondary heat to the water. The heat pump circuit includes refrigerant tubing in which a compressor disposed within the base, a condenser in heat exchange external contact with the tank, a refrigerant expansion device, and an evaporator disposed within the base are connected in series. A vertical duct, external to the tank, has an inlet adjacent the upper tank end, and a fan is operative to sequentially flow air inwardly through the inlet, downwardly through the duct into the base, across the compressor, across the evaporator, and then outwardly from the base. 1. A water heater comprising:a hollow base;a tank adapted to hold a quantity of water to be heated, said tank having upper and lower ends and being supported atop said base;a heat pump circuit operable to provide primary heat to water in said tank, said heat pump circuit comprising refrigerant tubing in which (1) a compressor disposed within said base, (2) a condenser in heat exchange contact with said tank, (3) a refrigerant expansion device, and (4) an evaporator disposed within said base are connected in series in a manner such that said compressor is operative to flow refrigerant sequentially through said condenser, said expansion device, and said evaporator and then back to said compressor via said refrigerant tubing;a duct, external to said tank, through which air may be flowed into said base without being surrounded by said tank;a fan operative to sequentially flow air through said duct into said base, across said compressor, across said evaporator, and then outwardly from said base andsecondary heating apparatus operable to heat water in said tank.2. The water heater of wherein:said secondary heating apparatus includes a resistance type electric heating element extending through the ...

3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference. 232-. (canceled)36. The RNAi agent of claim 35 , wherein X is attached at the 3′ end of a strand of the RNAi agent.37. The RNAi agent of claim 36 , wherein the strand of the RNAi agent terminates at its 3′ end in a phosphate or modified internucleoside linker claim 36 , and X is attached at the phosphate or modified internucleoside linker.38. The RNAi agent of claim 36 , wherein the strand of the RNAi agent terminates at its 3′ end in a phosphate or modified internucleoside linker claim 36 , the phosphate or modified internucleoside linker is substituted by a spacer claim 36 , which is substituted by a second phosphate or modified internucleoside linker claim 36 , in 5′ to 3′ order claim 36 , and X is attached at the second phosphate or modified internucleoside linker.40. The RNAi agent of claim 35 , wherein the strand of the RNAi agent is a first strand and X further comprises a second strand.41. The RNAi agent of claim 40 , wherein the first strand is an antisense strand.42. The RNAi agent of claim 40 , wherein the first and/or second strands are no more than about 30 nucleotides long.43. The RNAi agent of having 1 or 2 blunt ends.44. The RNAi agent of having an overhang on at least one 5′ end or 3′ end.45. The RNAi agent of claim 40 , wherein X further comprises a spacer.46. The RNAi agent of claim 45 , wherein the spacer is an abasic nucleotide.47. The RNAi agent of claim 45 , wherein the spacer is a ribitol claim 45 , 2′-deoxy-ribitol claim 45 , diribitol claim 45 , 2′-methoxyethoxy-ribitol (ribitol with 2′-MOE) claim 45 , C3 claim 45 , C4 claim 45 , C5 claim 45 , C6 claim 45 , or 4-methoxybutane-1 claim 45 ,3-diol.48. The RNAi agent of claim 40 , wherein at least one nucleotide of the ...

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): 7. The method of claim 1 , wherein the composition comprises one or more of a helper lipid claim 1 , a neutral lipid claim 1 , and a stealth lipid.8. The method of claim 7 , wherein the helper lipid is cholesterol claim 7 , the neutral lipid is DSPC claim 7 , and the stealth lipid is PEG-DMG claim 7 , S010 claim 7 , or S011.9. The method of claim 3 , wherein the composition comprises one or more of a helper lipid claim 3 , a neutral lipid claim 3 , and a stealth lipid.10. The method of claim 9 , wherein the helper lipid is cholesterol claim 9 , the neutral lipid is DSPC claim 9 , and the stealth lipid is PEG-DMG claim 9 , S010 claim 9 , or S011.11. The method of claim 5 , wherein the composition comprises one or more of a helper lipid claim 5 , a neutral lipid claim 5 , and a stealth lipid.12. The method of claim 11 , wherein the helper lipid is cholesterol claim 11 , the neutral lipid is DSPC claim 11 , and the stealth lipid is PEG-DMG claim 11 , S010 claim 11 , or S011.13. The method of claim 1 , wherein the composition is in a form of a lipid nanoparticle.14. The method of claim 3 , wherein the composition is in a form of a lipid nanoparticle.15. The method of claim 5 , wherein the composition is in a form of a lipid nanoparticle.16. The method of claim 8 , wherein the stealth lipid is PEG-DMG.17. The method of claim 10 , wherein the stealth lipid is PEG-DMG.18. The method of claim 12 , wherein the stealth lipid is PEG-DMG.19. The method of claim 8 , wherein the lipid composition has a molar ratio of about 40/about 38/about 10/about 2 of the compound of formula (I)/cholesterol/DSPC/PEG-DMG claim 8 , S010 claim 8 , or S011 claim 8 , respectively.20. The method of claim 10 , wherein the lipid composition has a molar ratio of about 40/about 38/about 10/about 2 of the compound of (9Z claim 10 , 9′Z claim 10 , 12Z claim 10 , 12′Z)-((5-((dimethylamino)methyl)-1 claim 10 ,3-phenylene)bis(oxy))bis(butane-4 claim 10 , ...

TUBULAR CUTTING TOOL

A method of cutting a tubular includes providing a rotatable cutting tool in the tubular, the cutting tool having a blade with a cutting structure thereon; extending the blade relative to the cutting tool; rotating the cutting tool relative to the tubular; guiding the cutting structure into contact with the tubular; cutting the tubular using the blade; and limiting extension of the blade. A rotatable blade for cutting a tubular includes a blade body extendable from a retracted position; a cutting structure disposed on a leading edge of the blade body, the cutting structure configured to cut the tubular; a stop on a first surface of the blade body; and an initial engagement point on a second surface of the blade body, the initial engagement point configured to guide the cutting structure into contact with the tubular. 1. A method of cutting a tubular , comprising:providing a rotatable cutting tool in the tubular, the cutting tool having a blade with a cutting structure thereon;extending the blade relative to the cutting tool;rotating the cutting tool relative to the tubular;guiding the cutting structure into contact with the tubular;cutting the tubular using the blade; andlimiting extension of the blade.2. The method of claim 1 , wherein an actuation assembly acts to extend the blade relative to the cutting tool.3. The method of claim 2 , wherein the actuation assembly is hydraulic claim 2 , the method further comprising limiting extension of the blade regardless of a fluid pressure in the housing of the cutting tool.4. The method of claim 1 , wherein limiting extension of the blade comprises engaging a stop with the tubular.5. The method of claim 4 , further including at least one of:stabilizing the cutting tool by engaging the stop with the tubular,laterally moving the cutting tool by engaging the stop with the tubular, andcentralizing the cutting tool by engaging the stop with the tubular.6. The method of claim 1 , wherein the extending the blade relative to the ...

TUBULAR CUTTING TOOL

A method of cutting a tubular includes providing a rotatable cutting tool in the tubular, the cutting tool having a blade with a cutting structure thereon; extending the blade relative to the cutting tool; rotating the cutting tool relative to the tubular; guiding the cutting structure into contact with the tubular; cutting the tubular using the blade; and limiting extension of the blade. 1. A method of cutting a tubular , comprising:providing a rotatable cutting tool in the tubular, the cutting tool having a blade with a cutting structure thereon;extending the blade relative to the cutting tool;rotating the cutting tool relative to the tubular;guiding the cutting structure into contact with the tubular;cutting the tubular using the blade; andlimiting extension of the blade.2. The method of claim 1 , wherein an actuation assembly acts to extend the blade relative to the cutting tool.3. The method of claim 2 , wherein the actuation assembly is hydraulic claim 2 , the method further comprising limiting extension of the blade regardless of a fluid pressure in the housing of the cutting tool.4. The method of claim 1 , wherein limiting extension of the blade comprises engaging a stop with the tubular.5. The method of claim 4 , further including at least one of:stabilizing the cutting tool by engaging the stop with the tubular,laterally moving the cutting tool by engaging the stop with the tubular, andcentralizing the cutting tool by engaging the stop with the tubular.6. The method of claim 1 , wherein the extending the blade relative to the cutting tool happens while at least one of:the rotating the cutting tool relative to the tubular,the guiding the cutting structure into contact with the tubular,a moving the cutting structure upward within the tubular, anda pivoting the blade about a pivot point.7. The method of claim 1 , wherein guiding the cutting structure into contact with the tubular includes making initial contact with the tubular with a wearable member on the ...

COMPETITOR-SPECIFIC BID RECOMMENDATIONS

Systems, methods, and computer-readable storage media that may be used to generate competitor-specific bidding recommendations are provided. One method includes identifying, at a computerized analysis system, at least one competitor of a content provider within a plurality of content auctions for displaying content items. The method further includes calculating, at the analysis system, at least one bidding action estimated to improve performance of the content provider in future content auctions with respect to the at least one competitor from a current level to a goal level of the performance metric. The method further includes providing a recommendation to the content provider to implement the at least one bidding action. 1. A method comprising:identifying, at a computerized analysis system, at least one competitor of a content provider within a plurality of content auctions for displaying content items;determining one or more current bid settings of the content provider;determining a current level of a performance metric within the plurality of content auctions for the content provider with respect to a performance of the at least one competitor;identifying a goal level of the performance metric for the content provider with respect to the performance of the at least one competitor;retrieving, from an historical auction database, historical competitor bid data;retrieving, from the historical auction database, historical content provider bid data comprising one or more content provider bid parameters, and adjusting at least one of the one or more content provider bid data parameters by a bid setting adjustment;determining a revised outcome of the historical auction based on the historical competitor bid data and the adjusted content provider bid data;calculating a revised performance metric for the content provider based on the revised outcome;determining, based on a comparison of the revised performance metric for the content provider to the goal level of the ...

ULTRAVIOLET LIGHT SENSING

A method of measuring ultraviolet light includes observing an ultraviolet portion of ambient light with an ultraviolet light sensor, measuring an intensity of a visible portion of the ambient light with a visible light sensor, and estimating an intensity of the ultraviolet portion of the ambient light based on the measured intensity of the visible portion of the ambient light if the observed ultraviolet portion of the ambient light exceeds a threshold intensity. 1. A method of measuring ultraviolet light , comprising:observing an ultraviolet portion of ambient light with an ultraviolet light sensor;measuring an intensity of a visible portion of the ambient light with a visible light sensor; andestimating an intensity of the ultraviolet portion of the ambient light based on the measured intensity of the visible portion of the ambient light if the observed ultraviolet portion of the ambient light exceeds a threshold intensity.2. The method of claim 1 , further comprising estimating the intensity of the ultraviolet portion of the ambient light to be negligible regardless of the measured intensity of the visible portion of the ambient light if the observed ultraviolet portion of the ambient light is less than the threshold intensity.3. The method of claim 1 , wherein the visible light sensor is sensitive to visible light and not ultraviolet light.4. The method of claim 1 , further comprising estimating an index of the ultraviolet portion of the ambient light based on the estimated intensity of the ultraviolet portion of the ambient light.5. The method of claim 1 , wherein the ultraviolet light sensor and the visible light sensor comprise a single light sensor having a first portion sensitive to ultraviolet light and not visible light claim 1 , and a second portion sensitive to the visible light and not the ultraviolet light.6. The method of claim 1 , wherein the ultraviolet light sensor includes a photosensitive surface doped such that the photosensitive surface is ...

FRAMELESS TELECOMMUNICATIONS ENCLOSURE

Telecommunications enclosures are described in this document. In one aspect, a telecommunications enclosure includes side panels having seals and an enclosure top connected, independent of a frame, to top ends of the side panels. The enclosure top has an enclosure top outer end that extends between the side panels and includes a seal. An interior panel is connected, independent of a frame, to side panels and has an interior panel outer end that extends between the side panels. The interior panel is separated from the enclosure top by a first distance and separated by a second distance from bottom ends of the side panels. A removable door is formed to engage the seals when the removable door is secured to the frameless telecommunications enclosure. 1. A frameless telecommunications enclosure comprising:a first side panel having a first outer end that includes a first seal;a second side panel having a second outer end that includes a second seal;an enclosure top connected, independent of a frame, to a top end of the first side panel and a top end of the second side panel, the enclosure top having an enclosure top outer end that extends from the first side panel to the second side panel and includes a third seal;an interior panel connected, independent of a frame, to each of the first side panel and the second side panel and having an interior panel outer end that extends from the first side panel to the second side panel and includes a fourth seal, the interior panel being separated from the enclosure top by a first specified distance and being separated by a second specified distance from a bottom end of each of the first side panel and the second side panel; anda removable door that is formed to engage each of the first seal, the second seal, the third seal, and the fourth seal when the removable door is secured to the frameless telecommunications enclosure.2. The frameless telecommunications enclosure of claim 1 , wherein the removable door has a main door portion ...

Use of Nanoparticles in Cleaning Well Bores

Embodiments relate to removing residue from a well bore and well bore equipment with a treatment fluid composition, and in some embodiments, to treatment fluid compositions that comprise nanoparticles. An embodiment provides a method of removing drilling fluid residue from the surfaces of well equipment. The method comprising: applying a solid nanoparticle film to at least a portion of the surfaces of the well equipment with a treatment fluid comprising solid nanoparticles; and allowing the solid nanoparticles to interact with the surfaces of the well equipment and the drilling fluid residue adhered to the surfaces of the well equipment to remove at least a portion of the drilling fluid residue from the surfaces of the well equipment. 1. A method of treating drilling fluid residue , the method comprising:providing a treatment fluid comprising solid nanoparticles;contacting the surfaces of well equipment with a treatment fluid, the surfaces of the well equipment comprising a drilling fluid residue adhered to said surfaces;allowing the solid nanoparticles to interact with the surfaces of the well equipment and the drilling fluid residue adhered to the surfaces of the well equipment to remove at least a portion of the drilling fluid residue from the surfaces of the well equipment; wherein the removal of the drilling fluid residue from the surfaces of the well equipment further comprises changing the surfaces of the well equipment from an oil-wet surface to a water-wet surface; andrecovering the treatment fluid and the removed drilling fluid residue out of the well bore.2. The method of wherein the solid nanoparticles comprise at least one unit selected from the group consisting of: nano-silica claim 1 , nano-alumina claim 1 , nano-zinc oxide claim 1 , nano-boron claim 1 , SiO claim 1 , AlO claim 1 , boehmite claim 1 , TiO claim 1 , ZnO claim 1 , FeO claim 1 , ZrO claim 1 , CaCO claim 1 , SiC claim 1 , SiN claim 1 , graphite claim 1 , fullerenes claim 1 , activated ...

Secure Transmission Over Satellite Phone Network

A reach back secure communications terminal includes a modem to satellite interconnect board that captures DTMF tones, demodulates encrypted modem information, and converts both into an ASCII string for presentation to a data port of a satellite phone, allowing out-of-band control of a non-secure satellite system (e.g., AT command control of a data port) by a user on a secure side of an encryption device, by including the ability to interpret control signals and control the satellite system appropriately. A false dial tone is presented to the encryption device, and the data stream coming from the encryption device is monitored for the presence of dual-tone, multi-frequency (DTMF) tones representing control signals, the DTMF tones are converted to ASCII characters, which are in turn received as control signals by the satellite phone, allowing control of the functions of the satellite system directly from the secure side of the encryption device. 114-. (canceled)15. An interface between an encryption device and a satellite phone , comprising:a modem interface; anda control signal converter module to receive a Voice over Internet Protocol (VoIP) data stream from said modem interface, removing in-band control signaling from said VoIP data stream, and to present said removed control signaling out-of-band to a USB data port of said satellite phone.16. The interface between an encryption device and a satellite phone according to claim 15 , wherein said data port of said satellite phone comprises:a USB data port.17. The interface between an encryption device and a satellite phone according to claim 15 , wherein:said modem interface conforms to V.34 standards.18. The interface between an encryption device and a satellite phone according to claim 15 , wherein:said control signal converter module is formed in a programmable integrated circuit (PIC).19. The interface between an encryption device and a satellite phone according to claim 15 , further comprising:a FAX/data ...

POLICY ENFORCEMENT AND INTROSPECTION ON AN AUTHENTICATION SYSTEM

An authentication system handles authentication requests to apply introspection and policy enforcement. A policy server obtains a client security policy and an authenticator security policy. The policy server obtains an encrypted credential request with client metadata from a client and determines whether the client metadata satisfies the client security policy. The policy server provides the encrypted credential request to an authenticator device and obtains an encrypted credential response with authenticator metadata in response. The policy server determines whether the authenticator metadata satisfies the authenticator security policy. The policy server processes the encrypted credential response, without decrypting the encrypted credential request or the encrypted credential response, based on a determination of whether the client metadata satisfies the client security policy and the authenticator metadata satisfies the authenticator security policy. 1. A method comprising:at a policy server, obtaining a client security policy and an authenticator security policy;obtaining an encrypted credential request with client metadata from a client;determining whether the client metadata satisfies the client security policy;providing the encrypted credential request to an authenticator device;obtaining an encrypted credential response with authenticator metadata from the authenticator device;determining whether the authenticator metadata satisfies the authenticator security policy; andprocessing the encrypted credential response, without decrypting the encrypted credential request or the encrypted credential response, based on a determination of whether the client metadata satisfies the client security policy and the authenticator metadata satisfies the authenticator security policy.2. The method of claim 1 , further comprising storing a record of the encrypted credential request claim 1 , the record including at least a portion of the client metadata.3. The method of ...

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

This invention provides for a compound of formula (I): 143.-. (canceled)44. A compound , or a pharmaceutically acceptable salt thereof , selected from:1-(3,5-bis((Z)-octadec-9-en-1-yloxy)phenyl)-N,N-dimethylmethanamine;1-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)phenyl)-N,N-dimethylmethanamine;2,2′-((3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl)azanediyl)diethanol;1-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl)pyrrolidine;1-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl)azetidin-3-ol;ethyl 2-((3,5-bis((Z)-octadec-9-en-1-yloxy)benzyl)methyl)amino)acetate;1-(3,5-bis((Z)-octadec-9-en-1-yloxy)benzyl)pyrrolidine;2-((3,5-bis((Z)-octadec-9-en-1-yloxy)benzyl)(methyl)amino)acetic acid1-((2-(3,5-bis((Z)-octadec-9-en-1-yloxy)phenyl)-1,3-dioxolan-4-yl)methyl)pyrrolidine;1-(2-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)phenyl)-1,3-dioxolan-4-yl)-N,N-dimethylmethanamine;1-((2-(3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)phenyl)-1,3-dioxolan-4-yl)methyl)piperidine;(2-(3,5-bis((Z)-octadec-9-en-1-yloxy)phenyl)-1,3-dioxolan-4-yl)methyl 2-(dimethylamino)acetate;3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl 4-(dimethylamino)butanoate;3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl 3-(dimethylamino)propanoate;3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl 2-(dimethylamino)acetate;4-methyl-3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl 3-(dimethylamino)propanoate;3,5-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)benzyl 13-(dimethylamino)-2-methylpropanoate;2-(dimethylamino)ethyl 2,6-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)isonicotinate;3-(dimethylamino)propyl 2,6-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)isonicotinate;(9Z,9′Z,12Z,12′Z)-5-(((3-(dimethylamino)propanoyl)oxy)methyl)-1,3-phenylene bis(octadeca-9,12-dienoate);(9Z,9′Z,12Z,12′Z)-5-(((4-(dimethylamino)butanoyl)oxy)methyl)-1,3-phenylene bis(octadeca-9,12-dienoate);(2,6-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy)pyridin-4-yl)methyl 3-(diethylamino)propanoate;(2,6-bis((9Z,12Z)-octadeca-9,12-dien-1-yloxy) ...

3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

TIRE TREAD

A tire tread includes a plurality of circumferential grooves, each of the plurality extending continuously in a tire circumferential direction. The plurality of circumferential grooves define a circumferentially extending shoulder rib. The shoulder rib has a plurality of shoulder elements. Each shoulder element is defined by two lateral shoulder grooves. Each shoulder element has an axially outer shoulder element and a corresponding axially adjacent and axially inner shoulder element separated by a circumferential groove. The axially outer shoulder elements each have a pair of angled outer lateral S-shaped blind grooves extending axially away from the inner shoulder elements. 1. A tire tread comprises:a plurality of circumferential grooves, each of the plurality extending continuously in a tire circumferential direction,the plurality of circumferential grooves defining a circumferentially extending shoulder rib, the shoulder rib having a plurality of shoulder elements, each shoulder element being defined by two lateral shoulder grooves, each shoulder element having an axially outer shoulder element and a corresponding axially adjacent and axially inner shoulder element separated by a circumferential groove, the axially outer shoulder elements each having a pair of angled outer lateral S-shaped blind grooves extending axially away from the inner shoulder elements.2. The tire tread of wherein each of the outer lateral S-shaped blind grooves has a straight circumferential sipe extending circumferentially to a lateral shoulder groove.3. The tire tread of wherein each of the axially inner shoulder elements has two spaced apart inner lateral S-shaped blind grooves extending axially outward from one of the circumferential grooves.4. The tire tread of wherein each inner lateral S-shaped blind groove has a straight circumferential sipe extending circumferentially to the lateral shoulder groove.5. The tire tread of wherein the axial widths of the circumferential grooves ...

CATIONIC LIPID COMPOUNDS AND LIPID AND PHARMACEUTICAL COMPOSITIONS

COMPOSTOS DE LIPÍDIO CATIÔNICO, SEUS USOS, E COMPOSIÇÕES DE LIPÍDIOS E FAR-MACÊUTICAS. Esta invenção fornece um composto de fórmula (l): (I) ou um sal farmaceuticamente aceitável do mesmo, em que R1 - R4, L e X são definidos aqui. Os compostos de fórmula (l) e sais farmaceuticamente aceitáveis dos mesmos são lipídios catiôni-cos úteis na liberação de agentes biologicamente ativos às células e tecidos. CATIONIC LIPID COMPOUNDS, THEIR USES, AND LIPID AND PHARMACEUTICAL COMPOSITIONS. This invention provides a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R 1 - R 4 , L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in delivering biologically active agents to cells and tissues.

Organic compositions to treat hepcidin-related diseases

The present disclosure relates to methods of treating Hepcidin-related diseases such as anemia, iron-deficient erythropoiesis, hypoferremia, impaired dietary iron uptake, iron sequestration, anemia of inflammation (AI) (sometimes designated anemia of chronic disease or ACD), atherosclerosis, diabetes, and multiple neurodegenerative disorders such as Alzheimers disease, Parkinsons disease and Friedrichs ataxia, heart failure, chronic kidney disease, cardiorenal-anemia syndrome, infection, blood loss, hemolysis, vitamin B12 or folate deficiency, hyperparathyroidism, hemoglobinopathies and malignancies, cancer, AIDS, surgery, runted growth, and hair loss, using a therapeutically effective amount of a RNAi agent to Hepcidin.

Novel formats for organic compounds for use in rna interference

The disclosure relates to compositions comprising a RNAi agent having a novel format. These RNAi agents comprise a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3' end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. In some embodiments, the 3' end of both the sense and anti-sense strand further comprise, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3' end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the first two base-pairing nucleotides on the 3' end of the sense and/or anti-sense strand are 2'-MOE. Optionally, the RNAi agent can be modified on one or both 5' end. Optionally, the sense strand can comprise a 5' end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Novel formats for organic compounds for use in rna interference

The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent having a novel format: an 18-mer format with at least one internal spacer. These RNAi agents comprise a first and a second 18-mer strand, wherein the first strand is 18 ribonucleotides or 18 total ribonucleotides and spacer subunit(s), and the second strand is 18 total ribonucleotides and spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand; the two strands form a duplex with at least one blunt end; and the 3 end of one or both strands terminates in a phosphate or modified internucleoside linker and further comprises, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker, and a 3 end cap. In various embodiments, the RNAi agents comprise a first and a second strand, wherein each strand is a 30-mer or shorter, the first strand comprises ribonucleotides, and the second strand comprises ribonucleotides and one or more spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand. In some embodiments, the 3 end of both strands further comprise, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker; and a 3 end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3 end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the first two base-pairing nucleotides on the 3 end of the one or both strand are 2-MOE. Optionally, the RNAi agent can be modified on one or both 5 end. ...

3' end caps for rnai agents for use in rna interference

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Rnai compositions to treat apoc3-related diseases

Organic compositions to treat apoc3-related diseases

The present disclosure relates to compositions and methods for treating APOC3-related diseases such as: hypertriglyceridemia (e.g., Type V Hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including Type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a RNAi agent to APOC3.

Rnai compositions to treat apoc3-related diseases

The present disclosure relates to compositions and methods for treating APOC3-related diseases such as : hypertriglyceridemia (e.g., Type V Hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including Type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a RNAi agent to APOC3.

System and method for managing tools at a worksite

A method receiving image information with one or more processor(s) and from a sensor disposed at a worksite and determining an identity of a work tool disposed at the worksite based at least partly on the image information. The method further includes receiving location information with the one or more processor(s), the location information indicating a first location of the sensor at the worksite. Additionally, the method includes determining a second location of the work tool at the worksite based at least partly on the location information. In some instances, the method includes generating a worksite map with the one or more processor(s), the worksite map identifying the work tool and indicating the second location of the work tool at the worksite, and at least one of providing the worksite map to an additional processor and causing the worksite map to be rendered via a display.

Sieve screen deck

ABSTRACT A seive screen deck, the screen of which comprises a plurality of horizontal wedge wires connected to an array of backing bars running longitudinally of the screen parallel to its fall line. The screen is connected to a frame at its two ends, at least one end being connected by resilient means such that the screen may vibrate and flex under the influence of rapping or vibrating means. Side walls are provided along sides of the sieve screen, to prevent material flowing over sides of the screen, are also formed of a resilient material in order that they do not substatially impede the ability of the sieve screen to vibrate and flex under the influence of the rapping or vibrating means.

Conveyor system for vehicle

In one representative embodiment, a vehicle has a frame, a material hopper mounted on the frame, a swing arm assembly coupled to the frame, and a conveyor mounted on the swing arm assembly. The swing arm assembly can have a support bracket configured to pivot relative to the hopper about a vertical pivot axis, the support bracket also configured to pivot relative to the hopper about a horizontal pivot axis, wherein the support bracket is configured to support the conveyor for pivoting movement of the conveyor relative to the hopper about the vertical pivot axis and about the horizontal pivot axis to move the conveyor from a first, stowed position extending alongside one of the sides of the hopper to a second, use position extending rearwardly away from the rear end of the hopper.

3'end caps for rna-interferring agents for use in rna

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Method and apparatus for a light fixture having a security light and permanently mounted wall-washing leds

A light fixture (200) comprises a mounting fixture (501) that is configured and arranged to facilitate mounting the light fixture to a mounting surface other than ground along with at least a first light socket (502) and a plurality of permanently mounted light emitting diodes (LED's) (503). The light socket and the LED's are supported by the mounting fixture. The LED's are configured in an array and are oriented towards the mounting surface when the light fixture is installed on the mounting surface. This light fixture can further comprise an ambient light sensor (504), an animate object detector (505), and/or a timer (506). The wall-washing LED's can be switched on and off automatically (103) to provide the desired decorative effect during the evening hours. In addition, the light socket can be rendered controllable (105) as a function of whether it is dark out and whether an animate object has been detected.

Gaze swipe selection

Methods for enabling hands-free selection of virtual objects are described. In some embodiments, a gaze swipe gesture may be used to select a virtual object. The gaze swipe gesture may involve an end user of a head-mounted display device (HMD) performing head movements that are tracked by the HMD to detect whether a virtual pointer controlled by the end user has swiped across two or more edges of the virtual object. In some cases, the gaze swipe gesture may comprise the end user using their head movements to move the virtual pointer through two edges of the virtual object while the end user gazes at the virtual object. In response to detecting the gaze swipe gesture, the HMD may determine a second virtual object to be displayed on the HMD based on a speed of the gaze swipe gesture and a size of the virtual object.

Scavenging system including at least one mixed acetal compound to remove hydrogen sulfide and/or mercaptans from a fluid stream

A solution including at least one mixed acetal compound is used to remove hydrogen sulfide and/or mercaptans from a fluid stream, preferably a fluid gas stream. A mixed acetal compound, as provided in the general structure below, includes an N-glycosidic type bond. The mixed acetal includes nitrogen and oxygen as provided below.

Flask

Scavenging system including at least one mixed acetal compound to remove hydrogen sulfide and/or mercaptans from a fluid stream

A solution including at least one mixed acetal compound is used to remove hydrogen sulfide and/or mercaptans from a fluid stream, preferably a fluid gas stream. A mixed acetal compound, as provided in the general structure below, includes an N-glycosidic type bond. The mixed acetal includes nitrogen and oxygen as provided below:

Use of nanoparticles in cleaning well bores

Embodiments relate to removing residue from a well bore and well bore equipment with a treatment fluid composition, and in some embodiments, to treatment fluid compositions that comprise nanoparticles. An embodiment provides a method of removing drilling fluid residue from the surfaces of well equipment. The method comprising: applying a solid nanoparticle film to at least a portion of the surfaces of the well equipment with a treatment fluid comprising solid nanoparticles; and allowing the solid nanoparticles to interact with the surfaces of the well equipment and the drilling fluid residue adhered to the surfaces of the well equipment to remove at least a portion of the drilling fluid residue from the surfaces of the well equipment.

Method and system for inspecting a home for energy efficiency

A system is disclosed. The system includes a first information handling system (“IHS”) for receiving, via a user input, data associated with an inspection of a home for energy efficiency, and outputting the data to a network. The system also includes a second IHS for receiving the data from the network, and in response to the data, generating a report.

Double rapped sieve screen deck

A sieve screen deck for separating liquids from fine solids or for separating solid particles of different sizes, comprising a sieve screen supported on a frame and means to cause the screen to vibrate or flex. The invention is characterised in that the means to cause the sieve screen to vibrate or flex com­ prises first and second rapping or vibrating means the vibra­ tional or flexing motion induced in the sieve screen by the second means being substantially greater in amplitude and lower in frequency than the vibrational or flexing motion induced by the first means.

Endothermic base-mounted heat pump water heater.

Un calentador de agua de bomba de calor endotérmica tiene un tanque de agua soportado en la parte superior de una base hueca, un circuito de bomba de calor que puede operar para proporcionar calor primario al agua en el tanque, y un elemento calefactor de resistencia eléctrica que puede operar para proporcionar calor secundario al agua. El circuito de bomba de calor incluye una tubería de refrigerante en la cual se conectan en serie un compresor dispuesto dentro de la base, un condensador en contacto externo de intercambio térmico con el tanque, un dispositivo de expansión de refrigerante, y un evaporador dispuesto dentro de la base. Un conducto vertical, externo al tanque, tiene una entrada adyacente al extremo de tanque superior, y un ventilador es operativo para hacer fluir aire secuencial e internamente por la entrada, descendentemente a través del conducto dentro de la base, a través del compresor, a través del evaporador y después externamente desde la base.

Apparatus and methods for controlling an electronic expansion valve in a refrigerant circuit

A specially designed electronic expansion valve control system is provided for use with a refrigerant-based air conditioning circuit having a compressor, a condenser coil, an electronic expansion valve and an evaporator coil fluid coupled in series. The control system includes a unit control and an expansion valve control. The unit control is operative to receive compressor operation-related signal information and responsively generate at least one output signal representative of the received compressor operation-related signal information. The expansion valve control is operative to receive from the unit control only the at least one output signal, and to receive from one of the coils coil operation-related signal information, and to responsively output a control useable to control the expansion valve, the control signal being related in a predetermined manner to the signals received by the expansion valve control.

Ozone applicator and method for polymer oxidation

Apparatuses and methods are described for distributing gas which may be applicable in the field of polymer oxidation and melt curtain ozonation in particular. Ozone applicators and other features of ozonation apparatuses, which may be used separately or in combination, are also described.

Endothermic base-mounted heat pump water heater

An endothermic heat pump water heater has a water tank supported atop a hollow base, a heat pump circuit operable to provide primary heat to water in the tank, and an electric resistance heating element operable to provide secondary heat to the water. The heat pump circuit includes refrigerant tubing in which a compressor disposed within the base, a condenser in heat exchange external contact with the tank, a refrigerant expansion device, and an evaporator disposed within the base are connected in series. A vertical duct, external to the tank, has an inlet adjacent the upper tank end, and a fan is operative to sequentially flow air inwardly through the inlet, downwardly through the duct into the base, across the compressor, across the evaporator, and then outwardly from the base.

High release nip roll assembly.

Se describe aquí un montaje de rodillo de laminación de alta liberación, que comprende un rodillo de laminación con una cubierta que comprende un material de alta liberación. Las propiedades de liberación del material de rodillo de laminación pueden permitir contacto intermitente sin que el revestimiento se adhiera a la superficie del rodillo y que envuelva el punto de sujeción o la línea de contacto entre los rodillos. También se describe una banda de rodillo de laminación de alta liberación que se elabora de un material de alta liberación en la superficie superior e inferior de la banda. La banda puede ubicarse en cada extremo de un rodillo de laminación, de manera tal que áreas del rodillo de laminación típicamente vulnerables a contacto de material termoplástico fundido se protegen por una banda. También se describe un aparato para producción de banda. También se describe un montaje de bastidor para mover una banda longitudinalmente sobre un rodillo de laminación. También se describe un montaje de guía de cuerda para guiar una banda en relación a un rodillo de laminación y al menos un rodillo de banda.

Ozone applicator and method for polymer oxidation

Apparatuses and methods are described for distributing gas which may be applicable in the field of polymer oxidation and melt curtain ozonation in particular. Ozone applicators and other features of ozonation apparatuses, which may be used separately or in combination, are also described.

Bonding plastic floor pieces together

A method of bonding plastic floor pieces together includes several steps. One step involves laying plastic floor pieces near each other in order to produce a seam between neighboring plastic floor pieces. Another step involves cutting a groove into and along a part or more of the seam. Yet another step involves filling the groove with a bonding compound that can be composed of, among other constituents, methyl methacrylate.

Gate array structure having a plurality of programmable regions

【課題】カスタムＩＣをカスタマイズする際に必要なマスク数を削減する。 【解決手段】ウエハ上に設けた、カスタマイズ不可のマスク層を備えた第１の固定領域と、第１固定領域の上に設けた、カスタマイズ可能なマスク層を備えたプログラマブル領域と、を備えるカスタム集積回路を形成するためのシステムおよび方法であって、第１の固定領域は、ベースセルを形成する多数のトランジスタと、第１の相互接続層と、第１の相互接続層の上に設けた第２の相互接続層とを備える。プログラマブル領域のマスク層のうち少なくとも１層を第２の相互接続層と接続して、ベースセルのすべてのトランジスタノードへの電気的アクセスを可能にする。プログラマブル領域は、カスタマイズ可能なマスク層と接続する第３の相互接続層を備え、ＩＣをカスタマイズする。第２の固定領域をプログラム領域の上に形成し、固定領域を複数とする。 【選択図】図４

3'end caps for RNAi agents for use in RNA interference

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Gaze swipe selection

Methods for enabling hands-free selection of virtual objects are described. In some embodiments, a gaze swipe gesture may be used to select a virtual object. The gaze swipe gesture may involve an end user of a head-mounted display device (HMD) performing head movements that are tracked by the HMD to detect whether a virtual pointer controlled by the end user has swiped across two or more edges of the virtual object. In some cases, the gaze swipe gesture may comprise the end user using their head movements to move the virtual pointer through two edges of the virtual object while the end user gazes at the virtual object. In response to detecting the gaze swipe gesture, the HMD may determine a second virtual object to be displayed on the HMD based on a speed of the gaze swipe gesture and a size of the virtual object.

Chitin nanocrystal containing wellbore fluids

Chitin nanocrystal containing wellbore fluids

The current invention relates to the use of chitin nanocrystals and chitin nanocrystal derivatives. More specifically, the present invention relates to the use of chitin nanocrystals and chitin nanocrystals used in oil and gas operations. The chitin nanocrystals and chitin nanocrystals derivatives can be used as additives to cement and wellbore fluids and can be used to inhibit corrosion in pipelines, on downhole tools and on other oil and gas related equipment.

Method and apparatus for synchronizing display streams

Beauty tool head with flexible bristle base

A beauty tool includes a handle portion configured to house an associated heating assembly and a bristle portion connected to the handle portion. The bristle portion includes a primary heating element configured to be heated by the associated heating assembly. A bristle base heated member is mounted to an outer periphery of the heating element. The bristle base heated member has a secondary heating element configured to be heated by the primary heating element. A non-conductive, heat insulating bristle spacer is secured between the bristle base heated member and the heating element. A bristle bar is secured by the bristle spacer and has bristles extending through the bristle spacer and the bristle base heated member. The bristle spacer is configured to thermally isolate the bristle bar from both the heating element and the bristle base heated member.

Conductive metal-containing nucleic acids

The invention provides conductive polymers comprising metal-containing nucleic acid duplexes electrically coupled to an electron source. Methods for making conductive metal-containing nucleic acid duplexes are provided, comprising subjecting a nucleic acid duplex to basic conditions in the presence of a divalent metal cation. Methods of using conductive metal-containing nucleic acid duplexes are provided, including methods of genomic analysis, methods of molecular screening and immunological methods that produce antibodies to such molecules.

Tubular installation monitoring system and method

Embodiments of the disclosure include a casing installation monitoring system that monitors surface equipment (that is, equipment of a rig), provides information on casing installation operations (for example, hook load, torque, RPM, and cumulative fatigue) at various times and depths, provides initial casing installation guidelines, and provides alarms before and during the casing installation operation.