Antineoplastic transferrin and albumin conjugates of cytostatic compounds from the group of the anthracyclines, alkylating agents, antimetabolites and cisplatin analogues and medicaments containing them
Номер патента: DE19636889A1
Опубликовано: 12-03-1998
Автор(ы): Felix Dr Kratz
Принадлежит: Felix Dr Kratz
Опубликовано: 12-03-1998
Автор(ы): Felix Dr Kratz
Принадлежит: Felix Dr Kratz
Реферат: This invention concerns conjugates of transferrin, albumin and polyethylene glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approx. 5000 and 200 000) with at least one HS-, HO- or H2N group and cytostatic compounds derived through maleinimide or N-hydroxysuccinimide ester-compounds, such as doxorubicene, daunorubicene, epirubicene, idarubicene, mitoxandrone, chlorambucil, melphalan, 5-fluorouracyl, 5'-desoxy-5-fluorouridene, thioguanine, methotrexate, paclitaxel, docetaxel, topotecan, 9-aminocamptothecene, etoposide, teniposide, mitopodoside, vinblastine, vincristine, vindesine, vinorelbin or a compound of general formula A, B, C or D, where n = 0-6, X = -NH2, -OH, -COOH, -O-CO-R-COR*, -NH-CO-R-COR*, where R is an aliphatic carbon chain with 1-6 carbon atoms or a substituted or unsubstitued phenylene group and R* H, phenyl, alkyl with 1-6 carbon atoms.
Conjugates of antibody and functional substance or salts thereof, and compounds used in production of the same or salts thereof
Номер патента: CA3222015A1. Автор: Yutaka Matsuda,Tomohiro Fujii,Ryusuke Hirama,Tomohiro Watanabe,Thomas Markotan,Christopher Wong,Konstantinos PLAKAS,Allan Prior. Владелец: Ajinomoto Co Inc. Дата публикации: 2022-12-08.