Variants of the group-5 allergens of the poaceae with reduced allergenicity by mutagenesis of proline residues
Номер патента: EP2523685A1
Опубликовано: 21-11-2012
Автор(ы): Andreas Nandy, Bernhard Weber, Gerald Reese, Helga Kahlert, Helmut Fiebig, Martin Wald, Oliver Cromwell
Принадлежит: Merck Patent GmBH
Опубликовано: 21-11-2012
Автор(ы): Andreas Nandy, Bernhard Weber, Gerald Reese, Helga Kahlert, Helmut Fiebig, Martin Wald, Oliver Cromwell
Принадлежит: Merck Patent GmBH
Реферат: The present invention relates to the preparation and the use of recombinant variants of the group-5 allergens of the poaceae which are characterized by the fact that their IgE reactivity is reduced in comparison with the known wild-type allergens while simultaneously the reactivity with T-lyphocytes is largely retained.
Variants of group 5 allergens of cereals with reduced allergenicity due to mutagenesis of proline residues
Номер патента: RU2658767C1. Автор: Хельмут ФИБИГ,Андреас НАНДИ,Мартин ВАЛЬД,Бернхард ВЕБЕР,Хельга КАЛЕРТ,Геральд РЕЗЕ,Оливер КРОМВЕЛЛЬ. Владелец: Мерк Патент Гмбх. Дата публикации: 2018-06-22.