A method for preventing the formation of a crystalline hydrate in a dispersion of liquid in a nonaqueous matrix
Номер патента: IE61680B1
Опубликовано: 16-11-1994
Автор(ы): Arnold Kaufman, David J Enscore, Patricia S Campbell, Robert M Gale
Принадлежит: Alza Corp
Опубликовано: 16-11-1994
Автор(ы): Arnold Kaufman, David J Enscore, Patricia S Campbell, Robert M Gale
Принадлежит: Alza Corp
Реферат: A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.
Transdermal therapeutical system for preventing poisoning by organophosphoric neurotoxins that consists of a combination of active substances including a parasympathomimetric and a parasympatholytic agent
Номер патента: CA2178603C. Автор: Bodo Asmussen,Walter Müller,Thomas Hille. Владелец: LTS Lohmann Therapie Systeme AG. Дата публикации: 2005-08-09.