Process to chloroketones using oxazolines
Номер патента: CA2233792A1
Опубликовано: 15-10-1998
Автор(ы): Heather Lynnette Rayle, Randall Wayne Stephens, Renee Caroline Roemmele
Принадлежит: Rohm and Haas Co
Опубликовано: 15-10-1998
Автор(ы): Heather Lynnette Rayle, Randall Wayne Stephens, Renee Caroline Roemmele
Принадлежит: Rohm and Haas Co
Реферат: This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (see.fig.I) (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate (see fig.II) and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone (see fig.III) wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1 and R2 are each independently an alkyl or substituted alkyl group, or R1 and R2 together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.
Process to chloroketones using oxazolines
Номер патента: US5936096A. Автор: Randall Wayne Stephens,Renee Caroline Roemmele,Heather Lynnette Rayle. Владелец: Rohm and Haas Co. Дата публикации: 1999-08-10.