L-n-n-propylipecolic acid-2,6-xylidide and method for preparing the same.
Номер патента: MY101904A
Опубликовано: 15-02-1992
Автор(ы): Af Ekenstam Bo Thuresson, Christer Bovin
Принадлежит: Astra Laekemedel Ab
Опубликовано: 15-02-1992
Автор(ы): Af Ekenstam Bo Thuresson, Christer Bovin
Принадлежит: Astra Laekemedel Ab
Реферат: (FORMULA. 1) THE LOCAL ANESTHETIC, L-N-N PROPYLIPECOLIC ACID- 2, 6-XYLIDIDE OF FORMULA (1).THIS COMPOUND IS PREPARED BY CHLORINATING L-PIPECOLIC ACID TO YIELD ACID CHLORIDE, NAMELY L-PIPECOLIC ACID CHLORIDE. THE ACID CHLORIDE IS THEN REACTED WITH 2, 6-XYLIDINE TO YIELD L- PIPECOLIC ACID 2, 6-XYLIDIDE. THE L-N-PIPECOLIC ACID-2,6-XYLIDIDE IS THEN PROPYLATED TO YIELD THE L-N-N- PROPYLPIPECOLIC ACID -2, 6- ZYLIDIDE, WHICH IS A POTENT LOCAL ANESTHETIC FOR MAMMALS INCLUDING MAN AND IS OF RELATIVELY LOW TOXICITY.
Processes for preparing (3r,4r)-1-benzyl-n,4-dimethylpiperidin-3-amine or a salt thereof and processes for preparing tofacitinib using the same
Номер патента: EP3927689A1. Автор: Ji-hye CHOI,Sung-Hee Cho,Sang-Won Kim,Doo-Byung Lee,Sang-Ho Oh,Su-Young Lee,Kyoung-Chan Kwon,Hyo-Ick HWANG,Kyeong-Sill LEE,Ik-Su JO. Владелец: Yuhan Corp . Дата публикации: 2021-12-29.