Timing of logged molecular events
Номер патента: EP3478834A2
Опубликовано: 08-05-2019
Автор(ы): Kris K. Ganjam
Принадлежит: Microsoft Technology Licensing LLC
Опубликовано: 08-05-2019
Автор(ы): Kris K. Ganjam
Принадлежит: Microsoft Technology Licensing LLC
Реферат: A log of molecular events experienced by a cell and timing indicators for those events are stored in existing polynucleotides through a process of creating a double strand break ("DSB") in a polynucleotide and inserting a new polynucleotide sequence by repairing the DSB with homology directed repair ("HDR"). The presence, order, and number of new polynucleotide sequences provides a log of events and timing of those events. Cellular mechanisms for creating the DSB and/or repairing with HDR are regulated by intra- or extra-cellular signals. When the log is created in the DNA of a cell, the changes may be heritably passed to subsequent generations of the cell. A correlation between the cellular signals and sequence of inserted HDR templates allows for identification of events and the timing experienced by the cell.
Timing of logged molecular events
Номер патента: EP3636758A1. Автор: Kris Ganjam. Владелец: Microsoft Technology Licensing LLC. Дата публикации: 2020-04-15.